BETH Study: Treatment of HER2 Positive Breast Cancer With Chemotherapy Plus Trastuzumab vs Chemotherapy Plus Trastuzumab Plus Bevacizumab
BETH
A Multicenter Phase III Randomized Trial of Adjuvant Therapy for Patients With HER2-Positive Node-Positive or High Risk Node-Negative Breast Cancer Comparing Chemotherapy Plus Trastuzumab With Chemotherapy Plus Trastuzumab Plus Bevacizumab
4 other identifiers
interventional
3,509
37 countries
595
Brief Summary
The trial will determine the value of adding bevacizumab to chemotherapy plus trastuzumab in patients with resected node-positive or high risk node-negative, HER2-positive breast cancer.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3 breast-cancer
Started Apr 2008
Typical duration for phase_3 breast-cancer
595 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 21, 2008
CompletedFirst Posted
Study publicly available on registry
February 29, 2008
CompletedStudy Start
First participant enrolled
April 1, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2014
CompletedSeptember 10, 2020
March 1, 2020
5.2 years
February 21, 2008
September 9, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Invasive Disease-free Survival (IDFS)
up to 10 years
Secondary Outcomes (8)
Invasive disease-free survival (IDFS) within chemotherapy cohorts
up to 10 years
Disease-free survival (DFS)
up to 10 years
Overall survival (OS)
Time from randomization until death from any cause or up to a maximum of 10 years from study entry
Recurrence-free interval (RFI)
Time from randomization until local, regional or distant recurrence or up to a maximum of 10 years from study entry
Distant recurrence-free interval (DRFI)
Time from randomization until distant disease recurrence only or up to a maximum of 10 years from study entry
- +3 more secondary outcomes
Study Arms (4)
1A: TCH-H
ACTIVE COMPARATORDocetaxel (T), Carboplatin (C), and Trastuzumab (H) followed by Trastuzumab (H)
1B: TCHB-HB
EXPERIMENTALDocetaxel (T), Carboplatin (C), Trastuzumab (H), Bevacizumab (B) followed by Trastuzumab (T) and Bevacizumab (B)
2A: TH-FEC-H
ACTIVE COMPARATORDocetaxel (T) and Trastuzumab (H) followed by 5-fluorouracil (F), Epirubicin (E), and Cyclophosphamide (C) followed by Trastuzumab (H)
2B: THB-FEC-HB
EXPERIMENTALDocetaxel (T), Trastuzumab (H), and Bevacizumab (B) followed by 5-Fluorouracil (F), Epirubicin (E), and Cyclophosphamide (C) followed by Trastuzumab (H) and Bevacizumab (B)
Interventions
75 mg/m2 IV on day 1 every 3 weeks for cycles 1-6, Arms 1A and 1B 100 mg/m2 on day 1 every 3 weeks for cycles 1-3, Arms 2A and 2B
First dose: 8 mg/kg IV on day 1 of cycle 1 only. Subsequent doses: 6 mg/kg IV on day 1 every 3 weeks for cycles 2-6. Following completion of chemotherapy cycles: 6 mg/kg IV every 3 weeks until 1 year following first trastuzumab dose. Arms 1A and 1B First dose: 8 mg/kg IV on day 1 of cycle 1 only. Subsequent doses: 6 mg/kg IV on day 1 every 3 weeks for cycles 2-3. 21 days after last dose of FEC: 8 mg/kg IV first post-FEC dose only; subsequent doses 6 mg/kg IV every 3 weeks for a total of 1 year. Arms 2A and 2B
15 mg/kg IV on day 1 every 3 weeks for cycles 1-6. Following completion of chemotherapy cycles: 15 mg/kg IV on day 1 every 3 weeks until 1 year following first bevacizumab dose. Arm 1B 15 mg/kg IV on day 1 every 3 weeks for cycles 1-3. 21 days after the last dose of FEC: 15 mg/kg IV on day 1 every 3 weeks until 1 year following first bevacizumab dose. Arm 2B
Eligibility Criteria
You may qualify if:
- Life expectancy of at least 10 years, excluding their diagnosis of breast cancer.
- Women who have had breast reconstruction utilizing tissue expanders must be in agreement with delaying surgery to replace the tissue expanders with permanent implants until 3 months following the last dose of bevacizumab
- Women of reproductive potential must agree to use an effective non-hormonal method of contraception (for example condoms, some intrauterine devices, diaphragms, vasectomized partner, or abstinence) during therapy and for at least 6 months after the last dose of bevacizumab and/or trastuzumab.
- Submission of tumor samples from the breast surgery for central HER2 testing is required for all patients prior to enrollment in the BETH Trial
- Signed and dated IRB/EC-approved consent
- ECOG performance status of 0 or 1
- The tumor must be unilateral invasive adenocarcinoma of the breast on histologic examination.
- The breast cancer must be HER2-positive based on test results as follows: Local testing (if available) should demonstrate that the tumor is IHC 2+ or 3+ or is considered to be HER2-positive for gene amplification by FISH, CISH, or other in situ hybridization (ISH) method. If local ISH test results are considered equivocal, the tumor can be submitted for central HER2 testing. (If local testing is not possible, the tumor can be submitted for central HER2 testing.) Central testing (a requirement for ALL patients) must demonstrate that the tumor is HER2-positive which is defined as FISH-positive and/or IHC 3+.
- All of the following staging criteria (according to the 6th edition of the AJCC Cancer Staging Manual) must be met: By pathologic evaluation, primary tumor must be pT1-3; By pathologic evaluation, ipsilateral nodes must be pN0, pN1 (pN1mi, pN1a, pN1b, pN1c), pN2a, pN3a, or pN3b. If pN0, at least one of the following criteria must be met: Pathologic tumor size \> 2.0 cm; ER negative and PgR negative; Histologic and/or nuclear grade 2 (intermediate) or 3 (high); or Age \< 35 years
- Patients must have undergone either a total mastectomy or breast conserving surgery (lumpectomy).
- For patients who undergo lumpectomy, the margins of the resected specimen must be histologically free of invasive tumor and ductal carcinoma in situ (DCIS) as determined by the local pathologist. If pathologic examination demonstrates tumor at the line of resection, additional operative procedures may be performed to obtain clear margins. If tumor is still present at the resected margin after re-excision(s), the patient must undergo total mastectomy to be eligible. (Patients with margins positive for lobular carcinoma in situ \[LCIS\] are eligible without additional resection.)
- For patients who undergo mastectomy, margins must be free of gross residual tumor. Patients with microscopic positive margins are eligible.
- Patients must have completed one of the following procedures for evaluation of pathologic nodal status: Sentinel lymphadenectomy followed by removal of additional non-sentinel lymph nodes if the sentinel node (SN) is positive; Sentinel lymphadenectomy alone if pathologic nodal staging based on sentinel lymphadenectomy is pN0, pN1mi or pN1b; or Axillary lymphadenectomy without SN isolation procedure.
- The interval between the last surgery for breast cancer (treatment or staging) and randomization must be at least 28 days but no more than 84 days.
- Patients must have ER analysis performed on the primary tumor prior to randomization. If ER analysis is negative, then PgR analysis must also be performed.
- +6 more criteria
You may not qualify if:
- Inflammatory breast cancer.
- Definitive clinical or radiologic evidence of metastatic disease. (Chest imaging \[mandatory for all patients\] and other imaging \[if required\] must have been performed within 3 months prior to randomization.)
- Synchronous or previous contralateral invasive breast cancer (Patients with synchronous or previous contralateral DCIS or LCIS are eligible).
- History of ipsilateral invasive breast cancer regardless of treatment or ipsilateral DCIS treated with excision and RT. (Patients with history of ipsilateral LCIS are eligible.)
- History of non-breast malignancies within the 5 years prior to study entry, except for the following: carcinoma in situ of the cervix, carcinoma in situ of the colon, melanoma in situ, and basal cell and squamous cell carcinomas of the skin.
- Previous therapy with anthracyclines, taxanes, carboplatin, trastuzumab, or bevacizumab for any malignancy.
- RT, chemotherapy, and/or targeted therapy, administered for the currently diagnosed breast cancer prior to randomization.
- Continued therapy with any hormonal agent such as raloxifene or tamoxifen (or other SERM) or an aromatase inhibitor. (Patients are eligible if these medications are discontinued prior to randomization.)
- Any sex hormonal therapy, e.g., birth control pills, ovarian hormone replacement therapy, etc. Patients are eligible if these medications are discontinued prior to randomization.
- Cardiac disease (history of and/or active disease) that would preclude the use of the drugs included in the treatment regimens. This includes but is not confined to: Active cardiac disease - angina pectoris that requires the use of anti-anginal medication; ventricular arrhythmias except for benign premature ventricular contractions; supraventricular and nodal arrhythmias requiring a pacemaker or not controlled with medication; conduction abnormality requiring a pacemaker; valvular disease with documented compromise in cardiac function; and symptomatic pericarditis. History of cardiac disease - myocardial infarction documented by elevated cardiac enzymes or persistent regional wall abnormalities on assessment of LV function; history of documented CHF; and documented cardiomyopathy.
- Uncontrolled hypertension defined as systolic blood pressure (BP) \> 150 mmHg or diastolic BP \> 90 mmHg, with or without anti-hypertensive medication. (BP must be assessed within 28 days prior to randomization.) Patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria.
- History of hypertensive crisis or hypertensive encephalopathy.
- History of TIA or CVA.
- History of any arterial thrombotic event within 12 months before randomization.
- Symptomatic peripheral vascular disease.
- +19 more criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- NSABP Foundation Inclead
- Cancer International Research Group (CIRG)collaborator
- Hoffmann-La Rochecollaborator
- Genentech, Inc.collaborator
Study Sites (649)
University of Alabama at Birmingham
Birmingham, Alabama, 35294, United States
Clearview Cancer Institute-Decatur
Decatur, Alabama, 35601, United States
Clearview Cancer Institute
Huntsville, Alabama, 35801, United States
Clearview Cancer Institute- Huntsville
Huntsville, Alabama, 35805, United States
Northern Arizona Hematology & Onclogy Associates
Flagstaff, Arizona, 86001, United States
Northern Arizona Hematology & Oncology Associates
Sedona, Arizona, 86336, United States
Central Hematology/Oncology Medical Group, Inc.
Alhambra, California, 91801, United States
Comprehensive Blood and Cancer Center
Bakersfield, California, 93309, United States
Kaiser Permanente-Baldwin Park
Baldwin Park, California, 91706, United States
Kaiser Permanente-Bellflower
Bellflower, California, 90706, United States
Providence Saint Joseph Medical Center
Burbank, California, 91505, United States
Hematology-Encinitas
Encinitas, California, 92024, United States
Scripps Clinic Encinitas
Encinitas, California, 92024, United States
Kaiser Permanente-Fontana
Fontana, California, 92335, United States
St. Jude Heritage Healthcare
Fullerton, California, 92835, United States
Breastlink Medical Group, Inc
Hawthorne, California, 90250, United States
Pacific Shores Medical Group
Huntington Beach, California, 92648, United States
Kaiser Permanente-Irvine
Irvine, California, 92618, United States
Hematology-La Jolla
La Jolla, California, 92037, United States
Sabina R. Wallach, MD., AMC
La Jolla, California, 92037, United States
Scripps Cancer Center-San Diego
La Jolla, California, 92037, United States
Antelope Valley Cancer Center
Lancaster, California, 93534, United States
Kaiser Permanente-Sunset
Los Angeles, California, 90027, United States
Kaiser Permanente-West Los Angeles
Los Angeles, California, 90034, United States
Kaiser Permanente-Oakland
Oakland, California, 94611, United States
North County Oncology Medical Clinic, Inc.
Oceanside, California, 92056, United States
Kaiser Permanente-Panorama City
Panorama City, California, 91042, United States
Kaiser Permanente-Orange County
Panorama City, California, 92807, United States
Wilshire Oncology Medical Group
Pasadena, California, 91750, United States
Cancer Care Associates Medical Group, Inc.
Redondo Beach, California, 90277, United States
Kaiser Permanente-Riverside
Riverside, California, 92505, United States
Kaiser Permanente-Roseville
Roseville, California, 95661, United States
Sutter Roseville Medical Center
Roseville, California, 95661, United States
Kaiser Permanente-Sacramento
Roseville, California, 95825, United States
Sutter Medical Center
Sacramento, California, 95816, United States
Sutter Medical Group
Sacramento, California, 95816, United States
Peter T. Reissman, MD, Inc
San Diego, California, 92103, United States
William Stanton, MD, Inc
San Diego, California, 92103, United States
Kaiser Permanente-San Diego
San Diego, California, 92120, United States
Sharp Rees-Stealy
San Diego, California, 92123, United States
Scripps Clinic-Rancho Bernardo
San Diego, California, 92128, United States
Kaiser Permanente-San Francisco
San Francisco, California, 94115, United States
Kaiser Permanente-Hayward
San Francisco, California, 94545, United States
Sansum Clinic
Santa Barbara, California, 93105, United States
Santa Barbara Hematology Oncology Medical Group
Santa Barbara, California, 93105, United States
Kaiser Permanente-Santa Clara
Santa Clara, California, 95051, United States
Central Coast Medical Oncology Corporation
Santa Maria, California, 93454, United States
Kaiser Permanente-South San Francisco
South San Francisco, California, 94080, United States
Stanford University Medical Center
Stanford, California, 94305, United States
UCLA/Santa Clarita Valley Cancer Center
Valencia, California, 91355, United States
Kaiser Permanente-Vallejo
Vallejo, California, 94589, United States
San Diego Pacific Oncology & Hematology-Vista
Vista, California, 92803, United States
Kaiser Permanente-Walnut Creek
Walnut Creek, California, 94596, United States
Kaiser Permanente-Woodland Hills
Woodland Hills, California, 91367, United States
University of Colorado Cancer Center
Aurora, Colorado, 80045, United States
Penrose Cancer Center
Colorado Springs, Colorado, 80907, United States
Kaiser Permanente-Franklin
Denver, Colorado, 80205, United States
Cypress Hematology/Oncology
Denver, Colorado, 80210, United States
Rocky Mountain Cancer Center - Midtown
Denver, Colorado, 80218, United States
CCOP-Colorado Cancer Research Prog. Inc.(Administrative Only)
Denver, Colorado, 80224, United States
Shaw Regional Cancer Center
Edwards, Colorado, 81632, United States
North Colorado Medical Center
Greeley, Colorado, 80631, United States
Kaiser Permanente Rock Creek
Lafayette, Colorado, 80026, United States
McKee Medical Center
Loveland, Colorado, 80538, United States
Exempla Lutheran Medical Center
Wheat Ridge, Colorado, 80033, United States
Oncology Associates P.C.-Avon
Avon, Connecticut, 06001, United States
Medical Specialists of SWIM
Bridgeport, Connecticut, 06606, United States
Bridgeport Hospital
Bridgeport, Connecticut, 06610, United States
Medical Specialists of Fairfield
Fairfield, Connecticut, 06824, United States
Oncology Associates of Bridgeport-Fairfield
Fairfield, Connecticut, 06824, United States
Hartford Hospital
Hartford, Connecticut, 06102, United States
Connecticut Multi Specialty Group-Hartford
Hartford, Connecticut, 06106, United States
Oncology Associates P.C.-Hartford
Hartford, Connecticut, 06106, United States
Medical Oncology and Hematology, P.C.
Meriden, Connecticut, 06451, United States
Eastern Connecticut Hematology & Oncology Associates
Norwich, Connecticut, 06360, United States
Black Rock Medical Group
Trumbull, Connecticut, 06611, United States
Oncology Associates of Bridgeport-Trumbull
Trumbull, Connecticut, 06611, United States
Medical Oncology & Hematology, P.C.
Waterbury, Connecticut, 06708, United States
Connecticut Multi Specialty Group-Wethersfield
Wethersfield, Connecticut, 06109, United States
Oncology Associates P.C.-Willimantic
Willimantic, Connecticut, 06226, United States
CCOP, Christiana Care Health Services Inc.
Newark, Delaware, 19718, United States
Washington Cancer Institute
Washington D.C., District of Columbia, 20010, United States
Sibley Memorial Hospital
Washington D.C., District of Columbia, 20016, United States
Washington Oncology-Hematology Center, PC-Washington
Washington D.C., District of Columbia, 20037, United States
Lynn Cancer Institute
Boca Raton, Florida, 33428, United States
Florida Cancer Specialists-Bonita Springs
Bonita Springs, Florida, 34135, United States
Florida Cancer Specialists-Bradenton
Bradenton, Florida, 34209, United States
Florida Cancer Specialists, Brandon
Brandon, Florida, 33511, United States
Florida Cancer Specialists-Cape Coral Parkway
Cape Coral, Florida, 33914, United States
Florida Cancer Specialists-Cape Coral Del Prado
Cape Coral, Florida, 33990, United States
Florida Cancer Specialists
Clearwater, Florida, 33756, United States
Florida Cancer Specialists-Englewood
Englewood, Florida, 34223, United States
Florida Cancer Specialists-Fort Myers Broadway
Fort Myers, Florida, 33901, United States
Florida Cancer Specialists-Fort Myers Summerlin
Fort Myers, Florida, 33908, United States
Robert R. Carroll, MD, PA
Gainesville, Florida, 32605, United States
Integrated Community Oncology Network
Jacksonville, Florida, 32258, United States
Lakeland Regional Cancer Center
Lakeland, Florida, 33805, United States
Florida Cancer Specialists-Naples Goodlette
Naples, Florida, 34102, United States
Florida Cancer Specialists-NAPA Ridge
Naples, Florida, 34119, United States
Integrated Community Oncology Network
Orange Park, Florida, 32073, United States
Florida Hospital Cancer Institute
Orlando, Florida, 32804, United States
Florida Cancer Specialists, Cornerstone
Palm Harbor, Florida, 34684, United States
Florida Cancer Specialists-Port Charlotte
Port Charlotte, Florida, 33980, United States
Florida Cancer Specialist-Cattleman
Sarasota, Florida, 34232, United States
Florida Cancer Specialists-Downtown
Sarasota, Florida, 34236, United States
Florida Cancer Specialists-Park Place
St. Petersburg, Florida, 33756, United States
Florida Cancer Specialists
Tampa, Florida, 33603, United States
Florida Cancer Specialists
Tampa, Florida, 33614, United States
Florida Cancer Specialists-Venice Island
Venice, Florida, 34285, United States
Florida Cancer Specialists-Venice
Venice, Florida, 34292, United States
Palm Beach Cancer Institute
West Palm Beach, Florida, 33401, United States
Phoebe Putney Memorial Hospital
Albany, Georgia, 31701, United States
Northeast Georgia Cancer Care, LLC
Athens, Georgia, 30607, United States
Grady Healthsystem
Atlanta, Georgia, 30303, United States
Emory University
Atlanta, Georgia, 30322, United States
Augusta Oncology Associates
Augusta, Georgia, 30901, United States
Northwest Georgia Oncology Centers PC
Austell, Georgia, 30106, United States
Northwest Georgia Oncology Centers PC
Carrollton, Georgia, 30117, United States
Northwest Georgia Oncology Centers PC
Cartersville, Georgia, 30121, United States
Suburban Hematology-Oncology Associates
Lawrenceville, Georgia, 30045, United States
Central Georgia Cancer Care
Macon, Georgia, 31201, United States
Georgia Cancer Specialists
Macon, Georgia, 31217, United States
Georgia Cancer Specialists
Marietta, Georgia, 30060, United States
Suburban Hematology Oncology Associates PC
Snellville, Georgia, 30078, United States
Oncare Hawaii, Inc-POB2
Honolulu, Hawaii, 96813, United States
Straub Clinic and Hospital
Honolulu, Hawaii, 96813, United States
University of Hawaii
Honolulu, Hawaii, 96813, United States
Oncare Hawaii, Inc-KMP
Honolulu, Hawaii, 96817, United States
Kootenai Cancer Center
Coeur d'Alene, Idaho, 83814, United States
Mountain States Tumor Institute
Meridian, Idaho, 83642, United States
Mountain States Tumor Institute
Twin Falls, Idaho, 83301, United States
Cancer Care & Hematology Specialists of Chicagoland
Arlington, Illinois, 60005, United States
MBCCOP, John H. Stroger, JR., Hospital of Cook County-Chicago
Chicago, Illinois, 60612, United States
Rush University Medical Center
Chicago, Illinois, 60612, United States
Crossroads Cancer Center
Decatur, Illinois, 62401, United States
Cancer Care Specialists-Central Illinois
Decatur, Illinois, 62526, United States
Decatur Memorial Hospital
Decatur, Illinois, 62526, United States
Edward Hospital
Naperville, Illinois, 60540, United States
Edward Cancer Center Plainfield
Plainfield, Illinois, 60585, United States
Cancer Care and Hematology Specialists of Chicagoland
Winfield, Illinois, 60190, United States
Yorkville Family Practice
Yorkville, Illinois, 60560, United States
Cancer Care of Southern Indiana
Bloomington, Indiana, 47403, United States
Corydon Hospital Medical Plaza
Corydon, Indiana, 47112, United States
Elkhart Clinic
Elkhart, Indiana, 46514, United States
Michiana Hematology-Oncology, P.C. (Elkhart)
Elkhart, Indiana, 46514, United States
Waverly Hematology Oncology
Gary, Indiana, 27518, United States
Clark Medical Building
Jeffersonville, Indiana, 47130, United States
Howard Regional Health System
Kokomo, Indiana, 46904, United States
Michiana Hematology-Oncology, P.C. (LaPorte)
La Porte, Indiana, 46350, United States
Cancer Care Center
New Albany, Indiana, 47150, United States
Michiana Hematology-Oncology PC
Plymouth, Indiana, 46563, United States
Oncology, P.C. Plymouth
Plymouth, Indiana, 46563, United States
South Bend Clinic
South Bend, Indiana, 46117, United States
Michiana Hematology-Oncology, P.C. (Main Office)
South Bend, Indiana, 46601, United States
Northern Indiana Cancer Research Consortium
South Bend, Indiana, 46601, United States
Michiana Hematology-Oncology, P.C. Cedar St.
South Bend, Indiana, 46617, United States
Providence Medical Group
Terre Haute, Indiana, 47802, United States
Hematology and Medical Oncology Consultants-Bettendorf
Bettendorf, Iowa, 52722, United States
Hematology and Medical Oncology Consultants-Davenport
Davenport, Iowa, 52804, United States
University of Iowa
Iowa City, Iowa, 52242, United States
Lawrence Memorial Hospital
Lawrence, Kansas, 66044, United States
University of Kentucky Medical Center
Lexington, Kentucky, 40536, United States
NortonHealthcare Pavillion
Louisville, Kentucky, 40202, United States
Norton Medical Plaza II
Louisville, Kentucky, 40207, United States
Norton Medical Plaza West
Louisville, Kentucky, 40217, United States
Old Brownsboro Crossing
Louisville, Kentucky, 40241, United States
Baton Rouge General Medical Center
Baton Rouge, Louisiana, 70806, United States
Eastern Maine Medical Center
Bangor, Maine, 04401, United States
Mercy Medical Center
Baltimore, Maryland, 21202, United States
Greater Baltimore Medical Center
Baltimore, Maryland, 21204, United States
Franklin Square Hospital Center
Baltimore, Maryland, 21237, United States
Harry & Jeannette Weinberg Cancer Institute
Baltimore, Maryland, 21237, United States
Hematology-Oncology Associates
Baltimore, Maryland, 21237, United States
Carolyn Hendricks, MD
Bethesda, Maryland, 20817, United States
Suburban Hospital
Bethesda, Maryland, 20817, United States
The Office of Frederik Smith
Chevy Chase, Maryland, 20815, United States
Washington Oncology-Hematology Center, PC-Chevy Chase
Chevy Chase, Maryland, 20815, United States
Associates in Oncology/Hematology
Rockville, Maryland, 20850, United States
Peninsula Regional Oncology & Hematology
Salisbury, Maryland, 20817, United States
Peninsula Regional Medical Center
Salisbury, Maryland, 21801, United States
Holy Cross Hospital
Silver Spring, Maryland, 20910, United States
Oncology Care Associates
Wheaton, Maryland, 20902, United States
Berkshire Hematology Oncology, P.C.-North Adams
North Adams, Massachusetts, 01247, United States
Berkshire Hematology Oncology, P.C.
Pittsfield, Massachusetts, 01201, United States
Bixby Medical Center
Adrian, Michigan, 49221, United States
CCOP, St. Joseph Mercy Hospital
Ann Arbor, Michigan, 48106, United States
Battle Creek Health System
Battle Creek, Michigan, 49016, United States
Bay Regional Medical Center
Bay City, Michigan, 48706, United States
Dr. Cook and Abramson - Bay City
Bay City, Michigan, 48706, United States
St. Joseph Mercy Woodland Health Center
Brighton, Michigan, 48114, United States
Josephone Ford Cancer Center
Brownstown, Michigan, 48183, United States
Henry Ford Medical Center-Fairlane
Dearborn, Michigan, 48126, United States
Henry Ford Hospital
Detroit, Michigan, 48202, United States
UP Hematology/Oncology Assoc.-Doctor's Park Family Physicians
Escanaba, Michigan, 49829, United States
CCOP Hurley Medical Center
Flint, Michigan, 48503, United States
Genesys Hurley
Flint, Michigan, 48503, United States
Sing and Arora
Flint, Michigan, 48532, United States
Genesys Regional Medical Center
Grand Blanc, Michigan, 48439, United States
Grand Rapids Clinical Oncology Program
Grand Rapids, Michigan, 49503, United States
Spectrum Health Hospitals
Grand Rapids, Michigan, 49503, United States
St. Mary's Health Services
Grand Rapids, Michigan, 49503, United States
CCOP, St. John Hospital and Medical Center
Grosse Pointe Woods, Michigan, 19229, United States
Portage Internal Medical Associates
Hancock, Michigan, 49935, United States
UP Hematology/Oncology Associates
Iron Mountain, Michigan, 49801, United States
UP Hematology/Oncology Associates-Gogebic Range
Ironwood, Michigan, 49938, United States
West Michigan Cancer Center
Kalamazoo, Michigan, 49007, United States
Hematology/Oncology Associates of OH and MI, PC
Lambertville, Michigan, 48144, United States
CCOP, Sparrow Health System
Lansing, Michigan, 48909, United States
Michigan State University - Breslin Cancer Center
Lansing, Michigan, 48910, United States
Hematology Oncology-Lapeer
Lapeer, Michigan, 48446, United States
Lapeer Regional Hospital
Lapeer, Michigan, 48446, United States
Keewanaw Memorial Hospital
Laurium, Michigan, 49913, United States
St. Mary Mercy Hospital - Livonia
Livonia, Michigan, 48154, United States
Marquette General Hospital
Marquette, Michigan, 49855, United States
Upper Peninsula Hematology/Oncology Associates
Marquette, Michigan, 49855, United States
Community Cancer Care Specialists-Mt. Clemens
Mount Clemens, Michigan, 48043, United States
Mount Clemens Regional Medical Center
Mount Clemens, Michigan, 48043, United States
Hackley Hospital
Muskegon, Michigan, 49443, United States
Michiana Hematology-Oncology PC
Niles, Michigan, 49120, United States
CCOP, William Beaumont Hospital
Royal Oak, Michigan, 48073, United States
CCOP, St. Mary's Medical Center
Saginaw, Michigan, 48601, United States
Lakeside Cancer Specialists, PLLC
Saint Joseph, Michigan, 49085, United States
Michiana Hematology-Oncology, PC Lakeland
Saint Joseph, Michigan, 49085, United States
Chippewa Medical Associates
Sault Ste. Marie, Michigan, 49783, United States
Osteopathic Medical Oncology Hematology
Shelby, Michigan, 48315, United States
Munson Medical Center
Traverse City, Michigan, 49684, United States
CCOP, St. John Macomb Hospital
Warren, Michigan, 48093, United States
Henry Ford Medical Center-West Bloomfield
West Bloomfield, Michigan, 48322, United States
Metro Health Hospital
Wyoming, Michigan, 49519, United States
Minnesota Oncology Hematology-Burnsville
Burnsville, Minnesota, 55337, United States
Park Nicollet Clinic
Burnsville, Minnesota, 55337, United States
Hubert H. Humphrey Cancer Center - Coon Rapids
Coon Rapids, Minnesota, 55433, United States
Minnesota Oncology Hematology-Edina
Edina, Minnesota, 55435, United States
Fairview Southdale Medical Oncology Clinic
Edina, Minnesota, 55455, United States
Hubert H. Humphrey Cancer Center - Fridley
Fridley, Minnesota, 55432, United States
Minnesota Oncology Hematology PA - Maplewood
Maplewood, Minnesota, 55109, United States
Minnesota Oncology Hematology-Minneapolis
Minneapolis, Minnesota, 55407, United States
Hubert H. Humphrey Cancer Center-Robbinsdale
Robbinsdale, Minnesota, 55422, United States
Park Nicollet Health Services
Saint Louis Park, Minnesota, 55416, United States
Minnesota Hematology Oncology-St. Paul
Saint Paul, Minnesota, 55102, United States
Minnesota Oncology Hematology-Waconia
Waconia, Minnesota, 55387, United States
Minnesota Oncology Hematology
Woodbury, Minnesota, 55125, United States
University of Tennessee Cancer Institute
Southaven, Mississippi, 38671, United States
University of Missouri-Ellis Fischel
Columbia, Missouri, 65203, United States
Freeman Cancer Institute
Joplin, Missouri, 64804, United States
St. John's Regional Health Center-Joplin
Joplin, Missouri, 64804, United States
Saint Luke's Hospital
Kansas City, Missouri, 64111, United States
CCOP, Kansas City (Administrative Only)
Kansas City, Missouri, 64131, United States
St. John's Regional Health Center
Springfield, Missouri, 65805, United States
Cox Health Systems
Springfield, Missouri, 65807, United States
Hematology Oncology Centers of the Northern Rockies
Billings, Montana, 59101, United States
Comprehensive Cancer Centers of Nevada (Siena)
Henderson, Nevada, 89052, United States
University Medical Center of Southern Nevada
Las Vegas, Nevada, 89102, United States
Cancer and Blood Specialists- Shadow Lane
Las Vegas, Nevada, 89106, United States
Cancer Consultants
Las Vegas, Nevada, 89106, United States
Nevada Cancer Institute
Las Vegas, Nevada, 89135, United States
Renown Regional Medical Center
Reno, Nevada, 89502, United States
Alpine Hematology-Oncology
Reno, Nevada, 89503, United States
Summit Medical Group
Berkeley Heights, New Jersey, 07922, United States
Drs. Forte, Schleider, Attas and Condemi, PA
Englewood, New Jersey, 07631, United States
Cancer Institute of New Jersey at Hamilton
Hamilton, New Jersey, 08690, United States
Monmouth Medical Center
Long Branch, New Jersey, 07740, United States
Morristown Memorial Hospital
Morristown, New Jersey, 07960, United States
Cancer Institute of New Jersey
New Brunswick, New Jersey, 08901, United States
University of Medicine and Dentistry of New Jersey
Newark, New Jersey, 07103-2425, United States
Newark Beth Israel Medical Center
Newark, New Jersey, 07112, United States
Sparta Cancer Treatment Center
Sparta, New Jersey, 07871, United States
Overlook Hospital
Summit, New Jersey, 07901, United States
New York Oncology Hematology PC-Albany
Albany, New York, 12206, United States
NY Oncology Hematology PC at Albany Medical Center
Albany, New York, 12208, United States
Amsterdam Community Cancer Program
Amsterdam, New York, 12010, United States
Interlakes Oncology & Hematology, P.C.
Canandaigua, New York, 14424, United States
Hematology Oncology Assaociates of CNY, CCOP
East Syracuse, New York, 12010, United States
NY Oncology Hematology PC-Hudson Carvell Cancer Tx Prog.
Hudson, New York, 12534, United States
NY Oncology Hematology PC- Latham- Capital District Oncology Hematology
Latham, New York, 12110, United States
Beth Israel Medical Center
New York, New York, 10003, United States
St. Luke's-Roosevelt Hospital Center
New York, New York, 10019, United States
Riverview Cancer Care Medical Association
Rexford, New York, 12148, United States
Hematology Oncology Associates of CNY, CCOP
Rome, New York, 13440, United States
University Hospital and Medical Center - SUNY
Stony Brook, New York, 11794, United States
University Hospital and Medical Center-SUNY
Stony Brook, New York, 11794, United States
Hematology Oncology Assoc. of CNY, CCOP (Comm. General Hospital Satellite Office)
Syracuse, New York, 13215, United States
Troy Cancer Treatment Program
Troy, New York, 12180, United States
Cancer Care of Western North Carolina
Asheville, North Carolina, 28801, United States
CCOP, Mission Hospitals, Inc.
Asheville, North Carolina, 28801, United States
Cancer Center of NC at Asheville
Asheville, North Carolina, 28803, United States
Carolinas Hematology-Oncology Associates - Tyron St
Charlotte, North Carolina, 28203, United States
Carolinas Medical Center - Blumenthal Cancer Center
Charlotte, North Carolina, 28204, United States
CCOP Presbyterian Hospital
Charlotte, North Carolina, 28204, United States
Mecklenburg Medical Group - Morehead Medical Dr
Charlotte, North Carolina, 28204, United States
Mecklenburg Medical Group - Cameron Valley Pkwy
Charlotte, North Carolina, 28211, United States
Carolinas Hematology Oncology Associates - Harris Blvd.
Charlotte, North Carolina, 28262, United States
Carolinas Hematology-Oncology - John J. Delaney
Charlotte, North Carolina, 28277, United States
CCOP, Wayne Memorial Hospital
Goldsboro, North Carolina, 27534, United States
Moses Cone Regional Cancer Center
Greensboro, North Carolina, 27403, United States
Northwestern Carolina Oncology & Hematology, PA
Hickory, North Carolina, 28603, United States
Carolina BioOncology Institute
Huntersville, North Carolina, 28078, United States
Akron City Hospital
Akron, Ohio, 44304, United States
Akron General Medical Center
Akron, Ohio, 44307, United States
Alliance Cancer Center
Alliance, Ohio, 44601, United States
Aultman Hospital
Canton, Ohio, 44710, United States
Tri County Hematology/Oncology
Canton, Ohio, 44781, United States
Kenwood Office
Cincinnati, Ohio, 45236, United States
Oncology/Hematology Care Clinical Trials LLC
Cincinnati, Ohio, 45236, United States
North Treatment Center - Blue Ash Medical Center
Cincinnati, Ohio, 45242, United States
Oncology/Hematology Care Clinical Trials LLC, Cincinnati, OH Blue Ash Med. Cntr. (Administrative Only)
Cincinnati, Ohio, 45242, United States
Oncology/Hematology Care Clinical Trials LLC
Cincinnati, Ohio, 45242, United States
Case Western Reserve/University Hospitals-Ireland Cancer Cntr.
Cleveland, Ohio, 44106, United States
Dayton Physicians-LLC-Hematology & Medical Oncology Division
Dayton, Ohio, 45415, United States
Healthplex
Fairfield, Ohio, 45014, United States
Dayton Physicians, LLC - Greenville
Greenville, Ohio, 45331, United States
Hamilton Office
Hamilton, Ohio, 45013, United States
Dayton Clinical Oncology Program-Kettering
Kettering, Ohio, 45429, United States
Marian A. Llenado Lee, MD, Inc.
Kettering, Ohio, 45429, United States
Northwest Ohio Oncology Center
Maumee, Ohio, 43537, United States
UHHS - Chagrin Highlands
Orange, Ohio, 44122, United States
UHHS Green Road-Ireland Cancer Center
South Euclid, Ohio, 44121, United States
Flower Memorial Hospital
Sylvania, Ohio, 43560, United States
Bayview Oncology Associates
Toledo, Ohio, 43616, United States
Toledo Clinic
Toledo, Ohio, 43617, United States
UHHS Westlake-Ireland Cancer Center
Westlake, Ohio, 44145, United States
Northwest Cancer Specialists-Portland
Portland, Oregon, 97213, United States
Providence Portland Medical Center
Portland, Oregon, 97213, United States
Adventist Medical Center
Portland, Oregon, 97216, United States
Northwest Cancer Specialists-Adventist Office
Portland, Oregon, 97216, United States
CCOP, Columbia River Oncology
Portland, Oregon, 97225, United States
Providence Oncology and Hematology Care Clinic
Portland, Oregon, 97225, United States
Providence St. Vincent Medical Center
Portland, Oregon, 97225, United States
Lehigh Valley Hospital
Allentown, Pennsylvania, 18105, United States
Geisinger Clinic
Danville, Pennsylvania, 17882-2170, United States
Hematology Oncology Associates of NE PA
Donora, Pennsylvania, 18142, United States
Ephrata Cancer Center at Ephrata Community Hospital
Ephrata, Pennsylvania, 17522, United States
UPMC Cancer Centers Arnold Palmer Pavilion-Mountainview
Greensburg, Pennsylvania, 15601, United States
UPMC Cancer Centers Arnold Palmer-Oakbrook
Greensburg, Pennsylvania, 15601, United States
UPMC Cancer Centers-Indiana
Indiana, Pennsylvania, 15701, United States
UPMC Cancer Centers-John P. Murtha Cancer Center
Johnstown, Pennsylvania, 15901, United States
UPMC Cancer Centers - McKeesport Hospital
McKeesport, Pennsylvania, 15132, United States
Riddle Memorial Hospital
Media, Pennsylvania, 19063, United States
UPMC Cancer Centers Arnold Palmer-Mt. Pleasant
Mount Pleasant, Pennsylvania, 15666, United States
Kimmel Cancer Center at Jefferson
Philadelphia, Pennsylvania, 19107, United States
Cancer Center at Center One
Philadelphia, Pennsylvania, 19115, United States
Albert Einstein Healthcare Network
Philadelphia, Pennsylvania, 19141-3098, United States
Allegheny General Hospital/Allegheny-Singer Research Institute
Pittsburgh, Pennsylvania, 15212, United States
NSABP Foundation, Inc
Pittsburgh, Pennsylvania, 15212, United States
University of Pittsburgh
Pittsburgh, Pennsylvania, 15213, United States
UPMC Cancer Centers - UPMC St. Margaret
Pittsburgh, Pennsylvania, 15215, United States
Hillman Cancer Center
Pittsburgh, Pennsylvania, 15232, United States
UPMC Cancer Centers - UPMC Passavant
Pittsburgh, Pennsylvania, 15237, United States
Mercy Hospital
Scranton, Pennsylvania, 18501, United States
Scranton Hematology Oncology
Scranton, Pennsylvania, 18501, United States
Hematology and Oncology Associates
Scranton, Pennsylvania, 18510, United States
Mount Nittany Medical Center
State College, Pennsylvania, 16803, United States
UPMC Cancer Centers-Uniontown
Uniontown, Pennsylvania, 15401, United States
UPMC Cancer Centers - Wexford
Wexford, Pennsylvania, 15090, United States
York Hospital
York, Pennsylvania, 17403, United States
Thompson Oncology Group-Blount
Knoxville, Tennessee, 37804, United States
Thompson Cancer Survival Center-Dowell Springs
Knoxville, Tennessee, 37909, United States
Thompson Cancer Survival Center
Knoxville, Tennessee, 37916, United States
Thompson Oncology Group-West
Knoxville, Tennessee, 37932, United States
The West Clinic
Memphis, Tennessee, 38120, United States
Texas Oncology- Sammons CC
Dallas, Texas, 75246, United States
The Center for Cancer and Blood Disorders
Fort Worth, Texas, 76104, United States
Baylor College of Medicine
Houston, Texas, 77030, United States
Ben Taub General Hospital
Houston, Texas, 77030, United States
Covenant Health System dba Joe Arrington Cancer Research & Treatment Center
Lubbock, Texas, 79410, United States
North Texas Regional Cancer Center
Plano, Texas, 75075, United States
Intermountain Medical Center
Murray, Utah, 84107, United States
McKay-Dee Hospital
Ogden, Utah, 84403, United States
Utah Valley Regional Medical Center
Provo, Utah, 84604, United States
LDS Hospital
Salt Lake City, Utah, 84143, United States
Dixie Medical Center
St. George, Utah, 84780, United States
VCU Massey Cancer Center at Stony Point
Richmond, Virginia, 23235, United States
MBCCOP, Virginia Commonwealth University
Richmond, Virginia, 23298, United States
Overlake Internal Medicine
Bellevue, Washington, 98004, United States
Rockwood Cancer Treatment Center - Sinto Ave
Spokane, Washington, 99204, United States
Rockwood Cancer Treatment Center
Spokane, Washington, 99204, United States
Southwest Washington Hospital
Vancouver, Washington, 98664, United States
Northwest Cancer Specialists-136th Ave
Vancouver, Washington, 98684, United States
Northwest Cancer Specialists-134th St.
Vancouver, Washington, 98686, United States
West Virginia University Hospitals Inc.
Morgantown, West Virginia, 26506-9162, United States
Oncology Alliance-Burlington
Burlington, Wisconsin, 53105, United States
Oncology Alliance-Franklin
Franklin, Wisconsin, 53132, United States
Oncology Alliance
Glendale, Wisconsin, 53212, United States
Aurora BayCare Medical Center
Green Bay, Wisconsin, 54311, United States
Oncology Alliance-Kenosha South
Kenosha, Wisconsin, 53143, United States
Oncology Alliance-Kenosha North
Kenosha, Wisconsin, 53144, United States
CCOP, Marshfield Clinic
Marshfield, Wisconsin, 54449, United States
Oncology Alliance-Menomonee Falls
Menomonee Falls, Wisconsin, 53051, United States
Oncology Alliance-Mequon
Mequon, Wisconsin, 53092, United States
Oncology Alliance-South
Milwaukee, Wisconsin, 53215, United States
Oncology Alliance-Racine
Racine, Wisconsin, 53406, United States
Oncology Alliance-Waukeska
Waukesha, Wisconsin, 53188, United States
Marshfield Clinic Weston Center
Weston, Wisconsin, 54476, United States
Breast Clinica de la mama
La Plata, Buenos Aires, B1902CMV, Argentina
Hospital Universitario Austral
Presidente Derqui, Buenos Aires, B1629ODT, Argentina
Centro Oncologico Rosario (COR)
Rosario, Sante Fe, S2000DSK, Argentina
Hospital Britanico de Buenos Aires
Buenos Aires, C1280AEB, Argentina
CEMIC
Buenos Aires, C1431FWO, Argentina
Macarthur Cancer Center
Campbelltown, New South Wales, 2560, Australia
St. George Hospital
Kogarah, New South Wales, 2217, Australia
Cancer Therapy Center
Liverpool, New South Wales, 1871, Australia
North Shore Private Hospital
St Leonards, New South Wales, 2065, Australia
Royal North Shore Hospital
St Leonards, New South Wales, 2065, Australia
Southern Medical Day Care
Wollongong, New South Wales, 2500, Australia
Royal Brisbane & Women's Hospital
Herston, Queensland, 4029, Australia
Mater Adult Hospital
South Brisbane, Queensland, 4101, Australia
Ashford Cancer Center
Ashford, South Australia, 5035, Australia
Flinders Medical Centre
Bedford, South Australia, 5042, Australia
Frankston Hospital
Frankston, Victoria, 3199, Australia
The Alfred Hospital
Melbourne, Victoria, 3004, Australia
Mount Medical Center
Perth, Western Australia, 6000, Australia
Berdat Family Comprehensive Cancer Centre
Subiaco, Western Australia, 6008, Australia
Krankenhaus Barmherzige Brueder Graz, Medizinische Abteilung
Graz, 8020, Austria
Universitatsfrauenklinik Graz
Graz, 8036, Austria
Medizinische Universitat Graz - Onkologie
Graz, A-8036, Austria
AI University Hospital Innsbruck
Innsbruck, A-6020, Austria
Bezirkskrankenhaus Kufstein, Innere Medizin
Kufstein, 6330, Austria
Landeskrankenhaus Leoben, Abteilung fur Haemato-Onkologie
Leoben, 8700, Austria
Krankenhaus Barmherzige Schwestern Linz, Kooperative Studiengruppe, Chirurgie
Linz, 4010, Austria
AI Universitätsklinikum der PMU Landeskliniken
Salzburg, 5020, Austria
AKH Vienna
Vienna, 1090, Austria
Medizinische Universitaet Wien-Allgemeines Krankenhaus, Onkologie
Vienna, 1090, Austria
Krankenhaus Hietzing, Gynaekologische Abteilung
Vienna, 1130, Austria
Landeskrankenhaus Voecklabruck, 2. Medizinische Abteilung
Vöcklabruck, 4840, Austria
Klinikum Wels-Grieskirchen, Kooperative Gruppe Wels/4. Medizinische Abteilung
Wels, 4600, Austria
AZ Klina
Brasschaat, 2930, Belgium
C. H. Notre-Dame and Reine Fabiola
Charleroi, 6000, Belgium
Clinique St Pierre
Ottignies, 1340, Belgium
Medical Institute St. Augustinus
Wilrijk, 2610, Belgium
Clinical Centre University of Sarajevo
Sarajevo, 71000, Bosnia and Herzegovina
Centro Goiano de oncologia
Goiânia, Goiás, 74075-040, Brazil
Lifecenter Sistema de Saude S/A
Belo Horizonte, Minas Gerais, 30110-090, Brazil
Instituto Nacional de Cancer
Rio de Janeiro, Rio de Janeiro, 20560-120, Brazil
Clinica Oncologistas Associados
Rio de Janeiro, Rio de Janeiro, 22260-020, Brazil
Assoiacao hospital de caridade de ijui
Ijuí, Rio Grande do Sul, 98700-000, Brazil
Hospital Das Clinicas de Porto Alegre-HCPA
Porto Alegre, Rio Grande do Sul, 90035-003, Brazil
Irmandade da Santa Casa de Misericoria de Porto Alegre Nucleo de Novos Tratamentos
Porto Alegre, Rio Grande do Sul, 90050-170, Brazil
Clinica de Oncologia de Porto Alegre
Porto Alegre, Rio Grande do Sul, 90430-090, Brazil
Fundacao Dr. Amaral Carvalho
Jaú, São Paulo, 17210-080, Brazil
Instituto de Oncologia Clinica de Piracicaba
Piracicaba, São Paulo, 13419-155, Brazil
Centro de Oncologia e Hematologia da Faculdade de Medicina do ABC
Santo André, São Paulo, 09060-650, Brazil
Instituto do Cancer de Sao Paulo
São Paulo, São Paulo, 01246-000, Brazil
Conjunto Hospitalar de Sorocaba
Sorocaba, 18030-075, Brazil
District Oncology Dispensary Plovdiv
Plovdiv, 4000, Bulgaria
MHAT "Tsaritsa Yoanna-ISUL" EOOD
Sofia, 1527, Bulgaria
Tom Baker Cancer Centre
Calgary, Alberta, T2N 4N2, Canada
Cross Cancer Institute, Dept of Medicine
Edmonton, Alberta, T6G 1Z2, Canada
Lion's Gate Hospital
North Vancouver, British Columbia, V7L 2L7, Canada
Dr. H. Bliss Murphy Cancer Centre
St. John's, Newfoundland and Labrador, AIB 3V6, Canada
William Osler Health Center
Brampton, Ontario, L6R 3J7, Canada
Credit Valley Hospital
Mississauga, Ontario, L5M 2N1, Canada
Southlake Regional Health Centre
Newmarket, Ontario, L3Y 2P9, Canada
Ottawa Hospital Regional Cancer Centre
Ottawa, Ontario, K1H 8L6, Canada
St. Michaels Hospital
Toronto, Ontario, M5B 1W8, Canada
Humber River Regional Hospital
Weston, Ontario, M9N 1N8, Canada
Windsor Regional Cancer Centre
Windsor, Ontario, N8W 2X3, Canada
Hopital Charles LeMoyne
Greenfield Park, Quebec, J4V 2H1, Canada
Hopital Maisonneuve Rosemont
Montreal, Quebec, H1T 2M4, Canada
Royal Victoria Hospital
Montreal, Quebec, H3A 1A1, Canada
Montreal General Hospital
Montreal, Quebec, H3G 1A4, Canada
Jewish General Hospital
Montreal, Quebec, H3T 1E2, Canada
Hospital du Sacre-Coeur
Montreal, Quebec, H4J 1C5, Canada
University of Montreal Hospital Group
Montreal, Quebec, Canada
Centre Hospitalier Affilie Universitaire De Quebec, Hospital du St-Sacrement
Québec, Quebec, G1S 4L8, Canada
Hospital Regional Rancagua
Rancagua, Región del Libertador General Bernardo O’Higgins, 2820000, Chile
Chinese Academy of Medical Science
Beijing, 100021, China
The Pla 307 Hospital
Beijing, 100071, China
Chinese PLA General Hospital
Beijing, 100853, China
Jilin Cancer Hospital
Changchun, 130012, China
West China Hospital, Sichuan University
Chengdu, 610041, China
Fuzhou General Hospital of Nanjing Military Area
Fuzhou, 354200, China
Sun Yat-sen University Hospital
Guangzhou, 510060, China
1st Affiliated Hospital of Zhejiang University
Hangzhou, 310003, China
Zhejiang Tumor Hospital
Hangzhou, 310022, China
Tianjin Cancer Hospital
Tianjin, 300060, China
University Hospital Zagreb
Zagreb, 10000, Croatia
FN Na Bulovce
Prague, 180 81, Czechia
National Cancer Institute
Cairo, 11796, Egypt
Tartu University Hospital Clinic of Hematology and Oncology
Tartu, 51014, Estonia
CHU D'Amiens
Amiens, 80054, France
CH-Service Hemato-Oncologie
Beauvais, 60000, France
Clinique Bordeaux Nord Aquitaine
Bordeaux, 33300, France
CHU Morvan
Brest, 29609, France
Hopital Pasteur
Colmar, 68024, France
Ch intercommunal de creteil
Créteil, 94000, France
Centre Leonard de Vinci
Dechy, 59187, France
Institut Daniel Hollard
Grenoble, 38028, France
CHD les Oudairies
La Roche-sur-Yon, 85925, France
Clinique Francois Chenieux
Limoges, 87039, France
CHU Dupuytren
Limoges, 87042, France
Hopital St. Joseph
Marseille, 13008, France
Centre Regional de Lutte contre le Cancer (CRLC) Val d'Aurelle
Montpellier, 34298, France
Centre Catherine de Sienne
Nantes, 44202, France
Clinique Hartmann
Neuilly-sur-Seine, 92200, France
CHU Hotel Dieu
Paris, 75004, France
Hopital St. Antoine
Paris, 75571, France
Clinique Saint Hilaire
Rouen, 76000, France
Pole de cancerologie prive
Strasbourg, 67000, France
CLCC Paul Strauss
Strasbourg, 67085, France
Institution Claudius Regaud
Toulouse, 31052, France
Polyclinique du Parc
Toulous, 31400, France
Klinikum St. Marien Amberg
Amberg, 92224, Germany
Hochwaldkrankenhaus
Bad Nauheim, 61231, Germany
Klinikverbund Suedwest - Sindelfingen-Böeblingen Clinical Centre
Böeblingen, 71032, Germany
Klinikum Chemnitz
Chemnitz, 09116, Germany
Universitaetsklinikum Dresden
Dresden, 01307, Germany
Luisenkrankenhaus
Düsseldorf, 40235, Germany
Universitaetsfrauenklinik
Essen, 45122, Germany
Zentrum fur Frauenheilkunde und Geburtshilfe
Frankfurt, D-60590, Germany
Medizinisches Versorgungszentrum Osthessen
Fulda, 36043, Germany
Kreiskrankenhaus Hameln
Hamelin, 31785, Germany
Klinikum Stadt Hanau
Hanau, 63450, Germany
Klinikum Hannover Nordstadt
Hanover, 30167, Germany
Universitat Frauenklinik Jena
Jena, 07743, Germany
Onkologische schwerpunktpraxis
Leer, 26789, Germany
Klinikum Lippe Lemgo
Lemgo, D-32657, Germany
Asklepios Kliniken Lich GmbH
Lich, 35423, Germany
Universitaetsklinikum Mainz
Mainz, 55101, Germany
St. Vincenz u. Elisabeth Hospital
Mainz, 55131, Germany
Ev Krankenhaus Bethesda
Mönchengladbach, 41061, Germany
RotKreuzKlinikum München GmbH
Munich, 80637, Germany
Universitaetsklinikum Munster
Münster, 48129, Germany
Praxis und Tagesklinik fuer Onkologie und
Recklinghausen, 45657, Germany
Klinikum Rosenheim
Rosenheim, 83022, Germany
Klinikum Schaumburg
Stadhagen, 31655, Germany
Johanniter Krankenhaus
Stendal, D-39576, Germany
Robert-Bosch-Krankenhaus
Stuttgart, 70376, Germany
Fachärzte fürlnnere Medizin, Hämatologie
Traunstein, 83278, Germany
P.G. Hospital of Thessaloniki "Papageorgiou"
Thessaloniki, 56429, Greece
Prince of Wales Hospital
Hong Kong, Hong Kong
Queen Elizabeth Hospital
Hong Kong, Hong Kong
Semmelweis Egyetem Clinic of Radiology
Budapest, 1082, Hungary
DEOEC Onkologiai Tanszek
Debrecen, 4012, Hungary
Petz Aladar Megyei Oktato
Győr, Hungary
Kaposi Mor oktato korhaz Onkologiai tanszek
Kaposvár, H-7400, Hungary
Cork University Hospital
Cork, Ireland
Beaumont Hospital
Dublin, 0009, Ireland
St. James's Hospital
Dublin, 8, Ireland
Adelaide and Meath National Childrens Hospital
Dublin, Ireland
Institute for Cancer Research
Dublin, Ireland
Mater Private Hospital
Dublin, Ireland
St. Vincent's University Hospital
Dublin, Ireland
University College Hospital Galway
Galway, Ireland
Midwestern Regional Hospital
Limerick, Ireland
Sligo General Hospital
Sligo, Ireland
The Lady Davis Carmel Medical Center/Lynn
Haifa, Israel
Meir Medical Center
Kfar, 13100, Israel
Kaplan Medical Center
Rehovot, Israel
Ziv Medical Center
Safed, Israel
Sourasky (Ichilov) Medical Center
Tel Aviv, Israel
Assaf Harofeh Medical Center
Ẕerifin, Israel
Humanitas Centro Catanese
Catania, 95126, Italy
(Azienda u.s.I. chieti) - Policinico Ospedaliero
Chieti, 66100, Italy
Ospedale vito fazzi
Lecce, Italy
Ospedale di Mirano
Mirano, Italy
IRCCS - Instituto Nazionale per lo Studio e la Cura
Napoli, 80131, Italy
Fondazione Salvatore Maugeri
Pavia, 27100, Italy
Ospedale S. Filippo Neri
Roma, 00135, Italy
Regina Elena Cancer Institute
Rome, Italy
Ospedale casa sollievo della sofferenza
San Giovanni, Italy
Universita-istituto Clinica Medica
Sassari, 07100, Italy
Asl n. 5 -Ospedale s. Vincenzo
Taormina, Italy
P. Stradina Clinical University Hospital
Riga, Latvia
Opcion Oncologia
Monterrey, 64060, Mexico
Hospital Nacional Carlos Alberto Seguin
Arequipa, Peru
Hospital Nacional Edgardo Rebagliati Martins
Lima, Lima 11, Peru
Cebu Doctors University Hospital
Cebu City, 6000, Philippines
Regional Oncology Center
Bialystok, Poland
Centrum Onkologii Instytut im. M.
Gliwice, 44-101, Poland
ZOZ MSWiA z Warminsko-Mazurskim Centrum
Olsztyn, 10-228, Poland
Olsztynski Osrodek Onkologiczny "Kopernik"
Olsztyn, 10-513, Poland
Samodzielny Publiczny Zaklad Opieki
Rybnik, 44-200, Poland
Breast Cancer Clinic
Warsaw, 02-781, Poland
HUC
Coimbra, 3000-073, Portugal
IPO Francisco Gentil-Porto
Porto, 4200-319, Portugal
County Hospital Alba-Iulia
Alba Iulia, 510000, Romania
Institute of Oncology "AI.Trestioreanu"
Bucharest, 022338, Romania
Institutul Oncologic "Prof. Dr. I. Chiricuta" Cluj-Napoca
Cluj-Napoca, Romania
State Medical Institution "Republican Clinical Oncology Dispensary Ministry of Health of Republic Tatarstan"
Kazan', Russia
State Institution "Russian Oncological Research Center n.a. N.N. Blokhin of RAMS"
Moscow, Russia
Federal State Institution "Research Institute of Oncology n.a. N.N. Petrov Rosmedtechnologiy"
Saint Petersburg, Russia
Saint-Petersburg State Medical Institution "City Clinical Oncology Dispensary"
Saint Petersburg, Russia
Clinical Hospital Center Bezanijska Kosa
Belgrade, 11080, Serbia
Clinic of Oncology, Clinical Center nis
Niš, 18000, Serbia
University Clinical Centre
Maribor, 2101, Slovenia
Department of Oncotherapy National Hospital
Bloemfontein, 9301, South Africa
Hopelands Cancer Centre
Durban, 4001, South Africa
Johannesburg Hospital
Johannesburg, South Africa
Seoul National University Bundang Hospital
Gyeonggi-do, 463-707, South Korea
Seoul National University Hospital
Seoul, 110-744, South Korea
Severance Hospital
Seoul, 120-752, South Korea
Samsung Medical Center
Seoul, 135-710, South Korea
Asan Medical Center
Seoul, 138-736, South Korea
Hospital Universitario Insular de Gran Canaria
Las Palmas, Canary Islands, 33106, Spain
Complejo Hospitalario Universitario A Coruna
A Coruña, 15006, Spain
Centro Oncologico de Galicia
A Coruña, 15009, Spain
Fundacion Hospitalaria de Alcorcon
Alcorcón, 28922, Spain
Hospital General de Alicante
Alicante, 03010, Spain
Hospital Perpetuo Socorro
Badajoz, 6010, Spain
Hospital Germans Trias l Pujol
Badalona (Barcelona), 08916, Spain
Hospital Comarcal de Barbastro
Barbastro, 22300, Spain
Hospital Del Mar
Barcelona, 08003, Spain
Hospital Santa Crue l San Pau
Barcelona, 08025, Spain
Hospital Clinic i Provincial
Barcelona, 08036, Spain
Consorci Sanitari de Terrassa
Barcelona, 08227, Spain
Althaia Xarxa Assistencial de Manresa
Barcelona, 08243, Spain
Hospital Espiritu Santo
Barcelona, 08923, Spain
Hospital De San Pedro de Alcantara
Cáceres, 10003, Spain
Instituto Oncologico de Guipuzcoa
Donostia / San Sebastian, Spain
Hospital Gral. De Elche
Elche, 03202, Spain
Hospital de Cabueñes, Oncologia Médica
Gijón, 33394, Spain
Instituto Catalan Oncologia de Girona
Girona, 17007, Spain
Complejo Hospitalario de Jaen
Jaén, 23007, Spain
Hospital Xera Calde
Lugo, Spain
Hospital Universitario Gregorio Maranon
Madrid, 28007, Spain
Hospital Ruber International
Madrid, 28034, Spain
Fundacion Jimenez Diaz
Madrid, 28040, Spain
Hospital Universitario San Carlos
Madrid, 28040, Spain
Centro Integral de Oncologia "Clara Campal"
Madrid, 28050, Spain
Hospital Clinico Virgen de la Victoria
Málaga, 29010, Spain
Hospital Univesitario Carlos Haya
Málaga, 29010, Spain
Hospital Santa Maria Nai Dr. Cabaleiro
Ourense, Spain
Complejo Hospitalario de Pontevedra
Pontevedra, 36001, Spain
Hospital del Parc Tauli
Sabadell, 08208, Spain
Hospital Universitario de Salamanca
Salamanca, 37007, Spain
Hospital Universitario de Canarias
San Cristóbal de La Laguna, 38320, Spain
Hospital Universitario Virgen del Rocio
Seville, 41013, Spain
Hospital Torrevieja Salud, UTE
Torrevieja, 03186, Spain
Hospital Clinico Universitario de Valencia
Valencia, 46010, Spain
Hospital Clinico Universitario Lozano Blesa
Zaragoza, 50009, Spain
Hospital U. Miguel Servet
Zaragoza, 50009, Spain
Sahlgrenska University Hospital
Gothenburg, 41345, Sweden
Karolinska University Hospital
Stockholm, S-118, Sweden
Changhua Christian Hospital
Changhua, 500, Taiwan
Kaohsiung Medical University Chung
Kaohsiung City, 807, Taiwan
National Cheng Kung University
Tainan, 704, Taiwan
Sun Yat-Sen Cancer Center
Taipei, 112, Taiwan
Taipei Veterans General Hospital
Taipei, 112, Taiwan
Chang Gung Memorial Hospital
Taoyuan District, 3330, Taiwan
Chulalongkorn Hospital
Patumwan, Bangkok, 10330, Thailand
National Cancer Institute
Bangkok, 10400, Thailand
Songklanagarind Hospital
Songkhla, Thailand
Royal Bournemouth Hospital
Bournemouth, BH7 7DW, United Kingdom
Bristol Hematology - Oncology Centre
Bristol, BS2 8ED, United Kingdom
Ipswich Hospital
Ipswich, IP4 5PD, United Kingdom
Christie Hospital NHS Trust
Manchester, M20 4BX, United Kingdom
Nottingham City Hospital
Nottingham, NG5 1PB, United Kingdom
Peterborough District Hospital
Peterborough, PE3 6DA, United Kingdom
Sunrise Cancer Centre
Truro, TR1 3IJ, United Kingdom
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Norman Wolmark, MD
NSABP Foundation Inc
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- NETWORK
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 21, 2008
First Posted
February 29, 2008
Study Start
April 1, 2008
Primary Completion
June 1, 2013
Study Completion
July 1, 2014
Last Updated
September 10, 2020
Record last verified: 2020-03