Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Low Risk

Score: 30/100

Failure Rate

12.1%

308 terminated/withdrawn out of 2553 trials

Success Rate

86.0%

-0.5% vs industry average

Late-Stage Pipeline

35%

893 trials in Phase 3/4

Results Transparency

55%

1036 of 1896 completed trials have results

Key Signals

123 recruiting1036 with results258 terminated50 withdrawn

Enrollment Performance

Analytics

Phase 3
640(30.0%)
Phase 2
608(28.5%)
Phase 1
543(25.5%)
Phase 4
253(11.9%)
N/A
85(4.0%)
Early Phase 1
3(0.1%)
2132Total
Phase 3(640)
Phase 2(608)
Phase 1(543)
Phase 4(253)
+2 more

Activity Timeline

Global Presence

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Clinical Trials (2553)

Showing 20 of 2553 trials
NCT04544436Phase 3Active Not Recruiting

A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Relapsing Multiple Sclerosis (RMS)

Role: lead

NCT07234942Phase 1Recruiting

A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7812653 in Participants With Early Symptomatic Alzheimer's Disease (eAD)

Role: lead

NCT07081958Phase 2Completed

A Study Evaluating the Effect of Daily Oral RO7795081 in Participants With Obesity or Overweight With at Least One Weight-Related Comorbidity

Role: lead

NCT02486718Phase 3Active Not Recruiting

Study to Assess Safety and Efficacy of Atezolizumab (MPDL3280A) Compared to Best Supportive Care Following Chemotherapy in Patients With Lung Cancer [IMpower010]

Role: lead

NCT03075696Phase 1Active Not Recruiting

A Dose Escalation Study of Glofitamab (RO7082859) as a Single Agent and in Combination With Obinutuzumab, Administered After a Fixed, Single Pre-treatment Dose of Obinutuzumab in Participants With Relapsed/Refractory B-cell Non-hodgkin's Lymphoma

Role: lead

NCT04712643Phase 3Active Not Recruiting

A Study of TACE Combined With Atezolizumab Plus Bevacizumab or TACE Alone in Patients With Untreated Heaptocellular Carcionma

Role: lead

NCT05269004Phase 3Active Not Recruiting

A Rollover Study to Evaluate the Long-Term Safety and Efficacy of Ocrelizumab In Patients With Multiple Sclerosis

Role: lead

NCT06795048Phase 4Active Not Recruiting

A Study to Determine the Efficacy, Safety, and Durability of Faricimab in Participants With Neovascular Age-Related Macular Degeneration

Role: lead

NCT06704672Not ApplicableRecruiting

Clinical Study to Evaluate the Impact of the Accu-Chek SmartGuide CGM Solution on the Mean Change in Time in Range Compared With Self-Monitoring of Blood Glucose in Participants With Type 1 and Type 2 Diabetes Mellitus

Role: lead

NCT04432584Phase 3Active Not Recruiting

A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Complement Inhibitors

Role: lead

NCT05009069Phase 2Active Not Recruiting

A Study of Atezolizumab With or Without Tiragolumab Following Neoadjuvant Chemoradiotherapy in Participants With Locally Advanced Rectal Cancer

Role: lead

NCT05645692Phase 2Active Not Recruiting

A Study Evaluating Different Immunotherapies (LAG-3 and PD-1 With or Without TIGIT, Compared to PD-L1 Alone) in Participants With Untreated Locally Advanced Metastatic Urothelial Cancer

Role: lead

NCT06667414Completed

Frequency of Selected Single Nucleotide Polymorphisms in Huntington Disease Gene Expansion Carriers

Role: lead

NCT07455136Recruiting

A Study to Develop a Blood-based Test for Aiding the Diagnosis/Prognosis of Traumatic Brain Injury in Adults and for Monitoring the Development of Secondary Events in Patients Diagnosed With Traumatic Brain Injury

Role: lead

NCT07025811Phase 4Completed

A Study to Explore Signs, Symptoms, and Biomarkers in Dry Eye Disease Participants Following Anti-inflammatory Treatment

Role: lead

NCT07598396Phase 2Recruiting

A Study to Evaluate Mosunetuzumab in Participants With Systemic Lupus Erythematosus With or Without Active Lupus Nephritis

Role: lead

NCT01760005Phase 2Active Not Recruiting

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001

Role: collaborator

NCT07137598Phase 2Recruiting

A Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have Not Responded to or Who Cannot Tolerate Tumor Necrosis Factor (TNF) and/or Janus Kinase (JAK Inhibitors)

Role: lead

NCT02286089Phase 1Active Not Recruiting

Safety and Efficacy Study of OpRegen for Treatment of Advanced Dry-Form Age-Related Macular Degeneration

Role: lead

NCT05181618Phase 4Active Not Recruiting

A Study to Evaluate Overall Health, Physical Activity, and Joint Outcomes in Participants With Severe or Moderate Hemophilia A Without Factor VIII Inhibitors on Emicizumab Prophylaxis

Role: lead