Success Metrics

Clinical Success Rate
78.7%

Based on 1,357 completed trials

Completion Rate
79%(1357/1724)
Active Trials
678(23%)
Results Posted
64%(865 trials)
Terminated
367(13%)

Phase Distribution

Ph phase_4
42
1%
Ph phase_2
1,293
44%
Ph phase_1
936
32%
Ph early_phase_1
47
2%
Ph not_applicable
101
3%
Ph phase_3
471
16%

Phase Distribution

983

Early Stage

1293

Mid Stage

513

Late Stage

Phase Distribution2890 total trials
Early Phase 1First-in-human
47(1.6%)
Phase 1Safety & dosage
936(32.4%)
Phase 2Efficacy & side effects
1,293(44.7%)
Phase 3Large-scale testing
471(16.3%)
Phase 4Post-market surveillance
42(1.5%)
N/ANon-phased studies
101(3.5%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

73.3%

1357 of 1851 finished

Non-Completion Rate

26.7%

494 ended early

Currently Active

678

trials recruiting

Total Trials

2,922

all time

Status Distribution
Active(746)
Completed(1357)
Terminated(494)
Other(325)

Detailed Status

Completed1357
Recruiting390
Terminated367
unknown307
Active, not recruiting288
Withdrawn127

Development Timeline

Analytics

Development Status

Total Trials
2922
Active
678
Success Rate
78.7%
Most Advanced
Phase 4

Trials by Phase

Early Phase 147 (1.6%)
Phase 1936 (32.4%)
Phase 21293 (44.7%)
Phase 3471 (16.3%)
Phase 442 (1.5%)
N/A101 (3.5%)

Trials by Status

withdrawn1274%
enrolling_by_invitation50%
completed135746%
recruiting39013%
suspended181%
active_not_recruiting28810%
terminated36713%
unknown30711%
not_yet_recruiting632%

Recent Activity

Clinical Trials (2,922)

Showing 20 of 2,922 trialsScroll for more
NCT04859946Phase 2

Itacitinib for the Prevention of Graft Versus Host Disease

Active Not Recruiting
NCT01857934Phase 2

Therapy for Children With Advanced Stage Neuroblastoma

Completed
NCT06083883Phase 1

Phase I/Ib Study of NK Expressing an Affinity-enhanced T-cell Receptor (TCR) Against the NY-ESO-1

Recruiting
NCT07101432Phase 1

Phase I Study of Preconditioning Radiation Therapy With IL-15 Transduced TGFBR2 KO CAR.TROP2-engineered Cord Blood-derived NK Cells in Patients With Advanced Head and Neck Cancer (RADIANCE-NK)

Recruiting
NCT07349771Phase 2

Axatilimab Plus Standard of Care Therapy for the Prevention of Graft Versus Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation in Patients With Hematologic Cancer, ABRAXAS Trial

Not Yet Recruiting
NCT06717347Phase 3

A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)

Recruiting
NCT06904066Phase 1

Autologous T Cells Transduced With Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients With Hematologic Malignancies

Recruiting
NCT07224100Phase 2

Dose-Adjusted EPOCH With or Without Rituximab Plus Ponatinib for the Treatment of Newly-Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia/Lymphoma

Recruiting
NCT07509034Phase 1

Autologous B7-H3 Chimeric Antigen Receptor T Cells in Previously Treated Extensive-Stage Small Cell Lung Cancer With Recurrent or Refractory Disease

Not Yet Recruiting
NCT06828796Phase 2

Early Use of Tacrolimus in HLA-Mismatched Haploidentical Allogeneic Hematopoietic Transplantation With Post-Transplant Cyclophosphamide

Recruiting
NCT06464965Phase 1

Clinical Study of Cord Blood-Derived CAR-NK Cells in Gastric Cancer and Pancreatic Cancer

Completed
NCT06660420Phase 1

Phase 1 Dose Escalation and Expansion Study of PRAME T Cell Receptor (TCR) Engineered NK Cells in Participants With Recurrent and/or Refractory Melanoma (PRAMETIME-Mel)

Recruiting
NCT00466531Phase 1

Treatment of Relapsed or Chemotherapy Refractory Chronic Lymphocytic Leukemia or Indolent B Cell Lymphoma Using Autologous T Cells Genetically Targeted to the B Cell Specific Antigen CD19

Active Not Recruiting
NCT06058377Phase 3

Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer

Recruiting
NCT06317662Phase 2

Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia

Recruiting
NCT06615050Phase 3

A Study of Tacrolimus/Methotrexate/Ruxolitinib Versus Post-Transplant Cyclophosphamide/Tacrolimus/Mycophenolate Mofetil in Non-Myeloablative/Reduced Intensity Conditioning Allogeneic Peripheral Blood Stem Cell Transplantation (BMT CTN 2203)

Recruiting
NCT06066424Phase 1

Phase 1 Dose Escalation and Expansion Study of TROP2 CAR Engineered IL15-transduced Cord Blood-derived NK Cells in Patients With Advanced Solid Tumors (TROPIKANA)

Recruiting
NCT05470283Phase 1

Phase I, Open-Label, Study of Tumor Infiltrating Lymphocytes Engineered With Membrane Bound IL15 Plus Acetazolamide in Adult Patients With Metastatic Melanoma

Active Not Recruiting
NCT06083922Phase 2

A Study of CyBorD (Cyclophosphamide, Bortezomib, Dexamethasone) Plus Daratumumab in People With Monoclonal Gammopathy of Renal Significance (MGRS)

Recruiting
NCT07524530Phase 2

Stem Cell Transplantation for Participants With Germline RUNX1 Associated Blood Cancers

Not Yet Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
2,922