Success Metrics

Clinical Success Rate
80.3%

Based on 334 completed trials

Completion Rate
80%(334/416)
Active Trials
141(21%)
Results Posted
70%(234 trials)
Terminated
82(12%)

Phase Distribution

Ph early_phase_1
5
1%
Ph phase_1
146
22%
Ph phase_3
119
18%
Ph not_applicable
13
2%
Ph phase_2
345
52%
Ph phase_4
10
2%

Phase Distribution

151

Early Stage

345

Mid Stage

129

Late Stage

Phase Distribution638 total trials
Early Phase 1First-in-human
5(0.8%)
Phase 1Safety & dosage
146(22.9%)
Phase 2Efficacy & side effects
345(54.1%)
Phase 3Large-scale testing
119(18.7%)
Phase 4Post-market surveillance
10(1.6%)
N/ANon-phased studies
13(2.0%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

75.9%

334 of 440 finished

Non-Completion Rate

24.1%

106 ended early

Currently Active

141

trials recruiting

Total Trials

666

all time

Status Distribution
Active(164)
Completed(334)
Terminated(106)
Other(62)

Detailed Status

Completed334
Terminated82
Recruiting72
Active, not recruiting69
unknown60
Withdrawn24

Development Timeline

Analytics

Development Status

Total Trials
666
Active
141
Success Rate
80.3%
Most Advanced
Phase 4

Trials by Phase

Early Phase 15 (0.8%)
Phase 1146 (22.9%)
Phase 2345 (54.1%)
Phase 3119 (18.7%)
Phase 410 (1.6%)
N/A13 (2.0%)

Trials by Status

terminated8212%
recruiting7211%
withdrawn244%
active_not_recruiting6910%
not_yet_recruiting233%
completed33450%
suspended20%
unknown609%

Recent Activity

Clinical Trials (666)

Showing 20 of 666 trialsScroll for more
NCT03179904Phase 2

TVB-2640 and Trastuzumab With Paclitaxel or Endocrine Therapy for Treatment of HER2 Positive Metastatic Breast Cancer

Active Not Recruiting
NCT04266249Phase 2

CompassHER2-pCR: Decreasing Chemotherapy for Breast Cancer Patients After Pre-surgery Chemo and Targeted Therapy

Active Not Recruiting
NCT03738553

Multiparametric MRI for Assessing Breast Cancer Response to Anti-HER2 Therapy

Terminated
NCT05408845Phase 2

Testing the Use of Ado-Trastuzumab Emtansine Compared to the Usual Treatment (Chemotherapy With Docetaxel Plus Trastuzumab) or Trastuzumab Deruxtecan for Recurrent, Metastatic, or Unresectable HER2-Expressing Salivary Gland Cancers

Recruiting
NCT02465060Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

Active Not Recruiting
NCT07214766Phase 1

A Study to Assess the Bioequivalence of Trastuzumab Via Different Subcutaneous Delivery Platforms in Healthy Male Participants

Recruiting
NCT06324357Phase 1

Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread

Recruiting
NCT07102381Phase 2

A Phase 2 Neoadjuvant Study of Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast Cancer

Recruiting
NCT06589830Phase 2

TL938 and Trastuzumab for Patients With HER2-positive Metastatic Colorectal Cancer

Recruiting
NCT05187182Phase 1

CA-4948 in Combination With FOLFOX/PD-1 Inhibitor +/- Trastuzumab for Untreated Unresectable Gastric and Esophageal Cancer

Recruiting
NCT03417544Phase 2

Atezolizumab + Pertuzumab + Trastuzumab In CNS Mets In BC

Active Not Recruiting
NCT04158258

A Study to Describe the Diagnosis, Anti-Cancer Treatment and Clinical Outcome in Patients With Newly Diagnosed Breast Cancer in Latin America

Active Not Recruiting
NCT07402473Phase 2

Optimize Neoadjuvant Therapy in HER2-Positive Early-Stage Breast Cancer

Recruiting
NCT07545044Phase 2

A Study of JSKN003 Versus Trastuzumab in Combination With Pertuzumab and Docetaxel as First-Line Treatment for HER2-Positive Recurrent or Metastatic Breast Cancer

Not Yet Recruiting
NCT05132582Phase 3

A Study of Tucatinib or Placebo With Trastuzumab and Pertuzumab for Metastatic HER2+ Breast Cancer

Active Not Recruiting
NCT03820141Phase 2

Durvalumab With Trastuzumab and Pertuzumab in HER2-Enriched Breast Cancer

Active Not Recruiting
NCT05152147Phase 3

A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers

Active Not Recruiting
NCT04661150Phase 2

A Study of Atezolizumab and Trastuzumab in Combination With Capecitabine and Oxaliplatin in Patients With HER2 Positive Locally Advanced Resectable Gastric Cancer of Adenocarcinoma of Gastroesophageal Junction

Active Not Recruiting
NCT07528898Phase 2

Neoadjuvant SHR-A1811 Combined With Pertuzumab in HER2-Positive Breast Cancer: An Exploratory Clinical Study.

Not Yet Recruiting
NCT02705859Phase 1

Phase Ib/II Trial of coPANlisib in Combination With Trastuzumab in HER2-positive Breast Cancer. (Panther Study)

Completed

Drug Details

Intervention Type
BIOLOGICAL
Total Trials
666