Success Metrics

Clinical Success Rate
80.3%

Based on 338 completed trials

Completion Rate
80%(338/421)
Active Trials
139(21%)
Results Posted
70%(237 trials)
Terminated
83(12%)

Phase Distribution

Ph phase_1
147
22%
Ph phase_4
10
1%
Ph phase_2
348
52%
Ph not_applicable
13
2%
Ph phase_3
121
18%
Ph early_phase_1
5
1%

Phase Distribution

152

Early Stage

348

Mid Stage

131

Late Stage

Phase Distribution644 total trials
Early Phase 1First-in-human
5(0.8%)
Phase 1Safety & dosage
147(22.8%)
Phase 2Efficacy & side effects
348(54.0%)
Phase 3Large-scale testing
121(18.8%)
Phase 4Post-market surveillance
10(1.6%)
N/ANon-phased studies
13(2.0%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

76.0%

338 of 445 finished

Non-Completion Rate

24.0%

107 ended early

Currently Active

139

trials recruiting

Total Trials

672

all time

Status Distribution
Active(164)
Completed(338)
Terminated(107)
Other(63)

Detailed Status

Completed338
Terminated83
Active, not recruiting70
Recruiting69
unknown60
Not yet recruiting25

Development Timeline

Analytics

Development Status

Total Trials
672
Active
139
Success Rate
80.3%
Most Advanced
Phase 4

Trials by Phase

Early Phase 15 (0.8%)
Phase 1147 (22.8%)
Phase 2348 (54.0%)
Phase 3121 (18.8%)
Phase 410 (1.6%)
N/A13 (2.0%)

Trials by Status

active_not_recruiting7010%
recruiting6910%
suspended30%
not_yet_recruiting254%
terminated8312%
withdrawn244%
completed33850%
unknown609%

Recent Activity

Clinical Trials (672)

Showing 20 of 672 trialsScroll for more
NCT02654119Phase 2

Cyclophosphamide, Paclitaxel, and Trastuzumab in Treating Stage I-II HER2/Neu Positive Breast Cancer After Surgery

Completed
NCT04784715Phase 3

Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive Metastatic Breast Cancer (DESTINY-Breast09)

Active Not Recruiting
NCT06136897Phase 2

Testing Trastuzumab and Pertuzumab in Patients With Higher Than Normal Copies of the HER2 Gene Found in Their Tumors (MATCH - Subprotocol J)

Active Not Recruiting
NCT02465060Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

Active Not Recruiting
NCT03304080Phase 1

Anastrozole, Palbociclib, Trastuzumab and Pertuzumab in HR-positive, HER2-positive Metastatic Breast

Active Not Recruiting
NCT02252887Phase 2

Gemcitabine, Trastuzumab, and Pertuzumab in the Treatment of Metastatic HER2-Positive Breast Cancer After Prior Trastuzumab/Pertuzumab, or Pertuzumab Based Therapy

Completed
NCT07683754Phase 3

T-DXd Based Therapy Followed by Endocrine Therapy Plus Dual HER2 Blockade in First-line HER2+/ HR+ Metastatic Breast Cancer and Retreatment With T-DXd

Not Yet Recruiting
NCT05253651Phase 3

A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer

Recruiting
NCT05132582Phase 3

A Study of Tucatinib or Placebo With Trastuzumab and Pertuzumab for Metastatic HER2+ Breast Cancer

Active Not Recruiting
NCT07716046Phase 2

Fulvestaciclib Combined With Anti-HER2 and Endocrine Therapy for HR+/HER2+ Advanced Breast Cancer

Not Yet Recruiting
NCT03414658Phase 2

The AVIATOR Study: Trastuzumab and Vinorelbine With Avelumab OR Avelumab & Utomilumab in Advanced HER2+ Breast Cancer

Active Not Recruiting
NCT07214766Phase 1

A Study to Assess the Bioequivalence of Trastuzumab Via Different Subcutaneous Delivery Platforms in Healthy Male Participants

Completed
NCT05152147Phase 3

A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers

Active Not Recruiting
NCT04285671Phase 1

Necitumumab and Trastuzumab in Combination With Osimertinib for the Treatment of Refractory Epidermal Growth Factor Receptor (EGFR)-Mutated Stage IV Non-small Cell Lung Cancer

Active Not Recruiting
NCT07102381Phase 2

A Phase 2 Neoadjuvant Study of Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast Cancer

Recruiting
NCT04158258

A Study to Describe the Diagnosis, Anti-Cancer Treatment and Clinical Outcome in Patients With Newly Diagnosed Breast Cancer in Latin America

Active Not Recruiting
NCT06731478Phase 3

Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer

Recruiting
NCT04661150Phase 2

A Study of Atezolizumab and Trastuzumab in Combination With Capecitabine and Oxaliplatin in Patients With HER2 Positive Locally Advanced Resectable Gastric Cancer of Adenocarcinoma of Gastroesophageal Junction

Active Not Recruiting
NCT07386938Phase 3

A Study of the Efficacy, Safety and Pharmacokinetics of RPH-051 and Perjeta® in Combination With Trastuzumab and Docetaxel as the 1st Line Therapy in Patients With HER2-positive Breast Cancer

Active Not Recruiting
NCT04379596Phase 2

Ph1b/2 Study of the Safety and Efficacy of T-DXd Combinations in Advanced HER2-expressing Gastric Cancer (DESTINY-Gastric03)

Recruiting

Drug Details

Intervention Type
BIOLOGICAL
Total Trials
672