Success Metrics

Clinical Success Rate
80.3%

Based on 343 completed trials

Completion Rate
80%(343/427)
Active Trials
137(20%)
Results Posted
69%(238 trials)
Terminated
84(12%)

Phase Distribution

Ph not_applicable
13
2%
Ph phase_1
147
22%
Ph early_phase_1
5
1%
Ph phase_3
122
18%
Ph phase_4
10
1%
Ph phase_2
353
52%

Phase Distribution

152

Early Stage

353

Mid Stage

132

Late Stage

Phase Distribution650 total trials
Early Phase 1First-in-human
5(0.8%)
Phase 1Safety & dosage
147(22.6%)
Phase 2Efficacy & side effects
353(54.3%)
Phase 3Large-scale testing
122(18.8%)
Phase 4Post-market surveillance
10(1.5%)
N/ANon-phased studies
13(2.0%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

76.1%

343 of 451 finished

Non-Completion Rate

23.9%

108 ended early

Currently Active

137

trials recruiting

Total Trials

679

all time

Status Distribution
Active(166)
Completed(343)
Terminated(108)
Other(62)

Detailed Status

Completed343
Terminated84
Recruiting69
Active, not recruiting68
unknown59
Not yet recruiting29

Development Timeline

Analytics

Development Status

Total Trials
679
Active
137
Success Rate
80.3%
Most Advanced
Phase 4

Trials by Phase

Early Phase 15 (0.8%)
Phase 1147 (22.6%)
Phase 2353 (54.3%)
Phase 3122 (18.8%)
Phase 410 (1.5%)
N/A13 (2.0%)

Trials by Status

terminated8412%
recruiting6910%
suspended30%
withdrawn244%
unknown599%
not_yet_recruiting294%
active_not_recruiting6810%
completed34351%

Recent Activity

Clinical Trials (679)

Showing 20 of 679 trialsScroll for more
NCT07856303Phase 2

SHR-A1811 Versus Trastuzumab Plus Pertuzumab in ctDNA-Positive HER2-Positive Early Breast Cancer After Pathologic Complete Response

Not Yet Recruiting
NCT07102381Phase 2

A Phase 2 Neoadjuvant Study of Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast Cancer

Recruiting
NCT02465060Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

Active Not Recruiting
NCT06625775Phase 1

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

Recruiting
NCT06324357Phase 1

Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread

Recruiting
NCT04789096Phase 2

Tucatinib Together With Pembrolizumab and Trastuzumab

Terminated
NCT05132582Phase 3

A Study of Tucatinib or Placebo With Trastuzumab and Pertuzumab for Metastatic HER2+ Breast Cancer

Active Not Recruiting
NCT07007559Phase 2

ASPEN-09-03: A Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Metastatic HER2-Positive Breast Cancer

Recruiting
NCT05152147Phase 3

A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers

Active Not Recruiting
NCT02390427Phase 1

Phase Ib Dose-escalation Trial of Taselisib (GDC-0032) in Combination With Anti-HER2 Therapies in Participants With Advanced HER2+ Breast Cancer

Completed
NCT03716180Phase 1

DAPHNe: Paclitaxel/Trastuzumab/Pertuzumab in HER2-Positive BC

Active Not Recruiting
NCT00295893Phase 2

Combination Chemotherapy With or Without Trastuzumab in Treating Patients With Stage II or Stage III Breast Cancer

Active Not Recruiting
NCT07407920Phase 2

Ph2 Study for Optimization of Adjunct Systemic Therapy in HER2+ Patients, MolecularPCR Trial

Recruiting
NCT06123338Phase 2

A Study of Pembrolizumab With Trastuzumab and Chemotherapy in People With Esophagogastric Cancer

Recruiting
NCT03367676Phase 2

12 weekS Adjuvant dOcetaxel Plus trastuzumaB in Patients With Small, Node-negative, HER2-positive Breast cancER (SOBER)

Terminated
NCT07315750Phase 3

A Study of Disitamab Vedotin Combined With Trastuzumab and Tislelizumab Versus Chemotherapy Combined With Trastuzumab With or Without Pembrolizumab in HER2-high Expression Advanced Gastric or Gastroesophageal Junction Adenocarcinoma.

Recruiting
NCT07829900

First-Line Dual Versus Single HER2-Targeted Therapy With Docetaxel for Advanced HER2-Positive Breast Cancer

Completed
NCT04208178Phase 3

Study of Alpelisib (BYL719) in Combination With Trastuzumab and Pertuzumab as Maintenance Therapy in Patients With HER2-positive Advanced Breast Cancer With a PIK3CA Mutation

Active Not Recruiting
NCT07679269Phase 2

Roll-Over Study of Alpelisib (BYL719) for Continued Access and Long-Term Safety.

Not Yet Recruiting
NCT01613482Phase 3

TraStuzumAb-Radiotherapy : Impact on the Cerebral Prevention

Terminated

Drug Details

Intervention Type
DRUG
Total Trials
679