Chemotherapy and Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Neuroblastoma
Neuroblastoma Study Phase II Study of Various Therapies in Patients With Neuroblastoma
4 other identifiers
interventional
N/A
3 countries
94
Brief Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy or radiation therapy used to kill tumor cells. Combining these therapies may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combining chemotherapy and radiation therapy with or without peripheral stem cell transplantation in treating patients who have neuroblastoma.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
Started May 1997
Longer than P75 for phase_2
94 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 1997
CompletedFirst Submitted
Initial submission to the registry
June 6, 2001
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2002
CompletedFirst Posted
Study publicly available on registry
January 27, 2003
CompletedAugust 2, 2013
August 1, 2002
June 6, 2001
August 1, 2013
Conditions
Keywords
Interventions
Eligibility Criteria
Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.
Sponsors & Collaborators
Study Sites (94)
Urologische Klinik - Universitaetsklinikum Aachen
Aachen, D-52074, Germany
Kinderkrankenhaus Josefinum
Augsburg, 86154, Germany
Zentralklinikum Augsburg
Augsburg, DOH-86156, Germany
Caritaskrankenhaus
Bad Mergentheim, 97980, Germany
Klinikum Bayreuth
Bayreuth, 95445, Germany
Helios Klinikum Berlin
Berlin, 13122, Germany
Charite - Campus Virchow Klinikum
Berlin, D-13353, Germany
Krankenanstalten Gilead
Biefeld, 33617, Germany
Kinderklinik der Universitaet-Bonn
Bonn, DOH-53113, Germany
Stadt Klinikum - Howedestrase
Braunschweig, 38118, Germany
Zentralkrankenhaus
Bremen, D-28205, Germany
Klinikum Chemnitz GMBH
Chemnitz, D-09116, Germany
Klinikum Coburg
Coburg, 96450, Germany
Medizinische Universitaetsklinik I
Cologne, D-50924, Germany
Carl - Thiem - Klinkum Cottbus
Cottbus, D-03048, Germany
Vestische Kinderklinik
Datteln, 45704, Germany
Klinikum Lippe - Detmold
Detmold, 32756, Germany
Stadt. Kliniken
Dortmund, 44123, Germany
Stadt. KH Dresden - Neustadt
Dresden, 01229, Germany
Universitatsklinikum Carl Gustav Carl Carus
Dresden, D-01307, Germany
Universitaetsklinik Duesseldorf
Düsseldorf, D-40225, Germany
Helios Klinikum Erfurt GmbH
Erfurt, 99012, Germany
Universitaets - Kinderklinik
Erlangen, D-91054, Germany
Universitaetsklinikum Essen
Essen, D-45122, Germany
Klinikum der J.W. Goethe Universitaet
Frankfurt, D-60590, Germany
Universitaetskinderklinik - Universitaetsklinikum Freiburg
Freiburg im Breisgau, 79106, Germany
Stadt. Kinderklinik
Gelsenkirchen, 45892, Germany
Kinderklinik
Giessen, D-35385, Germany
Universitaetsklinikum Goettingen
Göttingen, D-37075, Germany
Universitats - Kinderklinik
Greiswald, 17487, Germany
Kreiskrankenhaus Gummersbach GMBH
Gummersbach, D-51643, Germany
St. Barbara Krankenhaus
Halle, 06003, Germany
Martin Luther Universitaet
Halle, 06097, Germany
Altonaer Kinderkrankenhaus
Hamburg, 22763, Germany
Universitaets-Krankenhaus Eppendorf
Hamburg, D-20246, Germany
Evangelische Krankenhaus Hamm
Hamm, DOH-59063, Germany
Kinderkrankenhaus auf der Bult
Hanover, 30173, Germany
Medizinische Hochschule Hannover
Hanover, D-30625, Germany
Universitaets-Kinderklinik Heidelberg
Heidelberg, D-69120, Germany
Gemeinschaftskrankenhaus
Herdecke, 58313, Germany
Universitatsklinik Homburg
Homburg, 66421, Germany
Marien Hospital
Homburg, D-66421, Germany
Praxis am Evangelischen Krankenhaus Bethanien
Iserlohn, D-58644, Germany
Universitaets - Kinderklinik
Jena, D-07745, Germany
Westpfalz-Klinikum GmbH
Kaiserslautern, D-67653, Germany
Stadt. Kinderklinik
Karlsruhe, 76131, Germany
Kinderkrankenhaus
Kassel, 34121, Germany
Klinikum Kassel
Kassel, D-34125, Germany
Staedtische Krankenhaus Kiel
Kiel, 23116, Germany
University Hospital Schleswig-Holstein - Kiel Campus
Kiel, D-24105, Germany
Stadt. Krankenhaus Kemperhof
Koblenz, 56065, Germany
Staedtisches Kinderkrankenhaus
Koln - Riehl, D-50735, Germany
Klinik Konstanz
Konstanz, 78461, Germany
Klinikum Krefeld GmbH
Krefeld, D-47805, Germany
Universitaets - Kinderklinik
Leipzig, 04317, Germany
Universitaets Klinik fuer Kinderchirurgie
Leipzig, D-04317, Germany
St. Annastift Krankenhaus
Ludwigshafen, 67065, Germany
Universitaets - Kinderklinik - Luebeck
Lübeck, 23538, Germany
Universitatsklinikum der MA
Magdeburg, 39112, Germany
Johannes Gutenberg University
Mainz, D-55131, Germany
Stadt. Klinik - Kinderklinik
Mannheim, 68167, Germany
Universitaets - Kinderklinik
Marburg, 35033, Germany
Klinikum Minden
Minden, D-32423, Germany
Universitaets - Kinderpoliklinik
Munich, 80336, Germany
Kinderklinik d. TU / Schwabing
Munich, 80804, Germany
Staedtisches Krankenhaus Muenchen - Harlaching
Munich, D-81545, Germany
Kinderklinik
Munich, DOH-80337, Germany
Klinik und Poliklinik fuer Kinderheilkunde - Universitaetsklinikum Muenster
Münster, D-48149, Germany
Kinderklinik Kohlhof
Neunkirchen, 66539, Germany
Cnopfche Kinderklinik
Nuremberg, 90419, Germany
Klinikum Oldenburg
Oldenburg, 26133, Germany
Kindershospital
Osnabrück, D-49082, Germany
Krankenhaus D Barmherzigen Brueder
Regensburg, 93049, Germany
Staedtische Klinikum-Kinderklinik
Rosenheim, 83022, Germany
Kinderklinik - Universitaetsklinikum Rostock
Rostock, D-18057, Germany
Saarbrucker Winterbergkliniken
Saarbrücken, 66119, Germany
Johanniter-Kinderklinik
Sankt Augustin, 53757, Germany
Diakone - Krankenhaus
Schwäbisch Hall, 74523, Germany
Klinikum Schwerin
Schwerin, D-19049, Germany
Leopoldina - Krankenhaus
Schwienfurt, 97422, Germany
Deutsches Rotes Kreuz
Siegen, 57072, Germany
Olgahospital
Stuttgart, DOH-70176, Germany
Mutterhaus der Borromaerinnen
Trier, D-54290, Germany
Universitaetsklinikum Tuebingen
Tübingen, D-72076, Germany
Universitaet Ulm
Ulm, D-89075, Germany
St. Marien Hospital
Vechta, D-49377, Germany
Reinhard - Nieter - Krankenhaus
Wilhelmshaven, 26389, Germany
Helios Klinikum Wuppertal
Wuppertal, D-42283, Germany
Universitaets - Kinderklinik Wuerzburg
Würzburg, D-97080, Germany
Academisch Ziekenhuis Maastricht
Maastricht, 6202 AZ, Netherlands
University Children's Hospital
Basel, CH-4005, Switzerland
Ospedale "la Carita", Locarno
Locarno, 6600, Switzerland
Kinderspital Luzerne
Luzerne 16, CH-6000, Switzerland
University Children's Hospital
Zurich, CH-8032, Switzerland
Related Publications (13)
Krams M, Hero B, Berthold F, Parwaresch R, Harms D, Rudolph P. Proliferation marker KI-S5 discriminates between favorable and adverse prognosis in advanced stages of neuroblastoma with and without MYCN amplification. Cancer. 2002 Feb 1;94(3):854-61.
PMID: 11857322BACKGROUNDSimon T, Hero B, Dupuis W, Selle B, Berthold F. The incidence of hearing impairment after successful treatment of neuroblastoma. Klin Padiatr. 2002 Jul-Aug;214(4):149-52. doi: 10.1055/s-2002-33179.
PMID: 12165893BACKGROUNDSpitz R, Hero B, Westermann F, Ernestus K, Schwab M, Berthold F. Fluorescence in situ hybridization analyses of chromosome band 1p36 in neuroblastoma detect two classes of alterations. Genes Chromosomes Cancer. 2002 Jul;34(3):299-305. doi: 10.1002/gcc.10070.
PMID: 12007190BACKGROUNDHero B, Simon T, Spitz R, Ernestus K, Gnekow AK, Scheel-Walter HG, Schwabe D, Schilling FH, Benz-Bohm G, Berthold F. Localized infant neuroblastomas often show spontaneous regression: results of the prospective trials NB95-S and NB97. J Clin Oncol. 2008 Mar 20;26(9):1504-10. doi: 10.1200/JCO.2007.12.3349.
PMID: 18349403BACKGROUNDSimon T, Hero B, Benz-Bohm G, von Schweinitz D, Berthold F. Review of image defined risk factors in localized neuroblastoma patients: Results of the GPOH NB97 trial. Pediatr Blood Cancer. 2008 May;50(5):965-9. doi: 10.1002/pbc.21343.
PMID: 17914735BACKGROUNDBerthold F, Hero B, Kremens B, Handgretinger R, Henze G, Schilling FH, Schrappe M, Simon T, Spix C. Long-term results and risk profiles of patients in five consecutive trials (1979-1997) with stage 4 neuroblastoma over 1 year of age. Cancer Lett. 2003 Jul 18;197(1-2):11-7. doi: 10.1016/s0304-3835(03)00076-4.
PMID: 12880954BACKGROUNDSpitz R, Hero B, Ernestus K, Berthold F. Deletions in chromosome arms 3p and 11q are new prognostic markers in localized and 4s neuroblastoma. Clin Cancer Res. 2003 Jan;9(1):52-8.
PMID: 12538451BACKGROUNDSpitz R, Hero B, Ernestus K, Berthold F. FISH analyses for alterations in chromosomes 1, 2, 3, and 11 define high-risk groups in neuroblastoma. Med Pediatr Oncol. 2003 Jul;41(1):30-5. doi: 10.1002/mpo.10313.
PMID: 12764740BACKGROUNDSpitz R, Hero B, Ernestus K, Berthold F. Gain of distal chromosome arm 17q is not associated with poor prognosis in neuroblastoma. Clin Cancer Res. 2003 Oct 15;9(13):4835-40.
PMID: 14581355BACKGROUNDvon Schweinitz D, Hero B, Berthold F. The impact of surgical radicality on outcome in childhood neuroblastoma. Eur J Pediatr Surg. 2002 Dec;12(6):402-9. doi: 10.1055/s-2002-36952.
PMID: 12548494BACKGROUNDSimon T, Hero B, Bongartz R, Schmidt M, Muller RP, Berthold F. Intensified external-beam radiation therapy improves the outcome of stage 4 neuroblastoma in children > 1 year with residual local disease. Strahlenther Onkol. 2006 Jul;182(7):389-94. doi: 10.1007/s00066-006-1498-8.
PMID: 16826357RESULTKremens B, Hero B, Esser J, Weinel P, Filger-Brillinger J, Fleischhack G, Graf N, Gruttner HP, Niemeyer C, Schulz A, Wickmann L, Berthold F. Ocular symptoms in children treated with human-mouse chimeric anti-GD2 mAb ch14.18 for neuroblastoma. Cancer Immunol Immunother. 2002 Apr;51(2):107-10. doi: 10.1007/s00262-001-0259-x. Epub 2002 Feb 1.
PMID: 11904735RESULTDecarolis B, Simon T, Krug B, Leuschner I, Vokuhl C, Kaatsch P, von Schweinitz D, Klingebiel T, Mueller I, Schweigerer L, Berthold F, Hero B. Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed. BMC Cancer. 2016 Jul 27;16:542. doi: 10.1186/s12885-016-2513-9.
PMID: 27465021DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Frank Berthold, MD
Children's Hospital Medical Center, Cincinnati