Key Insights

Highlights

Success Rate

82% trial completion

Published Results

71 trials with published results (15%)

Research Maturity

237 completed trials (49% of total)

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 72/100

Termination Rate

10.6%

51 terminated out of 483 trials

Success Rate

82.3%

-4.2% vs benchmark

Late-Stage Pipeline

6%

31 trials in Phase 3/4

Results Transparency

30%

71 of 237 completed with results

Key Signals

71 with results82% success51 terminated

Data Visualizations

Phase Distribution

408Total
Not Applicable (43)
Early P 1 (12)
P 1 (190)
P 2 (132)
P 3 (28)
P 4 (3)

Trial Status

Completed237
Recruiting74
Unknown55
Terminated51
Active Not Recruiting33
Withdrawn20

Trial Success Rate

82.3%

Benchmark: 86.5%

Based on 237 completed trials

Clinical Trials (483)

Showing 20 of 20 trials
NCT06465199Phase 1Recruiting

Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas

NCT04301843Phase 2Active Not RecruitingPrimary

Eflornithine (DFMO) and Etoposide for Relapsed/Refractory Neuroblastoma

NCT06172296Phase 3Recruiting

Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

NCT02679144Phase 2Active Not RecruitingPrimary

Neuroblastoma Maintenance Therapy Trial

NCT01192555Phase 1Active Not RecruitingPrimary

Allogeneic Tumor Cell Vaccination With Oral Metronomic Cytoxan in Patients With High-Risk Neuroblastoma

NCT06450041Phase 2RecruitingPrimary

NANT 2021-01 Phase II STING (Sequential Temozolomide, Irinotecan, NK Cells and GD2 mAb) Trial

NCT07635056Phase 2RecruitingPrimary

Haploidentical Donor Cytokine-Induced Memory-Like Natural Killer Cells (CIML-NK) for Relapsed & Refractory Neuroblastoma

NCT06942039Early Phase 1Recruiting

Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation

NCT06395103Phase 1Recruiting

Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)

NCT01005654Recruiting

Prospective Comprehensive Molecular Analysis of Endocrine Neoplasms

NCT06057948Phase 2RecruitingPrimary

A Study of a Vaccine in Combination With Beta-glucan in People With Neuroblastoma

NCT00911560Phase 1Active Not RecruitingPrimary

Bivalent Vaccine With Escalating Doses of the Immunological Adjuvant OPT-821, in Combination With Oral β-glucan for High-Risk Neuroblastoma

NCT00107289Phase 2RecruitingPrimary

Iodine I 131 Metaiodobenzylguanidine in Treating Patients With Recurrent, Progressive, or Refractory Neuroblastoma or Malignant Pheochromocytoma or Paraganglioma

NCT04559217Phase 2RecruitingPrimary

68Ga-DOTATATE Neuroblastoma Imaging Pilot

NCT06995872Phase 1RecruitingPrimary

Phase I Trial of rhIL-15 Plus Dinutuximab Plus Irinotecan/Temozolomide for Children and Young Adults With Relapsed/Refractory Neuroblastoma

NCT01109394Recruiting

Comprehensive Omics Analysis of Pediatric and Adult Solid Tumors and Establishment of a Repository for Related Biological Studies

NCT07172958Phase 1Recruiting

Selective Antigen Specific T Cells and CAR T Cells in Subjects With Relapsed/Refractory Embryonal Tumors (SABRE)

NCT01875601Phase 1Completed

NK White Blood Cells and Interleukin in Children and Young Adults With Advanced Solid Tumors

NCT04897321Phase 1Recruiting

B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR)

NCT02311621Phase 1Active Not RecruitingPrimary

Engineered Neuroblastoma Cellular Immunotherapy (ENCIT)-01

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