NCT02874638|Completed
Effect of Non-essential Amino Acids on Protein Requirements for Endurance Athletes
EA3
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EA3
Sponsor study identifier
interventional
7
0 countries
N/A
Study Start
September 2016
Actual (reported)Primary Completion
August 2017
Actual (reported)Study Completion
December 31, 2017
Actual (reported)Protein requirements in individuals who participate in endurance-based exercise training have been suggested to be greater than the current recommended dietary allowance (RDA). The biological value of protein depends on its amino acid composition. Essential amino acids are believed to have main role on whole body protein metabolism. However, it remains to be determined what role non-essential amino acids (NEAA) may have in regulating protein metabolism and contributing to the increased protein requirements after endurance exercise. The indicator amino acid oxidation (IAAO) method has clarified the individual amino acid requirement in children, normal healthy adult and clinical populations. However, the IAAO method has never been utilized for assessing the effect of NEAA on protein requirements after endurance exercise. The objective of the current study is to investigate the importance of NEAA for endurance-trained male subjects.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 31, 2017
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
August 17, 2016
Actual (reported)August 22, 2016
Actual (reported)September 2016
Actual (reported)August 2017
Actual (reported)December 31, 2017
Actual (reported)13CO2 (carbon dioxide) excretion rate (μmol/kg/h)
8 hours after exercise followed by ingesting 13C-labelled phenylalanine and one of 5 different amount of amino acids intake, 13CO2 excretion rate is determined by multiplying the enrichment of 13CO2 in breath measured by Mass spectrometry and CO2 production rate measured by metabolic cart.
at 8 hours after the end of exercise]
[13C]phenylalanine oxidation rate (μmol/kg/h)
at 8 hours after the end of exercise
0.8 g/kg/d of BASE protein provided as crystalline amino acid made after egg protein.
branched-chain amino acid-enriched egg protein
small amount of essential amino acids made after egg protein, which is equivalent to the amount of essential amino acids in BASE
0.8 g/kg/d of protein provided as crystalline amino acid modeled after egg protein
BCAA-enriched egg protein provided as crystalline amino acid.
Daniel Moore, Ph.D.
University of Toronto
7 participants (actual enrollment reported by the registry).
First Submitted
August 17, 2016
First Posted
August 22, 2016
Study Start
September 2016
Actual (reported)Protein Requirements for Active Children
large amount of essential amino acids made after egg protein, which is equivalent to the amount of amino acids in BCAA
essential amino acids modeled after egg protein, provided as crystalline amino acid, which is equivalent to the amount of essential amino acid in BASE egg protein
essential amino acids modeled after egg protein, provided as crystalline amino acid, which is equivalent to the amount of amino acid in BCAA-enriched egg protein
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Primary Completion
August 2017
Actual (reported)Study Completion
December 31, 2017
Actual (reported)Last Updated
April 1, 2019
Record last verified: 2019-03
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Source: ClinicalTrials.gov.
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