Protein Requirements In Active Populations
Evaluation of Protein Requirements in Active, Young Adult Males
1 other identifier
interventional
7
0 countries
N/A
Brief Summary
Protein requirements in active individuals have been suggested to be greater than the current recommended dietary allowance (RDA). Nutritional requirements for dietary amino acids in adults have traditionally been determined utilizing the nitrogen balance technique, which is prone to underestimating protein requirements. As a result, there is a need to re-evaluate recommendations in order to characterize how dietary amino acid needs may be modulated by physical activity. Recent studies using the minimally invasive indicator amino acid oxidation (IAAO) technique have suggested that protein requirements in young men are at least 50% higher than the RDA based on nitrogen balance data. The purpose of this study is to measure the protein requirement in active, young adult males using the IAAO technique in the presence of a variable intensity exercise stimulus.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Apr 2015
Typical duration for not_applicable
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2015
CompletedFirst Submitted
Initial submission to the registry
June 18, 2015
CompletedFirst Posted
Study publicly available on registry
June 23, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2017
CompletedApril 1, 2019
March 1, 2019
1.2 years
June 18, 2015
March 28, 2019
Conditions
Outcome Measures
Primary Outcomes (1)
13CO2 (carbon dioxide) excretion (μmol/kg/h)
4 hours / study day
Secondary Outcomes (1)
13C-Phenylalanine Oxidation (μmol/kg/h)
4 hours / study day
Study Arms (1)
Active, Young Adult Males
EXPERIMENTALSubjects will receive different levels of amino acid intakes varying from 0.2 to 2.6 g/kg/day.
Interventions
Amino acid intakes will be varied at 0.2-2.6 g/kg/day
Eligibility Criteria
You may qualify if:
- Healthy, active, young adult males who regularly participate in moderate-vigorous activity 5x per week, for a minimum of 1 hour
- A minimum score of 10 on the Beep Test (a measure of aerobic fitness)
You may not qualify if:
- Inability to meet health and physical activity guidelines according to the physical activity readiness questionnaire (PAR-Q+)
- Inability to adhere to any of the protocol guidelines (i.e. alcohol, caffeine consumption)
- Regular tobacco use
- Illicit drug use
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Torontolead
- Ajinomoto Co., Inc.collaborator
Related Publications (1)
Packer JE, Wooding DJ, Kato H, Courtney-Martin G, Pencharz PB, Moore DR. Variable-Intensity Simulated Team-Sport Exercise Increases Daily Protein Requirements in Active Males. Front Nutr. 2017 Dec 21;4:64. doi: 10.3389/fnut.2017.00064. eCollection 2017.
PMID: 29312948DERIVED
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor
Study Record Dates
First Submitted
June 18, 2015
First Posted
June 23, 2015
Study Start
April 1, 2015
Primary Completion
June 1, 2016
Study Completion
December 1, 2017
Last Updated
April 1, 2019
Record last verified: 2019-03