NCT02800239

Completed

Protein Requirements for Active Adolescent Females

University of Toronto Source

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Other study identifiers

Sponsor study identifier

IAAO-AF

Study Type

interventional

Actual enrollment (reported)

7

Locations

1 country

Sites

1

Timeline

Study Start

February 2016

Actual (reported)

Primary Completion

October 2017

Actual (reported)

Study Completion

December 31, 2017

Actual (reported)

Brief Summary

Protein requirements in active individuals have been suggested to be greater than the current recommended dietary allowance (RDA). Nutritional requirements for dietary amino acids in adolescents have traditionally been determined utilizing the nitrogen balance technique, which is prone to underestimating protein requirements. As a result, there is a need to re-evaluate recommendations in order to characterize how dietary amino acid needs may be modulated by physical activity. Recent studies using the minimally invasive indicator amino acid oxidation (IAAO) technique have suggested that protein requirements in young men are at least 50% higher than the RDA based on nitrogen balance data. The purpose of this study is to measure the protein requirement in adolescent, females using the IAAO technique in the presence of a variable intensity exercise stimulus.

Registry Overview

Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.

Recruitment status: completed
Actual enrollment (reported): 7 participants
Study completion date: December 31, 2017
Actual (reported)
Listed locations: 1 countries · 1 sites

Trial Relationships

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Some registry-reported names shown below are not yet linked in this graph.

Study Timeline

Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.

Study Start
February 2016
Actual (reported)
First Submitted
June 10, 2016
Actual (reported)
First Posted
June 15, 2016
Actual (reported)
Primary Completion
October 2017
Actual (reported)
Study Completion
December 31, 2017
Actual (reported)

Last Updated: April 1, 2019
Status Verified: March 2019
Last Update Submitted: March 28, 2019

Conditions

Healthy Increased Metabolic Requirement

Outcome Measures

Primary Outcomes (1)

13CO2 ([13]Carbon Dioxide) Excretion (µmol/kg/h)
4 hours/ study day

Secondary Outcomes (1)

[13C]Phenylalanine Oxidation (µmol/kg/h)
4 hours/ study day

Study Arms (1)

Active, adolescent females

EXPERIMENTAL

Subjects will receive different levels of amino acid intakes, varying from 0.2-2.67 g/kg/d

Dietary Supplement: Amino Acid Intake

Interventions

Amino Acid IntakeDietary supplement

Amino acid intakes will be varied at 0.2-2.67 g/kg/d

Active, adolescent females

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age10 Years - 15 Years

Sexfemale

Healthy VolunteersYes

Age GroupsChild (0-17)

You may qualify if:

Healthy, active adolescent who regularly participates in moderate to vigorous physical activity 5 times a week for a minimum of 1 hour.
Being -0.5 to +1.0 years from peak height velocity, determined by the ratio of standing to sitting height, with the maximal age for adolescents being 16 years.

Sponsors & Collaborators

Ajinomoto Co., Inc.
Industrycollaborator
University of Toronto
Otherlead

Study Sites (1)

Goldring Centre for High Performance Sport

Toronto, Ontario, M5S2C9, Canada

Study Officials

Daniel Moore, PhD
University of Toronto
PRINCIPAL INVESTIGATOR

Enrollment

7 participants (actual enrollment reported by the registry).

Study Design

Study Type: interventional
Phase: not applicable
Allocation: NA
Masking: NONE
Purpose: BASIC SCIENCE
Intervention Model: SINGLE GROUP
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Assistant Professor

Study Record Dates

First Submitted

June 10, 2016

First Posted

June 15, 2016

Study Start

February 2016

Actual (reported)

NCT02859181

Protein Requirements for Active Adolescent Males (IAAO-AM)

Not ApplicableCompleted

NCT03696264

Protein Requirements in Resistance-trained Males

Not ApplicableCompleted

NCT02874638

Effect of Non-essential Amino Acids on Protein Requirements for Endurance Athletes

Not ApplicableCompleted

NCT02628249

Rate-limiting Amino Acids in Endurance-trained Athlete

Not ApplicableCompleted

NCT06431334

Protein Requirements Amongst Male Masters-Level Athletes Following a Cycling Exercise Bout as Determined by the Indicator Amino Acid Oxidation Technique

Not ApplicableCompleted

NCT02801344

The Impact of Protein Intake on Protein Metabolism During Intensified Training

Not ApplicableCompleted

Obtaining a minimum level of 5.8 on the Beep Test

You may not qualify if:

Inability to meet health and physical activity guidelines according to the Physical Activity Readiness Questionnaire (PAR-Q+) and Physical Activity Questionnaire,
An inability to adhere to any of the protocol guidelines (i.e. caffeine consumption)
A biological age falling outside of the aforementioned ranges

Contact the study team to confirm eligibility.

Primary Completion

October 2017

Actual (reported)

Study Completion

December 31, 2017

Actual (reported)

Last Updated

April 1, 2019

Record last verified: 2019-03

Data Sharing

IPD Sharing: Will not share

Source record

Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.

Source: ClinicalTrials.gov.

JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.

Registry identifier: NCT02800239
Data provider: ClinicalTrials.gov
Source updated: 2019-04-01
Normalization version: ctgov-legacy-1

Open registry record

Source retrieved: 2026-10-25 22:18:17 UTC

Locations

CA(1)

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (1)

Study Arms (1)

Active, adolescent females

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations