NCT02628249|Completed
Rate-limiting Amino Acids in Endurance-trained Athlete
EA
Application of Indicator Amino Acid Oxidation Method to Investigate the Rate-limiting Amino Acids in Endurance Trained Athlete
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EA
Application of Indicator Amino Acid Oxidation Method to Investigate the Rate-limiting Amino Acids in Endurance Trained Athlete
Sponsor study identifier
interventional
5
0 countries
N/A
Study Start
September 2015
Actual (reported)Primary Completion
June 2017
Actual (reported)Study Completion
December 2017
Actual (reported)Protein requirements in individuals who participate in endurance-based exercise training have been suggested to be greater than the current recommended dietary allowance (RDA). The biological value of protein depends on the amino acid composition. As liebig's law of the minimum, the protein synthesis is limited due to the lack of single rate limiting amino acid. In this case, the first rate limiting amino acid determines protein intakes to maximize the protein synthesis. Adding a small amount of rate-limiting amino acid to the diet improves the biological value of its protein diet. The indicator amino acid oxidation (IAAO) method has clarified the individual amino acid requirement in children, normal healthy adult and clinical populations. however, the IAAO method has never been utilized for determining the first rate limiting amino acid. Therefore, the purpose of this study is to address of IAAO method to be applied for determining the rate-limiting amino acid in endurance athlete.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2017
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
September 2015
Actual (reported)December 7, 2015
Actual (reported)December 11, 2015
Actual (reported)June 2017
Actual (reported)December 2017
Actual (reported)13CO2 (carbon dioxide) excretion rate (μmol/kg/h)
8 hours after exercise followed by ingesting 13C-labelled phenylalanine and one of 5 different amount of amino acids intake, 13CO2 excretion rate is determined by multiplying the enrichment of 13CO2 in breath measured by Mass spectrometry and CO2 production rate measured by metabolic cart.
At 8 hours after the end of exercise
[13C]phenylalanine oxidation rate (μmol/kg/h)
at 8 hours after the end of exercise
0.8 g/kg/d of protein provided as crystalline amino acid made after egg protein.
1.75 g/kg/d protein provided as crystalline amino acid made after egg protein.
Base protein intake + Branched chain amino acids
0.8 g/kg/d of protein provided as crystalline amino acid modeled after egg protein
Kato H, Suzuki K, Bannai M, Moore DR. Branched-Chain Amino Acids Are the Primary Limiting Amino Acids in the Diets of Endurance-Trained Men after a Bout of Prolonged Exercise. J Nutr. 2018 Jun 1;148(6):925-931. doi: 10.1093/jn/nxy048.
5 participants (actual enrollment reported by the registry).
First Submitted
December 7, 2015
First Posted
December 11, 2015
Study Start
September 2015
Actual (reported)Protein Requirements for Active Children
Base protein intake + essential amino acids.
Base protein intake + non essential amino acids
1.75 g/kg/d protein provided as crystalline amino acid modeled after egg protein.
Branched chain amino acids modeled after egg protein.
Essential amino acids modeled after egg protein.
Non essential amino acids modeled after egg protein.
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Primary Completion
June 2017
Actual (reported)Study Completion
December 2017
Actual (reported)Last Updated
April 1, 2019
Record last verified: 2019-03
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Source: ClinicalTrials.gov.
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