Protein Requirements in Endurance-trained Athlete

NCT02478801 | Completed Early Phase 1

• 1 other identifier: IAAO-E
• Study Type: interventional
• Target: 9
• Locations: 0 countries
• Sites: N/A

Brief Summary

Protein requirements in individuals who participate in endurance-based exercise training have been suggested to be greater than the current recommended dietary allowance (RDA). Nutritional requirements for dietary amino acids in adults have traditionally been determined utilizing the nitrogen balance technique, which is prone to underestimating protein requirements. As a result, there is a need to re-evaluate recommendations in order to characterize how dietary amino acid needs may be modulated by physical activity. Recent studies using the minimally invasive indicator amino acid oxidation (IAAO) technique have suggested that protein requirements in young men are at least 50% higher than RDA based on nitrogen balance data. Therefore, the purpose of this study is to measure the protein requirement in endurance trained adults using the IAAO technique.

Conditions

Increased Metabolic Requirement; Healthy

Outcome Measures

Primary Outcomes (1)

• 13CO2 (carbon dioxide) excretion (μmol/kg/h)

  4 hours / study day

Secondary Outcomes (1)

• [13C]phenylalanine oxidation (μmol/kg/h)

  4 hours/study day

Study Arms (1)

Endurance trained

EXPERIMENTAL

subjects will receive different levels of amino acids intakes varying from 0.2 to 2.8 g/kg/day.

Dietary Supplement: amino acids intake

Interventions

amino acids intake DIETARY_SUPPLEMENT

amino acids intakes will be varied at 0.2-2.8 g/kg/day

Endurance trained

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy, male, endurance-trained participants who regularly more than 40 km/week
• Ability to perform the exercise stimulus (20 km run) on metabolic trial.

You may not qualify if:

• Inability to meet health and physical activity guidelines according to the physical activity readiness questionnaire (PAR-Q+)
• Inability to adhere to any of the protocol guidelines (i.e. alcohol, caffeine consumption)
• Regular tobacco use
• Illicit drug use

Sponsors & Collaborators

• University of Toronto: lead
• Ajinomoto Co., Inc.: collaborator

Related Publications (1)

• Kato H, Suzuki K, Bannai M, Moore DR. Protein Requirements Are Elevated in Endurance Athletes after Exercise as Determined by the Indicator Amino Acid Oxidation Method. PLoS One. 2016 Jun 20;11(6):e0157406. doi: 10.1371/journal.pone.0157406. eCollection 2016.

  PMID: 27322029 DERIVED

Study Design

• Study Type: interventional
• Phase: early phase 1
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: June 18, 2015
• First Posted: June 23, 2015
• Study Start: March 1, 2015
• Primary Completion: January 1, 2016
• Study Completion: May 1, 2016
• Last Updated: June 16, 2016

Record last verified: 2016-06