Protein Requirements for Active Adolescent Males (IAAO-AM)

NCT02859181 | Completed

• 1 other identifier: IAAO-AM
• Study Type: interventional
• Target: 7
• Locations: 1 country
• Sites: 1

Brief Summary

Protein requirements in active individuals have been suggested to be greater than the current recommended dietary allowance (RDA). Nutritional requirements for dietary amino acids in adolescents have traditionally been determined utilizing the nitrogen balance technique, which is prone to underestimating protein requirements. As a result, there is a need to re-evaluate recommendations in order to characterize how dietary amino acid needs may be modulated by physical activity. Recent studies using the minimally invasive indicator amino acid oxidation (IAAO) technique have suggested that protein requirements in young men are at least 50% higher than the RDA based on nitrogen balance data. The purpose of this study is to measure the protein requirement in adolescent, males using the IAAO technique in the presence of a variable intensity exercise stimulus.

Conditions

Healthy

Keywords

Increased Metabolic Requirement

Outcome Measures

Primary Outcomes (1)

• 13CO2 ([13]Carbon Dioxide) Excretion (µmol/kg/h)

  Each trial day will assess a different protein intake with 13CO2 excretion defining the level of protein adequacy. Each trial day will be separated by \~1wk washout with all trial being completed in approximately 3 months.

  4 hours per study day

Secondary Outcomes (1)

• [13C]Phenylalanine Oxidation (µmol/kg/h)

  4 hours per study day

Study Arms (1)

Active, Adolescent males

EXPERIMENTAL

Subjects will receive different levels of amino acid intakes, varying from 0.2-2.67 g/kg/d

Dietary Supplement: Amino Acid Intake

Interventions

Amino Acid Intake DIETARY_SUPPLEMENT

Amino acid intakes will be varied at 0.2-2.67 g/kg/d

Active, Adolescent males

Eligibility Criteria

• Age: 10 Years - 15 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• Healthy, active adolescent who regularly participates in moderate to vigorous physical activity 5 times a week for a minimum of 1 hour.
• Being -0.5 to +1.0 years from peak height velocity, determined by the ratio of standing to sitting height, with the maximal age for adolescents being 16 years.
• Obtaining a minimum level of 8.3 on the Beep Test

You may not qualify if:

• Inability to meet health and physical activity guidelines according to the Physical activity readiness questionnaire (PAR-Q+) and Physical Activity Questionnaire,
• an inability to adhere to any of the protocol guidelines (i.e. caffeine consumption)
• a biological age falling outside of the aforementioned ranges

Sponsors & Collaborators

• University of Toronto: lead
• Ajinomoto Co., Inc.: collaborator

Study Sites (1)

Goldring Centre for High Performance Sport

Toronto, Ontario, M5S2C9, Canada

Location

Study Officials

• Daniel Moore, PhD

  University of Toronto

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: June 10, 2016
• First Posted: August 8, 2016
• Study Start: October 1, 2016
• Primary Completion: November 15, 2017
• Study Completion: April 30, 2018
• Last Updated: March 29, 2019

Record last verified: 2019-03

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)