Protein Requirements In Active Female Populations

NCT02626429 | Completed

• 1 other identifier: IAAO-YF
• Study Type: interventional
• Target: 6
• Locations: 0 countries
• Sites: N/A

Brief Summary

Protein requirements in active individuals have been suggested to be greater than the current recommended dietary allowance (RDA). Nutritional requirements for dietary amino acids in adults have traditionally been determined utilizing the nitrogen balance technique, which is prone to underestimating protein requirements. As a result, there is a need to re-evaluate recommendations in order to characterize how dietary amino acid needs may be modulated by physical activity. Recent studies using the minimally invasive indicator amino acid oxidation (IAAO) technique have suggested that protein requirements in young men are at least 50% higher than the RDA based on nitrogen balance data. The purpose of this study is to measure the protein requirement in active, young adult females using the IAAO technique in the presence of a variable intensity exercise stimulus.

Conditions

Increased Metabolic Requirement; Healthy

Outcome Measures

Primary Outcomes (1)

• 13CO2 (carbon dioxide) excretion (μmol/kg/h)

  4 hours / study day

Secondary Outcomes (1)

• 13C-Phenylalanine Oxidation (μmol/kg/h)

  4 hours / study day

Study Arms (1)

Active, Young Adult Famale

EXPERIMENTAL

Participants will complete a bout of exercise and then consume a randomly assigned amino acid intake prior to measuring whole body 13CO2 excretion and phenylalanine oxidation.

Dietary Supplement: Amino acid intake

Interventions

Amino acid intake DIETARY_SUPPLEMENT

Amino acid intakes will be varied at 0.2-2.6 g/kg/day

Active, Young Adult Famale

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy, active, young adult females who regularly participate in moderate-vigorous activity 5x per week, for a minimum of 1 hour
• A minimum score of 10 on the Beep Test (a measure of aerobic fitness)

You may not qualify if:

• Inability to meet health and physical activity guidelines according to the physical activity readiness questionnaire (PAR-Q+)
• Inability to adhere to any of the protocol guidelines (i.e. alcohol, caffeine consumption)
• Regular tobacco use
• Illicit drug use

Sponsors & Collaborators

• University of Toronto: lead
• Ajinomoto Co., Inc.: collaborator

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant professaor

Study Record Dates

• First Submitted: December 7, 2015
• First Posted: December 10, 2015
• Study Start: May 1, 2015
• Primary Completion: June 1, 2017
• Study Completion: June 1, 2017
• Last Updated: December 11, 2017

Record last verified: 2017-12