Protein Requirements for Active Children

NCT03163043 | Completed

• 1 other identifier: IAAO-C
• Study Type: interventional
• Target: 8
• Locations: 1 country
• Sites: 1

Brief Summary

Nutritional requirements for dietary amino acids in children have traditionally been determined utilizing the nitrogen balance technique, which is prone to underestimating protein requirements. As a result, there is a need to re-evaluate recommendations in order to characterize how dietary amino acid needs may be modulated by physical activity in healthy, active children. The purpose of this study is to measure the protein requirement in children (boys and girls) using the IAAO technique in the presence of a variable intensity exercise stimulus. It is hypothesized that the present study will deem current amino acid requirements to be underestimates of appropriate amino acid requirements for this population.

Conditions

Increased Metabolic Requirement; Healthy

Outcome Measures

Primary Outcomes (1)

• 13CO2 ([13]Carbon Dioxide) Excretion (µmol/kg/h)

  4 hours/study day

Secondary Outcomes (1)

• [13C]Phenylalanine Oxidation (µmol/kg/h)

  4 hours/study day

Study Arms (1)

Active, Male and Female Children

EXPERIMENTAL

Participants will receive different levels of amino acid intakes, varying from 0.2-2.67 g/kg/d

Dietary Supplement: Amino Acid Intake

Interventions

Amino Acid Intake DIETARY_SUPPLEMENT

Amino acid intakes will be varied at 0.2-2.67 g/kg/d

Active, Male and Female Children

Eligibility Criteria

• Age: 7 Years - 12 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• Healthy, active children who regularly participates in moderate to vigorous physical activity 5 times a week for a minimum of 1 hour.
• Biological age less than or equal to -1.0 years from Peak Height Velocity (PHV), determined by the ratio of standing to sitting height
• An age and sex-specific minimum performance level on the Beep Test

You may not qualify if:

• Inability to meet health and physical activity guidelines according to the PAR-Q+ and Physical Activity Questionnaire
• Inability to adhere to any of the protocol guidelines (i.e., caffeine consumption)
• Biological age greater than -1.0 years from PHV

Sponsors & Collaborators

• Daniel Moore: lead
• Ajinomoto Co., Inc.: collaborator

Study Sites (1)

Goldring Centre For High Performance Sport

Toronto, Ontario, M5S 2C9, Canada

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Dr. Daniel Moore, Assistant Professor

Study Record Dates

• First Submitted: May 19, 2017
• First Posted: May 22, 2017
• Study Start: October 22, 2016
• Primary Completion: October 31, 2017
• Study Completion: December 31, 2017
• Last Updated: March 29, 2019

Record last verified: 2019-03

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)