NCT04855474|Completed
Protein Requirements in Male and Female Endurance Athletes
Estimating Post-exercise Protein Requirements in Male and Female Endurance Athletes
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Estimating Post-exercise Protein Requirements in Male and Female Endurance Athletes
Sponsor study identifier
interventional
16
1 country
1
Study Start
March 8, 2021
Actual (reported)Primary Completion
October 31, 2021
Actual (reported)Study Completion
December 30, 2022
Actual (reported)Protein is an essential macronutrient for post-exercise recovery through its ability to provide the amino acid building blocks that support increased rates of muscle and whole body protein synthesis. Despite the growing understanding of the importance of post-exercise protein in endurance athlete populations, the impact of sex and female menstrual cycle phase on protein metabolism is not fully understood. To date, no studies have examined protein requirements in female endurance trained athletes. The aim of the proposed study is to utilize the well-established IAAO method to determine protein requirements in endurance trained female and male athletes in a "real-world" and at-home setting.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 30, 2022
Actual (reported)Click on a node to explore related trials.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 8, 2021
Actual (reported)April 18, 2021
Actual (reported)April 22, 2021
Actual (reported)October 31, 2021
Actual (reported)December 30, 2022
Actual (reported)Phenylalanine excretion
13CO2 production in umol/kg/h
8 hours
Phenylalanine Oxidation
8 hours
Phenylalanine net balance
8 hours
Urinary 3-methylhistidine
8 hours
Protein requirement
8 hours
0.2 g/kg/day of protein provided as crystalline amino acid made after egg protein.
1.2g/kg/day of protein provided as crystalline amino acid made after egg protein.
2.0 g/kg/day of protein provided as crystalline amino acid made after egg protein.
Participants will consume hourly (8 hours) isoenergetic, isonitrogenous beverages containing one of the three protein intakes (0.2g/kg/d, 1.2 g/kg/d, 2.0g/kg/d) assigned in a randomized order between the three metabolic trials. Drinks will be enriched with stable isotope \[13C\]phenylalanine. The use of stable isotope \[13C\]phenylalanine will allow for the determination of the fate of AA in the body (incorporation into body protein or oxidation) which can be used to determine protein (AA) requirements.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Goldring Centre for High Performance Sport
Toronto, Ontario, M5S2C9, Canada
Williamson E, Fung HJW, Adams C, West DWD, Moore DR. Protein Requirements Are Increased in Endurance-Trained Athletes but Similar between Females and Males during Postexercise Recovery. Med Sci Sports Exerc. 2023 Oct 1;55(10):1866-1875. doi: 10.1249/MSS.0000000000003219. Epub 2023 May 19.
Daniel Moore, Ph.D
University of Toronto
16 participants (actual enrollment reported by the registry).
First Submitted
April 18, 2021
First Posted
April 22, 2021
Study Start
Protein Requirements in Resistance-trained Males
Contact the study team to confirm eligibility.
March 8, 2021
Actual (reported)Primary Completion
October 31, 2021
Actual (reported)Study Completion
December 30, 2022
Actual (reported)Last Updated
July 13, 2023
Record last verified: 2023-07
Data described in the manuscript will be made available upon request pending application and approval.
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Source: ClinicalTrials.gov.
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