Targeted Treatment for ALK Positive Patients Who Have Previously Been Treated for Non-squamous Non-small Cell Lung Cancer

NCT03737994 | Terminated Phase 2 Results FDA Drug

• 3 other identifiers: NCI-2018-02486NRG-LU003U10CA180868
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 491

Brief Summary

This National Cancer Institute (NCI)-NRG ALK Protocol phase II trial studies how well a combination of different biomarker/ALK inhibitors work in treating patients with stage IV ALK positive non-squamous non-small cell lung cancer. Lorlatinib, ceritinib, alectinib, brigatinib, ensartinib, and crizotinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as pemetrexed, cisplatin, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether a combination of biomarker/ALK inhibitors or chemotherapy may work better in treating patients with ALK positive non-squamous non-small cell lung cancer.

Conditions

Stage IVB Lung Cancer AJCC v8; Stage IV Lung Cancer AJCC v8; Lung Non-Squamous Non-Small Cell Carcinoma; Stage IVA Lung Cancer AJCC v8

Outcome Measures

Primary Outcomes (1)

• Objective Response Rate (ORR), Per Investigator Assessment Using the Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 Criteria

  ORR= number of subjects with best overall response (BOR) of complete or partial response (CR, PR) divided by number of evaluable subjects. BOR= best response recorded from start of treatment to first progression (PD)/new anticancer therapy, otherwise last follow-up. * CR: disappearance of target and non-target lesions; no new lesions; pathological lymph nodes \< 10mm. * PR: 30% decrease in target lesions; non-target lesions not progressed or not evaluated; no new lesions. * PD: 20% increase of target lesions and/or new lesion(s). ORR was to be compared using Fisher's exact test within each ALK inhibitor treatment arm (each mutation vs. no mutation) and also within the subset of subjects with no mutation comparing each experimental arm vs. pemetrexed. Due to early accrual closure (few subjects), only the number of subjects with BOR of CR or PR are provided, by mutation, no statistical testing. Analysis was to occur after each patient was potentially followed ≥ 24 weeks.

  Baseline to 24 weeks

Secondary Outcomes (5)

• Progression-free Survival (PFS), Per Investigator Assessment Using RECIST v1.1 Criteria

  Baseline to the date of the first disease progression / progressive disease, death, or last known follow-up. Maximum follow-up time was 33.6 months, median 8.9 months.

• Duration of Overall Response, Per Investigator Assessment Using RECIST v1.1

  Baseline to the date of the first disease progression / progressive disease, death, or last known follow-up. Maximum follow-up time was 33.6 months, median 8.9 months.

• Overall Survival (OS)

  Baseline to the date of death or last known follow-up. Maximum follow-up time was 33.6 months, median 8.9 months.

• Intracranial Objective Response Rate, Per Investigator Assessment Using RECIST v1.1

  Baseline to 24 weeks

• Number of Participants by Highest Grade Adverse Event Reported

  Baseline to the date of last known follow-up. Maximum follow-up time was 33.6 months, median 8.9 months.

Other Outcomes (1)

• Agreement of Biopsy Mutation and Circulating Free Deoxyribonucleic Acid (cfDNA) Mutation Results

  Baseline

Study Arms (10)

ALK L1198F mutation (alone or combination with ALK inhibitor)

EXPERIMENTAL

Patients with ALK L1198F mutation (alone or in combination with another ALK mutation) receive crizotinib PO QD. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.

Drug: Crizotinib

C1156Y

EXPERIMENTAL

Patients with Cy1156Y mutation receive either lorlatinib PO QD, alectinib PO BID, or brigatinib PO QD. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.

Drug: Alectinib; Drug: Brigatinib; Drug: Lorlatinib

Compound mutation

EXPERIMENTAL

Patients with a compound mutation receive lorlatinib PO QD. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.

Drug: Lorlatinib

F1174

EXPERIMENTAL

Patients with F1174 receive either lorlatinib PO QD, alectinib PO BID, or brigatinib PO QD. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.

Drug: Alectinib; Drug: Brigatinib; Drug: Lorlatinib

G1202 (including G1202del and G1202R)

EXPERIMENTAL

Patients with G1202 (including G1202del and G1202R) receive either lorlatinib PO QD or brigatinib PO QD. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.

Drug: Brigatinib; Drug: Lorlatinib

I1171

EXPERIMENTAL

Patients with I1171 mutation receive either lorlatinib PO QD, ceritinib PO QD, or brigatinib PO QD. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.

Drug: Brigatinib; Drug: Ceritinib; Drug: Lorlatinib

L1196 (including L1196M)

EXPERIMENTAL

Patients with L1196 (including L1196M) mutation receive either lorlatinib PO QD, ceritinib PO QD, alectinib PO BID, brigatinib PO QD, or ensartinib PO QD. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.

Drug: Alectinib; Drug: Brigatinib; Drug: Ceritinib; Drug: Crizotinib; Drug: Ensartinib; Drug: Lorlatinib

MET amplification

EXPERIMENTAL

Patients with MET amplification receive crizotinib PO QD. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.

Drug: Crizotinib

No ALK-resistance mutations

EXPERIMENTAL

Patients with no ALK-resistant mutations receive either lorlatinib PO QD, ceritinib PO QD, alectinib PO BID, brigatinib PO QD, ensartinib PO QD, or pemetrexed IV over 10 minutes on day 1 with or without either cisplatin IV or carboplatin IV on day 1. ALK inhibitor cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity. Pemetrexed-based treatment repeats every 21 days for up to 6 cycles in the absence of disease progression or unacceptable toxicity. Maintenance treatment of pemetrexed may continue until disease progression or unacceptable toxicity.

Drug: Alectinib; Drug: Brigatinib; Drug: Carboplatin; Drug: Ceritinib; Drug: Cisplatin; Drug: Ensartinib; Drug: Lorlatinib; Drug: Pemetrexed

V1180

EXPERIMENTAL

Patients with V1180 mutation receive either lorlatinib PO QD, ceritinib PO QD, or brigatinib PO QD. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.

Drug: Brigatinib; Drug: Ceritinib; Drug: Lorlatinib

Interventions

Alectinib DRUG

Given PO

Also known as: AF 802, AF-802, AF802, Alecensa, ALK Inhibitor RO5424802, CH 5424802, CH-5424802, CH5424802, RG 7853, RG-7853, RG7853, RO 5424802, RO-5424802, RO5424802

C1156Y; F1174; L1196 (including L1196M); No ALK-resistance mutations

Brigatinib DRUG

Given PO

Also known as: Alunbrig, AP 26113, AP-26113, AP26113, Biganib, Briganix, Trepmac

C1156Y; F1174; G1202 (including G1202del and G1202R); I1171; L1196 (including L1196M); No ALK-resistance mutations; V1180

Carboplatin DRUG

Given IV

Also known as: Blastocarb, Carboplat, Carboplatin Hexal, Carboplatino, Carboplatinum, Carbosin, Carbosol, Carbotec, CBDCA, Displata, Ercar, JM-8, JM8, Nealorin, Novoplatinum, Paraplatin, Paraplatin AQ, Paraplatine, Platinwas, Ribocarbo

No ALK-resistance mutations

Ceritinib DRUG

Given PO

Also known as: LDK 378, LDK-378, LDK378, Zykadia

I1171; L1196 (including L1196M); No ALK-resistance mutations; V1180

Cisplatin DRUG

Given IV

Also known as: Abiplatin, Blastolem, Briplatin, CDDP, Cis-diammine-dichloroplatinum, Cis-diamminedichloridoplatinum, Cis-diamminedichloro Platinum (II), Cis-diamminedichloroplatinum, Cis-dichloroammine Platinum (II), Cis-platinous Diamine Dichloride, Cis-platinum, Cis-platinum II, Cis-platinum II Diamine Dichloride, Cismaplat, Cisplatina, Cisplatinum, Cisplatyl, Citoplatino, Citosin, Cysplatyna, DDP, Lederplatin, Metaplatin, Neoplatin, Peyrone's Chloride, Peyrone's Salt, Placis, Plastistil, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platinol- AQ, Platinol-AQ, Platinol-AQ VHA Plus, Platinoxan, Platinum, Platinum Diamminodichloride, Platiran, Platistin, Platosin

No ALK-resistance mutations

Crizotinib DRUG

Given PO

Also known as: Alkixen, Crizocent, MET Tyrosine Kinase Inhibitor PF-02341066, PF 02341066, PF-02341066, PF-2341066, PF02341066, Xalkori

ALK L1198F mutation (alone or combination with ALK inhibitor); L1196 (including L1196M); MET amplification

Ensartinib DRUG

Given PO

Also known as: X 396, X-396, X396

L1196 (including L1196M); No ALK-resistance mutations

Lorlatinib DRUG

Given PO

Also known as: 2H-4,8-Methenopyrazolo(4,3-H)(2,5,11)benzoxadiazacyclotetradecine-3-carbonitrile, 7-amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-, (10R)-, Lorbrena, Lorviqua, PF 06463922, PF-06463922, PF06463922

C1156Y; Compound mutation; F1174; G1202 (including G1202del and G1202R); I1171; L1196 (including L1196M); No ALK-resistance mutations; V1180

Pemetrexed DRUG

Given IV

Also known as: MTA, Multitargeted Antifolate, Pemfexy

No ALK-resistance mutations

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• PRIOR TO STEP 1 REGISTRATION
• Patients must have histologically or cytologically confirmed stage IV ALK-positive non-squamous non-small cell lung carcinoma (NSCLC) (includes M1a, M1b, M1c stage disease, American Joint Committee on Cancer \[AJCC\] 8th edition). ALK rearrangement must have been demonstrated by a Food and Drug Administration (FDA) approved assay (Vysis fluorescence in situ hybridization \[FISH\] or Ventana immunohistochemistry \[IHC\]) or by next generation sequencing (NGS)
• Patient must be willing and able to undergo a fresh biopsy or if patient has a biopsy after progression on current tyrosine-kinase inhibitor (TKI) within 3 months of study enrollment (and has continued TKI for clinical benefit per treating physician) this tissue may be used. Must have sufficient tissue
• Patient must have progressive disease as defined by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 after one second generation ALK inhibitor, including LDK378 (ceritinib), alectinib, ensartinib, and brigatinib (may not have received more than one second-generation ALK inhibitor). Patient may have received prior crizotinib; however, the second generation ALK inhibitor received must be the last treatment given prior to study enrollment
• Prior lorlatinib (third-generation ALK inhibitor) is not allowed
• Prior chemotherapy is not allowed except for one prior cycle received at the time of original diagnosis of metastatic NSCLC with no evidence of disease progression following the cycle. NOTE: prior adjuvant or neoadjuvant chemotherapy is allowed if last dose was received more than 12 months prior to enrollment
• The patient or a legally authorized representative must provide study-specific informed consent prior to Step 1 Registration
• PRIOR TO STEP 2 REGISTRATION
• Absolute neutrophil count (ANC) \>= 1500 cells/mm\^3 (within 28 days prior to step 2 registration)
• Platelets \>= 100,000 cells/mm\^3 (within 28 days prior to step 2 registration)
• Estimated creatinine clearance \>= 60 mL/min by the Cockcroft Gault formula (within 28 days prior to step 2 registration)
• Total bilirubin =\< 1.5 x upper limit of normal (ULN) (except for patients with documented Gilbert's syndrome) (within 28 days prior to step 2 registration)
• Aspartate aminotransferase (AST) =\< 2.5 x ULN; =\< 5 x ULN if liver metastases are present (within 28 days prior to step 2 registration)
• Alanine aminotransferase (ALT) =\< 2.5 x ULN; =\< 5 x ULN if liver metastases are present (within 28 days prior to step 2 registration)
• Patients with asymptomatic treated or untreated brain metastases are eligible. Treated brain metastases are eligible as long as patients have measurable disease outside the brain according to RECIST 1.1. Patients must be on a stable or decreasing dose of steroids for at least 7 days prior to step 2 registration. Anticonvulsants are allowed as long as the patient is neurologically stable and not deteriorating

You may not qualify if:

• Major surgery within 2 weeks of study entry. Minor surgical procedures (e.g., port insertion, pleurex catheter placement) are allowed and all wounds must not show signs of infection or draining
• Palliative RT (\< 10 fractions) must have been completed at least 48 hours prior to study entry. Stereotactic or small field brain irradiation must have completed at least 1 week prior to study entry. Whole brain RT or other palliative RT must have been completed at least 2 weeks prior to study entry
• Prior dose of next generation ALK inhibitor (LDK378 \[ceritinib\], alectinib, ensartinib, lorlatinib) within 5 days prior to step 2 registration. Prior dose of brigatinib within 7 days prior to step 2 registration
• History of interstitial lung disease or interstitial fibrosis, including a history of pneumonitis, obliterative bronchiolitis, pulmonary fibrosis. Patients with a history of prior radiation pneumonitis are not excluded
• Active inflammatory gastrointestinal disease (such as Crohns, ulcerative colitis), chronic diarrhea, symptomatic diverticular disease, or any gastrointestinal disease that would affect the absorption of oral medications or increase the risk of toxicity
• Clinically significant cardiovascular abnormalities, as determined by the treating/registering physician, such as uncontrolled hypertension, congestive heart failure New York Heart Association (NYHA) classification of 3, unstable angina or poorly controlled arrhythmia, or myocardial infarction within 6 months
• Active and clinically significant bacterial, fungal, or viral infection
• Patients with active or chronic pancreatitis based on lipase elevation, symptoms, and radiographic findings
• Other concomitant serious illness or organ system dysfunction that in the opinion of the investigator would either compromise patient safety or interfere with the evaluation of the safety of the study drug
• Patients must not plan to receive any other investigational agents during the course of therapy
• Patients with active malignancy other than ALK-positive non-squamous NSCLC within the last 2 years are excluded (note: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, papillary thyroid cancer treated with curative intent, adequately treated stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for 2 years are eligible)
• No chemotherapy and/or immunotherapy allowed after step 1 registration

Sponsors & Collaborators

• National Cancer Institute (NCI): lead
• NRG Oncology: collaborator

Study Sites (491)

CTCA at Western Regional Medical Center

Goodyear, Arizona, 85338, United States

Location

Mayo Clinic Hospital in Arizona

Phoenix, Arizona, 85054, United States

Location

Mayo Clinic in Arizona

Scottsdale, Arizona, 85259, United States

Location

Mercy Hospital Fort Smith

Fort Smith, Arkansas, 72903, United States

Location

CHI Saint Vincent Cancer Center Hot Springs

Hot Springs, Arkansas, 71913, United States

Location

Kaiser Permanente-Anaheim

Anaheim, California, 92806, United States

Location

Kaiser Permanente-Deer Valley Medical Center

Antioch, California, 94531, United States

Location

Mission Hope Medical Oncology - Arroyo Grande

Arroyo Grande, California, 93420, United States

Location

Kaiser Permanente-Baldwin Park

Baldwin Park, California, 91706, United States

Location

Kaiser Permanente-Bellflower

Bellflower, California, 90706, United States

Location

Kaiser Permanente Dublin

Dublin, California, 94568, United States

Location

21st Century Oncology - El Segundo

El Segundo, California, 90245, United States

Location

Kaiser Permanente-Fontana

Fontana, California, 92335, United States

Location

Kaiser Permanente-Fremont

Fremont, California, 94538, United States

Location

Fresno Cancer Center

Fresno, California, 93720, United States

Location

Kaiser Permanente-Fresno

Fresno, California, 93720, United States

Location

Kaiser Permanente South Bay

Harbor City, California, 90710, United States

Location

Kaiser Permanente-Irvine

Irvine, California, 92618, United States

Location

UC San Diego Moores Cancer Center

La Jolla, California, 92093, United States

Location

Loma Linda University Medical Center

Loma Linda, California, 92354, United States

Location

Kaiser Permanente Los Angeles Medical Center

Los Angeles, California, 90027, United States

Location

Kaiser Permanente West Los Angeles

Los Angeles, California, 90034, United States

Location

Kaiser Permanente-Modesto

Modesto, California, 95356, United States

Location

Kaiser Permanente Oakland-Broadway

Oakland, California, 94611, United States

Location

Kaiser Permanente-Oakland

Oakland, California, 94611, United States

Location

Kaiser Permanente-Ontario

Ontario, California, 91761, United States

Location

Kaiser Permanente - Panorama City

Panorama City, California, 91402, United States

Location

Kaiser Permanente-Rancho Cordova Cancer Center

Rancho Cordova, California, 95670, United States

Location

Kaiser Permanente-Redwood City

Redwood City, California, 94063, United States

Location

Kaiser Permanente-Richmond

Richmond, California, 94801, United States

Location

Kaiser Permanente-Riverside

Riverside, California, 92505, United States

Location

Rohnert Park Cancer Center

Rohnert Park, California, 94928, United States

Location

Kaiser Permanente-Roseville

Roseville, California, 95661, United States

Location

The Permanente Medical Group-Roseville Radiation Oncology

Roseville, California, 95678, United States

Location

Kaiser Permanente Downtown Commons

Sacramento, California, 95814, United States

Location

Kaiser Permanente-South Sacramento

Sacramento, California, 95823, United States

Location

South Sacramento Cancer Center

Sacramento, California, 95823, United States

Location

Kaiser Permanente Sacramento Medical Center

Sacramento, California, 95825, United States

Location

Kaiser Permanente-San Diego Mission

San Diego, California, 92108, United States

Location

Kaiser Permanente-San Diego Zion

San Diego, California, 92120, United States

Location

Kaiser Permanente-San Francisco

San Francisco, California, 94115, United States

Location

Kaiser Permanente-Santa Teresa-San Jose

San Jose, California, 95119, United States

Location

Kaiser Permanente San Leandro

San Leandro, California, 94577, United States

Location

Pacific Central Coast Health Center-San Luis Obispo

San Luis Obispo, California, 93401, United States

Location

Kaiser Permanente-San Marcos

San Marcos, California, 92078, United States

Location

Kaiser Permanente-San Rafael

San Rafael, California, 94903, United States

Location

Kaiser San Rafael-Gallinas

San Rafael, California, 94903, United States

Location

Kaiser Permanente Medical Center - Santa Clara

Santa Clara, California, 95051, United States

Location

Mission Hope Medical Oncology - Santa Maria

Santa Maria, California, 93444, United States

Location

Kaiser Permanente-Santa Rosa

Santa Rosa, California, 95403, United States

Location

Kaiser Permanente Cancer Treatment Center

South San Francisco, California, 94080, United States

Location

Kaiser Permanente-South San Francisco

South San Francisco, California, 94080, United States

Location

Kaiser Permanente-Stockton

Stockton, California, 95210, United States

Location

Kaiser Permanente Medical Center-Vacaville

Vacaville, California, 95688, United States

Location

Kaiser Permanente-Vallejo

Vallejo, California, 94589, United States

Location

Kaiser Permanente-Walnut Creek

Walnut Creek, California, 94596, United States

Location

Kaiser Permanente-Woodland Hills

Woodland Hills, California, 91367, United States

Location

UCHealth University of Colorado Hospital

Aurora, Colorado, 80045, United States

Location

Penrose-Saint Francis Healthcare

Colorado Springs, Colorado, 80907, United States

Location

Rocky Mountain Cancer Centers-Penrose

Colorado Springs, Colorado, 80907, United States

Location

UCHealth Memorial Hospital Central

Colorado Springs, Colorado, 80909, United States

Location

Memorial Hospital North

Colorado Springs, Colorado, 80920, United States

Location

AdventHealth Porter

Denver, Colorado, 80210, United States

Location

CommonSpirit Cancer Center Mercy

Durango, Colorado, 81301, United States

Location

Mercy Medical Center

Durango, Colorado, 81301, United States

Location

Mountain Blue Cancer Care Center

Golden, Colorado, 80401, United States

Location

Rocky Mountain Cancer Centers-Lakewood

Lakewood, Colorado, 80228, United States

Location

Saint Anthony Hospital

Lakewood, Colorado, 80228, United States

Location

AdventHealth Littleton

Littleton, Colorado, 80122, United States

Location

Longmont United Hospital

Longmont, Colorado, 80501, United States

Location

Rocky Mountain Cancer Centers-Longmont

Longmont, Colorado, 80501, United States

Location

AdventHealth Parker

Parker, Colorado, 80138, United States

Location

Rocky Mountain Cancer Centers-Parker

Parker, Colorado, 80138, United States

Location

Saint Mary Corwin Medical Center

Pueblo, Colorado, 81004, United States

Location

Rocky Mountain Cancer Centers - Pueblo

Pueblo, Colorado, 81008, United States

Location

Rocky Mountain Cancer Centers-Thornton

Thornton, Colorado, 80260, United States

Location

Beebe Medical Center

Lewes, Delaware, 19958, United States

Location

Beebe South Coastal Health Campus

Millville, Delaware, 19967, United States

Location

Delaware Clinical and Laboratory Physicians PA

Newark, Delaware, 19713, United States

Location

Helen F Graham Cancer Center

Newark, Delaware, 19713, United States

Location

Medical Oncology Hematology Consultants PA

Newark, Delaware, 19713, United States

Location

Christiana Care Health System-Christiana Hospital

Newark, Delaware, 19718, United States

Location

Beebe Health Campus

Rehoboth Beach, Delaware, 19971, United States

Location

TidalHealth Nanticoke / Allen Cancer Center

Seaford, Delaware, 19973, United States

Location

Christiana Care Health System-Wilmington Hospital

Wilmington, Delaware, 19801, United States

Location

Sibley Memorial Hospital

Washington D.C., District of Columbia, 20016, United States

Location

GenesisCare USA - Aventura FP

Aventura, Florida, 33180, United States

Location

GenesisCare USA - Boca Raton FP02

Boca Raton, Florida, 33428, United States

Location

GenesisCare USA - Boca Ration FP06

Boca Raton, Florida, 33431, United States

Location

Holy Cross Hospital

Fort Lauderdale, Florida, 33308, United States

Location

Mayo Clinic in Florida

Jacksonville, Florida, 32224-9980, United States

Location

GenesisCare USA - Key West

Key West, Florida, 33040, United States

Location

GenesisCare USA - Lakewood Ranch

Lakewood Rch, Florida, 34202, United States

Location

GenesisCare USA - Palm Beach Gardens

Palm Beach Gardens, Florida, 33410, United States

Location

GenesisCare USA - Plantation

Plantation, Florida, 33324, United States

Location

Good Samaritan Medical Center

West Palm Beach, Florida, 33401, United States

Location

Grady Health System

Atlanta, Georgia, 30303, United States

Location

Emory University Hospital Midtown

Atlanta, Georgia, 30308, United States

Location

Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322, United States

Location

Emory Saint Joseph's Hospital

Atlanta, Georgia, 30342, United States

Location

Northside Hospital

Atlanta, Georgia, 30342, United States

Location

Northside Hospital - Duluth

Duluth, Georgia, 30096, United States

Location

Emory Johns Creek Hospital

Johns Creek, Georgia, 30097, United States

Location

Northside Hospital - Gwinnett

Lawrenceville, Georgia, 30046, United States

Location

CTCA at Southeastern Regional Medical Center

Newnan, Georgia, 30265, United States

Location

Suburban Hematology Oncology Associates - Snellville

Snellville, Georgia, 30078, United States

Location

Hawaii Cancer Care Inc - Waterfront Plaza

Honolulu, Hawaii, 96813, United States

Location

Island Urology

Honolulu, Hawaii, 96813, United States

Location

Queen's Cancer Cenrer - POB I

Honolulu, Hawaii, 96813, United States

Location

Queen's Medical Center

Honolulu, Hawaii, 96813, United States

Location

Straub Clinic and Hospital

Honolulu, Hawaii, 96813, United States

Location

University of Hawaii Cancer Center

Honolulu, Hawaii, 96813, United States

Location

Hawaii Cancer Care Inc-Liliha

Honolulu, Hawaii, 96817, United States

Location

Kuakini Medical Center

Honolulu, Hawaii, 96817, United States

Location

Queen's Cancer Center - Kuakini

Honolulu, Hawaii, 96817, United States

Location

The Cancer Center of Hawaii-Liliha

Honolulu, Hawaii, 96817, United States

Location

Kaiser Permanente Moanalua Medical Center

Honolulu, Hawaii, 96819, United States

Location

Kapiolani Medical Center for Women and Children

Honolulu, Hawaii, 96826, United States

Location

Wilcox Memorial Hospital and Kauai Medical Clinic

Lihue, Hawaii, 96766, United States

Location

Hawaii Cancer Care - Westridge

‘Aiea, Hawaii, 96701, United States

Location

Pali Momi Medical Center

‘Aiea, Hawaii, 96701, United States

Location

Queen's Cancer Center - Pearlridge

‘Aiea, Hawaii, 96701, United States

Location

The Cancer Center of Hawaii-Pali Momi

‘Aiea, Hawaii, 96701, United States

Location

Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, 83706, United States

Location

Saint Alphonsus Cancer Care Center-Caldwell

Caldwell, Idaho, 83605, United States

Location

Kootenai Health - Coeur d'Alene

Coeur d'Alene, Idaho, 83814, United States

Location

Walter Knox Memorial Hospital

Emmett, Idaho, 83617, United States

Location

Idaho Urologic Institute-Meridian

Meridian, Idaho, 83642, United States

Location

Saint Alphonsus Cancer Care Center-Nampa

Nampa, Idaho, 83687, United States

Location

Kootenai Clinic Cancer Services - Post Falls

Post Falls, Idaho, 83854, United States

Location

Kootenai Clinic Cancer Services - Sandpoint

Sandpoint, Idaho, 83864, United States

Location

Rush-Copley Medical Center

Aurora, Illinois, 60504, United States

Location

Illinois CancerCare-Bloomington

Bloomington, Illinois, 61704, United States

Location

Illinois CancerCare-Canton

Canton, Illinois, 61520, United States

Location

Memorial Hospital of Carbondale

Carbondale, Illinois, 62902, United States

Location

SIH Cancer Institute

Carterville, Illinois, 62918, United States

Location

Illinois CancerCare-Carthage

Carthage, Illinois, 62321, United States

Location

Centralia Oncology Clinic

Centralia, Illinois, 62801, United States

Location

University of Illinois

Chicago, Illinois, 60612, United States

Location

Carle at The Riverfront

Danville, Illinois, 61832, United States

Location

Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, 62526, United States

Location

Decatur Memorial Hospital

Decatur, Illinois, 62526, United States

Location

Illinois CancerCare-Dixon

Dixon, Illinois, 61021, United States

Location

Carle Physician Group-Effingham

Effingham, Illinois, 62401, United States

Location

Crossroads Cancer Center

Effingham, Illinois, 62401, United States

Location

Illinois CancerCare-Eureka

Eureka, Illinois, 61530, United States

Location

NorthShore University HealthSystem-Evanston Hospital

Evanston, Illinois, 60201, United States

Location

Illinois CancerCare-Galesburg

Galesburg, Illinois, 61401, United States

Location

Western Illinois Cancer Treatment Center

Galesburg, Illinois, 61401, United States

Location

NorthShore University HealthSystem-Glenbrook Hospital

Glenview, Illinois, 60026, United States

Location

NorthShore University HealthSystem-Highland Park Hospital

Highland Park, Illinois, 60035, United States

Location

Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois, 61443, United States

Location

Illinois CancerCare-Macomb

Macomb, Illinois, 61455, United States

Location

Carle Physician Group-Mattoon/Charleston

Mattoon, Illinois, 61938, United States

Location

SSM Health Good Samaritan

Mount Vernon, Illinois, 62864, United States

Location

Cancer Care Center of O'Fallon

O'Fallon, Illinois, 62269, United States

Location

Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, 61350, United States

Location

Illinois CancerCare-Pekin

Pekin, Illinois, 61554, United States

Location

Illinois CancerCare-Peoria

Peoria, Illinois, 61615, United States

Location

Methodist Medical Center of Illinois

Peoria, Illinois, 61636, United States

Location

Illinois CancerCare-Peru

Peru, Illinois, 61354, United States

Location

Valley Radiation Oncology

Peru, Illinois, 61354, United States

Location

Illinois CancerCare-Princeton

Princeton, Illinois, 61356, United States

Location

Southern Illinois University School of Medicine

Springfield, Illinois, 62702, United States

Location

Springfield Clinic

Springfield, Illinois, 62702, United States

Location

Springfield Memorial Hospital

Springfield, Illinois, 62781, United States

Location

Southwest Illinois Health Services LLP

Swansea, Illinois, 62226, United States

Location

Carle Cancer Center

Urbana, Illinois, 61801, United States

Location

The Carle Foundation Hospital

Urbana, Illinois, 61801, United States

Location

Rush-Copley Healthcare Center

Yorkville, Illinois, 60560, United States

Location

Indiana University/Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, 46202, United States

Location

Reid Health

Richmond, Indiana, 47374, United States

Location

Mary Greeley Medical Center

Ames, Iowa, 50010, United States

Location

McFarland Clinic - Ames

Ames, Iowa, 50010, United States

Location

McFarland Clinic - Boone

Boone, Iowa, 50036, United States

Location

Mercy Cancer Center-West Lakes

Clive, Iowa, 50325, United States

Location

UI Health Care Mission Cancer and Blood - West Des Moines Clinic

Clive, Iowa, 50325, United States

Location

Alegent Health Mercy Hospital

Council Bluffs, Iowa, 51503, United States

Location

Greater Regional Medical Center

Creston, Iowa, 50801, United States

Location

Mercy Medical Center - Des Moines

Des Moines, Iowa, 50314, United States

Location

UI Health Care Mission Cancer and Blood - Laurel Clinic

Des Moines, Iowa, 50314, United States

Location

McFarland Clinic - Trinity Cancer Center

Fort Dodge, Iowa, 50501, United States

Location

McFarland Clinic - Jefferson

Jefferson, Iowa, 50129, United States

Location

McFarland Clinic - Marshalltown

Marshalltown, Iowa, 50158, United States

Location

Mercy Medical Center-West Lakes

West Des Moines, Iowa, 50266, United States

Location

Flaget Memorial Hospital

Bardstown, Kentucky, 40004, United States

Location

Commonwealth Cancer Center-Corbin

Corbin, Kentucky, 40701, United States

Location

Saint Joseph Radiation Oncology Resource Center

Lexington, Kentucky, 40504, United States

Location

Saint Joseph Hospital East

Lexington, Kentucky, 40509, United States

Location

Saint Joseph London

London, Kentucky, 40741, United States

Location

Jewish Hospital

Louisville, Kentucky, 40202, United States

Location

Saints Mary and Elizabeth Hospital

Louisville, Kentucky, 40215, United States

Location

UofL Health Medical Center Northeast

Louisville, Kentucky, 40245, United States

Location

Jewish Hospital Medical Center South

Shepherdsville, Kentucky, 40165, United States

Location

Eastern Maine Medical Center

Bangor, Maine, 04401, United States

Location

Lafayette Family Cancer Center-EMMC

Brewer, Maine, 04412, United States

Location

Saint Agnes Hospital

Baltimore, Maryland, 21229, United States

Location

Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287, United States

Location

Massachusetts General Hospital Cancer Center

Boston, Massachusetts, 02114, United States

Location

Mercy Medical Center

Springfield, Massachusetts, 01104, United States

Location

Trinity Health Saint Joseph Mercy Hospital Ann Arbor

Ann Arbor, Michigan, 48106, United States

Location

Trinity Health IHA Medical Group Hematology Oncology - Brighton

Brighton, Michigan, 48114, United States

Location

Trinity Health Medical Center - Brighton

Brighton, Michigan, 48114, United States

Location

Henry Ford Cancer Institute-Downriver

Brownstown, Michigan, 48183, United States

Location

Trinity Health IHA Medical Group Hematology Oncology - Canton

Canton, Michigan, 48188, United States

Location

Trinity Health Medical Center - Canton

Canton, Michigan, 48188, United States

Location

Caro Cancer Center

Caro, Michigan, 48723, United States

Location

Chelsea Hospital

Chelsea, Michigan, 48118, United States

Location

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

Chelsea, Michigan, 48118, United States

Location

Hematology Oncology Consultants-Clarkston

Clarkston, Michigan, 48346, United States

Location

Michigan Healthcare Professionals Clarkston

Clarkston, Michigan, 48346, United States

Location

Newland Medical Associates-Clarkston

Clarkston, Michigan, 48346, United States

Location

Henry Ford Macomb Hospital-Clinton Township

Clinton Township, Michigan, 48038, United States

Location

Henry Ford Medical Center-Fairlane

Dearborn, Michigan, 48126, United States

Location

Henry Ford Hospital

Detroit, Michigan, 48202, United States

Location

Henry Ford Health Saint John Hospital

Detroit, Michigan, 48236, United States

Location

Henry Ford River District Hospital

East China Township, Michigan, 48054, United States

Location

Michigan Healthcare Professionals Farmington

Farmington Hills, Michigan, 48334, United States

Location

Cancer Hematology Centers - Flint

Flint, Michigan, 48503, United States

Location

Genesee Hematology Oncology PC

Flint, Michigan, 48503, United States

Location

Genesys Hurley Cancer Institute

Flint, Michigan, 48503, United States

Location

Hurley Medical Center

Flint, Michigan, 48503, United States

Location

Henry Ford Saint John Hospital - Academic

Grosse Pointe Woods, Michigan, 48236, United States

Location

Henry Ford Saint John Hospital - Breast

Grosse Pointe Woods, Michigan, 48236, United States

Location

Henry Ford Saint John Hospital - Van Elslander

Grosse Pointe Woods, Michigan, 48236, United States

Location

Allegiance Health

Jackson, Michigan, 49201, United States

Location

University of Michigan Health - Sparrow Lansing

Lansing, Michigan, 48912, United States

Location

Hope Cancer Clinic

Livonia, Michigan, 48154, United States

Location

Trinity Health Saint Mary Mercy Livonia Hospital

Livonia, Michigan, 48154, United States

Location

Henry Ford Saint John Hospital - Macomb Medical

Macomb, Michigan, 48044, United States

Location

Henry Ford Warren Hospital - Breast Macomb

Macomb, Michigan, 48044, United States

Location

Michigan Healthcare Professionals Macomb

Macomb, Michigan, 48044, United States

Location

Michigan Healthcare Professionals Madison Heights

Madison Heights, Michigan, 48071, United States

Location

Saint Mary's Oncology/Hematology Associates of Marlette

Marlette, Michigan, 48453, United States

Location

Henry Ford Medical Center-Columbus

Novi, Michigan, 48377, United States

Location

Hope Cancer Center

Pontiac, Michigan, 48341, United States

Location

Michigan Healthcare Professionals Pontiac

Pontiac, Michigan, 48341, United States

Location

Newland Medical Associates-Pontiac

Pontiac, Michigan, 48341, United States

Location

Trinity Health Saint Joseph Mercy Oakland Hospital

Pontiac, Michigan, 48341, United States

Location

Henry Ford Rochester Hospital

Rochester Hills, Michigan, 48309, United States

Location

MyMichigan Medical Center Saginaw

Saginaw, Michigan, 48601, United States

Location

Oncology Hematology Associates of Saginaw Valley PC

Saginaw, Michigan, 48604, United States

Location

Henry Ford Macomb Health Center - Shelby Township

Shelby, Michigan, 48315, United States

Location

Bhadresh Nayak MD PC-Sterling Heights

Sterling Heights, Michigan, 48312, United States

Location

MyMichigan Medical Center Tawas

Tawas City, Michigan, 48764, United States

Location

Michigan Healthcare Professionals Troy

Troy, Michigan, 48098, United States

Location

Advanced Breast Care Center PLLC

Warren, Michigan, 48088, United States

Location

Henry Ford Health Warren Hospital

Warren, Michigan, 48093, United States

Location

Henry Ford Madison Heights Hospital - Breast

Warren, Michigan, 48093, United States

Location

Henry Ford Warren Hospital - GLCMS

Warren, Michigan, 48093, United States

Location

Macomb Hematology Oncology PC

Warren, Michigan, 48093, United States

Location

Henry Ford West Bloomfield Hospital

West Bloomfield, Michigan, 48322, United States

Location

Saint Mary's Oncology/Hematology Associates of West Branch

West Branch, Michigan, 48661, United States

Location

Huron Gastroenterology PC

Ypsilanti, Michigan, 48106, United States

Location

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

Ypsilanti, Michigan, 48197, United States

Location

Riverwood Healthcare Center

Aitkin, Minnesota, 56431, United States

Location

Sanford Joe Lueken Cancer Center

Bemidji, Minnesota, 56601, United States

Location

Essentia Health Saint Joseph's Medical Center

Brainerd, Minnesota, 56401, United States

Location

Fairview Ridges Hospital

Burnsville, Minnesota, 55337, United States

Location

Minnesota Oncology - Burnsville

Burnsville, Minnesota, 55337, United States

Location

Cambridge Medical Center

Cambridge, Minnesota, 55008, United States

Location

Mercy Hospital

Coon Rapids, Minnesota, 55433, United States

Location

Essentia Health - Deer River Clinic

Deer River, Minnesota, 56636, United States

Location

Essentia Health Saint Mary's - Detroit Lakes Clinic

Detroit Lakes, Minnesota, 56501, United States

Location

Essentia Health Cancer Center

Duluth, Minnesota, 55805, United States

Location

Essentia Health Saint Mary's Medical Center

Duluth, Minnesota, 55805, United States

Location

Miller-Dwan Hospital

Duluth, Minnesota, 55805, United States

Location

Fairview Southdale Hospital

Edina, Minnesota, 55435, United States

Location

Lake Region Healthcare Corporation-Cancer Care

Fergus Falls, Minnesota, 56537, United States

Location

Essentia Health - Fosston

Fosston, Minnesota, 56542, United States

Location

Unity Hospital

Fridley, Minnesota, 55432, United States

Location

Essentia Health Hibbing Clinic

Hibbing, Minnesota, 55746, United States

Location

Fairview Clinics and Surgery Center Maple Grove

Maple Grove, Minnesota, 55369, United States

Location

Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, 55109, United States

Location

Saint John's Hospital - Healtheast

Maplewood, Minnesota, 55109, United States

Location

Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407, United States

Location

Hennepin County Medical Center

Minneapolis, Minnesota, 55415, United States

Location

Health Partners Inc

Minneapolis, Minnesota, 55454, United States

Location

Monticello Cancer Center

Monticello, Minnesota, 55362, United States

Location

New Ulm Medical Center

New Ulm, Minnesota, 56073, United States

Location

Essentia Health - Park Rapids

Park Rapids, Minnesota, 56470, United States

Location

Fairview Northland Medical Center

Princeton, Minnesota, 55371, United States

Location

North Memorial Medical Health Center

Robbinsdale, Minnesota, 55422, United States

Location

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

Location

Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416, United States

Location

Regions Hospital

Saint Paul, Minnesota, 55101, United States

Location

United Hospital

Saint Paul, Minnesota, 55102, United States

Location

Essentia Health Sandstone

Sandstone, Minnesota, 55072, United States

Location

Saint Francis Regional Medical Center

Shakopee, Minnesota, 55379, United States

Location

Lakeview Hospital

Stillwater, Minnesota, 55082, United States

Location

Sanford Thief River Falls Medical Center

Thief River Falls, Minnesota, 56701, United States

Location

Essentia Health Virginia Clinic

Virginia, Minnesota, 55792, United States

Location

Ridgeview Medical Center

Waconia, Minnesota, 55387, United States

Location

Rice Memorial Hospital

Willmar, Minnesota, 56201, United States

Location

Minnesota Oncology Hematology PA-Woodbury

Woodbury, Minnesota, 55125, United States

Location

Sanford Cancer Center Worthington

Worthington, Minnesota, 56187, United States

Location

Fairview Lakes Medical Center

Wyoming, Minnesota, 55092, United States

Location

Baptist Memorial Hospital and Cancer Center-Desoto

Southhaven, Mississippi, 38671, United States

Location

Mercy Oncology and Hematology - Clayton-Clarkson

Ballwin, Missouri, 63011, United States

Location

Parkland Health Center-Bonne Terre

Bonne Terre, Missouri, 63628, United States

Location

Cox Cancer Center Branson

Branson, Missouri, 65616, United States

Location

Mercy Cancer Center - Cape Girardeau

Cape Girardeau, Missouri, 63703, United States

Location

Saint Francis Medical Center

Cape Girardeau, Missouri, 63703, United States

Location

Siteman Cancer Center at Saint Peters Hospital

City of Saint Peters, Missouri, 63376, United States

Location

Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, 63141, United States

Location

Parkland Health Center - Farmington

Farmington, Missouri, 63640, United States

Location

MU Health Care Goldschmidt Cancer Center

Jefferson City, Missouri, 65109, United States

Location

Freeman Health System

Joplin, Missouri, 64804, United States

Location

Mercy Hospital Joplin

Joplin, Missouri, 64804, United States

Location

Mercy Clinic-Rolla-Cancer and Hematology

Rolla, Missouri, 65401, United States

Location

Phelps Health Delbert Day Cancer Institute

Rolla, Missouri, 65401, United States

Location

Heartland Regional Medical Center

Saint Joseph, Missouri, 64506, United States

Location

Sainte Genevieve County Memorial Hospital

Sainte Genevieve, Missouri, 63670, United States

Location

Mercy Hospital Springfield

Springfield, Missouri, 65804, United States

Location

CoxHealth South Hospital

Springfield, Missouri, 65807, United States

Location

Mercy Infusion Center - Chippewa

St Louis, Missouri, 63109, United States

Location

Washington University School of Medicine

St Louis, Missouri, 63110, United States

Location

Mercy Hospital South

St Louis, Missouri, 63128, United States

Location

Siteman Cancer Center-South County

St Louis, Missouri, 63129, United States

Location

Missouri Baptist Medical Center

St Louis, Missouri, 63131, United States

Location

Siteman Cancer Center at Christian Hospital

St Louis, Missouri, 63136, United States

Location

Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States

Location

Missouri Baptist Sullivan Hospital

Sullivan, Missouri, 63080, United States

Location

BJC Outpatient Center at Sunset Hills

Sunset Hills, Missouri, 63127, United States

Location

Mercy Hospital Washington

Washington, Missouri, 63090, United States

Location

Community Hospital of Anaconda

Anaconda, Montana, 59711, United States

Location

Billings Clinic Cancer Center

Billings, Montana, 59101, United States

Location

Bozeman Health Deaconess Hospital

Bozeman, Montana, 59715, United States

Location

Benefis Sletten Cancer Institute

Great Falls, Montana, 59405, United States

Location

Great Falls Clinic

Great Falls, Montana, 59405, United States

Location

Saint Peter's Community Hospital

Helena, Montana, 59601, United States

Location

Logan Health Medical Center

Kalispell, Montana, 59901, United States

Location

Community Medical Center

Missoula, Montana, 59804, United States

Location

Nebraska Cancer Specialists/Oncology Hematology West PC

Grand Island, Nebraska, 68803, United States

Location

Fred and Pamela Buffett Cancer Center - Kearney

Kearney, Nebraska, 68845, United States

Location

CHI Health Good Samaritan

Kearney, Nebraska, 68847, United States

Location

Saint Elizabeth Regional Medical Center

Lincoln, Nebraska, 68510, United States

Location

Nebraska Methodist Hospital

Omaha, Nebraska, 68114, United States

Location

Alegent Health Immanuel Medical Center

Omaha, Nebraska, 68122, United States

Location

Hematology and Oncology Consultants PC

Omaha, Nebraska, 68122, United States

Location

Alegent Health Bergan Mercy Medical Center

Omaha, Nebraska, 68124, United States

Location

Alegent Health Lakeside Hospital

Omaha, Nebraska, 68130, United States

Location

Creighton University Medical Center

Omaha, Nebraska, 68131, United States

Location

Midlands Community Hospital

Papillion, Nebraska, 68046, United States

Location

Mount Sinai Chelsea

New York, New York, 10011, United States

Location

Mount Sinai Hospital

New York, New York, 10029, United States

Location

University of Rochester

Rochester, New York, 14642, United States

Location

ECU Health Oncology Kenansville

Kenansville, North Carolina, 28349, United States

Location

ECU Health Oncology Kinston

Kinston, North Carolina, 28501, United States

Location

ECU Health Oncology Richlands

Richlands, North Carolina, 28574, United States

Location

Sanford Bismarck Medical Center

Bismarck, North Dakota, 58501, United States

Location

Essentia Health Cancer Center-South University Clinic

Fargo, North Dakota, 58103, United States

Location

Sanford South University Medical Center

Fargo, North Dakota, 58103, United States

Location

Southpointe-Sanford Medical Center Fargo

Fargo, North Dakota, 58103, United States

Location

Sanford Medical Center Fargo

Fargo, North Dakota, 58104, United States

Location

Sanford Broadway Medical Center

Fargo, North Dakota, 58122, United States

Location

Sanford Roger Maris Cancer Center

Fargo, North Dakota, 58122, United States

Location

Essentia Health - Jamestown Clinic

Jamestown, North Dakota, 58401, United States

Location

Indu and Raj Soin Medical Center

Beavercreek, Ohio, 45431, United States

Location

Strecker Cancer Center-Belpre

Belpre, Ohio, 45714, United States

Location

Saint Elizabeth Boardman Hospital

Boardman, Ohio, 44512, United States

Location

Dayton Physicians LLC-Miami Valley South

Centerville, Ohio, 45459, United States

Location

Miami Valley Hospital South

Centerville, Ohio, 45459, United States

Location

Adena Regional Medical Center

Chillicothe, Ohio, 45601, United States

Location

University of Cincinnati Cancer Center-UC Medical Center

Cincinnati, Ohio, 45219, United States

Location

Good Samaritan Hospital - Cincinnati

Cincinnati, Ohio, 45220, United States

Location

Oncology Hematology Care Inc-Kenwood

Cincinnati, Ohio, 45236, United States

Location

Bethesda North Hospital

Cincinnati, Ohio, 45242, United States

Location

TriHealth Cancer Institute-Westside

Cincinnati, Ohio, 45247, United States

Location

TriHealth Cancer Institute-Anderson

Cincinnati, Ohio, 45255, United States

Location

Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States

Location

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States

Location

Mount Carmel East Hospital

Columbus, Ohio, 43213, United States

Location

Columbus Oncology and Hematology Associates Inc

Columbus, Ohio, 43214, United States

Location

Riverside Methodist Hospital

Columbus, Ohio, 43214, United States

Location

Grant Medical Center

Columbus, Ohio, 43215, United States

Location

The Mark H Zangmeister Center

Columbus, Ohio, 43219, United States

Location

Mount Carmel Health Center West

Columbus, Ohio, 43222, United States

Location

Doctors Hospital

Columbus, Ohio, 43228, United States

Location

Good Samaritan Hospital - Dayton

Dayton, Ohio, 45406, United States

Location

Miami Valley Hospital

Dayton, Ohio, 45409, United States

Location

Dayton Physician LLC - Englewood

Dayton, Ohio, 45415, United States

Location

Miami Valley Hospital North

Dayton, Ohio, 45415, United States

Location

Delaware Health Center-Grady Cancer Center

Delaware, Ohio, 43015, United States

Location

Grady Memorial Hospital

Delaware, Ohio, 43015, United States

Location

Dublin Methodist Hospital

Dublin, Ohio, 43016, United States

Location

Armes Family Cancer Center

Findlay, Ohio, 45840, United States

Location

Blanchard Valley Hospital

Findlay, Ohio, 45840, United States

Location

Orion Cancer Care

Findlay, Ohio, 45840, United States

Location

Atrium Medical Center-Middletown Regional Hospital

Franklin, Ohio, 45005-1066, United States

Location

Dayton Physicians LLC-Atrium

Franklin, Ohio, 45005, United States

Location

Central Ohio Breast and Endocrine Surgery

Gahanna, Ohio, 43230, United States

Location

Dayton Physicians LLC-Wayne

Greenville, Ohio, 45331, United States

Location

Wayne Hospital

Greenville, Ohio, 45331, United States

Location

Mount Carmel Grove City Hospital

Grove City, Ohio, 43123, United States

Location

Greater Dayton Cancer Center

Kettering, Ohio, 45409, United States

Location

First Dayton Cancer Care

Kettering, Ohio, 45420, United States

Location

Kettering Medical Center

Kettering, Ohio, 45429, United States

Location

Fairfield Medical Center

Lancaster, Ohio, 43130, United States

Location

OhioHealth Mansfield Hospital

Mansfield, Ohio, 44903, United States

Location

Marietta Memorial Hospital

Marietta, Ohio, 45750, United States

Location

OhioHealth Marion General Hospital

Marion, Ohio, 43302, United States

Location

Knox Community Hospital

Mount Vernon, Ohio, 43050, United States

Location

Licking Memorial Hospital

Newark, Ohio, 43055, United States

Location

Newark Radiation Oncology

Newark, Ohio, 43055, United States

Location

Southern Ohio Medical Center

Portsmouth, Ohio, 45662, United States

Location

Springfield Regional Cancer Center

Springfield, Ohio, 45504, United States

Location

Springfield Regional Medical Center

Springfield, Ohio, 45504, United States

Location

Dayton Physicians LLC - Troy

Troy, Ohio, 45373, United States

Location

Upper Valley Medical Center

Troy, Ohio, 45373, United States

Location

Saint Joseph Warren Hospital

Warren, Ohio, 44484, United States

Location

University of Cincinnati Cancer Center-West Chester

West Chester, Ohio, 45069, United States

Location

Saint Ann's Hospital

Westerville, Ohio, 43081, United States

Location

Saint Elizabeth Youngstown Hospital

Youngstown, Ohio, 44501, United States

Location

Genesis Healthcare System Cancer Care Center

Zanesville, Ohio, 43701, United States

Location

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States

Location

Mercy Hospital Oklahoma City

Oklahoma City, Oklahoma, 73120, United States

Location

Cancer Treatment Centers of America

Tulsa, Oklahoma, 74133, United States

Location

Oklahoma Cancer Specialists and Research Institute-Tulsa

Tulsa, Oklahoma, 74146, United States

Location

Saint Alphonsus Cancer Care Center-Baker City

Baker City, Oregon, 97814, United States

Location

Legacy Mount Hood Medical Center

Gresham, Oregon, 97030, United States

Location

Saint Alphonsus Cancer Care Center-Ontario

Ontario, Oregon, 97914, United States

Location

Legacy Good Samaritan Hospital and Medical Center

Portland, Oregon, 97210, United States

Location

Lehigh Valley Hospital-Cedar Crest

Allentown, Pennsylvania, 18103, United States

Location

UPMC Altoona

Altoona, Pennsylvania, 16601, United States

Location

UPMC Cancer Center-Bethel Park

Bethel Park, Pennsylvania, 15102, United States

Location

Lehigh Valley Hospital - Muhlenberg

Bethlehem, Pennsylvania, 18017, United States

Location

Bryn Mawr Hospital

Bryn Mawr, Pennsylvania, 19010, United States

Location

Christiana Care Health System-Concord Health Center

Chadds Ford, Pennsylvania, 19317, United States

Location

Geisinger Medical Center

Danville, Pennsylvania, 17822, United States

Location

Pocono Medical Center

East Stroudsburg, Pennsylvania, 18301, United States

Location

UPMC Pinnacle Cancer Center/Community Osteopathic Campus

Harrisburg, Pennsylvania, 17109, United States

Location

Geisinger Medical Center-Cancer Center Hazleton

Hazleton, Pennsylvania, 18201, United States

Location

Lehigh Valley Hospital-Hazleton

Hazleton, Pennsylvania, 18201, United States

Location

Geisinger Medical Oncology-Lewisburg

Lewisburg, Pennsylvania, 17837, United States

Location

Lewistown Hospital

Lewistown, Pennsylvania, 17044, United States

Location

UPMC Cancer Center at UPMC McKeesport

McKeesport, Pennsylvania, 15132, United States

Location

Riddle Memorial Hospital

Media, Pennsylvania, 19063, United States

Location

Arnold Palmer Cancer Center Medical Oncology Norwin

N. Huntingdon, Pennsylvania, 15642, United States

Location

Paoli Memorial Hospital

Paoli, Pennsylvania, 19301, United States

Location

Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States

Location

Eastern Regional Medical Center

Philadelphia, Pennsylvania, 19124, United States

Location

Oncology Hematology Association

Pittsburgh, Pennsylvania, 15215, United States

Location

UPMC-Mercy Hospital

Pittsburgh, Pennsylvania, 15219, United States

Location

University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, Pennsylvania, 15232, United States

Location

UPMC-Passavant Hospital

Pittsburgh, Pennsylvania, 15237, United States

Location

Saint Clair Hospital

Pittsburgh, Pennsylvania, 15243, United States

Location

Geisinger Cancer Services-Pottsville

Pottsville, Pennsylvania, 17901, United States

Location

Community Medical Center

Scranton, Pennsylvania, 18510, United States

Location

Geisinger Medical Oncology-Selinsgrove

Selinsgrove, Pennsylvania, 17870, United States

Location

Geisinger Medical Group

State College, Pennsylvania, 16801, United States

Location

UPMC Cancer Center-Washington

Washington, Pennsylvania, 15301, United States

Location

Geisinger Wyoming Valley/Henry Cancer Center

Wilkes-Barre, Pennsylvania, 18711, United States

Location

Lankenau Medical Center

Wynnewood, Pennsylvania, 19096, United States

Location

Sanford Cancer Center Oncology Clinic

Sioux Falls, South Dakota, 57104, United States

Location

Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134, United States

Location

Memorial Hospital

Chattanooga, Tennessee, 37404, United States

Location

Pulmonary Medicine Center of Chattanooga-Hixson

Hixson, Tennessee, 37343, United States

Location

Baptist Memorial Hospital and Cancer Center-Memphis

Memphis, Tennessee, 38120, United States

Location

Memorial GYN Plus

Ooltewah, Tennessee, 37363, United States

Location

Saint Joseph Regional Cancer Center

Bryan, Texas, 77802, United States

Location

Parkland Memorial Hospital

Dallas, Texas, 75235, United States

Location

UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390, United States

Location

M D Anderson Cancer Center

Houston, Texas, 77030, United States

Location

Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112, United States

Location

University of Virginia Cancer Center

Charlottesville, Virginia, 22908, United States

Location

Highline Medical Center-Main Campus

Burien, Washington, 98166, United States

Location

Saint Elizabeth Hospital

Enumclaw, Washington, 98022, United States

Location

Saint Francis Hospital

Federal Way, Washington, 98003, United States

Location

Saint Clare Hospital

Lakewood, Washington, 98499, United States

Location

Harrison HealthPartners Hematology and Oncology-Poulsbo

Poulsbo, Washington, 98370, United States

Location

Saint Michael Cancer Center

Silverdale, Washington, 98383, United States

Location

Franciscan Research Center-Northwest Medical Plaza

Tacoma, Washington, 98405, United States

Location

Northwest Medical Specialties PLLC

Tacoma, Washington, 98405, United States

Location

Legacy Salmon Creek Hospital

Vancouver, Washington, 98686, United States

Location

Duluth Clinic Ashland

Ashland, Wisconsin, 54806, United States

Location

Northwest Wisconsin Cancer Center

Ashland, Wisconsin, 54806, United States

Location

Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, 54701, United States

Location

Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449, United States

Location

Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States

Location

Marshfield Medical Center - Minocqua

Minocqua, Wisconsin, 54548, United States

Location

ProHealth D N Greenwald Center

Mukwonago, Wisconsin, 53149, United States

Location

Cancer Center of Western Wisconsin

New Richmond, Wisconsin, 54017, United States

Location

ProHealth Oconomowoc Memorial Hospital

Oconomowoc, Wisconsin, 53066, United States

Location

Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, 54868, United States

Location

Marshfield Medical Center-River Region at Stevens Point

Stevens Point, Wisconsin, 54482, United States

Location

ProHealth Waukesha Memorial Hospital

Waukesha, Wisconsin, 53188, United States

Location

UW Cancer Center at ProHealth Care

Waukesha, Wisconsin, 53188, United States

Location

Marshfield Medical Center - Weston

Weston, Wisconsin, 54476, United States

Location

Billings Clinic-Cody

Cody, Wyoming, 82414, United States

Location

Welch Cancer Center

Sheridan, Wyoming, 82801, United States

Location

MeSH Terms

Conditions

Lung Neoplasms

Interventions

alectinib; brigatinib; Carboplatin; ceritinib; Cisplatin; 1,2-diaminocyclohexaneplatinum II citrate; Platinum; Crizotinib; ensartinib; lorlatinib; Pemetrexed

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Coordination Complexes; Organic Chemicals; Chlorine Compounds; Inorganic Chemicals; Nitrogen Compounds; Platinum Compounds; Metals, Heavy; Elements; Transition Elements; Metals; Piperidines; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds; Aminopyridines; Pyridines; Guanine; Hypoxanthines; Purinones; Purines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Glutamates; Amino Acids, Acidic; Amino Acids; Amino Acids, Peptides, and Proteins; Amino Acids, Dicarboxylic

Limitations and Caveats

This study stopped accrual early due to unmet targeted accrual goals with 10 subjects randomized out of 660 planned. Study assessments and data collection continued only for those participants still receiving study treatment and ceased at treatment completion.

Results Point of Contact

• Title: Wendy Seiferheld
• Organization: NRG Oncology

seiferheldw@nrgoncology.org

215-574-3208

Study Officials

• Jessica J Lin

  NRG Oncology

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restriction Type: OTHER
• Restrictive Agreement: Yes

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 9, 2018
• First Posted: November 13, 2018
• Study Start: July 25, 2019
• Primary Completion: July 21, 2021
• Study Completion: March 17, 2026
• Last Updated: April 23, 2026
• Results First Posted: November 21, 2023

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will share

Locations

US (491)