Success Metrics

Clinical Success Rate
74.0%

Based on 288 completed trials

Completion Rate
74%(288/389)
Active Trials
193(27%)
Results Posted
84%(241 trials)
Terminated
101(14%)

Phase Distribution

Ph not_applicable
11
2%
Ph phase_4
10
1%
Ph phase_1
176
25%
Ph phase_3
157
22%
Ph early_phase_1
4
1%
Ph phase_2
336
48%

Phase Distribution

180

Early Stage

336

Mid Stage

167

Late Stage

Phase Distribution694 total trials
Early Phase 1First-in-human
4(0.6%)
Phase 1Safety & dosage
176(25.4%)
Phase 2Efficacy & side effects
336(48.4%)
Phase 3Large-scale testing
157(22.6%)
Phase 4Post-market surveillance
10(1.4%)
N/ANon-phased studies
11(1.6%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

68.4%

288 of 421 finished

Non-Completion Rate

31.6%

133 ended early

Currently Active

193

trials recruiting

Total Trials

703

all time

Status Distribution
Active(215)
Completed(288)
Terminated(133)
Other(67)

Detailed Status

Completed288
Recruiting107
Terminated101
Active, not recruiting86
unknown65
Withdrawn32

Development Timeline

Analytics

Development Status

Total Trials
703
Active
193
Success Rate
74.0%
Most Advanced
Phase 4

Trials by Phase

Early Phase 14 (0.6%)
Phase 1176 (25.4%)
Phase 2336 (48.4%)
Phase 3157 (22.6%)
Phase 410 (1.4%)
N/A11 (1.6%)

Trials by Status

active_not_recruiting8612%
completed28841%
terminated10114%
unknown659%
recruiting10715%
enrolling_by_invitation10%
not_yet_recruiting213%
withdrawn325%
suspended20%

Recent Activity

Clinical Trials (703)

Showing 20 of 703 trialsScroll for more
NCT06694454Phase 1

Neoadjuvant Inhaled Azacytidine With Platinum-Based Chemotherapy and Durvalumab (MEDI4736) - a Combined Epigenetic-Immunotherapy (AZA-AEGEAN) Regimen for Operable Early-Stage Non-Small Cell Lung Cancer (NSCLC)

Recruiting
NCT07486817Phase 2

Beamion 44: A Study to Test How Well Zongertinib is Tolerated by People With Advanced Non-small Cell Lung Cancer With HER2 Mutations When Given in Combination With Chemotherapy With or Without Pembrolizumab

Recruiting
NCT06630416Phase 2

Pemetrexed Response in Relation to Tumor Alterations of Gene Status for the Treatment of Patients With Metastatic Urothelial Bladder Cancer and Other Solid Tumors

Recruiting
NCT07252739Phase 2

KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With Non-Small Cell Lung Cancer (NSCLC) With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) G12C Mutations (MK-3475-01J/KEYMAKER-U01J)

Recruiting
NCT07190248Phase 3

A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)

Recruiting
NCT06772623Phase 1

Study to Evaluate Adverse Events and Efficacy of Intravenous (IV) Telisotuzumab Adizutecan in Combination With a PD-1 Immune Checkpoint Inhibitor in Adult Participants With Advanced or Metastatic Non-Squamous NSCLC With No Prior Treatment for Advanced Disease, and No Actionable Genomic Alterations

Recruiting
NCT06096844Phase 3

Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial

Recruiting
NCT07642024Phase 2

A Study of BL-B01D1 in Combination With Osimertinib as Perioperative Therapy in Patients With EGFR-mutated Resectable Non-small Cell Lung Cancer(PANKU-Lung09)

Not Yet Recruiting
NCT06448754Phase 2

Volrustomig Priming Regimens Exploratory Phase II Platform Study

Recruiting
NCT05198830Phase 2

Testing the Addition of an Anti-Cancer Drug, TRC102, to the Usual Chemotherapy Treatment (Pemetrexed, Cisplatin or Carboplatin) During Radiation Therapy for Stage III Non-Squamous Non-Small Cell Lung Cancer

Recruiting
NCT06318286Phase 2

Study of Pembrolizumab Plus Chemotherapy With Lenvatinib for Malignant Pleural Mesothelioma

Active Not Recruiting
NCT05083481Phase 1

A Study of ASP1570 Taken by Itself, or ASP1570 Taken Together With Either Pembrolizumab, Standard Therapies, or Both, in Adults With Solid Tumors

Terminated
NCT06305754Phase 3

Sacituzumab Tirumotecan (MK-2870) Versus Pemetrexed and Carboplatin Combination Therapy in Participants With Epidermal Growth Factor (EGFR)-Mutated, Advanced Nonsquamous Non-small Cell Lung Cancer (NSCLC) Who Have Progressed on Prior EGFR Tyrosine Kinase Inhibitors (MK-2870-009)

Active Not Recruiting
NCT06097728Phase 3

MEDI5752 in Combination With Carboplatin Plus Pemetrexed in Unresectable Pleural Mesothelioma

Active Not Recruiting
NCT06793215Phase 3

A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer

Recruiting
NCT07586202Phase 2

A Study of Neoadjuvant Amivantamab With Either Lazertinib or Chemotherapy in Participants With Resectable EGFR-Mutated NSCLC

Not Yet Recruiting
NCT05918107Phase 2

A Study of PM8002 Injection in Combination With Standard Chemotherapy as First Line Therapy in MPM

Completed
NCT07005102Phase 2

A Study to Assess Adverse Events, Change in Disease Activity of Intravenous Telisotuzumab Adizutecan in Combination With Osimertinib as First-Line Treatment in Adult Participants With Locally Advanced Unresectable or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer

Recruiting
NCT04988295Phase 3

A Study of Amivantamab and Lazertinib in Combination With Platinum-Based Chemotherapy Compared With Platinum-Based Chemotherapy in Patients With Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non- Small Cell Lung Cancer After Osimertinib Failure

Active Not Recruiting
NCT04538664Phase 3

A Study of Combination Amivantamab and Carboplatin-Pemetrexed Therapy, Compared With Carboplatin-Pemetrexed, in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer Characterized by Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions

Active Not Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
703