Success Metrics

Clinical Success Rate
65.0%

Based on 13 completed trials

Completion Rate
65%(13/20)
Active Trials
4(14%)
Results Posted
77%(10 trials)
Terminated
7(24%)

Phase Distribution

Ph phase_2
10
34%
Ph phase_1
11
38%
Ph phase_3
3
10%
Ph phase_4
1
3%

Phase Distribution

11

Early Stage

10

Mid Stage

4

Late Stage

Phase Distribution25 total trials
Phase 1Safety & dosage
11(44.0%)
Phase 2Efficacy & side effects
10(40.0%)
Phase 3Large-scale testing
3(12.0%)
Phase 4Post-market surveillance
1(4.0%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

56.5%

13 of 23 finished

Non-Completion Rate

43.5%

10 ended early

Currently Active

4

trials recruiting

Total Trials

29

all time

Status Distribution
Active(5)
Completed(13)
Terminated(10)
Other(1)

Detailed Status

Completed13
Terminated7
Active, not recruiting3
Withdrawn3
Not yet recruiting1
unknown1

Development Timeline

Analytics

Development Status

Total Trials
29
Active
4
Success Rate
65.0%
Most Advanced
Phase 4

Trials by Phase

Phase 111 (44.0%)
Phase 210 (40.0%)
Phase 33 (12.0%)
Phase 41 (4.0%)

Trials by Status

completed1345%
not_yet_recruiting13%
terminated724%
unknown13%
active_not_recruiting310%
recruiting13%
withdrawn310%

Recent Activity

Clinical Trials (29)

Showing 20 of 29 trialsScroll for more
NCT03784014Phase 3

Molecular Profiling of Advanced Soft-tissue Sarcomas

Completed
NCT02559778Phase 2

Pediatric Precision Laboratory Advanced Neuroblastoma Therapy

Recruiting
NCT03737994Phase 2

Targeted Treatment for ALK Positive Patients Who Have Previously Been Treated for Non-squamous Non-small Cell Lung Cancer

Terminated
NCT02584933Phase 4

Roll-over Study to Allow Access to Certinib (LDK378) for Patients Who Are on Ceritinib Treatment in a Novartis-sponsored Study

Active Not Recruiting
NCT05100134

Managed Access Programs for LDK378, Ceritinib

Unknown
NCT02780128Phase 1

Next Generation Personalized Neuroblastoma Therapy

Terminated
NCT03501368Phase 1

Study of Trametinib + Ceritinib in Patients With Unresectable Melanoma

Completed
NCT03611738Phase 1

Ceritinib Plus Docetaxel in ALK-Negative, EGFR WT Advanced NSCLC

Active Not Recruiting
NCT02321501Phase 1

Ceritinib and Everolimus in Treating Patients With Locally Advanced or Metastatic Solid Tumors or Stage IIIB-IV Non-small Cell Lung Cancer

Active Not Recruiting
NCT05834348

A Study to Learn About the Effectiveness of Cancer Medicines in Patients With Metastatic Non-small Cell Lung Cancer in Norway.

Completed
NCT06813079Phase 2

Using Tumor Models to Determine Treatments

Not Yet Recruiting
NCT01828112Phase 3

LDK378 Versus Chemotherapy in ALK Rearranged (ALK Positive) Patients Previously Treated With Chemotherapy (Platinum Doublet) and Crizotinib

Completed
NCT01828099Phase 3

LDK378 Versus Chemotherapy in Previously Untreated Patients With ALK Rearranged Non-small Cell Lung Cancer

Completed
NCT03546894

A Study to Determine Progression-free Survival (PFS) and Evaluate Participant Experience for Participants With Metastatic Anaplastic Lymphoma Kinase-positive (ALK+) Non-Small Cell Lung Cancer (NSCLC) Treated With Anaplastic Lymphoma Kinase (ALK) Inhibitors

Completed
NCT04647110

Real-world Therapy of ALK-positive NSCLC in Sweden: the Sequencing of ALK Tyrosine Kinase Inhibitor Drugs and Their Therapeutic Outcomes Based on Data From National Registers.

Completed
NCT02513667Phase 2

Ceritinib in Combination With Stereotactic Ablative Radiation Metastatic Lung Adenocarcinoma

Terminated
NCT03087448Phase 1

Ceritinib + Trametinib in Patients With Advanced ALK-Positive Non-Small Cell Lung Cancer (NSCLC)

Terminated
NCT02227940Phase 1

Ceritinib and Combination Chemotherapy in Treating Patients With Advanced Solid Tumors or Locally Advanced or Metastatic Pancreatic Cancer

Completed
NCT02299505Phase 1

Pharmacokinetic and Safety Study of Lower Doses of Ceritinib Taken With a Low-fat Meal Versus 750 mg of Ceritinib in the Fasted State in Adult Patients With (ALK-positive) Metastatic Non-small Cell Lung Cancer (NSCLC)

Completed
NCT02186821Phase 2

Ceritinib (LDK378) for Patients Whose Tumors Have Aberrations in ALK or ROS1 (SIGNATURE)

Terminated

Drug Details

Intervention Type
DRUG
Total Trials
29