Success Metrics

Clinical Success Rate
70.0%

Based on 14 completed trials

Completion Rate
70%(14/20)
Active Trials
18(36%)
Results Posted
86%(12 trials)
Terminated
6(12%)

Phase Distribution

Ph early_phase_1
1
2%
Ph phase_3
3
6%
Ph not_applicable
1
2%
Ph phase_1
9
18%
Ph phase_4
5
10%
Ph phase_2
17
34%

Phase Distribution

10

Early Stage

17

Mid Stage

8

Late Stage

Phase Distribution36 total trials
Early Phase 1First-in-human
1(2.8%)
Phase 1Safety & dosage
9(25.0%)
Phase 2Efficacy & side effects
17(47.2%)
Phase 3Large-scale testing
3(8.3%)
Phase 4Post-market surveillance
5(13.9%)
N/ANon-phased studies
1(2.8%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

66.7%

14 of 21 finished

Non-Completion Rate

33.3%

7 ended early

Currently Active

18

trials recruiting

Total Trials

50

all time

Status Distribution
Active(23)
Completed(14)
Terminated(7)
Other(6)

Detailed Status

Completed14
Active, not recruiting10
Recruiting8
unknown6
Terminated6
Not yet recruiting4

Development Timeline

Analytics

Development Status

Total Trials
50
Active
18
Success Rate
70.0%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (2.8%)
Phase 19 (25.0%)
Phase 217 (47.2%)
Phase 33 (8.3%)
Phase 45 (13.9%)
N/A1 (2.8%)

Trials by Status

active_not_recruiting1020%
unknown612%
withdrawn12%
completed1428%
not_yet_recruiting48%
enrolling_by_invitation12%
recruiting816%
terminated612%

Recent Activity

Clinical Trials (50)

Showing 20 of 50 trialsScroll for more
NCT07556549

A Study to Learn About Study Medicine Lorlatinib, as a First-line Treatment in Chinese Adults With ALK-positive a/mNSCLC

Active Not Recruiting
NCT07750704Phase 2

Lorlatinib Plus Sacituzumab Tirumotecan With Peripheral ctDNA Guidance as First-Line Therapy for ALK Fusion-Positive NSCLC

Not Yet Recruiting
NCT06007937Phase 1

A Study of Lorlatinib in Combination With Ramucirumab in People With Lung Cancer

Recruiting
NCT06678555

A Study to Learn About Lorlatinib in Patients With Non-Small Cell Lung Cancer (NSCLC) Which Has Spread Out.

Completed
NCT06333899Early Phase 1

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

Recruiting
NCT03505554Phase 2

A Study of Oral Lorlatinib in Patients With Relapsed ALK Positive Lymphoma

Completed
NCT04800822Phase 1

PF-07284892 in Participants With Advanced Solid Tumors

Terminated
NCT07617337Phase 1

AQUA07 in Patients With ALK-Positive Non-Small Cell Lung Cancer

Not Yet Recruiting
NCT05297890Phase 2

A Study of Lorlatinib in Subjects With ROS1-Positive Non-Small Cell Lung Cancer

Active Not Recruiting
NCT07567352

A Study to Learn About Patients With Non-Small Cell Lung Cancer (NSCLC) Who Took Lorlatinib as Their First Treatment

Active Not Recruiting
NCT06487078Not Applicable

Analysis of the Effectiveness and Safety of Lorlatinib in Untreated ALK-Positive NSCLC Patients in a French Real-World Context

Recruiting
NCT07415005Phase 2

Lorlatinib Plus Local Consolidation Therapy In ALK Positive Advanced Non-Small Cell Lung Cancer

Recruiting
NCT03737994Phase 2

Targeted Treatment for ALK Positive Patients Who Have Previously Been Treated for Non-squamous Non-small Cell Lung Cancer

Terminated
NCT06282874Phase 4

Lorlatinib in Patients With ALK-Positive NSCLC With Brain or Leptomeningeal Metastases

Active Not Recruiting
NCT06282991

A Study to Learn About Lorlatinib in Patients With Non-Small Cell Lung Cancer Which Could Not Be Controlled

Completed
NCT03126916Phase 3

Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

Recruiting
NCT05740943Phase 2

Induction Lorlatinib in Stage III Non-small Cell Lung Cancer

Active Not Recruiting
NCT05144997Phase 4

Lorlatinib Continuation Study

Active Not Recruiting
NCT03052608Phase 3

A Study Of Lorlatinib Versus Crizotinib In First Line Treatment Of Patients With ALK-Positive NSCLC

Active Not Recruiting
NCT03909971Phase 2

A Study of Lorlatinib in ALK Inhibitor-Treated ALK-Positive NSCLC in China

Completed

Drug Details

Intervention Type
DRUG
Total Trials
50