Success Metrics

Clinical Success Rate
66.7%

Based on 12 completed trials

Completion Rate
67%(12/18)
Active Trials
17(35%)
Results Posted
100%(12 trials)
Terminated
6(13%)

Phase Distribution

Ph phase_1
8
17%
Ph phase_2
16
33%
Ph phase_3
3
6%
Ph phase_4
5
10%
Ph early_phase_1
1
2%
Ph not_applicable
1
2%

Phase Distribution

9

Early Stage

16

Mid Stage

8

Late Stage

Phase Distribution34 total trials
Early Phase 1First-in-human
1(2.9%)
Phase 1Safety & dosage
8(23.5%)
Phase 2Efficacy & side effects
16(47.1%)
Phase 3Large-scale testing
3(8.8%)
Phase 4Post-market surveillance
5(14.7%)
N/ANon-phased studies
1(2.9%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

63.2%

12 of 19 finished

Non-Completion Rate

36.8%

7 ended early

Currently Active

17

trials recruiting

Total Trials

48

all time

Status Distribution
Active(22)
Completed(12)
Terminated(7)
Other(7)

Detailed Status

Completed12
Active, not recruiting9
Recruiting8
unknown7
Terminated6
Not yet recruiting4

Development Timeline

Analytics

Development Status

Total Trials
48
Active
17
Success Rate
66.7%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (2.9%)
Phase 18 (23.5%)
Phase 216 (47.1%)
Phase 33 (8.8%)
Phase 45 (14.7%)
N/A1 (2.9%)

Trials by Status

terminated613%
enrolling_by_invitation12%
not_yet_recruiting48%
completed1225%
active_not_recruiting919%
recruiting817%
withdrawn12%
unknown715%

Recent Activity

Clinical Trials (48)

Showing 20 of 48 trialsScroll for more
NCT06487078Not Applicable

Analysis of the Effectiveness and Safety of Lorlatinib in Untreated ALK-Positive NSCLC Patients in a French Real-World Context

Recruiting
NCT07415005Phase 2

Lorlatinib Plus Local Consolidation Therapy In ALK Positive Advanced Non-Small Cell Lung Cancer

Recruiting
NCT07567352

A Study to Learn About Patients With Non-Small Cell Lung Cancer (NSCLC) Who Took Lorlatinib as Their First Treatment

Not Yet Recruiting
NCT07556549

A Study to Learn About Study Medicine Lorlatinib, as a First-line Treatment in Chinese Adults With ALK-positive a/mNSCLC

Not Yet Recruiting
NCT03737994Phase 2

Targeted Treatment for ALK Positive Patients Who Have Previously Been Treated for Non-squamous Non-small Cell Lung Cancer

Terminated
NCT06282874Phase 4

Lorlatinib in Patients With ALK-Positive NSCLC With Brain or Leptomeningeal Metastases

Active Not Recruiting
NCT06007937Phase 1

A Study of Lorlatinib in Combination With Ramucirumab in People With Lung Cancer

Recruiting
NCT06333899Early Phase 1

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

Recruiting
NCT06282991

A Study to Learn About Lorlatinib in Patients With Non-Small Cell Lung Cancer Which Could Not Be Controlled

Completed
NCT03126916Phase 3

Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

Recruiting
NCT06678555

A Study to Learn About Lorlatinib in Patients With Non-Small Cell Lung Cancer (NSCLC) Which Has Spread Out.

Active Not Recruiting
NCT05740943Phase 2

Induction Lorlatinib in Stage III Non-small Cell Lung Cancer

Active Not Recruiting
NCT05297890Phase 2

A Study of Lorlatinib in Subjects With ROS1-Positive Non-Small Cell Lung Cancer

Active Not Recruiting
NCT05144997Phase 4

Lorlatinib Continuation Study

Active Not Recruiting
NCT03052608Phase 3

A Study Of Lorlatinib Versus Crizotinib In First Line Treatment Of Patients With ALK-Positive NSCLC

Active Not Recruiting
NCT03909971Phase 2

A Study of Lorlatinib in ALK Inhibitor-Treated ALK-Positive NSCLC in China

Completed
NCT04621188Phase 2

Lorlatinib After Failure of First-line TKI in Patients With Advanced ROS1-positive NSCLC (ALBATROS)

Active Not Recruiting
NCT03107988Phase 1

NANT 2015-02: A Phase 1 Study of Lorlatinib (PF-06463922)

Completed
NCT04362072Phase 4

Study of Lorlatinib In People With ALK-positive Non-small Cell Lung Cancer

Completed
NCT04111705Phase 2

Lorlatinib After Failure of First-line Second-generation ALK Kinase Inhibitor in Patients With Advanced ALK-positive Non-small Cell Lung Cancer

Completed

Drug Details

Intervention Type
DRUG
Total Trials
48