Success Metrics

Clinical Success Rate
84.0%

Based on 42 completed trials

Completion Rate
84%(42/50)
Active Trials
26(28%)
Results Posted
90%(38 trials)
Terminated
8(9%)

Phase Distribution

Ph phase_1
29
31%
Ph not_applicable
2
2%
Ph phase_4
4
4%
Ph phase_2
34
36%
Ph phase_3
15
16%
Ph early_phase_1
1
1%

Phase Distribution

30

Early Stage

34

Mid Stage

19

Late Stage

Phase Distribution85 total trials
Early Phase 1First-in-human
1(1.2%)
Phase 1Safety & dosage
29(34.1%)
Phase 2Efficacy & side effects
34(40.0%)
Phase 3Large-scale testing
15(17.6%)
Phase 4Post-market surveillance
4(4.7%)
N/ANon-phased studies
2(2.4%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

79.2%

42 of 53 finished

Non-Completion Rate

20.8%

11 ended early

Currently Active

26

trials recruiting

Total Trials

94

all time

Status Distribution
Active(26)
Completed(42)
Terminated(11)
Other(15)

Detailed Status

Completed42
Active, not recruiting16
unknown15
Recruiting10
Terminated8
Withdrawn3

Development Timeline

Analytics

Development Status

Total Trials
94
Active
26
Success Rate
84.0%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (1.2%)
Phase 129 (34.1%)
Phase 234 (40.0%)
Phase 315 (17.6%)
Phase 44 (4.7%)
N/A2 (2.4%)

Trials by Status

completed4245%
withdrawn33%
terminated89%
active_not_recruiting1617%
recruiting1011%
unknown1516%

Recent Activity

Clinical Trials (94)

Showing 20 of 94 trialsScroll for more
NCT03194893Phase 3

A Rollover Study of Alectinib in Patients With Anaplastic Lymphoma Kinase (ALK)-Positive or Rearranged During Transfection (RET)-Positive Cancer

Completed
NCT03947385Phase 1

Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions

Recruiting
NCT02465060Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

Active Not Recruiting
NCT02075840Phase 3

A Study Comparing Alectinib With Crizotinib in Treatment-Naive Anaplastic Lymphoma Kinase-Positive Advanced Non-Small Cell Lung Cancer Participants

Completed
NCT02194738Not Applicable

Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial)

Active Not Recruiting
NCT04603807Phase 3

A Study to Compare the Efficacy and Safety of Entrectinib and Crizotinib in Participants With Advanced or Metastatic ROS1 Non-small Cell Lung Cancer (NSCLC) With and Without Central Nervous System (CNS) Metastases

Active Not Recruiting
NCT06360575Phase 2

Testing Crizotinib as Potentially Targeted Treatment in Cancers With MET Exon 14 Deletion Genetic Changes (MATCH - Subprotocol C2)

Active Not Recruiting
NCT04439266Phase 2

Testing Crizotinib as a Potential Targeted Treatment in Cancers With ALK Genetic Changes (MATCH-Subprotocol F)

Active Not Recruiting
NCT04439253Phase 2

Testing Crizotinib as a Potential Targeted Treatment in Cancers With ROS1 Genetic Changes (MATCH-Subprotocol G)

Active Not Recruiting
NCT02664935Phase 2

National Lung Matrix Trial: Multi-drug Phase II Trial in Non-Small Cell Lung Cancer

Completed
NCT03737994Phase 2

Targeted Treatment for ALK Positive Patients Who Have Previously Been Treated for Non-squamous Non-small Cell Lung Cancer

Terminated
NCT06563999Phase 2

Neoadjuvant Umbrella Trial for Patients With Unresectable Stage III NSCLC Harboring Rare Mutations.

Recruiting
NCT06564324Phase 3

A Phase III Study Comparing Taletrectinib With Standard Therapy in ROS1 Positive Locally Advanced or Metastatic Non-small Cell Lung Cancer Patients

Recruiting
NCT03375242

Safety and Efficacy of Xalkori ROS1

Active Not Recruiting
NCT05160922Phase 4

Crizotinib Continuation Clinical Study

Active Not Recruiting
NCT03297606Phase 2

Canadian Profiling and Targeted Agent Utilization Trial (CAPTUR)

Recruiting
NCT06357975Phase 2

Testing Crizotinib as Potentially Targeted Treatment in Cancers With MET Genetic Changes (MATCH - Subprotocol C1)

Active Not Recruiting
NCT02838420Phase 3

A Study to Evaluate and Compare the Efficacy and Safety of Alectinib Versus Crizotinib and to Evaluate the Pharmacokinetics of Alectinib in Asian Participants With Treatment-Naive Anaplastic Lymphoma Kinase (ALK)-Positive Advanced Non-Small Cell Lung Cancer (NSCLC)

Active Not Recruiting
NCT04283669Phase 2

Phase 2 Clinical Trial of Crizotinib for Children and Adults With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas

Completed
NCT04693468Phase 1

Talazoparib and Palbociclib, Axitinib, or Crizotinib for the Treatment of Advanced or Metastatic Solid Tumors, TalaCom Trial

Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
94