Protein Requirements in Resistance-trained Males

NCT03696264 | Completed

• 1 other identifier: RTM
• Study Type: interventional
• Target: 7
• Locations: 1 country
• Sites: 1

Brief Summary

In this study, the investigators will use the minimally invasive indicator amino acid oxidation (IAAO) technique to determine protein requirements in resistance-trained males. It is hypothesized that the present study will show that protein requirements for resistance-trained males are i) greater than the current recommended dietary allowance (RDA) for non-active individual's comparable estimates, and ii) greater than existing nitrogen balance-based estimates for resistance-training individuals.

Conditions

Healthy

Keywords

Protein Requirements

Outcome Measures

Primary Outcomes (1)

• Phenylalanine excretion

  Expressed as µmol/kg/h; phenylalanine excretion is determined via breath enrichment of the oral tracer

  Through study completion, an average of 1 year

Secondary Outcomes (2)

• Phenylalanine rate of appearance

  Through study completion, an average of 1 year

• Net Protein Balance

  Through study completion, an average of 1 year

Study Arms (1)

Resistance-trained, adult males

EXPERIMENTAL

Subjects receive varying levels of amino acid intakes ranging from 0.2-3.0g/kg/d

Dietary Supplement: Amino acid intake

Interventions

Amino acid intake DIETARY_SUPPLEMENT

Amino acid intake will range between 0.2-3.0g/kg/d

Resistance-trained, adult males

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy, male weight-trained individuals that have trained consistently for \>1 year.
• years old.
• Train each muscle group (i.e. chest, back, legs) at least twice a week.
• Body mass stable in last month
• Meets strength relative to body weight guidelines (see below)
• Bench Press:
• Males- body weight (kg)\*1.25
• Leg Press:
• Males- body weight (kg)\* 4.0

You may not qualify if:

• Inability to meet health and physical activity guidelines according to the Physical Activity Readiness Questionnaire
• Inability to adhere to any of the protocol guidelines (i.e. alcohol, caffeine consumption)
• Regular tobacco use
• Illicit drug use (e.g. growth hormone, testosterone, etc.) (screened by survey sheet for training log
• \>1 month sedentary in the last 6 months prior to study participation
• \>30 min of continuous cardio per exercise session
• BMI (Body Mass Index) \> 35.
• Individual plans to increase or decrease body mass in the next 3 months
• Habitually ingests greater than or equal to 3g protein kg/bw/day
• Use of supplements such as creatine and beta-alanine in the last 30 days.

Sponsors & Collaborators

• University of Toronto: lead

Study Sites (1)

Goldring Centre for High Performance Sport

Toronto, Ontario, M5S2C9, Canada

Location

Related Publications (6)

• Thomas DT, Erdman KA, Burke LM. Position of the Academy of Nutrition and Dietetics, Dietitians of Canada, and the American College of Sports Medicine: Nutrition and Athletic Performance. J Acad Nutr Diet. 2016 Mar;116(3):501-528. doi: 10.1016/j.jand.2015.12.006.

  PMID: 26920240 BACKGROUND

• Phillips SM. Protein requirements and supplementation in strength sports. Nutrition. 2004 Jul-Aug;20(7-8):689-95. doi: 10.1016/j.nut.2004.04.009.

  PMID: 15212752 BACKGROUND

• Rand WM, Pellett PL, Young VR. Meta-analysis of nitrogen balance studies for estimating protein requirements in healthy adults. Am J Clin Nutr. 2003 Jan;77(1):109-27. doi: 10.1093/ajcn/77.1.109.

  PMID: 12499330 BACKGROUND

• Humayun MA, Elango R, Ball RO, Pencharz PB. Reevaluation of the protein requirement in young men with the indicator amino acid oxidation technique. Am J Clin Nutr. 2007 Oct;86(4):995-1002. doi: 10.1093/ajcn/86.4.995.

  PMID: 17921376 BACKGROUND

• Tarnopolsky MA, Atkinson SA, MacDougall JD, Chesley A, Phillips S, Schwarcz HP. Evaluation of protein requirements for trained strength athletes. J Appl Physiol (1985). 1992 Nov;73(5):1986-95. doi: 10.1152/jappl.1992.73.5.1986.

  PMID: 1474076 BACKGROUND

• Mazzulla M, Abou Sawan S, Williamson E, Hannaian SJ, Volterman KA, West DWD, Moore DR. Protein Intake to Maximize Whole-Body Anabolism during Postexercise Recovery in Resistance-Trained Men with High Habitual Intakes is Severalfold Greater than the Current Recommended Dietary Allowance. J Nutr. 2020 Mar 1;150(3):505-511. doi: 10.1093/jn/nxz249.

  PMID: 31618421 DERIVED

Study Officials

• Daniel R Moore, PhD

  University of Toronto

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Masking Details: Participants blinded to the protein dose consumed in a given metabolic trial
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: October 1, 2018
• First Posted: October 4, 2018
• Study Start: March 6, 2017
• Primary Completion: July 1, 2017
• Study Completion: October 31, 2017
• Last Updated: October 4, 2018

Record last verified: 2018-10

Locations

CA (1)