Effect of Amino Acid on Muscle Damage
Effect of Leucine-enriched Essential Amino Acid on Integrated Muscle Protein Synthesis and Muscle Recovery After Resistance Exercise
1 other identifier
interventional
20
1 country
1
Brief Summary
The primary objective is to determine the impact of essential amino acids on integrated muscle protein synthesis over 4 days after resistance exercise. In addition, the secondary objective is to determine the effect of essential amino acids on satellite cell regulation and inflammatory responses during this prolonged recovery period.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable healthy
Started Oct 2017
Longer than P75 for not_applicable healthy
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 18, 2017
CompletedStudy Start
First participant enrolled
October 18, 2017
CompletedFirst Posted
Study publicly available on registry
October 24, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 15, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
October 30, 2019
CompletedApril 20, 2021
April 1, 2021
1.2 years
October 18, 2017
April 17, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Muscle protein synthesis
Skeletal muscle fractional synthesis rate (%/h) will be determined by oral pulse method using ring-\[D5\]phenylalanine
4 hours
Secondary Outcomes (3)
exercise performance
4 days
Muscle soreness
4 days
Muscle damage
4 days
Study Arms (2)
Placebo
PLACEBO COMPARATOR4g of maltodextrin
Active
ACTIVE COMPARATOR4g of essential amino acids
Interventions
Eligibility Criteria
You may qualify if:
- Healthy, male, recreationally-active participants
- Healthy will be defined as screened by the PAR-Q+ (The Physical Activity Readiness Questionnaire for everyone; Appendix. B). Active will be defined as being in the top 20% of age specific scores on iPAQ (the International Physical Activity Questionnaire; Appendix.C).
- Participants are required not to engage in lower limb RT (resistance training) for at least 6 months prior to the study.
- Participants will be 18-35 years old.
- Participants are willing to abide by the compliance rules of this study
You may not qualify if:
- Female
- Inability to adhere to any of the compliance rules judged by principle investigator or medical doctor
- Self-reported regular tobacco use
- Self-reported illicit drug use (e.g. growth hormone, testosterone, etc.)
- The individual who has allergy for milk
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Torontolead
- Ajinomoto Co., Inc.collaborator
Study Sites (1)
Goldring Centre for High Performance Sport
Toronto, Ontario, M5S2C9, Canada
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor
Study Record Dates
First Submitted
October 18, 2017
First Posted
October 24, 2017
Study Start
October 18, 2017
Primary Completion
January 15, 2019
Study Completion
October 30, 2019
Last Updated
April 20, 2021
Record last verified: 2021-04