Testing the Addition of the Pill Chemotherapy, Cabozantinib, to the Standard Immune Therapy Nivolumab Compared to Standard Chemotherapy for Non-small Cell Lung Cancer

NCT04310007 | Active Not Recruiting Phase 2 FDA Drug

• 3 other identifiers: NCI-2020-01541EA5191U10CA180820
• Study Type: interventional
• Target: 117
• Locations: 1 country
• Sites: 613

Brief Summary

This phase II trial compares cabozantinib alone and the combination of cabozantinib and nivolumab to standard chemotherapy in the treatment of patients with non-squamous non-small cell lung cancer (NSCLC). Cabozantinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Ramucirumab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as docetaxel, gemcitabine hydrochloride, paclitaxel, and nab-paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving cabozantinib alone or in combination with nivolumab may be more effective than standard chemotherapy in treating patients with non-small cell lung cancer.

Conditions

Stage IV Lung Cancer AJCC v8; Recurrent Lung Non-Squamous Non-Small Cell Carcinoma; Metastatic Lung Non-Squamous Non-Small Cell Carcinoma

Outcome Measures

Primary Outcomes (1)

• Progression-free survival (PFS) for patient population with non-squamous no-small cell lung cancer (NSCLC)

  The final analysis of PFS will be performed when the full information of PFS is reached (i.e., 58 events for each of the two primary comparisons). The two primary comparisons of PFS will each use a logrank test stratified on the randomization stratification factors with a one-sided type I error rate of 10%. Estimates of PFS including medians and confidence intervals, will be calculated using the Kaplan-Meier method. Cox proportional hazards models, stratified, on the same factors, will be used to estimate the treatment hazard ratios. At the final analyses, in the event that both primary PFS comparisons of the combination of nivolumab with cabozantinib and cabozantinib alone versus the standard chemotherapy are statistically significant, PFS will be compared between the two experimental arms (combination of nivolumab with cabozantinib versus \[vs.\] cabozantinib alone), using a stratified log rank test with a one-sided type I error rate of 10%.

  After 58 events (From time of randomization to documented disease progression [site review of imaging] or death from any cause, whichever occurs first)

Secondary Outcomes (3)

• Overall survival (OS) for each arm

  From time of randomization to documented disease progression (site review of imaging) or death from any cause, whichever occurs first, assessed up to 3 years

• Best objective response for each arm

  Every 6 weeks for the first year on study, and then every 12 weeks after year one

• Toxicity profile of monotherapy with cabozantinib, and the combination of nivolumab and cabozantinib

  Up to 3 years after completion of study treatment

Other Outcomes (3)

• The RECIST1.1 response at each time point

  Every 6 weeks for the first year on study, and then every 12 weeks after year one

• Agreement between central view and site review in terms of progression-free survival

  After the completion of study treatment

• Correlative biomarker research

  After the completion of study treatment

Study Arms (4)

Step 1, Arm A (cabozantinib S-malate)

EXPERIMENTAL

Patients in Step 1, Arm A receive cabozantinib S-malate PO QD. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity. Patients may continue to receive therapy after investigator-assessed RECIST 1.1 defined progression, including stable clinical and performance status and have potential for continued clinical benefit. Patients also undergo ECHO as clinically indicated, CT throughout the trial, and collection of blood on study.

Procedure: Biospecimen Collection; Drug: Cabozantinib S-malate; Procedure: Computed Tomography; Procedure: Echocardiography Test

Step 1, Arm B (cabozantinib S-malate, nivolumab)

EXPERIMENTAL

Patients in Step 1, Arm B receive cabozantinib S-malate PO QD and nivolumab IV over 30 minutes on day 1. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity. Patients may continue to receive therapy after investigator-assessed RECIST 1.1 defined progression, including stable clinical and performance status and have potential for continued clinical benefit. Patients also undergo ECHO as clinically indicated, CT throughout the trial, and collection of blood on study.

Procedure: Biospecimen Collection; Drug: Cabozantinib S-malate; Procedure: Computed Tomography; Procedure: Echocardiography Test; Biological: Nivolumab

Step 1, Arm C (standard chemotherapy)

ACTIVE COMPARATOR

Patients in Step 1, Arm C receive ramucirumab IV over 30-60 minutes and docetaxel IV over 1 hour on day 1, or docetaxel IV over 1 hour on days 1 and 8, or gemcitabine hydrochloride IV on days 1 and 8, or paclitaxel IV over 3 hours on day 1, or nab-paclitaxel IV over 30 minutes on days 1 and 8. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity and at the discretion of the treating physician. Patients also undergo ECHO as clinically indicated, CT throughout the trial, and collection of blood on study.

Procedure: Biospecimen Collection; Procedure: Computed Tomography; Drug: Docetaxel; Procedure: Echocardiography Test; Drug: Gemcitabine Hydrochloride; Drug: Nab-paclitaxel; Drug: Paclitaxel; Biological: Ramucirumab

Step 2, Arm Z (cabozantinib S-malate, nivolumab)

EXPERIMENTAL

Patients in Step 2, Arm Z receive cabozantinib S-malate PO QD and nivolumab IV over 30 minutes on day 1. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity. Patients may continue to receive therapy after investigator-assessed RECIST 1.1 defined progression, including stable clinical and performance status and have potential for continued clinical benefit. Patients also undergo ECHO as clinically indicated, CT throughout the trial, and collection of blood on study.

Procedure: Biospecimen Collection; Drug: Cabozantinib S-malate; Procedure: Computed Tomography; Procedure: Echocardiography Test; Biological: Nivolumab

Interventions

Cabozantinib S-malate DRUG

Given PO

Also known as: BMS-907351, Cabometyx, Cometriq, XL 184, XL-184, XL184

Step 1, Arm A (cabozantinib S-malate); Step 1, Arm B (cabozantinib S-malate, nivolumab); Step 2, Arm Z (cabozantinib S-malate, nivolumab)

Computed Tomography PROCEDURE

Undergo CT

Also known as: CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, Diagnostic CAT Scan, Diagnostic CAT Scan Service Type, tomography

Step 1, Arm A (cabozantinib S-malate); Step 1, Arm B (cabozantinib S-malate, nivolumab); Step 1, Arm C (standard chemotherapy); Step 2, Arm Z (cabozantinib S-malate, nivolumab)

Docetaxel DRUG

Given IV

Also known as: Docecad, RP 56976, RP-56976, RP56976, Taxotere, Taxotere Injection Concentrate

Step 1, Arm C (standard chemotherapy)

Nivolumab BIOLOGICAL

Given IV

Also known as: ABP 206, BCD-263, BMS 936558, BMS-936558, BMS936558, CMAB819, MDX 1106, MDX-1106, MDX1106, NIVO, Nivolumab Biosimilar ABP 206, Nivolumab Biosimilar BCD-263, Nivolumab Biosimilar CMAB819, ONO 4538, ONO-4538, ONO4538, Opdivo

Step 1, Arm B (cabozantinib S-malate, nivolumab); Step 2, Arm Z (cabozantinib S-malate, nivolumab)

Biospecimen Collection PROCEDURE

Undergo blood collection

Also known as: Biological Sample Collection, Biospecimen Collected, Sample Collection, Specimen Collection

Step 1, Arm A (cabozantinib S-malate); Step 1, Arm B (cabozantinib S-malate, nivolumab); Step 1, Arm C (standard chemotherapy); Step 2, Arm Z (cabozantinib S-malate, nivolumab)

Paclitaxel DRUG

Given IV

Also known as: Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat

Step 1, Arm C (standard chemotherapy)

Ramucirumab BIOLOGICAL

Given IV

Also known as: Anti-VEGFR-2 Fully Human Monoclonal Antibody IMC-1121B, Cyramza, IMC 1121B, IMC-1121B, IMC1121B, LY 3009806, LY-3009806, LY3009806, Monoclonal Antibody HGS-ETR2

Step 1, Arm C (standard chemotherapy)

Echocardiography Test PROCEDURE

Undergo ECHO

Also known as: EC, Echocardiography

Step 1, Arm A (cabozantinib S-malate); Step 1, Arm B (cabozantinib S-malate, nivolumab); Step 1, Arm C (standard chemotherapy); Step 2, Arm Z (cabozantinib S-malate, nivolumab)

Nab-paclitaxel DRUG

Given IV

Also known as: ABI 007, ABI-007, ABI007, Abraxane, Albumin-bound Paclitaxel, Albumin-Stabilized Nanoparticle Paclitaxel, Nanoparticle Albumin-bound Paclitaxel, Nanoparticle Paclitaxel, Naveruclif, Paclitaxel Albumin, paclitaxel albumin-stabilized nanoparticle formulation, Paclitaxel Nanoparticle Albumin-bound, Paclitaxel Protein-Bound, Protein-bound Paclitaxel

Step 1, Arm C (standard chemotherapy)

Gemcitabine Hydrochloride DRUG

Given PO

Also known as: dFdCyd, Difluorodeoxycytidine Hydrochloride, Gemcitabine HCI, Gemzar, LY 188011, LY-188011, LY188011

Step 1, Arm C (standard chemotherapy)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• RANDOMIZATION (STEP 1): Patient must be \>= 18 years of age
• RANDOMIZATION (STEP 1): Patient must have pathologically confirmed non-squamous non-small cell lung carcinoma (NSCLC). Patients with NSCLC not otherwise specified (NOS) are eligible. Mixed tumors will be categorized by predominant cell type. If small cell elements are present, the patient is ineligible
• RANDOMIZATION (STEP 1): Patient must have metastatic stage IVA or IVB disease (includes M1a, M1b, and M1c), according to the 8th edition of the lung cancer TNM classification system. Recurrent metastatic NSCLC ineligible for curative therapy (in the treating investigator's opinion) is also allowed
• RANDOMIZATION (STEP 1): Patient's tumor must be known negative for EGFR tyrosine kinase inhibitor (TKI) sensitizing mutations (for example at a minimum, negative for EGFR Exon 19 deletions, EGFR exon 20 insertions, and Exon 21 L858R, L861Q mutations ) AND negative for ALK gene rearrangements (by fluorescence in situ hybridization \[FISH\], next generation sequencing \[NGS\], or immunohistochemistry \[IHC\]) by routine Clinical Laboratory Improvement Amendments (CLIA)- or Food and Drug Administration (FDA)-certified clinical testing methods. CLIA or FDA approved circulating tumor deoxyribonucleic acid (DNA) testing is acceptable as an alternative to tissue testing
• RANDOMIZATION (STEP 1): Patient must have radiographic and/or clinical progression (per local investigator assessment) following one, but only one, line of platinum-based chemotherapy AND one, but only one, line of prior checkpoint inhibitor (anti-PD-1 or PD-L1) immunotherapy, either concurrently or sequentially in either order. A minimum of two doses of prior immunotherapy is required. Only one prior line of therapy is allowed if patients received chemotherapy and immunotherapy together (patients may not receive subsequent single agent chemotherapy), and greater than two prior lines of therapy are not allowed.
• NOTE: Lines of therapy are defined by clinical or radiographic progression. For patients with recurrent metastatic NSCLC following treatment for stage 1-3 NSCLC, platinum-based chemotherapy received within 12 months of recurrence and/or immunotherapy received within 6 months of recurrence will meet the requirement for prior chemotherapy and/or immunotherapy but subsequent receipt of more immunotherapy and/or platinum-based chemotherapy is also allowed.
• NOTE: Prior anti-VEGF antibody therapy (ie bevacizumab) is allowed. Prior ipilimumab, or investigational agents not excluded below, in combination with the required prior therapies above are allowed.
• NOTE: Prior receipt of one or two lines of targeted therapy for ROS1, RET, MET, BRAF, ERBB2/HER2, or KRAS G12C positive NSCLC is allowed and will not count toward the line of therapy limit. However, progression is still required after chemotherapy and immunotherapy as above. Patients with ROS1, RET, MET positive NSCLC are strongly encouraged to get appropriate targeted therapy (such as crizotinib, entrectinib, lorlatinib, selpercatinib, pralsetinib, capmatinib, tepotinib, or another investigational, off-label, or approved agent directed against ROS1, RET, or MET positive NSCLC) prior to participation and will be stratified.
• NOTE: No prior predominantly VEGFR directed TKI therapy (such as cabozantinib, lenvatinib, or sitravantinib) is allowed, except for the agents named above.
• RANDOMIZATION (STEP 1): The investigator must document the intended chemotherapy regimen should their patient be randomized to Arm C (docetaxel and ramucirumab, OR single agent chemotherapy - docetaxel, gemcitabine, paclitaxel, nab-paclitaxel). The patient must not have received the selected chemotherapy agent previously for metastatic disease
• RANDOMIZATION (STEP 1): Any prior chemotherapy (based on administration schedule) must have been completed in greater than or equal to the following times prior to randomization:
• FDA approved targeted oral therapy must be completed \>= 1 week prior
• Chemotherapy and/or immunotherapy must be completed \>= 2 weeks prior
• Prior investigational agents must be completed \>= 4 weeks prior.
• RANDOMIZATION (STEP 1): Prior radiation therapy is allowed with a 2 week washout prior to randomization. Patient must not receive any systemic treatment with radionuclides within 6 weeks prior to randomization. Patient must have no clinically relevant ongoing complication from prior radiation therapy

Sponsors & Collaborators

• National Cancer Institute (NCI): lead

Study Sites (613)

Veterans Administration Medical Center - Birmingham

Birmingham, Alabama, 35233, United States

Location

Anchorage Associates in Radiation Medicine

Anchorage, Alaska, 98508, United States

Location

Anchorage Radiation Therapy Center

Anchorage, Alaska, 99504, United States

Location

Alaska Breast Care and Surgery LLC

Anchorage, Alaska, 99508, United States

Location

Alaska Oncology and Hematology LLC

Anchorage, Alaska, 99508, United States

Location

Alaska Women's Cancer Care

Anchorage, Alaska, 99508, United States

Location

Anchorage Oncology Centre

Anchorage, Alaska, 99508, United States

Location

Katmai Oncology Group

Anchorage, Alaska, 99508, United States

Location

Providence Alaska Medical Center

Anchorage, Alaska, 99508, United States

Location

Fairbanks Memorial Hospital

Fairbanks, Alaska, 99701, United States

Location

CTCA at Western Regional Medical Center

Goodyear, Arizona, 85338, United States

Location

Kingman Regional Medical Center

Kingman, Arizona, 86401, United States

Location

Cancer Center at Saint Joseph's

Phoenix, Arizona, 85004, United States

Location

Banner University Medical Center - Tucson

Tucson, Arizona, 85719, United States

Location

University of Arizona Cancer Center-North Campus

Tucson, Arizona, 85719, United States

Location

Mercy Hospital Fort Smith

Fort Smith, Arkansas, 72903, United States

Location

CHI Saint Vincent Cancer Center Hot Springs

Hot Springs, Arkansas, 71913, United States

Location

Mission Hope Medical Oncology - Arroyo Grande

Arroyo Grande, California, 93420, United States

Location

PCR Oncology

Arroyo Grande, California, 93420, United States

Location

Providence Saint Joseph Medical Center/Disney Family Cancer Center

Burbank, California, 91505, United States

Location

Mercy Cancer Center - Carmichael

Carmichael, California, 95608, United States

Location

Mercy San Juan Medical Center

Carmichael, California, 95608, United States

Location

Mercy Cancer Center - Elk Grove

Elk Grove, California, 95758, United States

Location

Washington Hospital

Fremont, California, 94538, United States

Location

Fremont - Rideout Cancer Center

Marysville, California, 95901, United States

Location

Saint Joseph Hospital - Orange

Orange, California, 92868, United States

Location

Stanford Cancer Institute Palo Alto

Palo Alto, California, 94304, United States

Location

Mercy Cancer Center - Rocklin

Rocklin, California, 95765, United States

Location

Mercy Cancer Center - Sacramento

Sacramento, California, 95816, United States

Location

University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States

Location

Pacific Central Coast Health Center-San Luis Obispo

San Luis Obispo, California, 93401, United States

Location

Mission Hope Medical Oncology - Santa Maria

Santa Maria, California, 93444, United States

Location

Woodland Memorial Hospital

Woodland, California, 95695, United States

Location

Rocky Mountain Cancer Centers-Aurora

Aurora, Colorado, 80012, United States

Location

The Medical Center of Aurora

Aurora, Colorado, 80012, United States

Location

Boulder Community Foothills Hospital

Boulder, Colorado, 80303, United States

Location

Rocky Mountain Cancer Centers-Boulder

Boulder, Colorado, 80304, United States

Location

Rocky Mountain Cancer Centers - Centennial

Centennial, Colorado, 80112, United States

Location

Penrose-Saint Francis Healthcare

Colorado Springs, Colorado, 80907, United States

Location

Rocky Mountain Cancer Centers-Penrose

Colorado Springs, Colorado, 80907, United States

Location

Saint Francis Cancer Center

Colorado Springs, Colorado, 80923, United States

Location

Cancer Center of Colorado at Sloan's Lake

Denver, Colorado, 80204, United States

Location

National Jewish Health-Main Campus

Denver, Colorado, 80206, United States

Location

The Women's Imaging Center

Denver, Colorado, 80209, United States

Location

AdventHealth Porter

Denver, Colorado, 80210, United States

Location

Colorado Blood Cancer Institute

Denver, Colorado, 80218, United States

Location

Presbyterian - Saint Lukes Medical Center - Health One

Denver, Colorado, 80218, United States

Location

Rocky Mountain Cancer Centers-Midtown

Denver, Colorado, 80218, United States

Location

Saint Joseph Hospital - Cancer Centers of Colorado

Denver, Colorado, 80218, United States

Location

Rocky Mountain Cancer Centers-Rose

Denver, Colorado, 80220, United States

Location

Rose Medical Center

Denver, Colorado, 80220, United States

Location

Western Surgical Care

Denver, Colorado, 80220, United States

Location

CommonSpirit Cancer Center Mercy

Durango, Colorado, 81301, United States

Location

Mercy Medical Center

Durango, Colorado, 81301, United States

Location

Mountain Blue Cancer Care Center - Swedish

Englewood, Colorado, 80113, United States

Location

Rocky Mountain Cancer Centers - Swedish

Englewood, Colorado, 80113, United States

Location

Swedish Medical Center

Englewood, Colorado, 80113, United States

Location

The Melanoma and Skin Cancer Institute

Englewood, Colorado, 80113, United States

Location

Poudre Valley Hospital

Fort Collins, Colorado, 80524, United States

Location

Cancer Care and Hematology-Fort Collins

Fort Collins, Colorado, 80528, United States

Location

National Jewish Health-Western Hematology Oncology

Golden, Colorado, 80401, United States

Location

Saint Mary's Hospital and Regional Medical Center

Grand Junction, Colorado, 81501, United States

Location

Banner North Colorado Medical Center

Greeley, Colorado, 80631, United States

Location

UCHealth Greeley Hospital

Greeley, Colorado, 80631, United States

Location

UCHealth Highlands Ranch Hospital

Highlands Ranch, Colorado, 80129, United States

Location

Good Samaritan Hospital - Cancer Centers of Colorado

Lafayette, Colorado, 80026, United States

Location

CommonSpirit Saint Anthony Hospital Cancer Center

Lakewood, Colorado, 80228, United States

Location

Rocky Mountain Cancer Centers-Lakewood

Lakewood, Colorado, 80228, United States

Location

Rocky Mountain Cancer Centers-Littleton

Littleton, Colorado, 80120, United States

Location

AdventHealth Littleton

Littleton, Colorado, 80122, United States

Location

Rocky Mountain Cancer Centers-Sky Ridge

Lone Tree, Colorado, 80124, United States

Location

Sky Ridge Medical Center

Lone Tree, Colorado, 80124, United States

Location

Longmont United Hospital

Longmont, Colorado, 80501, United States

Location

Rocky Mountain Cancer Centers-Longmont

Longmont, Colorado, 80501, United States

Location

Medical Center of the Rockies

Loveland, Colorado, 80538, United States

Location

Banner North Colorado Medical Center - Loveland Campus

Loveland, Colorado, 80539, United States

Location

AdventHealth Parker

Parker, Colorado, 80138, United States

Location

Saint Mary Corwin Medical Center

Pueblo, Colorado, 81004, United States

Location

National Jewish Health-Northern Hematology Oncology

Thornton, Colorado, 80260, United States

Location

Rocky Mountain Cancer Centers-Thornton

Thornton, Colorado, 80260, United States

Location

Veterans Affairs Connecticut Healthcare System-West Haven Campus

West Haven, Connecticut, 06516, United States

Location

Mount Sinai Comprehensive Cancer Center at Aventura

Aventura, Florida, 33180, United States

Location

Holy Cross Hospital

Fort Lauderdale, Florida, 33308, United States

Location

Mount Sinai Medical Center

Miami Beach, Florida, 33140, United States

Location

Emory University Hospital Midtown

Atlanta, Georgia, 30308, United States

Location

Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322, United States

Location

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, 31405, United States

Location

Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, 83706, United States

Location

Saint Luke's Cancer Institute - Boise

Boise, Idaho, 83712, United States

Location

Saint Alphonsus Cancer Care Center-Caldwell

Caldwell, Idaho, 83605, United States

Location

Kootenai Health - Coeur d'Alene

Coeur d'Alene, Idaho, 83814, United States

Location

Walter Knox Memorial Hospital

Emmett, Idaho, 83617, United States

Location

Saint Luke's Cancer Institute - Fruitland

Fruitland, Idaho, 83619, United States

Location

Idaho Urologic Institute-Meridian

Meridian, Idaho, 83642, United States

Location

Saint Luke's Cancer Institute - Meridian

Meridian, Idaho, 83642, United States

Location

Saint Alphonsus Cancer Care Center-Nampa

Nampa, Idaho, 83687, United States

Location

Saint Luke's Cancer Institute - Nampa

Nampa, Idaho, 83687, United States

Location

Kootenai Clinic Cancer Services - Post Falls

Post Falls, Idaho, 83854, United States

Location

Kootenai Clinic Cancer Services - Sandpoint

Sandpoint, Idaho, 83864, United States

Location

Saint Luke's Cancer Institute - Twin Falls

Twin Falls, Idaho, 83301, United States

Location

OSF Saint Anthony's Health Center

Alton, Illinois, 62002, United States

Location

Rush-Copley Medical Center

Aurora, Illinois, 60504, United States

Location

Advocate Good Shepherd Hospital

Barrington, Illinois, 60010, United States

Location

Illinois CancerCare-Bloomington

Bloomington, Illinois, 61704, United States

Location

Illinois CancerCare-Canton

Canton, Illinois, 61520, United States

Location

Memorial Hospital of Carbondale

Carbondale, Illinois, 62902, United States

Location

SIH Cancer Institute

Carterville, Illinois, 62918, United States

Location

Illinois CancerCare-Carthage

Carthage, Illinois, 62321, United States

Location

Centralia Oncology Clinic

Centralia, Illinois, 62801, United States

Location

Saint Mary's Hospital

Centralia, Illinois, 62801, United States

Location

University of Illinois

Chicago, Illinois, 60612, United States

Location

Advocate Illinois Masonic Medical Center

Chicago, Illinois, 60657, United States

Location

AMG Crystal Lake - Oncology

Crystal Lake, Illinois, 60014, United States

Location

Carle at The Riverfront

Danville, Illinois, 61832, United States

Location

Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, 62526, United States

Location

Decatur Memorial Hospital

Decatur, Illinois, 62526, United States

Location

Illinois CancerCare-Dixon

Dixon, Illinois, 61021, United States

Location

Advocate Good Samaritan Hospital

Downers Grove, Illinois, 60515, United States

Location

Carle Physician Group-Effingham

Effingham, Illinois, 62401, United States

Location

Crossroads Cancer Center

Effingham, Illinois, 62401, United States

Location

Advocate Sherman Hospital

Elgin, Illinois, 60123, United States

Location

Illinois CancerCare-Eureka

Eureka, Illinois, 61530, United States

Location

Illinois CancerCare-Galesburg

Galesburg, Illinois, 61401, United States

Location

Western Illinois Cancer Treatment Center

Galesburg, Illinois, 61401, United States

Location

Advocate South Suburban Hospital

Hazel Crest, Illinois, 60429, United States

Location

Edward Hines Jr VA Hospital

Hines, Illinois, 60141, United States

Location

Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois, 61443, United States

Location

AMG Libertyville - Oncology

Libertyville, Illinois, 60048, United States

Location

Condell Memorial Hospital

Libertyville, Illinois, 60048, United States

Location

Illinois CancerCare-Macomb

Macomb, Illinois, 61455, United States

Location

Carle Physician Group-Mattoon/Charleston

Mattoon, Illinois, 61938, United States

Location

SSM Health Good Samaritan

Mount Vernon, Illinois, 62864, United States

Location

Cancer Care Center of O'Fallon

O'Fallon, Illinois, 62269, United States

Location

Advocate Christ Medical Center

Oak Lawn, Illinois, 60453-2699, United States

Location

Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, 61350, United States

Location

Advocate Lutheran General Hospital

Park Ridge, Illinois, 60068, United States

Location

Illinois CancerCare-Pekin

Pekin, Illinois, 61554, United States

Location

Illinois CancerCare-Peoria

Peoria, Illinois, 61615, United States

Location

Methodist Medical Center of Illinois

Peoria, Illinois, 61636, United States

Location

Illinois CancerCare-Peru

Peru, Illinois, 61354, United States

Location

Valley Radiation Oncology

Peru, Illinois, 61354, United States

Location

Illinois CancerCare-Princeton

Princeton, Illinois, 61356, United States

Location

UW Health Carbone Cancer Center Rockford

Rockford, Illinois, 61114, United States

Location

Southern Illinois University School of Medicine

Springfield, Illinois, 62702, United States

Location

Springfield Clinic

Springfield, Illinois, 62702, United States

Location

Springfield Memorial Hospital

Springfield, Illinois, 62781, United States

Location

Southwest Illinois Health Services LLP

Swansea, Illinois, 62226, United States

Location

Carle Cancer Center

Urbana, Illinois, 61801, United States

Location

The Carle Foundation Hospital

Urbana, Illinois, 61801, United States

Location

Illinois CancerCare - Washington

Washington, Illinois, 61571, United States

Location

Rush-Copley Healthcare Center

Yorkville, Illinois, 60560, United States

Location

Reid Health

Richmond, Indiana, 47374, United States

Location

Memorial Hospital of South Bend

South Bend, Indiana, 46601, United States

Location

Mary Greeley Medical Center

Ames, Iowa, 50010, United States

Location

McFarland Clinic - Ames

Ames, Iowa, 50010, United States

Location

University of Iowa Healthcare Cancer Services Quad Cities

Bettendorf, Iowa, 52722, United States

Location

McFarland Clinic - Boone

Boone, Iowa, 50036, United States

Location

Saint Anthony Regional Hospital

Carroll, Iowa, 51401, United States

Location

Mercy Cancer Center-West Lakes

Clive, Iowa, 50325, United States

Location

UI Health Care Mission Cancer and Blood - West Des Moines Clinic

Clive, Iowa, 50325, United States

Location

Alegent Health Mercy Hospital

Council Bluffs, Iowa, 51503, United States

Location

Heartland Oncology and Hematology LLP

Council Bluffs, Iowa, 51503, United States

Location

Methodist Jennie Edmundson Hospital

Council Bluffs, Iowa, 51503, United States

Location

Greater Regional Medical Center

Creston, Iowa, 50801, United States

Location

Iowa Methodist Medical Center

Des Moines, Iowa, 50309, United States

Location

UI Health Care Mission Cancer and Blood - Des Moines Clinic

Des Moines, Iowa, 50309, United States

Location

Broadlawns Medical Center

Des Moines, Iowa, 50314, United States

Location

Mercy Medical Center - Des Moines

Des Moines, Iowa, 50314, United States

Location

UI Health Care Mission Cancer and Blood - Laurel Clinic

Des Moines, Iowa, 50314, United States

Location

Iowa Lutheran Hospital

Des Moines, Iowa, 50316, United States

Location

McFarland Clinic - Trinity Cancer Center

Fort Dodge, Iowa, 50501, United States

Location

UI Healthcare Mission Cancer and Blood - Fort Dodge

Fort Dodge, Iowa, 50501, United States

Location

University of Iowa/Holden Comprehensive Cancer Center

Iowa City, Iowa, 52242, United States

Location

McFarland Clinic - Jefferson

Jefferson, Iowa, 50129, United States

Location

McFarland Clinic - Marshalltown

Marshalltown, Iowa, 50158, United States

Location

Methodist West Hospital

West Des Moines, Iowa, 50266-7700, United States

Location

Mercy Medical Center-West Lakes

West Des Moines, Iowa, 50266, United States

Location

Central Care Cancer Center - Garden City

Garden City, Kansas, 67846, United States

Location

Central Care Cancer Center - Great Bend

Great Bend, Kansas, 67530, United States

Location

HaysMed

Hays, Kansas, 67601, United States

Location

Lawrence Memorial Hospital

Lawrence, Kansas, 66044, United States

Location

The University of Kansas Cancer Center - Olathe

Olathe, Kansas, 66061, United States

Location

Saint Luke's South Hospital

Overland Park, Kansas, 66213, United States

Location

Freeman Physician Group of Pittsburg

Pittsburg, Kansas, 66762, United States

Location

Mercy Hospital Pittsburg

Pittsburg, Kansas, 66762, United States

Location

Salina Regional Health Center

Salina, Kansas, 67401, United States

Location

University of Kansas Health System Saint Francis Campus

Topeka, Kansas, 66606, United States

Location

Flaget Memorial Hospital

Bardstown, Kentucky, 40004, United States

Location

Commonwealth Cancer Center-Corbin

Corbin, Kentucky, 40701, United States

Location

Saint Joseph Hospital

Lexington, Kentucky, 40504, United States

Location

Saint Joseph Radiation Oncology Resource Center

Lexington, Kentucky, 40504, United States

Location

Saint Joseph Hospital East

Lexington, Kentucky, 40509, United States

Location

Saint Joseph London

London, Kentucky, 40741, United States

Location

Jewish Hospital

Louisville, Kentucky, 40202, United States

Location

Saints Mary and Elizabeth Hospital

Louisville, Kentucky, 40215, United States

Location

UofL Health Medical Center Northeast

Louisville, Kentucky, 40245, United States

Location

Saint Joseph Mount Sterling

Mount Sterling, Kentucky, 40353, United States

Location

Owensboro Health Mitchell Memorial Cancer Center

Owensboro, Kentucky, 42303, United States

Location

Mercy Health - Paducah Cancer Center

Paducah, Kentucky, 42003, United States

Location

Jewish Hospital Medical Center South

Shepherdsville, Kentucky, 40165, United States

Location

LSU Health Baton Rouge-North Clinic

Baton Rouge, Louisiana, 70805, United States

Location

Our Lady of the Lake Physician Group

Baton Rouge, Louisiana, 70808, United States

Location

Our Lady of The Lake

Baton Rouge, Louisiana, 70808, United States

Location

Louisiana Hematology Oncology Associates LLC

Baton Rouge, Louisiana, 70809, United States

Location

Mary Bird Perkins Cancer Center

Baton Rouge, Louisiana, 70809, United States

Location

Northshore Oncology Associates-Covington

Covington, Louisiana, 70433, United States

Location

Terrebonne General Medical Center

Houma, Louisiana, 70360, United States

Location

Harold Alfond Center for Cancer Care

Augusta, Maine, 04330, United States

Location

MaineHealth Maine Medical Center - Biddeford

Biddeford, Maine, 04005, United States

Location

MaineHealth Cancer Care and IV Therapy - Sanford

Sanford, Maine, 04073, United States

Location

MaineHealth Cancer Care and IV Therapy - South Portland

South Portland, Maine, 04106, United States

Location

Saint Agnes Hospital

Baltimore, Maryland, 21229, United States

Location

Boston Medical Center

Boston, Massachusetts, 02118, United States

Location

UMass Memorial Medical Center - University Campus

Worcester, Massachusetts, 01655, United States

Location

Hickman Cancer Center

Adrian, Michigan, 49221, United States

Location

Trinity Health Saint Joseph Mercy Hospital Ann Arbor

Ann Arbor, Michigan, 48106, United States

Location

Bronson Battle Creek

Battle Creek, Michigan, 49017, United States

Location

Trinity Health IHA Medical Group Hematology Oncology - Brighton

Brighton, Michigan, 48114, United States

Location

Trinity Health Medical Center - Brighton

Brighton, Michigan, 48114, United States

Location

Trinity Health IHA Medical Group Hematology Oncology - Canton

Canton, Michigan, 48188, United States

Location

Trinity Health Medical Center - Canton

Canton, Michigan, 48188, United States

Location

Caro Cancer Center

Caro, Michigan, 48723, United States

Location

Chelsea Hospital

Chelsea, Michigan, 48118, United States

Location

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

Chelsea, Michigan, 48118, United States

Location

Hematology Oncology Consultants-Clarkston

Clarkston, Michigan, 48346, United States

Location

Newland Medical Associates-Clarkston

Clarkston, Michigan, 48346, United States

Location

Henry Ford Health Saint John Hospital

Detroit, Michigan, 48236, United States

Location

Henry Ford River District Hospital

East China Township, Michigan, 48054, United States

Location

Cancer Hematology Centers - Flint

Flint, Michigan, 48503, United States

Location

Genesee Hematology Oncology PC

Flint, Michigan, 48503, United States

Location

Genesys Hurley Cancer Institute

Flint, Michigan, 48503, United States

Location

Hurley Medical Center

Flint, Michigan, 48503, United States

Location

Corewell Health Grand Rapids Hospitals - Butterworth Hospital

Grand Rapids, Michigan, 49503, United States

Location

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital

Grand Rapids, Michigan, 49503, United States

Location

Trinity Health Grand Rapids Hospital

Grand Rapids, Michigan, 49503, United States

Location

Henry Ford Saint John Hospital - Academic

Grosse Pointe Woods, Michigan, 48236, United States

Location

Henry Ford Saint John Hospital - Breast

Grosse Pointe Woods, Michigan, 48236, United States

Location

Henry Ford Saint John Hospital - Van Elslander

Grosse Pointe Woods, Michigan, 48236, United States

Location

Bronson Methodist Hospital

Kalamazoo, Michigan, 49007, United States

Location

West Michigan Cancer Center

Kalamazoo, Michigan, 49007, United States

Location

Beacon Kalamazoo Cancer Center

Kalamazoo, Michigan, 49009, United States

Location

Beacon Kalamazoo

Kalamazoo, Michigan, 49048, United States

Location

University of Michigan Health - Sparrow Lansing

Lansing, Michigan, 48912, United States

Location

Hope Cancer Clinic

Livonia, Michigan, 48154, United States

Location

Trinity Health Saint Mary Mercy Livonia Hospital

Livonia, Michigan, 48154, United States

Location

Henry Ford Saint John Hospital - Macomb Medical

Macomb, Michigan, 48044, United States

Location

Henry Ford Warren Hospital - Breast Macomb

Macomb, Michigan, 48044, United States

Location

Saint Mary's Oncology/Hematology Associates of Marlette

Marlette, Michigan, 48453, United States

Location

Toledo Clinic Cancer Centers-Monroe

Monroe, Michigan, 48162, United States

Location

Trinity Health Muskegon Hospital

Muskegon, Michigan, 49444, United States

Location

Corewell Health Lakeland Hospitals - Niles Hospital

Niles, Michigan, 49120, United States

Location

Cancer and Hematology Centers of Western Michigan - Norton Shores

Norton Shores, Michigan, 49444, United States

Location

Henry Ford Health Providence Novi Hospital

Novi, Michigan, 48374, United States

Location

Hope Cancer Center

Pontiac, Michigan, 48341, United States

Location

Michigan Healthcare Professionals Pontiac

Pontiac, Michigan, 48341, United States

Location

Newland Medical Associates-Pontiac

Pontiac, Michigan, 48341, United States

Location

Trinity Health Saint Joseph Mercy Oakland Hospital

Pontiac, Michigan, 48341, United States

Location

Corewell Health Reed City Hospital

Reed City, Michigan, 49677, United States

Location

Henry Ford Rochester Hospital

Rochester Hills, Michigan, 48309, United States

Location

MyMichigan Medical Center Saginaw

Saginaw, Michigan, 48601, United States

Location

Oncology Hematology Associates of Saginaw Valley PC

Saginaw, Michigan, 48604, United States

Location

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center

Saint Joseph, Michigan, 49085, United States

Location

Corewell Health Lakeland Hospitals - Saint Joseph Hospital

Saint Joseph, Michigan, 49085, United States

Location

Henry Ford Health Providence Southfield Hospital

Southfield, Michigan, 48075, United States

Location

Bhadresh Nayak MD PC-Sterling Heights

Sterling Heights, Michigan, 48312, United States

Location

MyMichigan Medical Center Tawas

Tawas City, Michigan, 48764, United States

Location

Munson Medical Center

Traverse City, Michigan, 49684, United States

Location

Advanced Breast Care Center PLLC

Warren, Michigan, 48088, United States

Location

Henry Ford Health Warren Hospital

Warren, Michigan, 48093, United States

Location

Henry Ford Madison Heights Hospital - Breast

Warren, Michigan, 48093, United States

Location

Henry Ford Warren Hospital - GLCMS

Warren, Michigan, 48093, United States

Location

Macomb Hematology Oncology PC

Warren, Michigan, 48093, United States

Location

Saint Mary's Oncology/Hematology Associates of West Branch

West Branch, Michigan, 48661, United States

Location

University of Michigan Health - West

Wyoming, Michigan, 49519, United States

Location

Huron Gastroenterology PC

Ypsilanti, Michigan, 48106, United States

Location

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

Ypsilanti, Michigan, 48197, United States

Location

Riverwood Healthcare Center

Aitkin, Minnesota, 56431, United States

Location

Essentia Health - Baxter Clinic

Baxter, Minnesota, 56425, United States

Location

Essentia Health Saint Joseph's Medical Center

Brainerd, Minnesota, 56401, United States

Location

Fairview Ridges Hospital

Burnsville, Minnesota, 55337, United States

Location

Minnesota Oncology - Burnsville

Burnsville, Minnesota, 55337, United States

Location

Cambridge Medical Center

Cambridge, Minnesota, 55008, United States

Location

Mercy Hospital

Coon Rapids, Minnesota, 55433, United States

Location

Essentia Health - Deer River Clinic

Deer River, Minnesota, 56636, United States

Location

Essentia Health Saint Mary's - Detroit Lakes Clinic

Detroit Lakes, Minnesota, 56501, United States

Location

Essentia Health Cancer Center

Duluth, Minnesota, 55805, United States

Location

Essentia Health Saint Mary's Medical Center

Duluth, Minnesota, 55805, United States

Location

Miller-Dwan Hospital

Duluth, Minnesota, 55805, United States

Location

Fairview Southdale Hospital

Edina, Minnesota, 55435, United States

Location

Essentia Health - Ely Clinic

Ely, Minnesota, 55731, United States

Location

Lake Region Healthcare Corporation-Cancer Care

Fergus Falls, Minnesota, 56537, United States

Location

Essentia Health - Fosston

Fosston, Minnesota, 56542, United States

Location

Unity Hospital

Fridley, Minnesota, 55432, United States

Location

Essentia Health Hibbing Clinic

Hibbing, Minnesota, 55746, United States

Location

Essentia Health - International Falls Clinic

International Falls, Minnesota, 56649, United States

Location

Fairview Clinics and Surgery Center Maple Grove

Maple Grove, Minnesota, 55369, United States

Location

Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, 55109, United States

Location

Saint John's Hospital - Healtheast

Maplewood, Minnesota, 55109, United States

Location

Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407, United States

Location

Hennepin County Medical Center

Minneapolis, Minnesota, 55415, United States

Location

Health Partners Inc

Minneapolis, Minnesota, 55454, United States

Location

Monticello Cancer Center

Monticello, Minnesota, 55362, United States

Location

Essentia Health - Moose Lake Clinic

Moose Lake, Minnesota, 55767, United States

Location

New Ulm Medical Center

New Ulm, Minnesota, 56073, United States

Location

Essentia Health - Park Rapids

Park Rapids, Minnesota, 56470, United States

Location

Fairview Northland Medical Center

Princeton, Minnesota, 55371, United States

Location

North Memorial Medical Health Center

Robbinsdale, Minnesota, 55422, United States

Location

Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416, United States

Location

Regions Hospital

Saint Paul, Minnesota, 55101, United States

Location

United Hospital

Saint Paul, Minnesota, 55102, United States

Location

Essentia Health Sandstone

Sandstone, Minnesota, 55072, United States

Location

Saint Francis Regional Medical Center

Shakopee, Minnesota, 55379, United States

Location

Lakeview Hospital

Stillwater, Minnesota, 55082, United States

Location

Essentia Health Virginia Clinic

Virginia, Minnesota, 55792, United States

Location

Ridgeview Medical Center

Waconia, Minnesota, 55387, United States

Location

Rice Memorial Hospital

Willmar, Minnesota, 56201, United States

Location

Minnesota Oncology Hematology PA-Woodbury

Woodbury, Minnesota, 55125, United States

Location

Fairview Lakes Medical Center

Wyoming, Minnesota, 55092, United States

Location

Mercy Oncology and Hematology - Clayton-Clarkson

Ballwin, Missouri, 63011, United States

Location

Central Care Cancer Center - Bolivar

Bolivar, Missouri, 65613, United States

Location

Cox Cancer Center Branson

Branson, Missouri, 65616, United States

Location

Mercy Cancer Center - Cape Girardeau

Cape Girardeau, Missouri, 63703, United States

Location

Saint Francis Medical Center

Cape Girardeau, Missouri, 63703, United States

Location

Siteman Cancer Center at Saint Peters Hospital

City of Saint Peters, Missouri, 63376, United States

Location

MU Health - University Hospital/Ellis Fischel Cancer Center

Columbia, Missouri, 65212, United States

Location

Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, 63141, United States

Location

Parkland Health Center - Farmington

Farmington, Missouri, 63640, United States

Location

MU Health Care Goldschmidt Cancer Center

Jefferson City, Missouri, 65109, United States

Location

Freeman Health System

Joplin, Missouri, 64804, United States

Location

Mercy Hospital Joplin

Joplin, Missouri, 64804, United States

Location

University Health Truman Medical Center

Kansas City, Missouri, 64108, United States

Location

Saint Luke's Hospital of Kansas City

Kansas City, Missouri, 64111, United States

Location

Saint Luke's East - Lee's Summit

Lee's Summit, Missouri, 64086, United States

Location

Mercy Clinic-Rolla-Cancer and Hematology

Rolla, Missouri, 65401, United States

Location

Phelps Health Delbert Day Cancer Institute

Rolla, Missouri, 65401, United States

Location

Heartland Regional Medical Center

Saint Joseph, Missouri, 64506, United States

Location

Sainte Genevieve County Memorial Hospital

Sainte Genevieve, Missouri, 63670, United States

Location

Mercy Hospital Springfield

Springfield, Missouri, 65804, United States

Location

CoxHealth South Hospital

Springfield, Missouri, 65807, United States

Location

Mercy Infusion Center - Chippewa

St Louis, Missouri, 63109, United States

Location

Washington University School of Medicine

St Louis, Missouri, 63110, United States

Location

Mercy Hospital South

St Louis, Missouri, 63128, United States

Location

Siteman Cancer Center-South County

St Louis, Missouri, 63129, United States

Location

Missouri Baptist Medical Center

St Louis, Missouri, 63131, United States

Location

Siteman Cancer Center at Christian Hospital

St Louis, Missouri, 63136, United States

Location

Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States

Location

Missouri Baptist Sullivan Hospital

Sullivan, Missouri, 63080, United States

Location

BJC Outpatient Center at Sunset Hills

Sunset Hills, Missouri, 63127, United States

Location

Mercy Hospital Washington

Washington, Missouri, 63090, United States

Location

Community Hospital of Anaconda

Anaconda, Montana, 59711, United States

Location

Billings Clinic Cancer Center

Billings, Montana, 59101, United States

Location

Saint Vincent Healthcare

Billings, Montana, 59101, United States

Location

Saint Vincent Frontier Cancer Center

Billings, Montana, 59102, United States

Location

Bozeman Health Deaconess Hospital

Bozeman, Montana, 59715, United States

Location

Benefis Sletten Cancer Institute

Great Falls, Montana, 59405, United States

Location

Great Falls Clinic

Great Falls, Montana, 59405, United States

Location

Logan Health Medical Center

Kalispell, Montana, 59901, United States

Location

Saint Patrick Hospital - Community Hospital

Missoula, Montana, 59802, United States

Location

Community Medical Center

Missoula, Montana, 59804, United States

Location

Nebraska Medicine-Bellevue

Bellevue, Nebraska, 68123, United States

Location

Nebraska Cancer Specialists/Oncology Hematology West PC

Grand Island, Nebraska, 68803, United States

Location

CHI Health Good Samaritan

Kearney, Nebraska, 68847, United States

Location

Saint Elizabeth Regional Medical Center

Lincoln, Nebraska, 68510, United States

Location

Nebraska Cancer Specialists/Oncology Hematology West PC - MECC

Omaha, Nebraska, 68114, United States

Location

Nebraska Methodist Hospital

Omaha, Nebraska, 68114, United States

Location

Oncology Associates PC

Omaha, Nebraska, 68114, United States

Location

Nebraska Medicine-Village Pointe

Omaha, Nebraska, 68118, United States

Location

Alegent Health Immanuel Medical Center

Omaha, Nebraska, 68122, United States

Location

Alegent Health Bergan Mercy Medical Center

Omaha, Nebraska, 68124, United States

Location

Alegent Health Lakeside Hospital

Omaha, Nebraska, 68130, United States

Location

Creighton University Medical Center

Omaha, Nebraska, 68131, United States

Location

University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States

Location

Midlands Community Hospital

Papillion, Nebraska, 68046, United States

Location

Carson Tahoe Regional Medical Center

Carson City, Nevada, 89703, United States

Location

Cancer and Blood Specialists-Henderson

Henderson, Nevada, 89052, United States

Location

Comprehensive Cancer Centers of Nevada - Henderson

Henderson, Nevada, 89052, United States

Location

Comprehensive Cancer Centers of Nevada-Horizon Ridge

Henderson, Nevada, 89052, United States

Location

Las Vegas Cancer Center-Henderson

Henderson, Nevada, 89052, United States

Location

Comprehensive Cancer Centers of Nevada-Southeast Henderson

Henderson, Nevada, 89074, United States

Location

Las Vegas Urology - Green Valley

Henderson, Nevada, 89074, United States

Location

Las Vegas Urology - Pebble

Henderson, Nevada, 89074, United States

Location

Oncology Las Vegas - Henderson

Henderson, Nevada, 89074, United States

Location

Urology Specialists of Nevada - Green Valley

Henderson, Nevada, 89074, United States

Location

Las Vegas Urology - Pecos

Las Vegas, Nevada, 89074, United States

Location

Desert West Surgery

Las Vegas, Nevada, 89102, United States

Location

OptumCare Cancer Care at Charleston

Las Vegas, Nevada, 89102, United States

Location

University Medical Center of Southern Nevada

Las Vegas, Nevada, 89102, United States

Location

Hope Cancer Care of Nevada

Las Vegas, Nevada, 89103, United States

Location

Cancer and Blood Specialists-Shadow

Las Vegas, Nevada, 89106, United States

Location

Radiation Oncology Centers of Nevada Central

Las Vegas, Nevada, 89106, United States

Location

Urology Specialists of Nevada - Central

Las Vegas, Nevada, 89106, United States

Location

HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway

Las Vegas, Nevada, 89109, United States

Location

Sunrise Hospital and Medical Center

Las Vegas, Nevada, 89109, United States

Location

HealthCare Partners Medical Group Oncology/Hematology-San Martin

Las Vegas, Nevada, 89113, United States

Location

Las Vegas Prostate Cancer Center

Las Vegas, Nevada, 89113, United States

Location

Las Vegas Urology - Sunset

Las Vegas, Nevada, 89113, United States

Location

Urology Specialists of Nevada - Southwest

Las Vegas, Nevada, 89113, United States

Location

Radiation Oncology Centers of Nevada Southeast

Las Vegas, Nevada, 89119, United States

Location

Ann M Wierman MD LTD

Las Vegas, Nevada, 89128, United States

Location

Cancer and Blood Specialists-Tenaya

Las Vegas, Nevada, 89128, United States

Location

Comprehensive Cancer Centers of Nevada - Northwest

Las Vegas, Nevada, 89128, United States

Location

HealthCare Partners Medical Group Oncology/Hematology-Tenaya

Las Vegas, Nevada, 89128, United States

Location

Las Vegas Urology - Cathedral Rock

Las Vegas, Nevada, 89128, United States

Location

Las Vegas Urology - Smoke Ranch

Las Vegas, Nevada, 89128, United States

Location

Oncology Las Vegas - Tenaya

Las Vegas, Nevada, 89128, United States

Location

OptumCare Cancer Care at MountainView

Las Vegas, Nevada, 89128, United States

Location

Urology Specialists of Nevada - Northwest

Las Vegas, Nevada, 89128, United States

Location

Alliance for Childhood Diseases/Cure 4 the Kids Foundation

Las Vegas, Nevada, 89135, United States

Location

Comprehensive Cancer Centers of Nevada - Town Center

Las Vegas, Nevada, 89144, United States

Location

Comprehensive Cancer Centers of Nevada-Summerlin

Las Vegas, Nevada, 89144, United States

Location

Summerlin Hospital Medical Center

Las Vegas, Nevada, 89144, United States

Location

Las Vegas Cancer Center-Medical Center

Las Vegas, Nevada, 89148-2405, United States

Location

Comprehensive Cancer Centers of Nevada

Las Vegas, Nevada, 89148, United States

Location

HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills

Las Vegas, Nevada, 89149, United States

Location

Comprehensive Cancer Centers of Nevada - Central Valley

Las Vegas, Nevada, 89169, United States

Location

University Cancer Center

Las Vegas, Nevada, 89169, United States

Location

OptumCare Cancer Care at Fort Apache

Las Vegas, Nevada, 89183, United States

Location

Hope Cancer Care of Nevada-Pahrump

Pahrump, Nevada, 89048, United States

Location

Renown Regional Medical Center

Reno, Nevada, 89502, United States

Location

Saint Mary's Regional Medical Center

Reno, Nevada, 89503, United States

Location

Radiation Oncology Associates

Reno, Nevada, 89509, United States

Location

New Hampshire Oncology Hematology PA-Concord

Concord, New Hampshire, 03301, United States

Location

Elliot Hospital

Manchester, New Hampshire, 03103, United States

Location

Solinsky Center for Cancer Care

Manchester, New Hampshire, 03103, United States

Location

Virtua Samson Cancer Center

Moorestown, New Jersey, 08057, United States

Location

Virtua Memorial

Mount Holly, New Jersey, 08060, United States

Location

Virtua Voorhees

Voorhees Township, New Jersey, 08043, United States

Location

University of New Mexico Cancer Center

Albuquerque, New Mexico, 87106, United States

Location

Glens Falls Hospital

Glens Falls, New York, 12801, United States

Location

Montefiore Medical Center-Einstein Campus

The Bronx, New York, 10461, United States

Location

Montefiore Medical Center-Weiler Hospital

The Bronx, New York, 10461, United States

Location

Montefiore Medical Center - Moses Campus

The Bronx, New York, 10467, United States

Location

ECU Health Oncology Kenansville

Kenansville, North Carolina, 28349, United States

Location

ECU Health Oncology Kinston

Kinston, North Carolina, 28501, United States

Location

FirstHealth of the Carolinas-Moore Regional Hospital

Pinehurst, North Carolina, 28374, United States

Location

ECU Health Oncology Richlands

Richlands, North Carolina, 28574, United States

Location

Marion L Shepard Cancer Center - ECU Health Beaufort Hospital

Washington, North Carolina, 27889, United States

Location

Essentia Health Cancer Center-South University Clinic

Fargo, North Dakota, 58103, United States

Location

Essentia Health - Jamestown Clinic

Jamestown, North Dakota, 58401, United States

Location

Aultman Alliance Community Hospital

Alliance, Ohio, 44601, United States

Location

Indu and Raj Soin Medical Center

Beavercreek, Ohio, 45431, United States

Location

Saint Elizabeth Boardman Hospital

Boardman, Ohio, 44512, United States

Location

Cleveland Clinic Mercy Hospital

Canton, Ohio, 44708, United States

Location

Aultman Health Foundation

Canton, Ohio, 44710, United States

Location

Dayton Physicians LLC-Miami Valley South

Centerville, Ohio, 45459, United States

Location

Miami Valley Hospital South

Centerville, Ohio, 45459, United States

Location

Good Samaritan Hospital - Cincinnati

Cincinnati, Ohio, 45220, United States

Location

Oncology Hematology Care Inc-Kenwood

Cincinnati, Ohio, 45236, United States

Location

Bethesda North Hospital

Cincinnati, Ohio, 45242, United States

Location

TriHealth Cancer Institute-Westside

Cincinnati, Ohio, 45247, United States

Location

TriHealth Cancer Institute-Anderson

Cincinnati, Ohio, 45255, United States

Location

Cleveland Clinic Cancer Center/Fairview Hospital

Cleveland, Ohio, 44111, United States

Location

Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States

Location

Miami Valley Hospital

Dayton, Ohio, 45409, United States

Location

Premier Blood and Cancer Center

Dayton, Ohio, 45409, United States

Location

Dayton Physician LLC - Englewood

Dayton, Ohio, 45415, United States

Location

Miami Valley Hospital North

Dayton, Ohio, 45415, United States

Location

Armes Family Cancer Center

Findlay, Ohio, 45840, United States

Location

Blanchard Valley Hospital

Findlay, Ohio, 45840, United States

Location

Orion Cancer Care

Findlay, Ohio, 45840, United States

Location

Atrium Medical Center-Middletown Regional Hospital

Franklin, Ohio, 45005-1066, United States

Location

Dayton Physicians LLC-Atrium

Franklin, Ohio, 45005, United States

Location

Dayton Physicians LLC-Wayne

Greenville, Ohio, 45331, United States

Location

Miami Valley Cancer Care and Infusion

Greenville, Ohio, 45331, United States

Location

Wayne Hospital

Greenville, Ohio, 45331, United States

Location

Greater Dayton Cancer Center

Kettering, Ohio, 45409, United States

Location

First Dayton Cancer Care

Kettering, Ohio, 45420, United States

Location

Kettering Medical Center

Kettering, Ohio, 45429, United States

Location

Cleveland Clinic Cancer Center Mansfield

Mansfield, Ohio, 44906, United States

Location

Toledo Clinic Cancer Centers-Maumee

Maumee, Ohio, 43537, United States

Location

Hillcrest Hospital Cancer Center

Mayfield Heights, Ohio, 44124, United States

Location

Mercy Health - Perrysburg Hospital

Perrysburg, Ohio, 43551, United States

Location

North Coast Cancer Care

Sandusky, Ohio, 44870, United States

Location

Springfield Regional Cancer Center

Springfield, Ohio, 45504, United States

Location

Springfield Regional Medical Center

Springfield, Ohio, 45504, United States

Location

Cleveland Clinic Cancer Center Strongsville

Strongsville, Ohio, 44136, United States

Location

Mercy Health - Saint Anne Hospital

Toledo, Ohio, 43623, United States

Location

Toledo Clinic Cancer Centers-Toledo

Toledo, Ohio, 43623, United States

Location

Dayton Physicians LLC - Troy

Troy, Ohio, 45373, United States

Location

Upper Valley Medical Center

Troy, Ohio, 45373, United States

Location

Saint Joseph Warren Hospital

Warren, Ohio, 44484, United States

Location

South Pointe Hospital

Warrensville Heights, Ohio, 44122, United States

Location

Cleveland Clinic Wooster Family Health and Surgery Center

Wooster, Ohio, 44691, United States

Location

Wright-Patterson Medical Center

Wright-Patterson Air Force Base, Ohio, 45433, United States

Location

Saint Elizabeth Youngstown Hospital

Youngstown, Ohio, 44501, United States

Location

Mercy Hospital Oklahoma City

Oklahoma City, Oklahoma, 73120, United States

Location

Saint Alphonsus Cancer Care Center-Baker City

Baker City, Oregon, 97814, United States

Location

Saint Charles Health System

Bend, Oregon, 97701, United States

Location

Clackamas Radiation Oncology Center

Clackamas, Oregon, 97015, United States

Location

Providence Cancer Institute Clackamas Clinic

Clackamas, Oregon, 97015, United States

Location

Bay Area Hospital

Coos Bay, Oregon, 97420, United States

Location

Providence Newberg Medical Center

Newberg, Oregon, 97132, United States

Location

Saint Alphonsus Cancer Care Center-Ontario

Ontario, Oregon, 97914, United States

Location

Providence Willamette Falls Medical Center

Oregon City, Oregon, 97045, United States

Location

Providence Portland Medical Center

Portland, Oregon, 97213, United States

Location

Providence Saint Vincent Medical Center

Portland, Oregon, 97225, United States

Location

Oregon Health and Science University

Portland, Oregon, 97239, United States

Location

Saint Charles Health System-Redmond

Redmond, Oregon, 97756, United States

Location

Lehigh Valley Hospital-Cedar Crest

Allentown, Pennsylvania, 18103, United States

Location

Saint Luke's Cancer Center - Allentown

Allentown, Pennsylvania, 18104, United States

Location

Saint Luke's University Hospital-Bethlehem Campus

Bethlehem, Pennsylvania, 18015, United States

Location

Lehigh Valley Hospital - Muhlenberg

Bethlehem, Pennsylvania, 18017, United States

Location

Bryn Mawr Hospital

Bryn Mawr, Pennsylvania, 19010, United States

Location

Chambersburg Hospital

Chambersburg, Pennsylvania, 17201, United States

Location

WellSpan Medical Oncology and Hematology

Chambersburg, Pennsylvania, 17201, United States

Location

Main Line Health Center-Collegeville

Collegeville, Pennsylvania, 19426, United States

Location

Pocono Medical Center

East Stroudsburg, Pennsylvania, 18301, United States

Location

Saint Luke's Hospital-Anderson Campus

Easton, Pennsylvania, 18045, United States

Location

Ephrata Cancer Center

Ephrata, Pennsylvania, 17522, United States

Location

Main Line Health Center-Exton

Exton, Pennsylvania, 19341, United States

Location

Adams Cancer Center

Gettysburg, Pennsylvania, 17325, United States

Location

WellSpan Medical Oncology and Hematology

Hanover, Pennsylvania, 17331, United States

Location

Lehigh Valley Hospital-Hazleton

Hazleton, Pennsylvania, 18201, United States

Location

Sechler Family Cancer Center

Lebanon, Pennsylvania, 17042, United States

Location

Riddle Memorial Hospital

Media, Pennsylvania, 19063, United States

Location

Bryn Mawr Health Center

Newtown Square, Pennsylvania, 19073, United States

Location

Paoli Memorial Hospital

Paoli, Pennsylvania, 19301, United States

Location

Penn Presbyterian Medical Center

Philadelphia, Pennsylvania, 19104, United States

Location

University of Pennsylvania/Abramson Cancer Center

Philadelphia, Pennsylvania, 19104, United States

Location

Pottstown Hospital

Pottstown, Pennsylvania, 19464, United States

Location

Saint Luke's Hospital - Upper Bucks Campus

Quakertown, Pennsylvania, 18951, United States

Location

Saint Luke's Hospital-Quakertown Campus

Quakertown, Pennsylvania, 18951, United States

Location

Guthrie Medical Group PC-Robert Packer Hospital

Sayre, Pennsylvania, 18840, United States

Location

Lankenau Medical Center

Wynnewood, Pennsylvania, 19096, United States

Location

Cancer Care Associates of York

York, Pennsylvania, 17403, United States

Location

WellSpan Health-York Cancer Center

York, Pennsylvania, 17403, United States

Location

WellSpan Health-York Hospital

York, Pennsylvania, 17403, United States

Location

Self Regional Healthcare

Greenwood, South Carolina, 29646, United States

Location

Saint Joseph Regional Cancer Center

Bryan, Texas, 77802, United States

Location

Bon Secours Memorial Regional Medical Center

Mechanicsville, Virginia, 23116, United States

Location

Bon Secours Westchester Emergency Center

Midlothian, Virginia, 23113, United States

Location

Bon Secours Saint Francis Medical Center

Midlothian, Virginia, 23114, United States

Location

Bon Secours DePaul Medical Center

Norfolk, Virginia, 23505, United States

Location

Bon Secours Maryview Medical Center

Portsmouth, Virginia, 23707, United States

Location

Bon Secours Richmond Community Hospital

Richmond, Virginia, 23223, United States

Location

Bon Secours Saint Mary's Hospital

Richmond, Virginia, 23226, United States

Location

Bon Secours Cancer Institute at Reynolds Crossing

Richmond, Virginia, 23230, United States

Location

VCU Massey Cancer Center at Stony Point

Richmond, Virginia, 23235, United States

Location

VCU Massey Comprehensive Cancer Center

Richmond, Virginia, 23298, United States

Location

Bon Secours Health Center at Harbour View

Suffolk, Virginia, 23435, United States

Location

Providence Regional Cancer System-Aberdeen

Aberdeen, Washington, 98520, United States

Location

Overlake Medical Center

Bellevue, Washington, 98004, United States

Location

PeaceHealth Saint Joseph Medical Center

Bellingham, Washington, 98225, United States

Location

Highline Medical Center-Main Campus

Burien, Washington, 98166, United States

Location

Providence Regional Cancer System-Centralia

Centralia, Washington, 98531, United States

Location

Swedish Cancer Institute-Edmonds

Edmonds, Washington, 98026, United States

Location

Saint Elizabeth Hospital

Enumclaw, Washington, 98022, United States

Location

Providence Regional Cancer Partnership

Everett, Washington, 98201, United States

Location

Saint Francis Hospital

Federal Way, Washington, 98003, United States

Location

Swedish Cancer Institute-Issaquah

Issaquah, Washington, 98029, United States

Location

Kadlec Clinic Hematology and Oncology

Kennewick, Washington, 99336, United States

Location

Providence Regional Cancer System-Lacey

Lacey, Washington, 98503, United States

Location

Saint Clare Hospital

Lakewood, Washington, 98499, United States

Location

PeaceHealth Saint John Medical Center

Longview, Washington, 98632, United States

Location

Jefferson Healthcare

Port Townsend, Washington, 98368, United States

Location

Harrison HealthPartners Hematology and Oncology-Poulsbo

Poulsbo, Washington, 98370, United States

Location

Valley Medical Center

Renton, Washington, 98055, United States

Location

Pacific Gynecology Specialists

Seattle, Washington, 98104, United States

Location

Swedish Medical Center-Ballard Campus

Seattle, Washington, 98107, United States

Location

Swedish Medical Center-Cherry Hill

Seattle, Washington, 98122-5711, United States

Location

Swedish Medical Center-First Hill

Seattle, Washington, 98122, United States

Location

PeaceHealth United General Medical Center

Sedro-Woolley, Washington, 98284, United States

Location

Providence Regional Cancer System-Shelton

Shelton, Washington, 98584, United States

Location

Saint Joseph Medical Center Hematology and Oncology - Silverdale

Silverdale, Washington, 98383, United States

Location

Franciscan Research Center-Northwest Medical Plaza

Tacoma, Washington, 98405, United States

Location

Northwest Medical Specialties PLLC

Tacoma, Washington, 98405, United States

Location

PeaceHealth Southwest Medical Center

Vancouver, Washington, 98664, United States

Location

Providence Saint Mary Regional Cancer Center

Walla Walla, Washington, 99362, United States

Location

North Star Lodge Cancer Center at Yakima Valley Memorial Hospital

Yakima, Washington, 98902, United States

Location

Providence Regional Cancer System-Yelm

Yelm, Washington, 98597, United States

Location

Edwards Comprehensive Cancer Center

Huntington, West Virginia, 25701, United States

Location

ThedaCare Regional Cancer Center

Appleton, Wisconsin, 54911, United States

Location

Duluth Clinic Ashland

Ashland, Wisconsin, 54806, United States

Location

Northwest Wisconsin Cancer Center

Ashland, Wisconsin, 54806, United States

Location

ThedaCare Cancer Care - Berlin

Berlin, Wisconsin, 54923, United States

Location

Aurora Cancer Care-Southern Lakes VLCC

Burlington, Wisconsin, 53105, United States

Location

Marshfield Clinic-Chippewa Center

Chippewa Falls, Wisconsin, 54729, United States

Location

Aurora Saint Luke's South Shore

Cudahy, Wisconsin, 53110, United States

Location

Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, 54701, United States

Location

Aurora Health Care Germantown Health Center

Germantown, Wisconsin, 53022, United States

Location

Aurora Cancer Care-Grafton

Grafton, Wisconsin, 53024, United States

Location

Aurora BayCare Medical Center

Green Bay, Wisconsin, 54311, United States

Location

Essentia Health-Hayward Clinic

Hayward, Wisconsin, 54843, United States

Location

Aurora Cancer Care-Kenosha South

Kenosha, Wisconsin, 53142, United States

Location

Gundersen Lutheran Medical Center

La Crosse, Wisconsin, 54601, United States

Location

Marshfield Medical Center - Ladysmith

Ladysmith, Wisconsin, 54848, United States

Location

Aurora Bay Area Medical Group-Marinette

Marinette, Wisconsin, 54143, United States

Location

Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449, United States

Location

Aurora Cancer Care-Milwaukee

Milwaukee, Wisconsin, 53209, United States

Location

Aurora Saint Luke's Medical Center

Milwaukee, Wisconsin, 53215, United States

Location

Aurora Sinai Medical Center

Milwaukee, Wisconsin, 53233, United States

Location

Marshfield Medical Center - Minocqua

Minocqua, Wisconsin, 54548, United States

Location

ProHealth D N Greenwald Center

Mukwonago, Wisconsin, 53149, United States

Location

Cancer Center of Western Wisconsin

New Richmond, Wisconsin, 54017, United States

Location

ProHealth Oconomowoc Memorial Hospital

Oconomowoc, Wisconsin, 53066, United States

Location

Vince Lombardi Cancer Clinic - Oshkosh

Oshkosh, Wisconsin, 54904, United States

Location

Aurora Cancer Care-Racine

Racine, Wisconsin, 53406, United States

Location

Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, 54868, United States

Location

Vince Lombardi Cancer Clinic-Sheboygan

Sheboygan, Wisconsin, 53081, United States

Location

Essentia Health-Spooner Clinic

Spooner, Wisconsin, 54801, United States

Location

Marshfield Medical Center-River Region at Stevens Point

Stevens Point, Wisconsin, 54482, United States

Location

Aurora Medical Center in Summit

Summit, Wisconsin, 53066, United States

Location

Essentia Health Saint Mary's Hospital - Superior

Superior, Wisconsin, 54880, United States

Location

Vince Lombardi Cancer Clinic-Two Rivers

Two Rivers, Wisconsin, 54241, United States

Location

ProHealth Waukesha Memorial Hospital

Waukesha, Wisconsin, 53188, United States

Location

UW Cancer Center at ProHealth Care

Waukesha, Wisconsin, 53188, United States

Location

Marshfield Clinic-Wausau Center

Wausau, Wisconsin, 54401, United States

Location

Aurora Cancer Care-Milwaukee West

Wauwatosa, Wisconsin, 53226, United States

Location

Marshfield Medical Center - Weston

Weston, Wisconsin, 54476, United States

Location

Marshfield Clinic - Wisconsin Rapids Center

Wisconsin Rapids, Wisconsin, 54494, United States

Location

Cheyenne Regional Medical Center-West

Cheyenne, Wyoming, 82001, United States

Location

Billings Clinic-Cody

Cody, Wyoming, 82414, United States

Location

Welch Cancer Center

Sheridan, Wyoming, 82801, United States

Location

MeSH Terms

Conditions

Lung Neoplasms

Interventions

Specimen Handling; cabozantinib; Docetaxel; Gemcitabine; 130-nm albumin-bound paclitaxel; Albumin-Bound Paclitaxel; Taxes; Nivolumab; Paclitaxel; Ramucirumab

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Investigative Techniques; Taxoids; Cyclodecanes; Cycloparaffins; Hydrocarbons, Alicyclic; Hydrocarbons, Cyclic; Hydrocarbons; Organic Chemicals; Diterpenes; Terpenes; Heterocyclic Compounds; Deoxycytidine; Cytidine; Pyrimidine Nucleosides; Pyrimidines; Heterocyclic Compounds, 1-Ring; Albumins; Proteins; Amino Acids, Peptides, and Proteins; Economics; Health Care Economics and Organizations; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal; Antibodies; Immunoglobulins; Immunoproteins; Blood Proteins; Serum Globulins; Globulins

Study Officials

• Joel W Neal

  ECOG-ACRIN Cancer Research Group

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 16, 2020
• First Posted: March 17, 2020
• Study Start: July 13, 2020
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: May 29, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will share

Locations

US (613)