Success Metrics

Clinical Success Rate
71.8%

Based on 510 completed trials

Completion Rate
72%(510/710)
Active Trials
451(34%)
Results Posted
92%(467 trials)
Terminated
200(15%)

Phase Distribution

Ph early_phase_1
26
2%
Ph phase_2
621
46%
Ph phase_4
10
1%
Ph phase_1
516
39%
Ph phase_3
117
9%
Ph not_applicable
12
1%

Phase Distribution

542

Early Stage

621

Mid Stage

127

Late Stage

Phase Distribution1302 total trials
Early Phase 1First-in-human
26(2.0%)
Phase 1Safety & dosage
516(39.6%)
Phase 2Efficacy & side effects
621(47.7%)
Phase 3Large-scale testing
117(9.0%)
Phase 4Post-market surveillance
10(0.8%)
N/ANon-phased studies
12(0.9%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

65.0%

510 of 785 finished

Non-Completion Rate

35.0%

275 ended early

Currently Active

451

trials recruiting

Total Trials

1,337

all time

Status Distribution
Active(473)
Completed(510)
Terminated(275)
Other(79)

Detailed Status

Completed510
Active, not recruiting266
Terminated200
Recruiting185
Withdrawn75
unknown66

Development Timeline

Analytics

Development Status

Total Trials
1337
Active
451
Success Rate
71.8%
Most Advanced
Phase 4

Trials by Phase

Early Phase 126 (2.0%)
Phase 1516 (39.6%)
Phase 2621 (47.7%)
Phase 3117 (9.0%)
Phase 410 (0.8%)
N/A12 (0.9%)

Trials by Status

withdrawn756%
recruiting18514%
active_not_recruiting26620%
enrolling_by_invitation50%
not_yet_recruiting171%
suspended131%
completed51038%
terminated20015%
unknown665%

Recent Activity

Clinical Trials (1,337)

Showing 20 of 1,337 trialsScroll for more
NCT03258567Phase 2

Nivolumab in Epstein-Barr Virus (EBV)-Positive Lymphoproliferative Disorders and EBV-Positive Non-HodgkinLymphomas

Recruiting
NCT02978625Phase 2

Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers

Active Not Recruiting
NCT05407675Phase 1

A Study to Evaluate the Safety and Tolerability of BMS-986408 Alone and in Combination With Nivolumab or Nivolumab and Ipilimumab in Participants With Advanced Solid Tumors

Completed
NCT06203600Phase 2

Adding Nivolumab to Usual Treatment for People With Advanced Stomach or Esophageal Cancer, PARAMUNE Trial

Recruiting
NCT05136196Phase 2

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

Recruiting
NCT07195695Phase 3

Beamion LUNG-3: Adjuvant Zongertinib vs Standard Treatment in People With Completely Resected Stage II-IIIB NSCLC Harboring Activating HER2 TKD Mutations

Recruiting
NCT03604991Phase 2

Nivolumab and Ipilimumab in Treating Patients With Esophageal and Gastroesophageal Junction Adenocarcinoma Undergoing Surgery

Suspended
NCT05675410Phase 3

A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab

Recruiting
NCT04126070Phase 2

Nivolumab + Docetaxel + ADT in mHSPC Patients With DDRD or Inflamed Tumors

Active Not Recruiting
NCT03203473Phase 2

Study of Optimized Management of Nivolumab Based on Response in Patients With Advanced RCC (OMNIVORE Study)

Active Not Recruiting
NCT07221149Phase 2

A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204)

Recruiting
NCT06561087Phase 2

Phase II Randomized, Placebo- Controlled Study of Intralesional Nivolumab for High-risk Oral Premalignant Lesions

Recruiting
NCT07187869Phase 1

Modulation of the Bone Immune Microenvironment Following Cabozantinib Treatment of Bone Metastatic Clear Cell Renal Cell Carcinoma: Proof of Concept Study

Recruiting
NCT03866382Phase 2

Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

Recruiting
NCT06250335Phase 2

Impact of a Prebiotic Food-enriched Diet (PreFED) in Combination With Ipilimumab/Nivolumab Combination Immune Checkpoint Blockade (ICB) in ICB-refractory Melanoma Patients

Active Not Recruiting
NCT07420439Phase 2

Treatment in Patients With Advanced Non-Small Cell Lung Carcinoma and Interstitial Lung Disease

Not Yet Recruiting
NCT01896999Phase 1

Brentuximab Vedotin and Nivolumab With or Without Ipilimumab in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma

Active Not Recruiting
NCT05987241Phase 2

Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Study

Recruiting
NCT07541170Phase 3

A Study to Evaluate the Efficacy and Safety of Divarasib Compared With Investigator's Choice of Immunotherapy or Observation in Participants With Resected Stage II-III KRAS G12C-Positive Non-Small Cell Lung Cancer (NSCLC)

Recruiting
NCT02955290Phase 1

CIMAvax Vaccine, Nivolumab, and Pembrolizumab in Treating Patients With Advanced Non-small Cell Lung Cancer or Squamous Head and Neck Cancer

Active Not Recruiting

Drug Details

Intervention Type
BIOLOGICAL
Total Trials
1,337