Success Metrics

Clinical Success Rate
82.9%

Based on 1,128 completed trials

Completion Rate
83%(1128/1361)
Active Trials
438(20%)
Results Posted
59%(660 trials)
Terminated
233(11%)

Phase Distribution

Ph phase_3
473
22%
Ph early_phase_1
11
1%
Ph not_applicable
34
2%
Ph phase_1
584
27%
Ph phase_2
1,004
47%
Ph phase_4
14
1%

Phase Distribution

595

Early Stage

1004

Mid Stage

487

Late Stage

Phase Distribution2120 total trials
Early Phase 1First-in-human
11(0.5%)
Phase 1Safety & dosage
584(27.5%)
Phase 2Efficacy & side effects
1,004(47.4%)
Phase 3Large-scale testing
473(22.3%)
Phase 4Post-market surveillance
14(0.7%)
N/ANon-phased studies
34(1.6%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

78.6%

1128 of 1436 finished

Non-Completion Rate

21.4%

308 ended early

Currently Active

438

trials recruiting

Total Trials

2,151

all time

Status Distribution
Active(490)
Completed(1128)
Terminated(308)
Other(225)

Detailed Status

Completed1128
Terminated233
Recruiting224
unknown218
Active, not recruiting214
Withdrawn75

Development Timeline

Analytics

Development Status

Total Trials
2151
Active
438
Success Rate
82.9%
Most Advanced
Phase 4

Trials by Phase

Early Phase 111 (0.5%)
Phase 1584 (27.5%)
Phase 21004 (47.4%)
Phase 3473 (22.3%)
Phase 414 (0.7%)
N/A34 (1.6%)

Trials by Status

withdrawn753%
recruiting22410%
completed112852%
unknown21810%
suspended70%
not_yet_recruiting492%
active_not_recruiting21410%
terminated23311%
enrolling_by_invitation30%

Recent Activity

Clinical Trials (2,151)

Showing 20 of 2,151 trialsScroll for more
NCT06841354Phase 3

A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)

Recruiting
NCT06966700Phase 3

A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)

Recruiting
NCT06843447Phase 1

A Clinical Study of Raludotatug Deruxtecan in People With Ovarian Cancer (MK-5909-003)

Recruiting
NCT07646301Phase 2

Iparomlimab and Tuvonralimab Plus Paclitaxel and Platinum as Neoadjuvant Therapy for Locally Advanced Cervical Cancer

Recruiting
NCT06422143Phase 3

Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]

Recruiting
NCT06694454Phase 1

Neoadjuvant Inhaled Azacytidine With Platinum-Based Chemotherapy and Durvalumab (MEDI4736) - a Combined Epigenetic-Immunotherapy (AZA-AEGEAN) Regimen for Operable Early-Stage Non-Small Cell Lung Cancer (NSCLC)

Recruiting
NCT01154920Phase 2

Paclitaxel, Carboplatin and Cetuximab (PCC) With Cetuximab, Docetaxel, Cisplatin and Fluorouracil (C-TPF) in Previously Untreated Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma

Active Not Recruiting
NCT06058377Phase 3

Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer

Recruiting
NCT07198074Phase 3

Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer

Recruiting
NCT07281417Phase 2

Testing the Addition of Cemiplimab (REGN2810) to Chemotherapy Treatment Given Prior to Surgery in Patients With Sinonasal Squamous Cell Carcinoma

Recruiting
NCT05319730Phase 1

A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B)

Recruiting
NCT00494182Phase 2

Sorafenib in Combination With Carboplatin and Paclitaxel in Treating Participants With Metastatic or Recurrent Head and Neck Squamous Cell Cancer

Active Not Recruiting
NCT07216703Phase 3

A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)

Recruiting
NCT04267848Phase 3

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

Recruiting
NCT05564377Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

Recruiting
NCT06524544Phase 3

A Study Comparing the Combination of Pembrolizumab and Sacituzumab Govitean-hziy Versus Standard of Care in the Treatment of Advanced Urothelial Cancer

Recruiting
NCT02726997Phase 1

Matched Paired Pharmacodynamics and Feasibility Study of Durvalumab in Combination With Chemotherapy in Frontline Ovarian Cancer (N-Dur)

Active Not Recruiting
NCT07640932Phase 2

Lurbinectedin Plus Paclitaxel Versus Paclitaxel in Patients With Previously Treated Small Cell Lung Cancer

Not Yet Recruiting
NCT06448754Phase 2

Volrustomig Priming Regimens Exploratory Phase II Platform Study

Recruiting
NCT04090398Phase 2

Testing the Addition of Radium Therapy (Radium-223 Dichloride) to the Usual Chemotherapy Treatment (Paclitaxel) for Advanced Breast Cancer That Has Spread to the Bones

Active Not Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
2,151