EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Preserved Ejection Fraction (EMPEROR-Preserved)
A Phase III Randomised, Double-blind Trial to Evaluate Efficacy and Safety of Once Daily Empagliflozin 10 mg Compared to Placebo, in Patients With Chronic Heart Failure With Preserved Ejection Fraction (HFpEF)
2 other identifiers
interventional
5,988
23 countries
619
Brief Summary
This is a study in adults with chronic heart failure. People with chronic heart failure may need to be hospitalised for their condition. Some people with chronic heart failure may eventually die from their condition. The purpose of the study is to find out whether a medicine called empagliflozin lowers the chances of patients having to go to hospital for heart failure and whether it improves their survival. The study is open to patients with a type of chronic heart failure called chronic heart failure with preserved ejection fraction. Participants stay in the study until researchers have enough information about how effective empagliflozin is. It is expected that participants who enter at the very beginning of the enrolment period may be in the study for over 3 years, while participants who enter near the end of the enrolment period may be in the study for less than 2 years. The participants are put into 2 groups. It is decided by chance who gets into which group. One group gets empagliflozin tablets every day and the other group gets placebo tablets every day. Placebo tablets look like empagliflozin tablets but contain no medicine. Participants visit the doctors regularly. During these visits, the doctors collect information about the participant's health. The doctors want to know how many patients had to go to hospital because of heart failure or who died from cardiovascular disease.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3 heart-failure
Started Mar 2017
Typical duration for phase_3 heart-failure
619 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 16, 2017
CompletedFirst Posted
Study publicly available on registry
February 20, 2017
CompletedStudy Start
First participant enrolled
March 2, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 26, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
April 26, 2021
CompletedResults Posted
Study results publicly available
June 6, 2022
CompletedJune 6, 2022
June 1, 2022
4.2 years
February 16, 2017
April 20, 2022
June 3, 2022
Conditions
Outcome Measures
Primary Outcomes (1)
Time to First Event of Adjudicated Cardiovascular (CV) Death or Adjudicated Hospitalisation for Heart Failure (HHF)
Failure with preserved Ejection Fraction (HFpEF). The incidence rate per 100 patient years (pt-yrs) is presented and calculated as followed: Incidence rate per 100 pt-yrs = 100 \* number of patients with event / time at risk \[years\]. Time at risk \[years\] = Sum of time at risk \[days\] over all patients in a treatment group / 365.25. Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.
From randomization until completion of the planned treatment phase, up to 1403 days.
Secondary Outcomes (9)
Occurrence of Adjudicated Hospitalisation for Heart Failure (HHF) (First and Recurrent)
From randomization until completion of the planned treatment phase, up to 1403 days.
eGFR (CKD-EPI) cr Slope of Change From Baseline
At baseline, week 4, 12, 32, 52, 76, 100, 124, 148, 172 and week 196, up to 1043 days.
Time to the First Event in the Composite Renal Endpoint: Chronic Dialysis, Renal Transplant, or Sustained Reduction in eGFR (CKD-EPI)cr
From randomization until completion of the planned treatment phase, up to 1403 days.
Time to First Adjudicated Hospitalisation for Heart Failure (HHF)
From randomization until completion of the planned treatment phase, up to 1403 days.
Time to Adjudicated Cardiovascular (CV) Death
From randomization until completion of the planned treatment phase, up to 1403 days.
- +4 more secondary outcomes
Study Arms (2)
10 mg Empagliflozin
EXPERIMENTALPlacebo
PLACEBO COMPARATORInterventions
Eligibility Criteria
You may qualify if:
- Male or female patient, age \>= 18 years at screening. For Japan only: Age \>=20 years at screening
- Patients with chronic HF (Chronic Heart Failure) NYHA (New York Heart Association classification) class II-IV and preserved EF (Ejection Fraction)(LVEF (Left Ventricular Ejection Fraction) \> 40 %) and elevated NT-proBNP (N-terminal of the prohormone brain natriuretic peptide) \> 300 pg/ml for patients without AF, OR \> 900 pg/ml for patients with AF, analysed at the Central laboratory at Visit 1
- Structural heart disease within 6 months prior to Visit 1, OR documented HHF (Hospitalisation for Heart Failure) within 12 months prior to Visit 1
- Stable dose of oral diuretics, if prescribed
- Signed and dated written ICF (informed consent form)
You may not qualify if:
- Myocardial infarction, coronary artery bypass graft surgery or other major cardiovascular surgery, stroke or TIA (Transient Ischaemic Attack) in past 90 days prior to Visit 1
- Heart transplant recipient or listed for heart transplant
- Acute decompensated HF (Heart Failure)
- Systolic blood pressure (SBP) \>= 180 mmHg at Visit 2.
- Symptomatic hypotension and/or a SBP \< 100 mmHg
- Indication of liver disease,
- Impaired renal function, defined as eGFR (Estimated Glomerular Filtration Rate) \< 20 mL/min/1.73 m2 (CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration Equation))cr or requiring dialysis
- History of ketoacidosis
- Current use or prior use of a SGLT (Sodium-glucose co-transporter) -2 inhibitor or combined SGLT-1 and 2 inhibitor
- Currently enrolled in another investigational device or drug trial
- Known allergy or hypersensitivity to empagliflozin or other SGLT-2 inhibitors
- Women who are pregnant, nursing, or who plan to become pregnant while in the trial
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Boehringer Ingelheimlead
- Eli Lilly and Companycollaborator
Study Sites (619)
Pinnacle Research Group, LLC
Anniston, Alabama, 36207, United States
University of Alabama at Birmingham
Birmingham, Alabama, 35249, United States
Heart Center Research, LLC
Huntsville, Alabama, 35801, United States
University of California San Francisco
Fresno, California, 93701, United States
La Mesa Cardiac Center
La Mesa, California, 91942, United States
Purushotham, Akther & Roshan Kotha, MD Inc.
La Mesa, California, 91942, United States
Long Beach Center for Clinical Research
Long Beach, California, 90807, United States
VA Greater Los Angeles Healthcare System
Los Angeles, California, 90073, United States
Merced Vein and Vascular Center
Merced, California, 95340, United States
Valley Clinical Trials, Inc.
Northridge, California, 91325, United States
University of California Irvine
Orange, California, 92865, United States
Covigilant Research, LLC
Riverside, California, 92506, United States
University of California San Francisco
San Francisco, California, 94143, United States
University of California
Torrance, California, 90502, United States
Orange County Research Center
Tustin, California, 92780, United States
Blue Coast Cardiology
Vista, California, 92083, United States
South Denver Cardiology Associates, PC
Littleton, Colorado, 80120, United States
Integrated Heart Care
Boca Raton, Florida, 33434, United States
Southeast Clinical Research, LLC
Chiefland, Florida, 32626, United States
Morton Plant Mease Health Care
Clearwater, Florida, 33756, United States
Accel Research Sites
DeLand, Florida, 32720, United States
Integrative Research Associates
Fort Lauderdale, Florida, 33312, United States
Nature Coast Clinical Research
Inverness, Florida, 34452, United States
East Coast Institute for Research, LLC
Jacksonville, Florida, 32216, United States
Jacksonville Center for Clinical Research
Jacksonville, Florida, 32216, United States
Elite Clinical Research
Miami, Florida, 33144, United States
Cardiovascular Research Center of South Florida
Miami, Florida, 33173, United States
Orlando Health Inc.
Orlando, Florida, 32806, United States
Peninsula Research, Inc.
Ormond Beach, Florida, 32174, United States
Clearwater Cardiovascular Consultants
Safety Harbor, Florida, 34695, United States
Sarasota Memorial Hospital
Sarasota, Florida, 34239, United States
University of South Florida
Tampa, Florida, 33606, United States
Advent Health Medical Group
Tampa, Florida, 33613, United States
Grady Clinical Research Center
Atlanta, Georgia, 30303, United States
Columbus Regional Research Institute
Columbus, Georgia, 31904, United States
Cardiovascular Group PC
Lawrenceville, Georgia, 30046, United States
Meridian Clinical Research, LLC
Savannah, Georgia, 31406, United States
Atlanta Heart Specialists, LLC
Tucker, Georgia, 30084, United States
Northwest Heart Clinical Research, LLC
Arlington Heights, Illinois, 60005, United States
Mount Sinai Hospital
Chicago, Illinois, 60608, United States
Advocate Health and Hospitals Corporation
Naperville, Illinois, 60540, United States
Captain James A. Lovell Federal Health Care Center
North Chicago, Illinois, 60064, United States
Rockford Cardiovascular Associates
Rockford, Illinois, 61107, United States
Midwest Cardiovascular Research and Education Foundation
Elkhart, Indiana, 46514, United States
St. Francis Medical Group-Indiana Heart Physicians, Inc
Indianapolis, Indiana, 46237, United States
Reid Hospital
Richmond, Indiana, 47374, United States
Beacon Medical Group Clinical Research
South Bend, Indiana, 46601, United States
Iowa Heart Center
Des Moines, Iowa, 50314, United States
Norton Heart Specialists
Louisville, Kentucky, 40202, United States
Research Integrity, LLC
Owensboro, Kentucky, 42303, United States
Grace Research, LLC
Bossier City, Louisiana, 71111, United States
Clinical Trials of America, LLC
Monroe, Louisiana, 71201, United States
LSU Health Sciences Center
New Orleans, Louisiana, 70112, United States
Maine Research Associates
Lewiston, Maine, 04240, United States
Anne Arundel Medical Center
Annapolis, Maryland, 21401, United States
Maryland Cardiovascular Specialists
Baltimore, Maryland, 21229, United States
MedStar Health Research Institute
Baltimore, Maryland, 21237, United States
Metropolitan Cardiovascular Consultants
Beltsville, Maryland, 20705, United States
MD Medical Research
Oxon Hill, Maryland, 20745, United States
Tufts Medical Center
Boston, Massachusetts, 02111, United States
Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
East Mountain Medical Associates, PC
Great Barrington, Massachusetts, 01230, United States
Alpena General Hospital
Alpena, Michigan, 49707, United States
McLaren Northern Michigan Hospital
Petoskey, Michigan, 49770, United States
Regions Hospital
Saint Paul, Minnesota, 55101, United States
Jackson Heart Clinic, P.A.
Jackson, Mississippi, 39216, United States
Saint Luke's Hospital of Kansas City
Kansas City, Missouri, 64111, United States
Saint Louis University
St Louis, Missouri, 63110, United States
St. Louis Center for Clinical Research
St Louis, Missouri, 63128, United States
St. Louis Heart and Vascular, P.C.
St Louis, Missouri, 63136, United States
Deaconess Billings Clinic Research Center
Billings, Montana, 59101, United States
Bozeman Health Clinical Research
Bozeman, Montana, 59718, United States
Nebraska Heart Institute
Grand Island, Nebraska, 68803, United States
CHI Health Midlands
Papillion, Nebraska, 68046, United States
Healthcare Partners LLC
Las Vegas, Nevada, 89109, United States
Palm Research Center
Las Vegas, Nevada, 89128, United States
Advanced Heart Care, LLC
Bridgewater, New Jersey, 08807, United States
Garden State Heart Care, PC
Manalapan, New Jersey, 07726, United States
Capital Cardiology Associates, PC
Albany, New York, 12211, United States
Trinity Medical WNY, PC
Cheektowaga, New York, 14227, United States
North Shore University Hospital
Manhasset, New York, 11030, United States
Long Island Cardiovascular Consultants
New Hyde Park, New York, 11042, United States
Mount Sinai - PRIME
New York, New York, 10025, United States
Harlem Cardiology
New York, New York, 10035, United States
Laurelton Heart Specialist, PC
Rosedale, New York, 11422, United States
Saratoga Clinical Research, LLC
Saratoga Springs, New York, 12866, United States
Northwell Health
Southampton, New York, 11968, United States
Stony Brook University Medical Center
Stony Brook, New York, 11794, United States
CHEAR Center LLC
The Bronx, New York, 10455, United States
Cardiac Care and Vascular Medicine, PLLC
The Bronx, New York, 10469, United States
Asheville Cardiology Associates
Asheville, North Carolina, 28803, United States
Kernodle Clinic West
Burlington, North Carolina, 27215, United States
The University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, 27599-5021, United States
Novant Health Heart and Vascular Institute
Charlotte, North Carolina, 28204, United States
Clinical Research of Gastonia
Gastonia, North Carolina, 28054, United States
Clinical Trials of America, Inc
Lenoir, North Carolina, 28645, United States
VA Northeast Ohio Healthcare System
Cleveland, Ohio, 44104-1702, United States
Rama Research LLC
Marion, Ohio, 43302, United States
South Oklahoma Heart Research Group
Oklahoma City, Oklahoma, 73135, United States
Doylestown Health Cardiology
Doylestown, Pennsylvania, 18901, United States
Lycoming Internal Medicine, Inc
Jersey Shore, Pennsylvania, 17740, United States
Richard M Kastelic and Associates
Johnstown, Pennsylvania, 15905, United States
York Hospital, WellSpan Health
York, Pennsylvania, 17403, United States
Lowcountry Center for Veterans Research
Charleston, South Carolina, 29401, United States
Palmetto Health
Columbia, South Carolina, 29203, United States
Clinical Research of Rock Hill
Rock Hill, South Carolina, 29732, United States
Palmetto Research Center, LLC
Spartanburg, South Carolina, 29302, United States
Sanford Research
Sioux Falls, South Dakota, 57104, United States
The Stern Cardiovascular Center
Germantown, Tennessee, 38138, United States
Apex Cardiology/ Research Associates of Jackson
Jackson, Tennessee, 38301, United States
Methodist University Hospital
Memphis, Tennessee, 38104, United States
Seton Heart Institute
Austin, Texas, 78705, United States
Baylor Heart and Vascular Hospital
Dallas, Texas, 75226, United States
Soltero Cardiovascular Research Center
Dallas, Texas, 75226, United States
University of Texas Southwestern Medical Center
Dallas, Texas, 75390-8837, United States
University of North Texas Health Science Center
Fort Worth, Texas, 76107, United States
University of Texas Medical Branch at Galveston
Galveston, Texas, 77555, United States
Angiocardiac Care of Texas
Houston, Texas, 77025, United States
The Methodist Hospital
Houston, Texas, 77030, United States
Biopharma Informatic, Inc. Research Center
Houston, Texas, 77084, United States
Private Practice Leadership, LLC
Katy, Texas, 77493, United States
Baylor Scott and White Health
Plano, Texas, 75024, United States
Alpine Research Organization
Farmington, Utah, 84025, United States
Cardiac Health Management Network, P.C.
Chester, Virginia, 23836, United States
Cardiology Consultants of Danville, Inc
Danville, Virginia, 24541, United States
Carient Heart and Vascular
Manassas, Virginia, 20109, United States
Hunter Holmes McGuire VA Medical Center
Richmond, Virginia, 23249, United States
Medical College of Virginia Hospitals
Richmond, Virginia, 23298, United States
Roanoke Heart Institute PLC
Roanoke, Virginia, 24014, United States
Salem VA Medical Center
Salem, Virginia, 24153, United States
Virginia Mason Medical Center
Seattle, Washington, 98101, United States
Cardiology Associates of Bellin Health
Green Bay, Wisconsin, 54301, United States
Meriter Wisconsin Heart
Madison, Wisconsin, 53713, United States
Marshfield Clinic
Marshfield, Wisconsin, 54449, United States
Aspirus Research Institute
Wausau, Wisconsin, 54401, United States
Hospital Interzonal General de Agudos Dr Jose Penna
Bahía Blanca, B8001DDU, Argentina
Hospital Italiano Regional del Sur, Bahia Blanca
Bahía Blanca, B8001HXM, Argentina
CIPREC
CABA, C1119ACN, Argentina
Hospital Italiano de Buenos Aires
CABA, C1199ABB, Argentina
Instituto Cardiovascular de Buenos Aires
Ciudad Autonoma Buenos Aires, C1428ART, Argentina
Glenny Corp. S.A. Bioclinica Argentina
Ciudad Autonoma Buenos Aires, C1430CKE, Argentina
Centro Médico Viamonte
Ciudad Autonoma de Bs As, C1120AAC, Argentina
Consultorios Asociados de Endocrinología e Invest Clínica
Ciudad Autonoma de BuenosAires, C1425AGC, Argentina
Sanatorio Güemes
Ciudad Autónoma de Bs As, C1180AAX, Argentina
Instituto Medico Elsa Perez SRL (IMEP)
Ciudadela, 1702, Argentina
Clinica Coronel Suarez SA
Coronel Suárez, B7540GHD, Argentina
Instituto de Cardiología de Corrientes
Corrientes, W3400AMZ, Argentina
Sanatorio Mayo Privado SA
Córdoba, 5000, Argentina
Centro de Investigaciones Clinicas Instituto del Corazon
Córdoba, X5000EVQ, Argentina
Sanatorio Allende S.A.
Córdoba, X5000JHQ, Argentina
Clinica Privada Colombo- Fundacion Clinica Colombo
Córdoba, X5002AOQ, Argentina
Instituto Médico DAMIC S.R.L.
Córdoba, X5003DCE, Argentina
Hospital Privado
Córdoba, X5016KEH, Argentina
Hospital Italiano de La Plata
La Plata, B1900AXI, Argentina
Centro de Investigaciones Médicas
Mar del Plata, B7600FYK, Argentina
Hospital Privado de Comunidad
Mar del Plata, B7602CBM, Argentina
CER Instituto Médico
Quilmes, B1878DVB, Argentina
Instituto de Investigaciones Clínicas de Quilmes
Quilmes, B1878GEG, Argentina
Instituto de Investigaciones Clinicas de Rosario
Rosario, 2000, Argentina
Instituto Medico Fundación Grupo Colaborativo Rosario
Rosario, 2000, Argentina
Sanatorio Británico
Rosario, 2000, Argentina
Sanatorio Plaza
Rosario, 2000, Argentina
Instituto CAICI
Rosario, S2000PBJ, Argentina
CORDIS S.A., Salta
Salta, A4400ANW, Argentina
Centro Cardiovascular Salta
Salta, A4406BFP, Argentina
Corporacion Medica de Gral. San Martin S.A.
San Martín, B1650CSQ, Argentina
Investigaciones Clinicas Tucuman
San Miguel de Tucumán, T4000ICL, Argentina
Instituto de Cardiología
San Miguel de Tucumán, T4000JCU, Argentina
Clinica Mayo
San Miguel de Tucumán, T4000, Argentina
Centro Medico Luquez
San Vicente, X5006CBI, Argentina
Centro de Investigaciones Clínicas del Litoral
Santa Fe, S3000FWO, Argentina
Hospital "Dr. José Maria Cullen"
Santa Fé, S3000EOZ, Argentina
Clínica Olivos
Vicente López, 1602, Argentina
CEMEDIC - Centro de Especialidades Medicas
Villa Luro, C1440CFD, Argentina
Pendlebury Research
Kotara, New South Wales, 2289, Australia
John Hunter Hospital
New Lambton Heights, New South Wales, 2305, Australia
CORE Research Group
Milton, Queensland, 4064, Australia
Gold Coast University Hospital
Southport, Queensland, 4215, Australia
Royal Adelaide Hospital
Adelaide, South Australia, 5000, Australia
Adelaide Medical Research
Ashford, South Australia, 5035, Australia
Flinders Medical Centre
Bedford Park, South Australia, 5042, Australia
Heart and Vascular Research
Fullarton, South Australia, 5063, Australia
The Queen Elizabeth Hospital
Woodville South, South Australia, 5011, Australia
The Northern Hospital
Epping, Victoria, 3076, Australia
Peninsula Private Hospital
Frankston, Victoria, 3199, Australia
University Hospital Geelong
Geelong, Victoria, 3220, Australia
Mount Hospital
Perth, Western Australia, 6000, Australia
C.H.U. de Charleroi
Charleroi, 6000, Belgium
AZ Sint-Blasius
Dendermonde, 9200, Belgium
Ziekenhuis Oost-Limburg - Campus Sint-Jan
Genk, 3600, Belgium
AZ Maria Middelares
Ghent, 9000, Belgium
Grand Hôpital de Charleroi
Gilly, 6060, Belgium
Jessa Ziekenhuis - Campus Virga Jesse
Hasselt, 3500, Belgium
La Louvière - UNIV CHU Tivoli
La Louvière, 7100, Belgium
UZ Leuven
Leuven, 3000, Belgium
Liège - HOSP CHR de la Citadelle
Liège, 4000, Belgium
FGM - Clínica Paulista de Doenças Cardiovasculares
Bela Vista, 01323-000, Brazil
Hospital Felicio Rocho
Belo Horizonte, 30110-060, Brazil
Hospital Vera Cruz
Belo Horizonte, 30140-092, Brazil
L2IP -Instituto de Pesquisas Clínicas Ltda.
Brasília, 70200-730, Brazil
ICDF - Instituto de Cardiologia do Distrito Federal
Brasília, 70673-900, Brazil
CECAP - Centro de Cardiologia Clínica
Brasília, 70710-100, Brazil
Irmandade da Santa Casa de Misericordia de Curitiba
Campina Grande do Sul, 83430-000, Brazil
Centro Especializado em Cardiol Loema Instituto de Pesq Clin
Campinas, 13010-001, Brazil
IPECC - Instituto de Pesquisa Clínica de Campinas
Campinas, 13060-080, Brazil
CAEP - Centro Avançado de Estudos e Pesquisas Ltda.,Campinas
Campinas, 13087-567, Brazil
Hospital Universitário
Canoas, 92425-900, Brazil
IPCEM - Instituto de Pesquisa Clínica para Estudos Multicêntricos - Universidade de Caxias do Sul
Caxias do Sul, 95070-560, Brazil
Irmandade da Santa Casa de Misericórdia de Curitiba
Curitiba, 80230-130, Brazil
Via Medica
Goiânia, 74223-130, Brazil
HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás
Goiânia, 74605-020, Brazil
ICM - Instituto do Coracao de Marilia
Marília, 17515-000, Brazil
Hospital São Vicente de Paulo
Passo Fundo, 99010-080, Brazil
Santa Casa de Misericórdia de Porto Alegre
Porto Alegre, 90035-074, Brazil
Centro de Pesquisas em Diabetes
Porto Alegre, 90035-170, Brazil
Hospital de Clínicas de Porto Alegre
Porto Alegre, 90035-903, Brazil
Instituto de Cardiologia Rio Grande do Sul
Porto Alegre, 90620-001, Brazil
Hospital Agamenon Magalhaes
Recife, 52051-380, Brazil
H.C.da Fac. de Medicina de Ribeirao Preto
Ribeirão Preto, 14048-900, Brazil
Hospital Universitário Pedro Ernesto UERJ
Rio de Janeiro, 20551-030, Brazil
CCBR - Rio de Janeiro - BR
Rio de Janeiro, 22271-100, Brazil
Cardresearch Cardiologia Assistencial e de Pesquisas Ltda
Santa Efigênia, 30150-240, Brazil
Pesquisare
Santo André, 09080-110, Brazil
Praxis Pesquisa Médica
Santo André, 09090-790, Brazil
CEMEC - Centro Multidisciplinar de Estudos Clínicos
São Bernardo do Campo, 09780-000, Brazil
Hospital de Base - Fac Med de Sao Jose do Rio Preto
São José do Rio Preto, 15090-000, Brazil
Centro de Pesquisa Clinica - CPCLIN
São Paulo, 01228-200, Brazil
CDEC BRASIL - Centro de Desenvolvimento em Estudos Clínicos Brasil
São Paulo, 04020-060, Brazil
CEPIC - Centro Paulista de Investigacao Clinica
São Paulo, 04266-010, Brazil
Dr. Consulta
São Paulo, 05016-090, Brazil
INCOR e Hospital das Clínicas da Universidade de São Paulo
São Paulo, 05403-000, Brazil
CEDOES - Diagnóstico e Pesquisa,Vitória
Vitória, 29055-450, Brazil
Santa Casa de Votuporanga
Votuporanga, 15500-003, Brazil
Royal Alexandra Hospital
Edmonton, Alberta, T5H 3V9, Canada
Medical Arts Health Research Group
North Vancouver, British Columbia, V7M 2H4, Canada
Vancouver General Hospital
Vancouver, British Columbia, V5Z 1M9, Canada
Victoria Heart Institute Foundation
Victoria, British Columbia, V8R 1B2, Canada
St. Boniface General Hospital
Winnipeg, Manitoba, R2H 2A6, Canada
G.A. Research Associates Ltd
Moncton, New Brunswick, E1G 1A7, Canada
QEII Health Sciences Centre
Halifax, Nova Scotia, B3H 3A7, Canada
Brampton Cardio Pulmonary Clinic
Brampton, Ontario, L6W 2X7, Canada
Brampton Research Associates
Brampton, Ontario, L6Z 4N5, Canada
JBN Medical Diagnostic Services Inc.
Burlington, Ontario, L7M 4Y1, Canada
Cambridge Cardiac Care Inc.
Cambridge, Ontario, N1R 6V6, Canada
Dr. Saul Vizel
Cambridge, Ontario, N1R 7R1, Canada
Cardiovascular Contract Research Organization LTD
Greater Sudbury, Ontario, P3E 3Y9, Canada
Curnew Medicine Professional Corporation
Hamilton, Ontario, L8L 0A9, Canada
Hamilton General Hospital
Hamilton, Ontario, L8L 2X2, Canada
University Hospital (LHSC)
London, Ontario, N6A 5A5, Canada
PACE (Partners in Advanced Cardiac Evaluation)
Newmarket, Ontario, L3Y 2P6, Canada
M Heffernan Medicine Professional Corp.
Oakville, Ontario, L6K 3W7, Canada
Kawartha Cardiology Clinical Trials
Peterborough, Ontario, K9J 0B2, Canada
Heart Health Institute
Scarborough Village, Ontario, M1B 4Z8, Canada
Scarborough Cardiology Research
Scarborough Village, Ontario, M1E 5E9, Canada
Canadian Phase Onward Inc.
Toronto, Ontario, M3J 0K2, Canada
North York Diagnostic and Cardiac Centre
Toronto, Ontario, M6B 1N6, Canada
Mohan Babapulle Medicine Professional Medicine
Waterloo, Ontario, N2T 0C1, Canada
Dr. Louis C.H. Yao
York, Ontario, M9N 1W4, Canada
ViaCar Recherche Clinique Inc
Brossard, Quebec, J4Z 2K9, Canada
ViaCar Recherche Clinique Inc
Greenfield Park, Quebec, J4V 2G8, Canada
Centre de Dépistage et Recherche Cardiovasculaire Rive-Sud
Longeuil, Quebec, J4M 2X1, Canada
Montreal Heart Institute
Montreal, Quebec, H1T 1C8, Canada
Clinique Santé Cardio MC
Montreal, Quebec, H1T 3Y7, Canada
Montreal General Hospital - McGill University Health Centre
Montreal, Quebec, H3G 1A4, Canada
McGill University Health Centre (MUHC)
Montreal, Quebec, H4A 3J1, Canada
Royal University Hospital
Saskatoon, Saskatchewan, S7N 0W8, Canada
IUCPQ (Laval University)
Québec, G1V 4G5, Canada
Cardiovascular Institute and Fu Wai Hospital
Beijing, 100037, China
Beijing Friendship Hospital
Beijing, 100050, China
First Hospital of Jilin University
Changchun, 130021, China
Hunan Provincial People's Hospital
Changsha, 410005, China
2nd Xiangya Hospital of Central South University
Changsha, 410011, China
The Third Hospital of Changsha
Changsha, 410015, China
Dongguan People's Hospital
Dongguan, 523059, China
The First Affiliated Hospital of Fujian Medical University
Fuzhou, 350005, China
The First Afiliated Hospital, Sun Yet-sen University
Guangzhou, 510080, China
Guangzhou First Municipal People's Hospital
Guangzhou, 510180, China
Haikou People's Hospital
Haikou, 570208, China
HaiNan Provincial People's Hospital
Haikou, 570311, China
The First Affiliated Hospital of Lanzhou University
Lanzhou, 730000, China
The Second Affiliated Hospital of Lanzhou Medical University
Lanzhou, 730030, China
The Affiliated Hospital of Southwest Medical University
Luzhou, 646099, China
Nanchang University Affiliated 3rd Hospital
Nanchang, 330008, China
First Hospital Affiliated with Nanjing Medical University
Nanjing, 210029, China
Huashan Hospital, Fudan University
Shanghai, 200040, China
General Hospital of Shenyang Military Region
Shenyang, 110016, China
Shengjing Hospital of China Medical University
Shenyang, 110072, China
Tianjin Union Medical Center Nankai University Affiliated Hospital
Tianjin, 300121, China
Tongji Hospital, Tongji University
Wuhan, 430030, China
Renmin Hospital of Wuhan University
Wuhan, 430060, China
First Affiliated Hospital of Xi'an JiaoTong University
Xi'an, 710061, China
Yanbian University Hospital
Yanji, 133000, China
the first people hospital of Yue Yang
Yueyang, 414000, China
Affiliated Hospital of Jiangsu University
Zhenjiang, 212013, China
Corazon IPS S.A.S.
Barranquilla, 080003, Colombia
Centro de Reumatologia y Ortopedia SAS, Barranquilla
Barranquilla, 080020, Colombia
IPS Centro Cientifico Asistencia
Barranquilla, 080020, Colombia
CardioColombia S.A.S.
Bogota D.C, 111611, Colombia
Endocare Research Institute
Bogotá, 111611, Colombia
IPS Centro Medico Julián Coronel S.A.
Cali, 760002, Colombia
Fundación Valle del Lili
Cali, 760032, Colombia
Centro de Investigaciones Clinicas S.A.S
Cali, 760036, Colombia
Centro de Diagnostico Cardilogico
Cartagena, 130001, Colombia
Centro cardiovascular Aristides
Cartagena, 130010, Colombia
Fundación Cardiovascular de Colombia
Floridablanca, 681002, Colombia
Asociacion IPS Medicos Internistas de Caldas
Manizales, 170004, Colombia
Promotora Medica Las Americas SA
Medellín, 050025, Colombia
Poliklinika Humanitas
Bílovec, 74301, Czechia
Internal and Cardiology Practice, MUDr. Karel Kamenik, Brno
Brno, 603 00, Czechia
MUDr. Alexandra Ludkova
Brno, 615 00, Czechia
University Hospital Brno
Brno, 625 00, Czechia
Vojenska nemocnice Brno
Brno, 63600, Czechia
Nemocnice Milosrdnych bratri
Brno, 63900, Czechia
Fakultni nemocnice u sv. Anny v Brne
Brno, 656 91, Czechia
Univ.Hosp U Svate Anny, I.Internal Clinic-Cardiology,Brno
Brno, 65691, Czechia
Edumed s.r.o
Broumov, 55001, Czechia
MUDr. Jan Hubac, s.r.o. Kardiologicka ambulance
Chrudim, 53702, Czechia
Hospital Frydek Mistek
Frýdek-Místek, 73818, Czechia
Nemocnice Havlickuv Brod p.o.
Havlíčkův Brod, 580 22, Czechia
Gepamed s.r.o., Pulm. Outpat. Office, Hradec Kralove
Hradec Králové, 50002, Czechia
KardioLouny s.r.o.
Louny, 440 01, Czechia
InterKardioML s.r.o.
Mariánské Lázně, 353 01, Czechia
Zdenek Vomacka
Olomouc, 779 00, Czechia
PV-Kardiologie s.r.o.
Pardubice, 53002, Czechia
Vseobecna fakultni nemocnice V Praze
Prague, 128 00, Czechia
Institute for Clinical and Experimental Medicine
Prague, 140 21, Czechia
University Hospital Motol
Prague, 15006, Czechia
Corintez s.r.o.
Prague, 158 00, Czechia
University Thomayer's Hospital
Praha 4 - Krc, 140 59, Czechia
Kardio Vaclavik s.r.o.
Přerov, 75000, Czechia
Kardiologicka ambulance MUDr. Ferkl s.r.o.
Trutnov, 541 01, Czechia
Nemocnice Trebic p.o.
Třebíč, 674 01, Czechia
Kardiologicka ambulance
Třemošná, 33011, Czechia
Clinical Trials Services s.r.o
Uherské Hradiště, 68601, Czechia
Cardiology Private Practice
Uničov, 783 91, Czechia
Angiocor s.r.o
Zlín, 76001, Czechia
KIGE s.r.o
Znojmo, 66902, Czechia
Universitätsklinikum Aachen, AöR
Aachen, 52074, Germany
Praxis Dr. Rieker, Berlin
Berlin, 10789, Germany
Vivantes Netzwerk für Gesundheit GmbH
Berlin, 10967, Germany
Charité - Universitätsmedizin Berlin
Berlin, 12203, Germany
Vivantes Netzwerk für Gesundheit GmbH
Berlin, 12351, Germany
Charité - Universitätsmedizin Berlin
Berlin, 13353, Germany
Klinikum Bielefeld gGmbH
Bielefeld, 33604, Germany
Augusta-Kranken-Anstalt gGmbH
Bochum, 44791, Germany
Praxis Dr. Menzel
Dessau, 06846, Germany
St. Johannes Hospital Dortmund
Dortmund, 44137, Germany
Städtisches Klinikum Dresden
Dresden, 01067, Germany
Universitätsklinikum Carl Gustav Carus Dresden
Dresden, 01307, Germany
Helios Klinikum Erfurt
Erfurt, 99089, Germany
Studienzentrum Bocholderstraße
Essen, 45355, Germany
ClinPhenomics GmbH & Co KG, Frankfurt
Frankfurt, 60596, Germany
Universitätsmedizin Göttingen, Georg-August-Universität
Göttingen, 37075, Germany
Medizinische Hochschule Hannover
Hanover, 30625, Germany
Universitätsklinikum Heidelberg
Heidelberg, 69120, Germany
Universitätsklinikum des Saarlandes
Homburg, 66421, Germany
Universitätsklinikum Jena
Jena, 07740, Germany
Universitätsklinikum Schleswig-Holstein, Campus Kiel
Kiel, 24105, Germany
Asklepios Klinik Langen-Seligenstadt GmbH
Langen, 63225, Germany
Märkische Gesundheitsholding GmbH & Co. KG, Klinikum Lüdenscheid
Lüdenscheid, 58515, Germany
Praxis Dr. Sarnighausen, Lüneburg
Lüneburg, 21339, Germany
Katholisches Klinikum Mainz
Mainz, 55131, Germany
Gemeinschaftspraxis Drs. Kohler/Salbach, Mannheim
Mannheim, 68165, Germany
Deutsches Herzzentrum München
München, 80636, Germany
Gemeinschaftspraxis Dres Haggenmiller/Jeserich
Nuremberg, 90402, Germany
Kardiologische Praxis Papenburg
Papenburg, 26871, Germany
Universitätsklinikum Regensburg
Regensburg, 93053, Germany
Praxis Dr. Stenzel, Riesa
Riesa, 01587, Germany
Zentrum für Klinische Forschung
Wangen, 88239, Germany
Josephs-Hospital Warendorf
Warendorf, 48231, Germany
Kardiologische Praxis, Wermsdorf
Wermsdorf, 04779, Germany
Petrus-Krankenhaus
Wuppertal, 42283, Germany
Lausmed Kft. Outpatient Unit of Internal Medicine
Baja, 6500, Hungary
Belgyogyaszati es Kardiologiai Maganrendelo
Békéscsaba, 5600, Hungary
Budai Irgalmasrendi Korhaz
Budapest, 1023, Hungary
Clinexpert Kft.
Budapest, 1033, Hungary
Bajcsy-Zsilinszky Hospital and Clinic
Budapest, 1106, Hungary
Semmelweis University
Budapest, 1122, Hungary
Milit.Hosp.-State Health Cent.
Budapest, 1134, Hungary
Uzsoki Street Hospital, Budapest
Budapest, 1145, Hungary
Nehezlegzes Ambulancia
Debrecen, 4027, Hungary
University Debrecen Hospital
Debrecen, 4032, Hungary
Bugat Pal Hospital, Gyongyos
Gyöngyös, 3200, Hungary
Studium Egeszseghaz Kft.
Kalocsa, 6300, Hungary
Selye Janos Hospital Komarom
Komárom, 2921, Hungary
Dorottya Kanizsai Hospital
Nagykanizsa, 8800, Hungary
Medifarma-98 Kft.
Nyíregyháza, 4400, Hungary
Dr. Nagy Laszlo Kardiologiai Maganrendeles
Orosháza, 5900, Hungary
University of Pecs
Pécs, 7624, Hungary
Da Vinci Private Clinic
Pécs, 7635, Hungary
Fejer County Saint George University Teaching Hospital
Székesfehérvár, 8000, Hungary
Veszpremi Sziv es Egeszseg Centrum
Veszprém, 8200, Hungary
Doctor Jivraj Mehta Smarak Health Foundation
Ahmedabad, 380007, India
Kamalnayan Bajaj Hospital
Aurangabad, 431 005, India
Narayana Institute of Cardiac Sciences
Bangalore, 560099, India
Rajarajeswari Medical College
Bengaluru, 560074, India
Madras Medical Mission,
Chennai, 600 037, India
Apollo Speciality Hospital
Chennai, 600006, India
GNRC Hospital
Guwahati, 781006, India
Medanta-The Medicity
Gūrgaon, 122001, India
B.M. Birla Heart research Centre
Kolkata, 700027, India
Vijan Cardiac and Critical Care Centre
Nashik, 422005, India
Siddhi Hospital
Nashik, 422007, India
GB Pant Hospital
New Delhi, 110002, India
Fortis Escorts Heart Institute
New Delhi, 110025, India
Sir Gangaram Hospital
New Delhi, 110060, India
Batra Hospital and Medical Research Centre
New Delhi, 110062, India
Azienda Ospedaliera G. Rummo
Benevento, 82100, Italy
ASST Papa Giovanni XXIII - A.O. Papa Giovanni XXIII
Bergamo, 24127, Italy
Azienda Ospedaliera Universitaria Arcispedale Sant'Anna
Cona (FE), 44124, Italy
Ospedale della Val di Chiana Santa Margherita
Cortona, 52040, Italy
Milano Fondazione IRCCS Ca'Granda-Ospedale Maggiore Policlinico
Milan, 20122, Italy
Centro Cardiologico Monzino-IRCCS
Milan, 20138, Italy
Azienda Ospedaliera Universitaria "Federico II"
Napoli, 80131, Italy
Azienda Ospedaliera Universitaria Pisana
Pisa, 56126, Italy
AOU Policlinico Umberto I
Roma, 00161, Italy
Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza
Roma, 00189, Italy
Istituto Clinico Humanitas
Rozzano (MI), 20089, Italy
IRCCS Gruppo Multimedica
Sesto San Giovanni (MI), 20099, Italy
Azienda Servizi Sanitari 1 Triestina
Trieste, 34128, Italy
Kasugai Municipal Hospital
Aichi, Kasugai, 486-8510, Japan
Japanese Red Cross Nagoya Daini Hospital
Aichi, Nagoya, 466-8650, Japan
Chiba Heart Clinic
Chiba, Chiba, 263-0043, Japan
Kimitsu Chuo Hospital
Chiba, Kisarazu, 292-8535, Japan
Seikeikai New Tokyo Heart Clinic
Chiba, Matsudo, 271-0077, Japan
Ehime Prefectural Central Hospital
Ehime, Matsuyama, 790-0024, Japan
Matsuyama Shimin Hospital
Ehime, Matsuyama, 790-0067, Japan
Uwajima City Hospital
Ehime, Uwajima, 798-8510, Japan
Fukuiken Saiseikai Hospital
Fukui, Fukui, 918-8503, Japan
Fukuoka University Chikushi Hospital
Fukuoka, Chikushino, 818-8502, Japan
Fukuokaken Saiseikai Futsukaichi Hospital
Fukuoka, Chikushino, 818-8516, Japan
Saiseikai Fukuoka General Hospital
Fukuoka, Fukuoka, 810-0001, Japan
National Hospital Organization Kyushu Medical Center
Fukuoka, Fukuoka, 810-8563, Japan
Kyushu University Hospital
Fukuoka, Fukuoka, 812-8582, Japan
Steel Memorial Yawata Hospital
Fukuoka, Kitakyushu, 805-8508, Japan
Japan Community Health Care Organization Kyushu Hospital
Fukuoka, Kitakyushu, 806-8501, Japan
Shirakawa Kosei General Hospital
Fukushima, Shirakawa, 961-0005, Japan
Ogaki Municipal Hospital
Gifu, Ogaki, 503-8502, Japan
Chuno Kosei Hospital
Gifu, Seki, 501-3802, Japan
Fukuyama City Hospital
Hiroshima, Fukuyama, 721-8511, Japan
Shobara Red Cross Hospital
Hiroshima, Shobara, 727-0013, Japan
Matsuda Cardiovascular Clinic
Hokkaido, Sapporo, 003-0026, Japan
Teine Keijinkai Clinic
Hokkaido, Sapporo, 006-0811, Japan
Tomakomai City Hospital
Hokkaido, Tomakomai, 053-8567, Japan
Otaru Kyokai Hospital
Hokkaido,Otaru, 047-8510, Japan
Hyogo Prefectural Amagasaki General Medical Center
Hyogo, Amagasaki, 660-8550, Japan
Hyogo Brain and Heart Center
Hyogo, Himeji, 670-0981, Japan
National Hospital Organization Kobe Medical Center
Hyogo, Kobe, 654-0155, Japan
Mito Medical Center
Ibaraki, Higashiibaraki-gun, 311-3193, Japan
Tokushukai Koga General Hospital
Ibaraki, Koga, 306-0041, Japan
National Hospital Organization Kanazawa Medical Center
Ishikawa, Kanazawa, 920-8650, Japan
Mitoyo General Hospital
Kagawa, Kanonji, 769-1695, Japan
Kagawa Prefectural Central Hospital
Kagawa, Takamatsu, 760-8557, Japan
Sekishinkai Second Kawasaki Saiwai Clinic
Kanagawa, Kawasaki, 212-0021, Japan
Yamamoto Clinic
Kanagawa, Sagamihara, 252-0311, Japan
Kanagawa Cardiovascular and Respiratory Center
Kanagawa, Yokohama, 236-0051, Japan
Japanese Red Cross Kumamoto Hospital
Kumamoto, Kumamoto, 861-8520, Japan
Seiwakai Suizenji Touya Hospital
Kumamoto, Kumamoto, 862-0950, Japan
Kumamoto Rosai Hospital
Kumamoto, Yatsushiro, 866-8533, Japan
Omi Medical Center
Kusatsu, 525-8585, Japan
Uji-Tokushukai Medical Center
Kyoto, Uji, 611-0041, Japan
Sendai Kousei Hospital
Miyagi, Sendai, 980-0873, Japan
Sendai Tokushukai Hospital
Miyagi, Sendai, 981-3131, Japan
National Hospital Organization Sendai Medical Center
Miyagi, Sendai, 983-8520, Japan
Miyazaki Medical Association Hospital
Miyazaki, Miyazaki, 880-2102, Japan
Hokushin General Hospital
Nagano, Nakano, 383-8505, Japan
Nagasaki Medical Center
Nagasaki, Omura, 856-8562, Japan
Oita Medical Center
Oita, Oita, 870-0263, Japan
Okayama City General Medical Center
Okayama, Okayama, 700-8557, Japan
Naha City Hospital
Okinawa, Naha, 902-8511, Japan
Nanbu Tokushukai Hospital
Okinawa, Shimajiri-gun, 901-0493, Japan
Urasoe General Hospital
Okinawa, Urasoe, 901-2132, Japan
Higashiosaka City Medical Center
Osaka, Higashiosaka, 578-8588, Japan
Kitano Hospital
Osaka, Osaka, 530-8480, Japan
Yodogawa Christian Hospital
Osaka, Osaka, 533-0024, Japan
Hokusetsu General Hospital
Osaka, Takatsuki, 569-8585, Japan
San-Ai Hospital
Saitama, Saitama, 338-0837, Japan
Kosekai Iwatsuki-minami Hospital
Saitama, Saitama, 339-0033, Japan
Tokushima Prefectural Central Hospital
Tokushima, Tokushima, 770-8539, Japan
National Hospital Organization Tokyo Medical Center
Tokyo, Meguro-ku, 152-8902, Japan
Ome Municipal General Hospital
Tokyo, Ome, 198-0042, Japan
Tokyo Rosai Hospital
Tokyo, Ota-ku, 143-0013, Japan
Sekino Hospital
Tokyo, Toshima-ku, 171-0014, Japan
Minami Wakayama Medical Center
Wakayama, Tanabe, 646-8558, Japan
Kanmon Medical Center
Yamaguchi, Shimonoseki, 752-8510, Japan
Hospital Cardiologica Aguascalientes
Aguascalientes, 20230, Mexico
Centro de Investigacion Biomedica y Farmaceutica, S.C.
Distrito Federal, 03100, Mexico
Hospital Ramon Garibay
Guadalajara, 44100, Mexico
Diseño y Planeación en Investigación Médica SC
Guadalajara, 44130, Mexico
Unidad de Investigacion Clinica Cardiometabolica de Occident
Guadalajara, 44150, Mexico
Cardiologia Clinica e Intervencionista
Guadalajara, 44670, Mexico
Centro de Investigación Clinica Acelerada, S.C.
México, 07020, Mexico
CEDOPEC-Ctro Esp en Diab, Obesidad y Prev de Enf Cardiovasc
México, C.P. 11650, Mexico
Instituto Cardiovascular de Monclova, S de RL de CV
Monclova, 25750, Mexico
Hospital Universitario Dr Jose Eleuterio Gonzalez
Nuevo León, 64460, Mexico
Centro Integral Medico SJR S.C.
San Juan del Río, 76800, Mexico
Cardioarritmias e Investigación S.C
San Luis Potosí City, 78213, Mexico
Centro de Investigacion Cardiovascular y Metabolica
Tijuana, 22500, Mexico
Centro de Investigacion Medica Alberto Bazzoni S.A. de C.V.
Torreón, 27000, Mexico
Ziekenhuisgroep Twente locatie Almelo
Almelo, 7609 PP, Netherlands
BovenIJ Ziekenhuis
Amsterdam, 1034 CS, Netherlands
Onze Lieve Vrouwe Gasthuis, Locatie West
Amsterdam, 1061 AE, Netherlands
Amsterdam UMC Locatie VUMC
Amsterdam, 1081HV, Netherlands
Onze Lieve Vrouwe Gasthuis
Amsterdam, 1091AC, Netherlands
Amsterdam UMC, Locatie AMC
Amsterdam, 1105 AZ, Netherlands
Rode Kruis Ziekenhuis Beverwijk
Beverwijk, 1942 LE, Netherlands
Tergooiziekenhuizen locatie Blaricum
Blaricum, 1261 AN, Netherlands
Amphia Ziekenhuis
Breda, 4818 CK, Netherlands
Ziekenhuis Gelderse Vallei
Ede, 6716 RP, Netherlands
Catharina Ziekenhuis
Eindhoven, 5623 EJ, Netherlands
Universitair Medisch Centrum Groningen
Groningen, 9713 GZ, Netherlands
Zuyderland Medisch Centrum
Heerlen, 6419 PC, Netherlands
Maastricht University
Maastricht, 6229 HX, Netherlands
Diaconessenhuis Meppel
Meppel, 7943 KA, Netherlands
St. Antonius ziekenhuis, locatie Nieuwegein
Nieuwegein, 3435 CM, Netherlands
Radboud Universitair Medisch Centrum
Nijmegen, 6525 GL, Netherlands
Franciscus Gasthuis
Rotterdam, 3045 PM, Netherlands
De Heel - Zaans Medisch Centrum
Zaandam, 1502 DV, Netherlands
Gelre Ziekenhuis Zutphen
Zutphen, 7207 AE, Netherlands
Univ. Clinic Hosp, Bialystok
Bialystok, 15-276, Poland
KLIMED Marek Klimkiewicz
Bialystok, 15-765, Poland
ClinicMed Badurski i wspolnicy Spolka Jawna, Bialystok
Bialystok, 15-879, Poland
American Heart of Poland Sp. z o.o.
Bielsko-Biala, 43-316, Poland
NZOZ Centrum Medyczne KERmed
Bydgoszcz, 85231, Poland
Polsko-Amerykanskie Kliniki Serca
Chorzów, 32-500, Poland
American Heart of Poland Sp. z o.o.
Dąbrowa Górnicza, 41-300, Poland
Poradnia Kardiologiczna Jaroslaw Jurowiecki
Gdansk, 80-286, Poland
University Clinical Center, Gdansk
Gdansk, 80-952, Poland
Indywidualna Specjalistyczna Praktyka Lekarska
Gdynia, 81-157, Poland
NZOZ Pro-Cordis Sopockie Centrum Bad. Kardiolog.
Gdynia, 81-423, Poland
Szpital Zakonu Bonifratow Sp. z o.o.
Katowice, 40-211, Poland
Specialistic Cardiology&Hypertension Out-patient Clin,Kielce
Kielce, 25525, Poland
Leszek Bryniarski Specialized Medical Cabinet
Krakow, 30-082, Poland
Krakow Specialistic Hospital of John Paul II
Krakow, 31-202, Poland
ETG Lodz
Lodz, 90-302, Poland
Nzoz Salus
Lodz, 91-002, Poland
Individual Specialized Practice
Lodz, 94-255, Poland
Lowickie Cardiology Center
Lowicz, 99-400, Poland
American Heart of Poland Sp. z o.o.
Nysa, 48-300, Poland
Medicome Sp. z o.o.
Oświęcim, 32-600, Poland
NZOZ HEUREKA, Piaseczno
Piaseczno, 05-500, Poland
Specialized Practice Dr. Janusz Spyra
Ruda Śląska, 41-709, Poland
Centrum Medyczne Medyk
Rzeszów, 35-055, Poland
Lukmed Lukasz Wozniak
Siedlce, 08-110, Poland
ETG Skierniewice
Skierniewice, 96-100, Poland
KO-MED Centra Kliniczne Staszow
Staszów, 28-200, Poland
The Provincial Polyclinical Hospital in Torun
Torun, 87-100, Poland
American Heart of Poland Sp. z o.o.
Tychy, 43-100, Poland
American Heart of Poland Sp. z o.o.
Ustroń, 43-450, Poland
Samodzielny Publiczny Centralny Szpital Kliniczny
Warsaw, 02-097, Poland
ETG Warszawa
Warsaw, 02-793, Poland
4. Military Clinical Hospital with Polyclinic SP ZOZ
Wroclaw, 50-981, Poland
Zgierskie Center of Cardiology MED-PRO
Zgierz, 95-100, Poland
Specialist Hospital J. Dietla NZOZ Specialized Clinic "Gemini"
Żychlin, 62-571, Poland
Spitalul Clinic De Urgenta "Prof. Dr. Agrippa Ionescu"
Baloteşti, 077015, Romania
C.M.D.T.A. NEOMED, Brasov
Brasov, 500283, Romania
CMDTA Washington, Bucharest
Bucharest, 011794, Romania
Spitalul Clinic Colentina
Bucharest, 020125, Romania
Emergency Clinical Hospital 'Sf. Panteliomon'
Bucharest, 021659, Romania
Emergency University Hospital, Bucharest
Bucharest, 022328, Romania
Prof.C.C.Iliescu Hospital, National Institute of Cardiology
Bucharest, 022328, Romania
Emergency University Hospital, Bucharest
Bucharest, 050098, Romania
Spitalul Clinic "Prof. Dr. Theodor Burghele"
Bucharest, 050659, Romania
Clinica Medicala Data Plus SRL
Bucharest, 10192, Romania
S.C Cardiomed S.R.L
Craiova, 200505, Romania
Spital Judetean Deva
Deva, 330084, Romania
S.C Medicali's S.R.L
Timișoara, 300043, Romania
Spitalul Clinic Judetean de Urgenta, Timisoara
Timișoara, 300723, Romania
National University Hospital
Singapore, 119074, Singapore
National Heart Center
Singapore, 169609, Singapore
Tan Tock Seng Hospital
Singapore, 308433, Singapore
Khoo Teck Puat Hospital
Singapore, 768828, Singapore
Cardiology Clinical Research
Alberton, 1449, South Africa
Iatros International
Bloemfontein, 9301, South Africa
Universitas Hospital Cardiology Research
Bloemfontein, 9301, South Africa
Corbod Research
Cape Town, 7500, South Africa
TREAD Research
Cape Town, 7500, South Africa
Tiervlei Trial Centre
Cape Town, 7530, South Africa
Excellentis Clinical Trials
George, 6529, South Africa
Clinresco
Johannesburg, 1619, South Africa
Chris Hani Baragwanath Hospital: Cardiology Department
Johannesburg, 1862, South Africa
MERC Research
Kempton Park, 1619, South Africa
Into Research
Pretoria, 181, South Africa
Dr JM Engelbrecht
Somerset West, 7130, South Africa
Clinical Projects Research
Worcester, 6850, South Africa
Inje University Busan Paik Hospital
Busan, 47392, South Korea
Dong-A University Hospital
Busan, 49201, South Korea
Chungbuk National University Hospital
Cheongju-si, 28644, South Korea
Chungnam National University Hospital
Daejeon, 35015, South Korea
Chonnam National University Hospital
Gwangju, 61469, South Korea
Seoul National University Bundang Hospital
Gyeonggi-do, 13620, South Korea
Gachon University Gil Medical Center
Incheon, 21565, South Korea
Seoul National University Hospital
Seoul, 03080, South Korea
Severance Hospital
Seoul, 03722, South Korea
Asan Medical Center
Seoul, 05505, South Korea
Samsung Medical Center
Seoul, 06351, South Korea
Korea University Guro Hospital
Seoul, 08308, South Korea
Wonju Severance Christian Hosp
Wŏnju, 26426, South Korea
Hospital Quiron. I.C.U.
Barcelona, 08023, Spain
Hospital Santa Creu i Sant Pau
Barcelona, 08025, Spain
Hospital Sanitas CIMA
Barcelona, 08034, Spain
Hospital Universitario Virgen de la Arrixaca
El Palmar, 30120, Spain
Hospital General Universitario Gregorio Marañón
Madrid, 28007, Spain
Hospital Ramón y Cajal
Madrid, 28034, Spain
Hospital La Paz
Madrid, 28046, Spain
Hospital Puerta de Hierro
Majadahonda, 28222, Spain
Hospital Virgen de la Victoria
Málaga, 29010, Spain
Hospital Clínico de Santiago
Santiago de Compostela, 15706, Spain
Hospital Virgen Macarena
Seville, 41009, Spain
Hospital General Universitario de Valencia
Valencia, 46014, Spain
Hospital Arnau de Vilanova
Valencia, 46015, Spain
Barnet General Hospital
Barnet, EN5 3DJ, United Kingdom
University Hospital of Wales
Cardiff, CF14 4XU, United Kingdom
Park & St Francis Surgery
Eastleigh, SO53 4ST, United Kingdom
Wycombe General Hospital
High Wycombe, HP11 2TT, United Kingdom
Glenfield Hospital
Leicester, LE3 9QP, United Kingdom
St Bartholomew's Hospital
London, EC1A 7BE, United Kingdom
St Mary's Hospital
Newport, PO30 5TG, United Kingdom
Morriston Hospital
Swansea, SA6 6NL, United Kingdom
Related Publications (20)
Ferreira JP, Packer M, Butler J, Vasques-Novoa F, Marques P, Pocock S, Filippatos G, Zannad F, Anker SD. Serum Magnesium, Outcomes, and the Effect of Empagliflozin in Heart Failure With Mildly Reduced and Preserved Ejection Fraction: Findings From EMPEROR-Preserved. JACC Heart Fail. 2025 Dec 29:102889. doi: 10.1016/j.jchf.2025.102889. Online ahead of print.
PMID: 41493412DERIVEDCarson P, Teerlink JR, Komajda M, Anand I, Packer M, Butler J, Doehner W, Ferreira JP, Filippatos G, Haass M, Miller A, Pehrson S, Pocock SJ, Iwata T, Brueckmann M, Gasior T, Zannad F, Anker SD. Comparison of Investigator-Reported and Centrally Adjudicated Heart Failure Outcomes in the EMPEROR-Preserved Trial. JACC Heart Fail. 2025 May;13(5):710-721. doi: 10.1016/j.jchf.2024.10.021. Epub 2025 Jan 29.
PMID: 39895437DERIVEDNatale P, Tunnicliffe DJ, Toyama T, Palmer SC, Saglimbene VM, Ruospo M, Gargano L, Stallone G, Gesualdo L, Strippoli GF. Sodium-glucose co-transporter protein 2 (SGLT2) inhibitors for people with chronic kidney disease and diabetes. Cochrane Database Syst Rev. 2024 May 21;5(5):CD015588. doi: 10.1002/14651858.CD015588.pub2.
PMID: 38770818DERIVEDFerreira JP, Packer M, Sattar N, Butler J, Pocock SJ, Anker SD, Maldonado SG, Panova-Noeva M, Sumin M, Masson S, Zannad F, Januzzi JL. Carbohydrate antigen 125 concentrations across the ejection fraction spectrum in chronic heart failure: The EMPEROR programme. Eur J Heart Fail. 2024 Apr;26(4):788-802. doi: 10.1002/ejhf.3166. Epub 2024 Mar 4.
PMID: 38439582DERIVEDZannad F, Macari S. Drug treatment with empagliflozin was beneficial in people with heart failure with preserved ejection fraction: plain language summary of the EMPEROR-Preserved study. Future Cardiol. 2023 Nov;19(14):671-677. doi: 10.2217/fca-2023-0091. Epub 2023 Nov 9.
PMID: 37942723DERIVEDPacker M, Butler J, Zeller C, Pocock SJ, Brueckmann M, Ferreira JP, Filippatos G, Usman MS, Zannad F, Anker SD. Blinded Withdrawal of Long-Term Randomized Treatment With Empagliflozin or Placebo in Patients With Heart Failure. Circulation. 2023 Sep 26;148(13):1011-1022. doi: 10.1161/CIRCULATIONAHA.123.065748. Epub 2023 Aug 24.
PMID: 37621153DERIVEDButler J, Usman MS, Filippatos G, Ferreira JP, Bohm M, Brueckmann M, Januzzi JL, Kaul S, Pina IL, Ponikowski P, Senni M, Sumin M, Verma S, Zaremba-Pechmann L, Pocock SJ, Packer M, Anker S. Safety and Efficacy of Empagliflozin and Diuretic Use in Patients with Heart Failure and Preserved Ejection Fraction: A Post Hoc Analysis of the EMPEROR-Preserved Trial. JAMA Cardiol. 2023 Jul 1;8(7):640-649. doi: 10.1001/jamacardio.2023.1090.
PMID: 37223933DERIVEDBhm M, Anker S, Mahfoud F, Lauder L, Filippatos G, Ferreira JP, Pocock SJ, Brueckmann M, Saloustros I, Schler E, Wanner C, Zannad F, Packer M, Butler J. Empagliflozin, irrespective of blood pressure, improves outcomes in heart failure with preserved ejection fraction: the EMPEROR-Preserved trial. Eur Heart J. 2023 Feb 1;44(5):396-407. doi: 10.1093/eurheartj/ehac693.
PMID: 36478225DERIVEDFerreira JP, Zannad F, Butler J, Filippatos G, Pocock SJ, Brueckmann M, Steubl D, Schueler E, Anker SD, Packer M. Association of Empagliflozin Treatment With Albuminuria Levels in Patients With Heart Failure: A Secondary Analysis of EMPEROR-Pooled. JAMA Cardiol. 2022 Nov 1;7(11):1148-1159. doi: 10.1001/jamacardio.2022.2924.
PMID: 36129693DERIVEDButler J, Filippatos G, Siddiqi TJ, Ferreira JP, Brueckmann M, Bocchi E, Bohm M, Chopra VK, Giannetti N, Iwata T, Januzzi JL, Kaul S, Pina IL, Ponikowski P, Rauch-Krohnert U, Shah SJ, Senni M, Sumin M, Verma S, Zhang J, Pocock SJ, Zannad F, Packer M, Anker SD. Effects of Empagliflozin in Women and Men With Heart Failure and Preserved Ejection Fraction. Circulation. 2022 Oct 4;146(14):1046-1055. doi: 10.1161/CIRCULATIONAHA.122.059755. Epub 2022 Sep 13.
PMID: 36098051DERIVEDZannad F, Ferreira JP, Butler J, Filippatos G, Januzzi JL, Sumin M, Zwick M, Saadati M, Pocock SJ, Sattar N, Anker SD, Packer M. Effect of empagliflozin on circulating proteomics in heart failure: mechanistic insights into the EMPEROR programme. Eur Heart J. 2022 Dec 21;43(48):4991-5002. doi: 10.1093/eurheartj/ehac495.
PMID: 36017745DERIVEDFilippatos G, Butler J, Farmakis D, Zannad F, Ofstad AP, Ferreira JP, Green JB, Rosenstock J, Schnaidt S, Brueckmann M, Pocock SJ, Packer M, Anker SD; EMPEROR-Preserved Trial Committees and Investigators. Empagliflozin for Heart Failure With Preserved Left Ventricular Ejection Fraction With and Without Diabetes. Circulation. 2022 Aug 30;146(9):676-686. doi: 10.1161/CIRCULATIONAHA.122.059785. Epub 2022 Jun 28.
PMID: 35762322DERIVEDFerreira JP, Zannad F, Butler J, Filipattos G, Ritter I, Schuler E, Kraus BJ, Pocock SJ, Anker SD, Packer M. Empagliflozin and serum potassium in heart failure: an analysis from EMPEROR-Pooled. Eur Heart J. 2022 Aug 14;43(31):2984-2993. doi: 10.1093/eurheartj/ehac306.
PMID: 35687107DERIVEDJanuzzi JL Jr, Butler J, Zannad F, Filippatos G, Ferreira JP, Pocock SJ, Sattar N, Verma S, Vedin O, Iwata T, Brueckmann M, Packer M, Anker SD; EMPEROR-Preserved Trial Study Group. Prognostic Implications of N-Terminal Pro-B-Type Natriuretic Peptide and High-Sensitivity Cardiac Troponin T in EMPEROR-Preserved. JACC Heart Fail. 2022 Jul;10(7):512-524. doi: 10.1016/j.jchf.2022.05.004. Epub 2022 Jun 1.
PMID: 35670067DERIVEDVaduganathan M, Claggett BL, Inciardi RM, Fonarow GC, McMurray JJV, Solomon SD. Estimating the Benefits of Combination Medical Therapy in Heart Failure With Mildly Reduced and Preserved Ejection Fraction. Circulation. 2022 Jun 7;145(23):1741-1743. doi: 10.1161/CIRCULATIONAHA.121.058929. Epub 2022 May 23. No abstract available.
PMID: 35603667DERIVEDFerreira JP, Butler J, Zannad F, Filippatos G, Schueler E, Steubl D, Zeller C, Januzzi JL, Pocock S, Packer M, Anker SD. Mineralocorticoid Receptor Antagonists and Empagliflozin in Patients With Heart Failure and Preserved Ejection Fraction. J Am Coll Cardiol. 2022 Mar 29;79(12):1129-1137. doi: 10.1016/j.jacc.2022.01.029.
PMID: 35331406DERIVEDButler J, Filippatos G, Jamal Siddiqi T, Brueckmann M, Bohm M, Chopra VK, Pedro Ferreira J, Januzzi JL, Kaul S, Pina IL, Ponikowski P, Shah SJ, Senni M, Vedin O, Verma S, Peil B, Pocock SJ, Zannad F, Packer M, Anker SD. Empagliflozin, Health Status, and Quality of Life in Patients With Heart Failure and Preserved Ejection Fraction: The EMPEROR-Preserved Trial. Circulation. 2022 Jan 18;145(3):184-193. doi: 10.1161/CIRCULATIONAHA.121.057812. Epub 2021 Nov 15.
PMID: 34779658DERIVEDKanie T, Mizuno A, Takaoka Y, Suzuki T, Yoneoka D, Nishikawa Y, Tam WWS, Morze J, Rynkiewicz A, Xin Y, Wu O, Providencia R, Kwong JS. Dipeptidyl peptidase-4 inhibitors, glucagon-like peptide 1 receptor agonists and sodium-glucose co-transporter-2 inhibitors for people with cardiovascular disease: a network meta-analysis. Cochrane Database Syst Rev. 2021 Oct 25;10(10):CD013650. doi: 10.1002/14651858.CD013650.pub2.
PMID: 34693515DERIVEDAnker SD, Butler J, Filippatos G, Ferreira JP, Bocchi E, Bohm M, Brunner-La Rocca HP, Choi DJ, Chopra V, Chuquiure-Valenzuela E, Giannetti N, Gomez-Mesa JE, Janssens S, Januzzi JL, Gonzalez-Juanatey JR, Merkely B, Nicholls SJ, Perrone SV, Pina IL, Ponikowski P, Senni M, Sim D, Spinar J, Squire I, Taddei S, Tsutsui H, Verma S, Vinereanu D, Zhang J, Carson P, Lam CSP, Marx N, Zeller C, Sattar N, Jamal W, Schnaidt S, Schnee JM, Brueckmann M, Pocock SJ, Zannad F, Packer M; EMPEROR-Preserved Trial Investigators. Empagliflozin in Heart Failure with a Preserved Ejection Fraction. N Engl J Med. 2021 Oct 14;385(16):1451-1461. doi: 10.1056/NEJMoa2107038. Epub 2021 Aug 27.
PMID: 34449189DERIVEDNassif ME, Kosiborod M. Effects of sodium glucose cotransporter type 2 inhibitors on heart failure. Diabetes Obes Metab. 2019 Apr;21 Suppl 2:19-23. doi: 10.1111/dom.13678.
PMID: 31081589DERIVED
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Results Point of Contact
- Title
- Boehringer Ingelheim, Call Centre
- Organization
- Boehringer Ingelheim
Study Officials
- STUDY CHAIR
Boehringer Ingelheim
Boehringer Ingelheim
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- OTHER
- Restrictive Agreement
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 16, 2017
First Posted
February 20, 2017
Study Start
March 2, 2017
Primary Completion
April 26, 2021
Study Completion
April 26, 2021
Last Updated
June 6, 2022
Results First Posted
June 6, 2022
Record last verified: 2022-06