EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Reduced Ejection Fraction (EMPEROR-Reduced)
A Phase III Randomised, Double-blind Trial to Evaluate Efficacy and Safety of Once Daily Empagliflozin 10 mg Compared to Placebo, in Patients With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF)
2 other identifiers
interventional
3,730
20 countries
520
Brief Summary
The aim of the study is to investigate the safety and efficacy of empagliflozin versus placebo on top of guideline-directed medical therapy in patients with heart failure with reduced ejection fraction.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3 heart-failure
Started Mar 2017
520 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 16, 2017
CompletedFirst Posted
Study publicly available on registry
February 20, 2017
CompletedStudy Start
First participant enrolled
March 6, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
May 28, 2020
CompletedResults Posted
Study results publicly available
May 18, 2021
CompletedMay 18, 2021
April 1, 2021
3.2 years
February 16, 2017
April 26, 2021
April 26, 2021
Conditions
Outcome Measures
Primary Outcomes (1)
Time to the First Event of Adjudicated Cardiovascular (CV) Death or Adjudicated Hospitalisation for Heart Failure (HHF)
Time to the first event of adjudicated cardiovascular (CV) death or adjudicated hospitalisation for heart failure (HHF). The incidence rate per 100 patient years (100 \* number of patients with event /time at risk \[years\]) is presented. With time at risk \[year\] calculated as: Sum of time at risk \[days\] over all patients in a treatment group / 365.25. Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier. Unit of Measure: Patients with events per 100 patient-years (pt-yrs) at risk.
From randomisation until completion of the planned treatment period, up to 1040 days.
Secondary Outcomes (9)
Occurrence of Adjudicated Hospitalisation for Heart Failure (HHF) (First and Recurrent)
From randomisation until completion of the planned treatment phase, up to 1040 days.
eGFR (CKD-EPI) cr Slope of Change From Baseline
Assessed at baseline, week 4, 12, 32, 52, 76, 100, 124, 148 and at end of treatment (EOT), up to 1040 days.
Time to First Event in Composite Renal Endpoint: Chronic Dialysis, Renal Transplant or Sustained Reduction of eGFR(CKD-EPI)cr
From randomisation until completion of the planned treatment period, up to 1040 days.
Time to First Adjudicated Hospitalisation for Heart Failure (HHF)
From randomisation until completion of the planned treatment period, up to 1040 days.
Time to Adjudicated Cardiovascular (CV) Death
From randomisation until completion of the planned treatment period, up to 1040 days.
- +4 more secondary outcomes
Study Arms (2)
Empagliflozin
EXPERIMENTALPlacebo
PLACEBO COMPARATORInterventions
Eligibility Criteria
You may qualify if:
- Male or female patient age \>= 18 years at screening. For Japan only: Age \>= 20 years at screening
- Patients with chronic HF (Chronic Heart Failure) NYHA (New York Heart Association Classification) class II-IV and reduced EF (Ejection Fraction) (LVEF (Left Ventricular Ejection Fraction) \<=40%) and elevated NT-proBNP (N-terminal of the prohormone brain natriuretic peptide)
- If EF \>= 36% to \<= 40%: NT-proBNP \>= 2500 pg/ml or patients without AF (atrial fibrillation/atrial flutter) and NT-proBNP \>= 5000 pg/ml for patients with AF
- If EF \>= 31% to \<= 35%: NT-proBNP \>= 1000 pg/ml for patients without AF and NT-proBNP \>=2000 pg/ml for patients with AF
- If EF\<= 30%: NT-proBNP \>= 600 pg/ml for patients without AF and NT-proBNP \>=1200 pg/ml for patients with AF
- EF ≤ 40% and hospitalization for heart failure in the past 12 months: NTproBNP ≥ 600 pg/ml for patients without AF and NT-proBNP \>= 1200 pg/ml for patients with AF
- Appropriate dose of medical therapy for HF consistent with prevailing local and international CV (Cardiovascular) guidelines, stable for at least 1 week prior to Visit 1
- Appropriate use of medical devices such as cardioverter defibrillator (ICD) or a cardiac resynchronization therapy (CRT) consistent with prevailing local or international CV guidelines
- Signed and dated written ICF (Informed Consent Form)
You may not qualify if:
- Myocardial infarction, coronary artery bypass graft surgery, or other major cardiovascular surgery, stroke or TIA (Transient Ischaemic Attack) in past 90 days prior to Visit 1
- Heart transplant recipient, or listed for heart transplant
- Acute decompensated HF
- Systolic blood pressure (SBP) \>= 180 mmHg at Visit 2.
- Symptomatic hypotension and/or a SBP \< 100 mmHg
- Indication of liver disease
- Impaired renal function, defined as eGFR (Estimated Glomerular Filtration Rate) \< 20 mL/min/1.73 m2 (CKD-EPI (Chronic Kidney Disease - Epidemiology Collaboration Equation)) or requiring dialysis
- History of ketoacidosis
- Current use or prior use of a SGLT (Sodium-glucose co-transporter)-2 inhibitor or combined SGLT-1 and 2 inhibitor
- Currently enrolled in another investigational device or drug study
- Known allergy or hypersensitivity to empagliflozin or other SGLT-2 inhibitors
- Women who are pregnant, nursing, or who plan to become pregnant while in the trial
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Boehringer Ingelheimlead
- Eli Lilly and Companycollaborator
Study Sites (520)
La Mesa Cardiac Center
La Mesa, California, 91942, United States
Long Beach Center for Clinical Research
Long Beach, California, 90807, United States
VA Greater Los Angeles Healthcare System
Los Angeles, California, 90073, United States
Merced Vein and Vascular Center
Merced, California, 95340, United States
University of California Irvine
Orange, California, 92865, United States
Covigilant Research, LLC
Riverside, California, 92506, United States
University of California
Torrance, California, 90502, United States
Orange County Research Center
Tustin, California, 92780, United States
Blue Coast Cardiology
Vista, California, 92083, United States
South Denver Cardiology Associates, PC
Littleton, Colorado, 80120, United States
Integrated Heart Care
Boca Raton, Florida, 33434, United States
Morton Plant Mease Health Care
Clearwater, Florida, 33756, United States
Nature Coast Clinical Research
Crystal River, Florida, 34429, United States
Avail Clinical Research, LLC
DeLand, Florida, 32720, United States
Holy Cross Hospital
Fort Lauderdale, Florida, 33308, United States
Integrative Research Associates
Fort Lauderdale, Florida, 33312, United States
Nature Coast Clinical Research
Inverness, Florida, 34452, United States
East Coast Institute for Research, LLC
Jacksonville, Florida, 32216, United States
Jacksonville Center for Clinical Research
Jacksonville, Florida, 32216, United States
Cardiovascular Research Center of South Florida
Miami, Florida, 33173, United States
Peninsula Research, Inc.
Ormond Beach, Florida, 32174, United States
Cardiology Consultants, Inc
Pensacola, Florida, 32501, United States
Sarasota Memorial Hospital
Sarasota, Florida, 34239, United States
Grady Clinical Research Center
Atlanta, Georgia, 30303, United States
Augusta University
Augusta, Georgia, 30912, United States
Columbus Regional Research Institute
Columbus, Georgia, 31904, United States
Cardiovascular Group PC
Lawrenceville, Georgia, 30046, United States
Meridian Clinical Research, LLC
Savannah, Georgia, 31406, United States
Northwest Heart Clinical Research, LLC
Arlington Heights, Illinois, 60005, United States
University of Chicago
Chicago, Illinois, 60637, United States
Captain James A. Lovell Federal Health Care Center
North Chicago, Illinois, 60064, United States
Rockford Cardiovascular Associates
Rockford, Illinois, 61107, United States
Midwest Cardiovascular Research and Education Foundation
Elkhart, Indiana, 46514, United States
St. Francis Medical Group-Indiana Heart Physicians, Inc
Indianapolis, Indiana, 46237, United States
Reid Hospital
Richmond, Indiana, 47374, United States
Beacon Medical Group Clinical Research
South Bend, Indiana, 46601, United States
Research Integrity, LLC
Owensboro, Kentucky, 42303, United States
Cambridge Medical Trials
Alexandria, Louisiana, 71301, United States
Louisiana Heart Center
Covington, Louisiana, 70433, United States
Clinical Trials of America, LLC
Monroe, Louisiana, 71201, United States
Tulane University Hospital and Clinic
New Orleans, Louisiana, 70112, United States
Anne Arundel Medical Center
Annapolis, Maryland, 21401, United States
Johns Hopkins University Hospital School of Medicine
Baltimore, Maryland, 21205, United States
MedStar Health Research Institute
Baltimore, Maryland, 21237, United States
Metropolitan Cardiovascular Consultants
Beltsville, Maryland, 20705, United States
Spectrum Clinical Research
Towson, Maryland, 21204, United States
Tufts Medical Center
Boston, Massachusetts, 02111, United States
East Mountain Medical Associates, PC
Great Barrington, Massachusetts, 01230, United States
Alpena General Hospital
Alpena, Michigan, 49707, United States
Regions Hospital
Saint Paul, Minnesota, 55101, United States
Saint Louis University
St Louis, Missouri, 63110, United States
SLHV
St Louis, Missouri, 63136, United States
Palm Research Center
Las Vegas, Nevada, 89148, United States
Advanced Heart Care, LLC
Bridgewater, New Jersey, 08807, United States
Trinity Medical WNY, PC
Cheektowaga, New York, 14227, United States
Northwell Health
Great Neck, New York, 11021, United States
Mount Sinai School of Medicine
Lake Success, New York, 11041, United States
St. Luke's Roosevelt Hospital
New York, New York, 10025, United States
Harlem Cardiology
New York, New York, 10035, United States
Stony Brook University Medical Center
Stony Brook, New York, 11794, United States
Cardiac Care and Vascular Medicine, PLLC
The Bronx, New York, 10469, United States
Asheville Cardiology Associates
Asheville, North Carolina, 28803, United States
Kernodle Clinic West
Burlington, North Carolina, 27215, United States
The University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, 27599-5021, United States
Novant Health Heart and Vascular Institute
Charlotte, North Carolina, 28204, United States
Duke University Medical Center
Durham, North Carolina, 27609, United States
Clinical Research of Gastonia
Gastonia, North Carolina, 28054, United States
Clinical Trials of America, Inc
Lenoir, North Carolina, 28645, United States
Rama Research LLC
Marion, Ohio, 43302, United States
University of Toledo
Toledo, Ohio, 43614, United States
South Oklahoma Heart Research Group
Oklahoma City, Oklahoma, 73135, United States
Doylestown Health Cardiology
Doylestown, Pennsylvania, 18901, United States
York Hospital, WellSpan Health
York, Pennsylvania, 17403, United States
AnMed Health Clinical Research
Anderson, South Carolina, 29621, United States
Ralph H. Johnson VA Medical Center
Charleston, South Carolina, 29401, United States
Palmetto Health
Columbia, South Carolina, 29203, United States
William Jennings Bryan Dorn VA Medical Center
Columbia, South Carolina, 29209, United States
Clinical Research of Rock Hill
Rock Hill, South Carolina, 29732, United States
Palmetto Research Center, LLC
Spartanburg, South Carolina, 29302, United States
Methodist University Hospital
Memphis, Tennessee, 38104, United States
Baylor Heart and Vascular Hospital
Dallas, Texas, 75226, United States
Soltero Cardiovascular Research Center
Dallas, Texas, 75226, United States
University of Texas Southwestern Medical Center
Dallas, Texas, 75390-8837, United States
University of North Texas Health Science Center
Fort Worth, Texas, 76107, United States
The Methodist Hospital
Houston, Texas, 77030, United States
The Heart Hospital
Plano, Texas, 75093, United States
Alpine Research Organization
Farmington, Utah, 84025, United States
Cardiac Health Management Network, P.C.
Chester, Virginia, 23836, United States
Hunter Holmes McGuire VA Medical Center
Richmond, Virginia, 23249, United States
Roanoke Heart Institute PLC
Roanoke, Virginia, 24014, United States
Salem VA Medical Center
Salem, Virginia, 24153, United States
Marshfield Clinic
Marshfield, Wisconsin, 54449, United States
Hospital Interzonal General de Agudos Dr Jose Penna
Bahía Blanca, B8001DDU, Argentina
Hospital Italiano Regional del Sur, Bahia Blanca
Bahía Blanca, B8001HXM, Argentina
CIPREC
CABA, C1119ACN, Argentina
Hospital Italiano de Buenos Aires
CABA, C1199ABB, Argentina
Consultorios Asociados de Endocrinología e Invest Clínica
Ciudad Autonoma Buenos Aires, C1425AGC, Argentina
Instituto Cardiovascular de Buenos Aires
Ciudad Autonoma Buenos Aires, C1428ART, Argentina
CCBR - Buenos Aires - AR
Ciudad Autonoma Buenos Aires, C1430CKE, Argentina
Centro Médico Viamonte
Ciudad Autonoma de Bs As, C1120AAC, Argentina
Sanatorio Güemes
Ciudad Autónoma de Bs As, C1180AAX, Argentina
Instituto Medico Elsa Perez SRL (IMEP)
Ciudadela, 1702, Argentina
Clinica Coronel Suarez SA
Coronel Suárez, B7540DOL, Argentina
Instituto de Cardiología de Corrientes
Corrientes, W3400AMZ, Argentina
Sanatorio Mayo Privado SA
Córdoba, 5000, Argentina
Centro de Investigaciones Clinicas Instituto del Corazon
Córdoba, X5000EVQ, Argentina
Sanatorio Allende S.A.
Córdoba, X5000JHQ, Argentina
Clínica Colombo
Córdoba, X5002AOQ, Argentina
Instituto Médico DAMIC S.R.L.
Córdoba, X5003DCE, Argentina
Hospital Privado
Córdoba, X5016KEH, Argentina
Hospital Italiano de La Plata
La Plata, B1900AXI, Argentina
Centro de Investigaciones Médicas
Mar del Plata, B7600FYK, Argentina
Hospital Privado de Comunidad
Mar del Plata, B7602CBM, Argentina
Clínica Olivos
Olivos, 1602, Argentina
CER Instituto Médico
Quilmes, B1878DVB, Argentina
Instituto de Investigaciones Clínicas de Quilmes
Quilmes, B1878GEG, Argentina
Instituto de Investigaciones Clinicas de Rosario
Rosario, 2000, Argentina
Instituto Medico Fundación Grupo Colaborativo Rosario
Rosario, 2000, Argentina
Sanatorio Británico
Rosario, 2000, Argentina
Sanatorio Plaza
Rosario, 2000, Argentina
Sanatorio Parque
Rosario, S2000DSV, Argentina
Instituto CAICI
Rosario, S2000PBJ, Argentina
CORDIS S.A., Salta
Salta, A4400ANW, Argentina
Centro Cardiovascular Salta
Salta, A4406BFP, Argentina
Corporacion Medica de Gral. San Martin S.A.
San Martín, B1650CSQ, Argentina
Investigaciones Clinicas Tucuman
San Miguel de Tucumán, T4000ICL, Argentina
Instituto de Cardiología
San Miguel de Tucumán, T4000JCU, Argentina
CCBR Tucuman
San Miguel de Tucumán, T4000, Argentina
Centro Medico Luquez
San Vicente, X5006CBI, Argentina
Centro de Investigaciones Clínicas del Litoral
Santa Fe, S3000FWO, Argentina
Hospital "Dr. José Maria Cullen "
Santa Fé, S3000EOZ, Argentina
CEMEDIC - Centro de Especialidades Medicas
Villa Luro, C1440CFD, Argentina
John Hunter Hospital
New Lambton Heights, New South Wales, 2305, Australia
CORE Research Group
Milton, Queensland, 4064, Australia
Mater Hospital Brisbane
South Brisbane, Queensland, 4101, Australia
SA-Heart Ashford Specialist Centre
Ashford, South Australia, 5035, Australia
Heart and Vascular Research
Fullarton, South Australia, 5063, Australia
The Northern Hospital
Epping, Victoria, 3076, Australia
St Vincent's Hospital Melbourne
Fitzroy, Victoria, 3065, Australia
University Hospital Geelong
Geelong, Victoria, 3220, Australia
Royal Melbourne Hospital
Parkville, Victoria, 3050, Australia
AZ Sint-Jan Brugge
Bruges, 3000, Belgium
C.H.U. de Charleroi
Charleroi, 6000, Belgium
AZ Sint-Blasius
Dendermonde, 9200, Belgium
Ziekenhuis Oost-Limburg - Campus Sint-Jan
Genk, 3600, Belgium
AZ Sint-Lucas - Campus Sint Lucas
Ghent, 9000, Belgium
Grand Hôpital de Charleroi
Gilly, 6060, Belgium
Jessa Ziekenhuis - Campus Virga Jesse
Hasselt, 3500, Belgium
La Louvière - UNIV CHU Tivoli
La Louvière, 7100, Belgium
UZ Leuven
Leuven, 3000, Belgium
AZ Sint-Maarten
Mechelen, 2800, Belgium
Hospital Felicio Rocho
Belo Horizonte, 30110-060, Brazil
Hospital Vera Cruz
Belo Horizonte, 30140-062, Brazil
Cardresearch Cardiologia Assistencial e de Pesquisas Ltda
Belo Horizonte, 30150-240, Brazil
CCBR - Brasília
Brasília, 70200-730, Brazil
ICDF - Instituto de Cardiologia do Distrito Federal
Brasília, 70673-900, Brazil
CECAP - Centro de Cardiologia Clínica
Brasília, 70710-100, Brazil
Hospital Angelina Caron
Campina Grande do Sul, 83430-000, Brazil
Centro Especializado em Cardiol Loema Instituto de Pesq Clin
Campinas, 13010-001, Brazil
IPECC - Instituto de Pesquisa Clínica de Campinas
Campinas, 13060-080, Brazil
CAEP - Centro Avançado de Estudos e Pesquisas Ltda.,Campinas
Campinas, 13087-567, Brazil
Hospital Universitário
Canoas, 92425-900, Brazil
IPCEM - Instituto de Pesquisa Clínica para Estudos Multicêntricos - Universidade de Caxias do Sul
Caxias do Sul, 95070-560, Brazil
Irmandade da Santa Casa de Misericórdia de Curitiba
Curitiba, 80230-130, Brazil
Hospital de Messejana Dr. Carlos Alberto Studart Gomes
Fortaleza, 60846-190, Brazil
Barroso e Sebba Ltda
Goiânia, 74223-130, Brazil
HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás
Goiânia, 74605-020, Brazil
ICM - Instituto do Coracao de Marilia
Marília, 17515-000, Brazil
Hospital São Vicente de Paulo
Passo Fundo, 99010-080, Brazil
Santa Casa de Misericórdia de Porto Alegre
Porto Alegre, 90035-074, Brazil
Centro de Pesquisas em Diabetes
Porto Alegre, 90035-170, Brazil
Hospital de Clínicas de Porto Alegre
Porto Alegre, 90035-903, Brazil
Instituto de Cardiologia Rio Grande do Sul
Porto Alegre, 90620-001, Brazil
Hospital Agamenon Magalhaes
Recife, 52051-380, Brazil
H.C.da Fac. de Medicina de Ribeirao Preto
Ribeirão Preto, 14048-900, Brazil
CCBR - Rio de Janeiro - BR
Rio de Janeiro, 22271-100, Brazil
Hospital Universitário Pedro Ernesto UERJ
Rio de Janeiro - RJ, CEP 20551, Brazil
Pesquisare
Santo André, 09080-110, Brazil
Praxis Pesquisa Médica
Santo André, 09090-790, Brazil
CEMEC - Centro Multidisciplinar de Estudos Clínicos
São Bernardo do Campo, 09780-000, Brazil
Fundacao Faculdade Regional de Medicina, Sao Jose
São José do Rio Preto, 15090-000, Brazil
Centro de Pesquisa Clinica - CPCLIN
São Paulo, 01244-030, Brazil
FGM - Clínica Paulista de Doenças Cardiovasculares
São Paulo, 01323-000, Brazil
CDEC BRASIL - Centro de Desenvolvimento em Estudos Clínicos Brasil
São Paulo, 04020-060, Brazil
Dr. Consulta
São Paulo, 04208-002, Brazil
CEPIC - Centro Paulista de Investigacao Clinica
São Paulo, 04266-010, Brazil
INCOR e Hospital das Clínicas da Universidade de São Paulo
São Paulo, 05403-000, Brazil
CEDOES - Diagnóstico e Pesquisa,Vitória
Vitória, 29055-450, Brazil
Santa Casa de Votuporanga
Votuporanga, 15500-003, Brazil
Royal Alexandra Hospital
Edmonton, Alberta, T5H 3V9, Canada
Vancouver General Hospital
Vancouver, British Columbia, V5Z 1M9, Canada
St. Paul's Hospital
Vancouver, British Columbia, V6Z 1Y6, Canada
Victoria Heart Institute Foundation
Victoria, British Columbia, V8R 4R2, Canada
St. Boniface General Hospital
Winnipeg, Manitoba, R2H 2A6, Canada
G.A. Research Associates Ltd
Moncton, New Brunswick, E1G 1A7, Canada
QEII Health Sciences Centre
Halifax, Nova Scotia, B3H 2Y9, Canada
Brampton Cardio Pulmonary Clinic
Brampton, Ontario, L6W 2X7, Canada
JBN Medical Diagnostic Services Inc.
Burlington, Ontario, L7M 4Y1, Canada
Cambridge Cardiac Care Inc.
Cambridge, Ontario, N1R 6V6, Canada
Health Sciences North
Greater Sudbury, Ontario, P3E 5J1, Canada
Curnew Medicine Professional Corporation
Hamilton, Ontario, L8L 0A9, Canada
Hamilton General Hospital
Hamilton, Ontario, L8L 2X2, Canada
Southlake Regional Health Centre
Newmarket, Ontario, L3Y 2P6, Canada
M Heffernan Medicine Professional Corp.
Oakville, Ontario, L6K 3W7, Canada
Kawartha Cardiology Clinical Trials
Peterborough, Ontario, K9J 0B2, Canada
Heart Health Institute
Scarborough Village, Ontario, M1B 4Z8, Canada
Scarborough Cardiology Research
Scarborough Village, Ontario, M1E 5E9, Canada
Canadian Phase Onward Inc.
Toronto, Ontario, M3J 2C5, Canada
North York Diagnostic and Cardiac Centre
Toronto, Ontario, M6B 1N6, Canada
Diabetes Heart Research Centre
Toronto, Ontario, M6G 1M2, Canada
Mohan Babapulle Medicine Professional Medicine
Waterloo, Ontario, N2T 0C1, Canada
Dr. Louis C.H. Yao
York, Ontario, M9N 1W4, Canada
ViaCar Recherche Clinique Inc
Greenfield Park, Quebec, J4V 2G8, Canada
Centre de Dépistage et Recherche Cardiovasculaire Rive-Sud
Longeuil, Quebec, J4M 2X1, Canada
Clinique Santé Cardio MC
Montreal, Quebec, H1T 3Y7, Canada
Montreal General Hospital - McGill University Health Centre
Montreal, Quebec, H3G 1A4, Canada
McGill University Health Centre (MUHC)
Montreal, Quebec, H4A 3J1, Canada
Centre de sante et de services sociaux de Beauce
Saint George-de-Beauce, Quebec, G5Y 4T8, Canada
IUCPQ (Laval University)
Québec, G1V 4G5, Canada
Cardiovascular Institute and Fu Wai Hospital
Beijing, 100037, China
Beijing Friendship Hospital
Beijing, 100050, China
First Hospital of Jilin University
Changchun, 130021, China
Hunan Provincial People's Hospital
Changsha, 410005, China
2nd Xiangya Hospital of Central South University
Changsha, 410011, China
The Third Hospital of Changsha
Changsha, 410015, China
Dongguan People's Hospital
Dongguan, 523059, China
The First Affiliated Hospital of Fujian Medical University
Fuzhou, 350005, China
The First Afiliated Hospital, Sun Yet-sen University
Guangzhou, 510080, China
Guangzhou First Municipal People's Hospital
Guangzhou, 510180, China
Haikou People's Hospital
Haikou, 570208, China
HaiNan Provincial People's Hospital
Haikou, 570311, China
The First Affiliated Hospital of Lanzhou University
Lanzhou, 730000, China
The Second Affiliated Hospital of Lanzhou Medical University
Lanzhou, 730030, China
The Affiliated Hospital of Southwest Medical University
Luzhou, 646099, China
Nanchang University Affiliated 3rd Hospital
Nanchang, 330008, China
First Hospital Affiliated with Nanjing Medical University
Nanjing, 210029, China
Huashan Hospital, Fudan University
Shanghai, 200040, China
General Hospital of Shenyang Military Region
Shenyang, 110015, China
Shengjing Hospital of China Medical University
Shenyang, 110072, China
Tianjin Union Medical Center Nankai University Affiliated Hospital
Tianjin, 300121, China
Tongji Hospital, Tongji University
Wuhan, 430030, China
Renmin Hospital of Wuhan University
Wuhan, 430060, China
First Affiliated Hospital of Xi'an JiaoTong University
Xi'an, 710061, China
Yanbian University Hospital
Yanji, 133000, China
the first people hospital of Yue Yang
Yueyang, 414000, China
Affiliated Hospital of Jiangsu University
Zhenjiang, 212013, China
Poliklinika Humanitas
Bílovec, 74301, Czechia
Medicus Services Ltd.
Brandys Nad, 250 01, Czechia
Internal and Cardiology Practice, MUDr. Karel Kamenik, Brno
Brno, 603 00, Czechia
MUDr. Alexandra Ludkova
Brno, 615 00, Czechia
Vojenska nemocnice Brno
Brno, 63600, Czechia
Nemocnice Milosrdnych bratri
Brno, 63900, Czechia
Edumed s.r.o
Broumov, 55001, Czechia
MUDr. Jan Hubac, s.r.o. Kardiologicka ambulance
Chrudim, 53702, Czechia
Nemocnice ve Frydku-Mistku, prispevkova organizace
Frýdek-Místek, 73818, Czechia
MUDr. Ladislav Busak
Louny, 440 01, Czechia
Zdenek Vomacka
Olomouc, 779 00, Czechia
PV-Kardiologie s.r.o.
Pardubice, 53002, Czechia
General Faculty Hospital, Prague
Prague, 128 08, Czechia
University Hospital Motol
Prague, 15006, Czechia
Thomayer Hospital
Praha 4 - Krc, 140 59, Czechia
Kardio Vaclavik s.r.o.
Přerov, 75000, Czechia
Clinic of Cardiology, Pribram
Příbram, 261 01, Czechia
Hospital Trebic, p.o.
Třebíč, 67401, Czechia
Masaryk Hospital, Usti nad Labem
Ústí nad Labem, 40113, Czechia
Angiocor s.r.o
Zlín, 76001, Czechia
KIGE s.r.o
Znojmo, 66902, Czechia
HOP de Bayonne
Bayonne, 64100, France
HOP Jean Minjoz
Besançon, 25030, France
HOP Louis Pradel
Bron, 69500, France
HOP Côte de Nacre
Caen, 14033, France
HOP Arnaud de Villeneuve
Montpellier, 34295, France
HOP La Pitié Salpêtrière
Paris, 75651, France
Centre Hospitalier de Pau
Pau, 64046, France
HOP Haut-Lévêque
Pessac, 33600, France
HOP Rangueil
Toulouse, 31059, France
INS Louis Mathieu
Vandœuvre-lès-Nancy, 54511, France
Universitätsklinikum Aachen, AöR
Aachen, 52074, Germany
Praxis Dr. Rieker, Berlin
Berlin, 10789, Germany
Charité - Universitätsmedizin Berlin
Berlin, 12200, Germany
Vivantes Netzwerk für Gesundheit GmbH
Berlin, 12351, Germany
Charité - Universitätsmedizin Berlin
Berlin, 13353, Germany
Klinikum Bielefeld gGmbH
Bielefeld, 33604, Germany
Praxis Dr. Menzel
Dessau, 06846, Germany
St. Johannes Hospital Dortmund
Dortmund, 44137, Germany
Städtisches Klinikum Dresden
Dresden, 01067, Germany
GWT-TUD GmbH
Dresden, 01307, Germany
Helios Klinikum Erfurt
Erfurt, 99089, Germany
Studienzentrum Bocholderstraße
Essen, 45355, Germany
ClinPhenomics GmbH & Co KG, Frankfurt
Frankfurt, 60594, Germany
Universitätsmedizin Göttingen, Georg-August-Universität
Göttingen, 37075, Germany
Asklepios Klinik St. Georg
Hamburg, 20099, Germany
Medizinische Hochschule Hannover
Hanover, 30625, Germany
Universitätsklinikum Heidelberg
Heidelberg, 69120, Germany
Universitätsklinikum des Saarlandes
Homburg, 66421, Germany
Universitätsklinikum Jena
Jena, 07740, Germany
Universitätsklinikum Schleswig-Holstein, Campus Kiel
Kiel, 24105, Germany
Asklepios Klinik Langen-Seligenstadt GmbH
Langen, 63225, Germany
Märkische Gesundheitsholding GmbH & Co. KG, Klinikum Lüdenscheid
Lüdenscheid, 58515, Germany
Praxis Dr. Sarnighausen, Lüneburg
Lüneburg, 21339, Germany
Katholisches Klinikum St. Hildegardiskrankenhaus, Mainz
Mainz, 55131, Germany
Deutsches Herzzentrum München
München, 80636, Germany
Kardiologische Gemeinschaftspraxis Nienburg
Nienburg, 31582, Germany
Kardiologische Praxis Papenburg
Papenburg, 26871, Germany
Universitätsklinikum Regensburg
Regensburg, 93053, Germany
Praxis Dr. Stenzel, Riesa
Riesa, 01587, Germany
Zentrum für Klinische Forschung
Wangen, 88239, Germany
Josephs-Hospital Warendorf
Warendorf, 48231, Germany
Petrus-Krankenhaus
Wuppertal, 42283, Germany
Lausmed Kft. Outpatient Unit of Internal Medicine
Baja, 6500, Hungary
Belgyogyaszati es Kardiologiai Maganrendelo
Békéscsaba, 5600, Hungary
Clinexpert Kft.
Budapest, 1033, Hungary
Gottsegen Gyorgy Hungarian Instit.of Cardiology,Budapest
Budapest, 1096, Hungary
Bajcsy-Zsilinszky Hospital and Clinic
Budapest, 1106, Hungary
Semmelweis University
Budapest, 1122, Hungary
Milit.Hosp.-State Health Cent.
Budapest, 1134, Hungary
Uzsoki Street Hospital, Budapest
Budapest, 1145, Hungary
Nehezlegzes Ambulancia
Debrecen, 4027, Hungary
Bugat Pal Hospital, Gyongyos
Gyöngyös, 3200, Hungary
Selye Janos Hospital Komarom
Komárom, 2900, Hungary
Dorottya Kanizsai Hospital
Nagykanizsa, 8800, Hungary
Dr. Nagy Laszlo Kardiologiai Maganrendeles
Orosháza, 5900, Hungary
Pecsi Tudomanyegyetem
Pécs, 7623, Hungary
Da Vinci Maganklinika
Pécs, 7635, Hungary
Fejer County Saint George University Teaching Hospital
Székesfehérvár, 8000, Hungary
Veszpremi Sziv es Egeszseg Centrum
Veszprém, 8200, Hungary
Doctor Jivraj Mehta Smarak Health Foundation
Ahmedabad, 380007, India
Kamalnayan Bajaj Hospital
Aurangabad, 431 005, India
Narayana Institute of Cardiac Sciences
Bangalore, 560099, India
Rajarajeswari Medical College
Bengaluru, 560074, India
Madras Medical Mission,
Chennai, 600 037, India
Apollo Speciality Hospital
Chennai, 600035, India
Medanta-The Medicity
Gūrgaon, 122001, India
B.M. Birla Heart research Centre
Kolkata, 700027, India
Vijan Cardiac and Critical Care Centre
Nashik, 422005, India
Siddhi Hospital
Nashik, 422007, India
Batra Hospital and Medical Research Centre
New Delhi, 110 062, India
GB Pant Hospital
New Delhi, 110002, India
Fortis Escorts Heart Institute
New Delhi, 110025, India
Sir Gangaram Hospital
New Delhi, 110060, India
Azienda Ospedaliera G. Rummo
Benevento, 82100, Italy
ASST Papa Giovanni XXIII - A.O. Papa Giovanni XXIII
Bergamo, 24127, Italy
Azienda Ospedaliera Universitaria Arcispedale Sant'Anna
Cona (FE), 44124, Italy
Ospedale della Val di Chiana Santa Margherita
Cortona (AR), 52040, Italy
Centro Cardiologico Monzino-IRCCS
Milan, 20138, Italy
Azienda Ospedaliera Universitaria "Federico II"
Napoli, 80131, Italy
Azienda Ospedaliera Universitaria Pisana
Pisa, 56126, Italy
Umberto I Pol. di Roma-Università di Roma La Sapienza
Roma, 00161, Italy
Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza
Roma, 00189, Italy
Azienda Servizi Sanitari 1 Triestina
Trieste, 34128, Italy
Kasugai Municipal Hospital
Aichi, Kasugai, 486-8510, Japan
Nagoya Kyoritsu Hospital
Aichi, Nagoya, 454-0933, Japan
Japanese Red Cross Nagoya Daini Hospital
Aichi, Nagoya, 466-8650, Japan
Toyota Memorial Hospital
Aichi, Toyota, 471-8513, Japan
Chiba Heart Clinic
Chiba, Chiba, 263-0043, Japan
Kimitsu Chuo Hospital
Chiba, Kisarazu, 292-8535, Japan
Seikeikai New Tokyo Heart Clinic
Chiba, Matsudo, 271-0077, Japan
Ehime Prefectural Central Hospital
Ehime, Matsuyama, 790-0024, Japan
Matsuyama Shimin Hospital
Ehime, Matsuyama, 790-0067, Japan
Uwajima City Hospital
Ehime, Uwajima, 798-8510, Japan
Fukuiken Saiseikai Hospital
Fukui, Fukui, 918-8503, Japan
Fukuoka University Chikushi Hospital
Fukuoka, Chikushino, 818-8502, Japan
Fukuokaken Saiseikai Futsukaichi Hospital
Fukuoka, Chikushino, 818-8516, Japan
Saiseikai Fukuoka General Hospital
Fukuoka, Fukuoka, 810-0001, Japan
National Hospital Organization Kyushu Medical Center
Fukuoka, Fukuoka, 810-8563, Japan
Kyushu University Hospital
Fukuoka, Fukuoka, 812-8582, Japan
Aso Co.,Ltd Iizuka Hospital
Fukuoka, Iizuka, 820-8505, Japan
Steel Memorial Yawata Hospital
Fukuoka, Kitakyushu, 805-8508, Japan
Japan Community Health Care Organization Kyushu Hospital
Fukuoka, Kitakyushu, 806-8501, Japan
Ogaki Municipal Hospital
Gifu, Ogaki, 503-8502, Japan
Chuno Kosei Hospital
Gifu, Seki, 501-3802, Japan
Fukuyama City Hospital
Hiroshima, Fukuyama, 721-8511, Japan
JA Hiroshima General Hospital
Hiroshima, Hatsukaichi, 738-8503, Japan
Shobara Red Cross Hospital
Hiroshima, Shobara, 727-0013, Japan
National Hospital Organization Hakodate Hospital
Hokkaido, Hakodate, 041-8512, Japan
Teine Keijinkai Clinic
Hokkaido, Sapporo, 006-0811, Japan
Tomakomai City Hospital
Hokkaido, Tomakomai, 053-8567, Japan
Hyogo Prefectural Amagasaki General Medical Center
Hyogo, Amagasaki, 660-8550, Japan
Hyogo Brain and Heart Center
Hyogo, Himeji, 670-0981, Japan
National Hospital Organization Kobe Medical Center
Hyogo, Kobe, 654-0155, Japan
Mito Medical Center
Ibaraki, Higashiibaraki-gun, 311-3193, Japan
National Hospital Organization Kanazawa Medical Center
Ishikawa, Kanazawa, 920-8650, Japan
Mitoyo General Hospital
Kagawa, Kanonji, 769-1695, Japan
Kagawa Prefectural Central Hospital
Kagawa, Takamatsu, 760-8557, Japan
Yamamoto Clinic
Kanagawa, Sagamihara, 252-0311, Japan
Kanagawa Cardiovascular and Respiratory Center
Kanagawa, Yokohama, 236-0051, Japan
Japanese Red Cross Kumamoto Hospital
Kumamoto, Kumamoto, 861-8520, Japan
Seiwakai Suizenji Touya Hospital
Kumamoto, Kumamoto, 862-0950, Japan
Kumamoto Rosai Hospital
Kumamoto, Yatsushiro, 866-8533, Japan
Uji-Tokushukai Medical Center
Kyoto, Uji, 611-0041, Japan
Sendai Kousei Hospital
Miyagi, Sendai, 980-0873, Japan
Sendai Tokushukai Hospital
Miyagi, Sendai, 981-3131, Japan
The Cardiovascular Center of Sendai
Miyagi, Sendai, 981-3133, Japan
National Hospital Organization Sendai Medical Center
Miyagi, Sendai, 983-8520, Japan
Miyazaki Medical Association Hospital
Miyazaki, Miyazaki, 880-0834, Japan
Hokushin General Hospital
Nagano, Nakano, 383-8505, Japan
Nagasaki Medical Center
Nagasaki, Omura, 856-8562, Japan
Okayama City General Medical Center
Okayama, Okayama, 700-8557, Japan
Naha City Hospital
Okinawa, Naha, 902-8511, Japan
Nanbu Tokushukai Hospital
Okinawa, Shimajiri-gun, 901-0493, Japan
Urasoe General Hospital
Okinawa, Urasoe, 901-2132, Japan
Higashiosaka City Medical Center
Osaka, Higashiosaka, 578-8588, Japan
Kitano Hospital
Osaka, Osaka, 530-8480, Japan
Yodogawa Christian Hospital
Osaka, Osaka, 533-0024, Japan
Seichokai Bell Land General Hospital
Osaka, Sakai, 599-8247, Japan
Hokusetsu General Hospital
Osaka, Takatsuki, 569-8585, Japan
San-Ai Hospital
Saitama, Saitama, 338-0837, Japan
Kosekai Iwatsuki-minami Hospital
Saitama, Saitama, 339-0033, Japan
Kusatsu General Hospital
Shiga, Kusatsu, 525-8585, Japan
Tokushima Prefectural Central Hospital
Tokushima, Tokushima, 770-8539, Japan
National Hospital Organization Tokyo Medical Center
Tokyo, Meguro-ku, 152-8902, Japan
Ome Municipal General Hospital
Tokyo, Ome, 198-0042, Japan
Tokyo Rosai Hospital
Tokyo, Ota-ku, 143-0013, Japan
Sekino Hospital
Tokyo, Toshima-ku, 171-0014, Japan
Minami Wakayama Medical Center
Wakayama, Tanabe, 646-8558, Japan
Kanmon Medical Center
Yamaguchi, Shimonoseki, 752-8510, Japan
Hospital Cardiologica Aguascalientes
Aguascalientes, 20230, Mexico
Centro de Investigacion Biomedica y Farmaceutica, S.C.
Distrito Federal, 03100, Mexico
Unidad de Investigacion Clinica Cardiometabolica de Occident
Guadalajara, 44150, Mexico
Diseño y Planeación en Investigación Médica SC
Guadalajara, 44656, Mexico
Cardiologia Clinica e Intervencionista
Guadalajara, 44670, Mexico
Instituto Nacional de Cardiologia Ignacio Chavez
Mexico City, 14080, Mexico
Centro de Investigación Clinica Acelerada, S.C.
México, 07020, Mexico
CEDOPEC-Ctro Esp en Diab, Obesidad y Prev de Enf Cardiovasc
México, 11650, Mexico
Instituto Cardiovascular de Monclova, S de RL de CV
Monclova, 25750, Mexico
Hospital Universitario Dr Jose Eleuterio Gonzalez
Nuevo León, 64460, Mexico
Centro Integral Medico SJR S.C.
San Juan del Río, 76800, Mexico
Cardioarritmias e Investigación S.C
San Luis Potosí City, 78213, Mexico
Centro de Investigacion Cardiovascular y Metabolica
Tijuana, 22500, Mexico
Centro de Investigacion Medica Alberto Bazzoni S.A. de C.V.
Torreón, 27000, Mexico
Hospital Dr Angel Leano
Zapopan, 45200, Mexico
Ziekenhuisgroep Twente locatie Almelo
Almelo, 7609 PP, Netherlands
BovenIJ Ziekenhuis
Amsterdam, 1034 CS, Netherlands
Onze Lieve Vrouwe Gasthuis, Locatie West
Amsterdam, 1061 AE, Netherlands
Amsterdam UMC Locatie VUMC
Amsterdam, 1081HV, Netherlands
Onze Lieve Vrouwe Gasthuis
Amsterdam, 1091AC, Netherlands
Amsterdam UMC, Locatie AMC
Amsterdam, 1105 AZ, Netherlands
Rode Kruis Ziekenhuis Beverwijk
Beverwijk, 1942 LE, Netherlands
Tergooiziekenhuizen locatie Blaricum
Blaricum, 1261 AN, Netherlands
Amphia Ziekenhuis
Breda, 4818 CK, Netherlands
Ziekenhuis Gelderse Vallei
Ede, 6716 RP, Netherlands
Catharina Ziekenhuis
Eindhoven, 5623 EJ, Netherlands
Universitair Medisch Centrum Groningen
Groningen, 9713 GZ, Netherlands
Zuyderland Medisch Centrum
Heerlen, 6419 PC, Netherlands
Vasculair Onderzoek Centrum
Hoorn, 1624 NP, Netherlands
Maastricht Universitair Medisch Centrum
Maastricht, 6229 HX, Netherlands
Diaconessenhuis Meppel
Meppel, 7943 KA, Netherlands
St. Antonius ziekenhuis, locatie Nieuwegein
Nieuwegein, 3435 CM, Netherlands
Radboud Universitair Medisch Centrum
Nijmegen, 6525 GL, Netherlands
HMC Bronovo
The Hague, 2597 AX, Netherlands
Ziekenhuis Bernhoven Uden
Uden, 5406 PT, Netherlands
Vie Curi Medisch Centrum
Venlo, 5912 BL, Netherlands
De Heel - Zaans Medisch Centrum
Zaandam, 1502 DV, Netherlands
Gelre Ziekenhuis Zutphen
Zutphen, 7207 AE, Netherlands
KLIMED Marek Klimkiewicz
Bialystok, 15-765, Poland
Univ. Clinic Hosp, Bialystok
Bialystok, 15276, Poland
American Heart of Poland Sp. z o.o.
Bielsko-Biala, 43-316, Poland
NZOZ Centrum Medyczne KERmed
Bydgoszcz, 85231, Poland
Polsko-Amerykanskie Kliniki Serca
Chorzów, 32-500, Poland
American Heart of Poland Sp. z o.o.
Dąbrowa Górnicza, 41-300, Poland
Poradnia Kardiologiczna Jaroslaw Jurowiecki
Gdansk, 80-286, Poland
University Clinical Center, Gdansk
Gdansk, 80952, Poland
Indywidualna Specjalistyczna Praktyka Lekarska
Gdynia, 81-157, Poland
Saint Wincenty a Paulo Hosp., Cardiology Dept., Gdynia
Gdynia, 81348, Poland
Szpital Zakonu Bonifratow Sp. z o.o.
Katowice, 40-211, Poland
Specialistic Cardiology&Hypertension Out-patient Clin,Kielce
Kielce, 25525, Poland
Leszek Bryniarski Specialized Medical Cabinet
Krakow, 30-082, Poland
Krakow Specialistic Hospital of John Paul II
Krakow, 31-202, Poland
SANTA FAMILIA Centrum Badan, Profilaktyki i Leczenia
Lodz, 90-302, Poland
Nzoz Salus
Lodz, 91-302, Poland
Individual Specialized Practice
Lodz, 94-255, Poland
Lowickie Cardiology Center
Lowicz, 99-400, Poland
American Heart of Poland Sp. z o.o.
Nysa, 48-300, Poland
Medicome Sp. z o.o.
Oświęcim, 32-600, Poland
Specialized Practice Dr. Janusz Spyra
Ruda Śląska, 41-709, Poland
Centrum Medyczne Medyk
Rzeszów, 35-055, Poland
Lukmed Lukasz Wozniak
Siedlce, 08-110, Poland
Clinmedica Research Omc sp. z o.o. sp.k., Skierniewice
Skierniewice, 96-100, Poland
KO-MED Centra Kliniczne Staszow
Staszów, 28-200, Poland
The Provincial Polyclinical Hospital in Torun
Torun, 87-100, Poland
American Heart of Poland Sp. z o.o.
Tychy, 43-100, Poland
American Heart of Poland Sp. z o.o.
Ustroń, 43-450, Poland
Central Hospital of Medical Academy, Warsaw
Warsaw, 02-097, Poland
McM Polimedica
Warsaw, 02-777, Poland
4. Military Clinical Hospital with Polyclinic SP ZOZ
Wroclaw, 50-981, Poland
Zgierskie Center of Cardiology MED-PRO
Zgierz, 95-100, Poland
Specialist Hospital J. Dietla NZOZ Specialized Clinic "Gemini"
Żychlin, 62-571, Poland
Dong-A University Hospital
Busan, 602-715, South Korea
Inje University Busan Paik Hospital
Busan, 614-735, South Korea
Chungbuk National University Hospital
Cheongju-si, 361-771, South Korea
Chungnam National University Hospital
Daejeon, 35015, South Korea
Gachon University Gil Medical Center
Incheon, 21565, South Korea
Seoul National University Hospital
Seoul, 03080, South Korea
Severance Hospital
Seoul, 03722, South Korea
Asan Medical Center
Seoul, 05505, South Korea
Samsung Medical Center
Seoul, 06351, South Korea
Korea University Guro Hospital
Seoul, 08308, South Korea
Seoul National University Bundang Hospital
Sungnam, 463-707, South Korea
Wonju Severance Christian Hosp
Wŏnju, 26426, South Korea
Hospital Quiron. I.C.U.
Barcelona, 08023, Spain
Hospital Santa Creu i Sant Pau
Barcelona, 08026, Spain
Hospital Universitario Virgen de la Arrixaca
El Palmar, 30120, Spain
Hospital de Bellvitge
L'Hospitalet de Llobregat, 08907, Spain
Hospital Ramón y Cajal
Madrid, 28034, Spain
Hospital Clínico San Carlos
Madrid, 28040, Spain
Hospital Universitario 12 de Octubre
Madrid, 28041, Spain
Hospital La Paz
Madrid, 28046, Spain
Hospital Virgen de la Victoria
Málaga, 29010, Spain
Complejo Hospitalario Universitario de Orense
Ourense, 32005, Spain
Hospital Clínico de Santiago
Santiago de Compostela, 15706, Spain
Hospital Clínico Universitario de Valladolid
Valladolid, 47003, Spain
Barnet General Hospital
Barnet, EN5 3DJ, United Kingdom
University Hospital of Wales
Cardiff, CF14 4XW, United Kingdom
Park & St Francis Surgery
Eastleigh, SO53 4ST, United Kingdom
Wycombe General Hospital
High Wycombe, HP11 2TT, United Kingdom
Glenfield Hospital
Leicester, LE3 9QP, United Kingdom
St Bartholomew's Hospital
London, EC1A 7BE, United Kingdom
Luton and Dunstable University Hospital
Luton, LU4 0DZ, United Kingdom
St Mary's Hospital
Newport, PO30 5TG, United Kingdom
Morriston Hospital
Swansea, SA6 6NL, United Kingdom
Related Publications (29)
Packer M, Ferreira JP, Butler J, Filippatos G, Januzzi JL Jr, Gonzalez Maldonado S, Panova-Noeva M, Pocock SJ, Prochaska JH, Saadati M, Sattar N, Sumin M, Anker SD, Zannad F. Reaffirmation of Mechanistic Proteomic Signatures Accompanying SGLT2 Inhibition in Patients With Heart Failure: A Validation Cohort of the EMPEROR Program. J Am Coll Cardiol. 2024 Nov 12;84(20):1979-1994. doi: 10.1016/j.jacc.2024.07.013. Epub 2024 Aug 31.
PMID: 39217550DERIVEDNatale P, Tunnicliffe DJ, Toyama T, Palmer SC, Saglimbene VM, Ruospo M, Gargano L, Stallone G, Gesualdo L, Strippoli GF. Sodium-glucose co-transporter protein 2 (SGLT2) inhibitors for people with chronic kidney disease and diabetes. Cochrane Database Syst Rev. 2024 May 21;5(5):CD015588. doi: 10.1002/14651858.CD015588.pub2.
PMID: 38770818DERIVEDFerreira JP, Packer M, Sattar N, Butler J, Pocock SJ, Anker SD, Maldonado SG, Panova-Noeva M, Sumin M, Masson S, Zannad F, Januzzi JL. Carbohydrate antigen 125 concentrations across the ejection fraction spectrum in chronic heart failure: The EMPEROR programme. Eur J Heart Fail. 2024 Apr;26(4):788-802. doi: 10.1002/ejhf.3166. Epub 2024 Mar 4.
PMID: 38439582DERIVEDZannad F, Macari S. Drug treatment with empagliflozin lowered risk for hospitalization in people with heart failure with reduced ejection fraction: plain language summary of the EMPEROR-Reduced study. Future Cardiol. 2023 Oct;19(13):625-630. doi: 10.2217/fca-2023-0090. Epub 2023 Nov 9.
PMID: 37942680DERIVEDDhingra NK, Verma S, Butler J, Anker SD, Ferreira JP, Filippatos G, Januzzi JL, Lam CSP, Sattar N, Zaremba-Pechmann L, Bohm M, Nordaby M, Brueckmann M, Pocock SJ, Zannad F, Packer M; EMPEROR-Reduced Trial Committees and Investigators. Efficacy and Safety of Empagliflozin According to Background Diuretic Use in HFrEF: Post-Hoc Analysis of EMPEROR-Reduced. JACC Heart Fail. 2024 Jan;12(1):35-46. doi: 10.1016/j.jchf.2023.06.036. Epub 2023 Sep 13.
PMID: 37715769DERIVEDPacker M, Butler J, Zeller C, Pocock SJ, Brueckmann M, Ferreira JP, Filippatos G, Usman MS, Zannad F, Anker SD. Blinded Withdrawal of Long-Term Randomized Treatment With Empagliflozin or Placebo in Patients With Heart Failure. Circulation. 2023 Sep 26;148(13):1011-1022. doi: 10.1161/CIRCULATIONAHA.123.065748. Epub 2023 Aug 24.
PMID: 37621153DERIVEDCarson P, Teerlink JR, Komajda M, Anand I, Anker SD, Butler J, Doehner W, Ferreira JP, Filippatos G, Haass M, Miller A, Pehrson S, Pocock SJ, Schnaidt S, Schnee JM, Zannad F, Packer M. Comparison of Investigator-Reported and Centrally Adjudicated Heart Failure Outcomes in the EMPEROR-Reduced Trial. JACC Heart Fail. 2023 Apr;11(4):407-417. doi: 10.1016/j.jchf.2022.11.017. Epub 2023 Feb 1.
PMID: 36881400DERIVEDKhan MS, Butler J, Anker SD, Filippatos G, Ferreira JP, Pocock SJ, Januzzi JL, Pina IL, Bohm M, Ponikowski P, Verma S, Brueckmann M, Vedin O, Zeller C, Zannad F, Packer M. Impact of Empagliflozin in Heart Failure With Reduced Ejection Fraction in Patients With Ischemic Versus Nonischemic Cause. J Am Heart Assoc. 2023 Jan 3;12(1):e027652. doi: 10.1161/JAHA.122.027652. Epub 2022 Dec 24.
PMID: 36565199DERIVEDFerreira JP, Zannad F, Butler J, Filippatos G, Pocock SJ, Brueckmann M, Steubl D, Schueler E, Anker SD, Packer M. Association of Empagliflozin Treatment With Albuminuria Levels in Patients With Heart Failure: A Secondary Analysis of EMPEROR-Pooled. JAMA Cardiol. 2022 Nov 1;7(11):1148-1159. doi: 10.1001/jamacardio.2022.2924.
PMID: 36129693DERIVEDZannad F, Ferreira JP, Butler J, Filippatos G, Januzzi JL, Sumin M, Zwick M, Saadati M, Pocock SJ, Sattar N, Anker SD, Packer M. Effect of empagliflozin on circulating proteomics in heart failure: mechanistic insights into the EMPEROR programme. Eur Heart J. 2022 Dec 21;43(48):4991-5002. doi: 10.1093/eurheartj/ehac495.
PMID: 36017745DERIVEDZannad F, Ferreira JP, Gregson J, Kraus BJ, Mattheus M, Hauske SJ, Butler J, Filippatos G, Wanner C, Anker SD, Pocock SJ, Packer M; EMPEROR-Reduced Trial Committees and Investigators. Early changes in estimated glomerular filtration rate post-initiation of empagliflozin in EMPEROR-Reduced. Eur J Heart Fail. 2022 Oct;24(10):1829-1839. doi: 10.1002/ejhf.2578. Epub 2022 Jul 7.
PMID: 35711093DERIVEDFerreira JP, Zannad F, Butler J, Filipattos G, Ritter I, Schuler E, Kraus BJ, Pocock SJ, Anker SD, Packer M. Empagliflozin and serum potassium in heart failure: an analysis from EMPEROR-Pooled. Eur Heart J. 2022 Aug 14;43(31):2984-2993. doi: 10.1093/eurheartj/ehac306.
PMID: 35687107DERIVEDFerreira JP, Butler J, Zannad F, Filippatos G, Schueler E, Steubl D, Zeller C, Januzzi JL, Pocock S, Packer M, Anker SD. Mineralocorticoid Receptor Antagonists and Empagliflozin in Patients With Heart Failure and Preserved Ejection Fraction. J Am Coll Cardiol. 2022 Mar 29;79(12):1129-1137. doi: 10.1016/j.jacc.2022.01.029.
PMID: 35331406DERIVEDFerreira JP, Anker SD, Butler J, Filippatos G, Iwata T, Salsali A, Zeller C, Pocock SJ, Zannad F, Packer M. Impact of anaemia and the effect of empagliflozin in heart failure with reduced ejection fraction: findings from EMPEROR-Reduced. Eur J Heart Fail. 2022 Apr;24(4):708-715. doi: 10.1002/ejhf.2409. Epub 2022 Jan 9.
PMID: 34957660DERIVEDVerma S, Dhingra NK, Butler J, Anker SD, Ferreira JP, Filippatos G, Januzzi JL, Lam CSP, Sattar N, Peil B, Nordaby M, Brueckmann M, Pocock SJ, Zannad F, Packer M; EMPEROR-Reduced trial committees and investigators. Empagliflozin in the treatment of heart failure with reduced ejection fraction in addition to background therapies and therapeutic combinations (EMPEROR-Reduced): a post-hoc analysis of a randomised, double-blind trial. Lancet Diabetes Endocrinol. 2022 Jan;10(1):35-45. doi: 10.1016/S2213-8587(21)00292-8. Epub 2021 Nov 30.
PMID: 34861154DERIVEDRyden L, Ferrannini G. Is the impact of add on heart failure therapy influenced by background therapy? Lancet Diabetes Endocrinol. 2022 Jan;10(1):3-5. doi: 10.1016/S2213-8587(21)00311-9. Epub 2021 Nov 30. No abstract available.
PMID: 34861151DERIVEDBohm M, Anker SD, Butler J, Filippatos G, Ferreira JP, Pocock SJ, Mahfoud F, Brueckmann M, Jamal W, Ofstad AP, Schuler E, Ponikowski P, Wanner C, Zannad F, Packer M; EMPEROR-Reduced Trial Committees and Investigators. Empagliflozin Improves Cardiovascular and Renal Outcomes in Heart Failure Irrespective of Systolic Blood Pressure. J Am Coll Cardiol. 2021 Sep 28;78(13):1337-1348. doi: 10.1016/j.jacc.2021.07.049.
PMID: 34556320DERIVEDJanuzzi JL Jr, Zannad F, Anker SD, Butler J, Filippatos G, Pocock SJ, Ferreira JP, Sattar N, Verma S, Vedin O, Schnee J, Iwata T, Cotton D, Packer M; EMPEROR-Reduced Trial Committees and Investigators. Prognostic Importance of NT-proBNP and Effect of Empagliflozin in the EMPEROR-Reduced Trial. J Am Coll Cardiol. 2021 Sep 28;78(13):1321-1332. doi: 10.1016/j.jacc.2021.07.046.
PMID: 34556318DERIVEDPacker M, Butler J, Zannad F, Filippatos G, Ferreira JP, Pocock SJ, Carson P, Anand I, Doehner W, Haass M, Komajda M, Miller A, Pehrson S, Teerlink JR, Schnaidt S, Zeller C, Schnee JM, Anker SD. Effect of Empagliflozin on Worsening Heart Failure Events in Patients With Heart Failure and Preserved Ejection Fraction: EMPEROR-Preserved Trial. Circulation. 2021 Oct 19;144(16):1284-1294. doi: 10.1161/CIRCULATIONAHA.121.056824. Epub 2021 Aug 29.
PMID: 34459213DERIVEDPocock SJ, Ferreira JP, Gregson J, Anker SD, Butler J, Filippatos G, Gollop ND, Iwata T, Brueckmann M, Januzzi JL, Voors AA, Zannad F, Packer M. Novel biomarker-driven prognostic models to predict morbidity and mortality in chronic heart failure: the EMPEROR-Reduced trial. Eur Heart J. 2021 Nov 14;42(43):4455-4464. doi: 10.1093/eurheartj/ehab579.
PMID: 34423361DERIVEDLam CSP, Ferreira JP, Pfarr E, Sim D, Tsutsui H, Anker SD, Butler J, Filippatos G, Pocock SJ, Sattar N, Verma S, Brueckmann M, Schnee J, Cotton D, Zannad F, Packer M. Regional and ethnic influences on the response to empagliflozin in patients with heart failure and a reduced ejection fraction: the EMPEROR-Reduced trial. Eur Heart J. 2021 Nov 14;42(43):4442-4451. doi: 10.1093/eurheartj/ehab360.
PMID: 34184057DERIVEDFerreira JP, Zannad F, Pocock SJ, Anker SD, Butler J, Filippatos G, Brueckmann M, Jamal W, Steubl D, Schueler E, Packer M. Interplay of Mineralocorticoid Receptor Antagonists and Empagliflozin in Heart Failure: EMPEROR-Reduced. J Am Coll Cardiol. 2021 Mar 23;77(11):1397-1407. doi: 10.1016/j.jacc.2021.01.044.
PMID: 33736821DERIVEDPacker M, Anker SD, Butler J, Filippatos G, Ferreira JP, Pocock SJ, Sattar N, Brueckmann M, Jamal W, Cotton D, Iwata T, Zannad F; EMPEROR-Reduced Trial Committees and Investigators. Empagliflozin in Patients With Heart Failure, Reduced Ejection Fraction, and Volume Overload: EMPEROR-Reduced Trial. J Am Coll Cardiol. 2021 Mar 23;77(11):1381-1392. doi: 10.1016/j.jacc.2021.01.033.
PMID: 33736819DERIVEDButler J, Anker SD, Filippatos G, Khan MS, Ferreira JP, Pocock SJ, Giannetti N, Januzzi JL, Pina IL, Lam CSP, Ponikowski P, Sattar N, Verma S, Brueckmann M, Jamal W, Vedin O, Peil B, Zeller C, Zannad F, Packer M; EMPEROR-Reduced Trial Committees and Investigators. Empagliflozin and health-related quality of life outcomes in patients with heart failure with reduced ejection fraction: the EMPEROR-Reduced trial. Eur Heart J. 2021 Mar 31;42(13):1203-1212. doi: 10.1093/eurheartj/ehaa1007.
PMID: 33420498DERIVEDAnker SD, Butler J, Filippatos G, Khan MS, Marx N, Lam CSP, Schnaidt S, Ofstad AP, Brueckmann M, Jamal W, Bocchi EA, Ponikowski P, Perrone SV, Januzzi JL, Verma S, Bohm M, Ferreira JP, Pocock SJ, Zannad F, Packer M. Effect of Empagliflozin on Cardiovascular and Renal Outcomes in Patients With Heart Failure by Baseline Diabetes Status: Results From the EMPEROR-Reduced Trial. Circulation. 2021 Jan 26;143(4):337-349. doi: 10.1161/CIRCULATIONAHA.120.051824. Epub 2020 Nov 11.
PMID: 33175585DERIVEDZannad F, Ferreira JP, Pocock SJ, Zeller C, Anker SD, Butler J, Filippatos G, Hauske SJ, Brueckmann M, Pfarr E, Schnee J, Wanner C, Packer M. Cardiac and Kidney Benefits of Empagliflozin in Heart Failure Across the Spectrum of Kidney Function: Insights From EMPEROR-Reduced. Circulation. 2021 Jan 26;143(4):310-321. doi: 10.1161/CIRCULATIONAHA.120.051685. Epub 2020 Oct 23.
PMID: 33095032DERIVEDPacker M, Anker SD, Butler J, Filippatos G, Ferreira JP, Pocock SJ, Carson P, Anand I, Doehner W, Haass M, Komajda M, Miller A, Pehrson S, Teerlink JR, Brueckmann M, Jamal W, Zeller C, Schnaidt S, Zannad F. Effect of Empagliflozin on the Clinical Stability of Patients With Heart Failure and a Reduced Ejection Fraction: The EMPEROR-Reduced Trial. Circulation. 2021 Jan 26;143(4):326-336. doi: 10.1161/CIRCULATIONAHA.120.051783. Epub 2020 Oct 21.
PMID: 33081531DERIVEDPacker M, Anker SD, Butler J, Filippatos G, Pocock SJ, Carson P, Januzzi J, Verma S, Tsutsui H, Brueckmann M, Jamal W, Kimura K, Schnee J, Zeller C, Cotton D, Bocchi E, Bohm M, Choi DJ, Chopra V, Chuquiure E, Giannetti N, Janssens S, Zhang J, Gonzalez Juanatey JR, Kaul S, Brunner-La Rocca HP, Merkely B, Nicholls SJ, Perrone S, Pina I, Ponikowski P, Sattar N, Senni M, Seronde MF, Spinar J, Squire I, Taddei S, Wanner C, Zannad F; EMPEROR-Reduced Trial Investigators. Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure. N Engl J Med. 2020 Oct 8;383(15):1413-1424. doi: 10.1056/NEJMoa2022190. Epub 2020 Aug 28.
PMID: 32865377DERIVEDNassif ME, Kosiborod M. Effects of sodium glucose cotransporter type 2 inhibitors on heart failure. Diabetes Obes Metab. 2019 Apr;21 Suppl 2:19-23. doi: 10.1111/dom.13678.
PMID: 31081589DERIVED
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Results Point of Contact
- Title
- Boehringer Ingelheim, Call Centre
- Organization
- Boehringer Ingelheim
Study Officials
- STUDY CHAIR
Boehringer Ingelheim
Boehringer Ingelheim
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- OTHER
- Restrictive Agreement
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 16, 2017
First Posted
February 20, 2017
Study Start
March 6, 2017
Primary Completion
May 1, 2020
Study Completion
May 28, 2020
Last Updated
May 18, 2021
Results First Posted
May 18, 2021
Record last verified: 2021-04