A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
EASi-HF Preserved - A Phase III Double-blind, Randomised, Parallel-group Superiority Trial to Evaluate Efficacy and Safety of the Combined Use of Oral Vicadrostat (BI 690517) and Empagliflozin Compared With Placebo and Empagliflozin in Participants With Symptomatic Heart Failure (HF: NYHA II-IV) and Left Ventricular Ejection Fraction (LVEF) ≥40%
3 other identifiers
interventional
6,000
30 countries
653
Brief Summary
This study is open to adults aged 18 or above legal age with heart failure. People can join the study if they have heart failure symptoms and a left ventricular ejection fraction (LVEF) of 40% or more. The purpose of this study is to find out whether vicadrostat (BI 690517) in combination with empagliflozin helps people with heart failure. Participants are put into 2 groups by chance. Every participant has an equal chance of being in each group. The groups are:
- Vicadrostat/empagliflozin group: participants take vicadrostat/empagliflozin as tablets once a day.
- Placebo/empagliflozin group: participants take placebo/empagliflozin as tablets once a day. Participants can stay in the study as long as they benefit from treatment and can tolerate it. During this time, they visit their doctors regularly. The doctors regularly check participants' health and take note of any unwanted effects. The study staff may also contact the participants by phone. Participants also regularly answer questions about their well-being. The study does not have a fixed duration. It continues until there is enough data to see if the treatment is working.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3 heart-failure
Started Jun 2024
Typical duration for phase_3 heart-failure
653 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 10, 2024
CompletedFirst Posted
Study publicly available on registry
May 22, 2024
CompletedStudy Start
First participant enrolled
June 17, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 22, 2028
ExpectedStudy Completion
Last participant's last visit for all outcomes
May 22, 2028
April 15, 2026
April 1, 2026
3.9 years
May 10, 2024
April 14, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Time to first event of Cardiovascular (CV) death, hospitalisation for heart failure (HHF) or urgent heart failure (HF) visit
up to 42 months
Secondary Outcomes (13)
Key secondary endpoint: Time to first event of CV death or HHF
up to 42 months
Key secondary endpoint: Occurrence of HHFs (first and recurrent)
up to 42 months
Key secondary endpoint: Absolute change from baseline in Kansas City Cardiomyopathy Questionnaire Total Symptom Score (KCCQ-TSS) at Week 32
at baseline, at week 32
Key secondary endpoint: Time to CV death
up to 42 months
Key secondary endpoint: Time to all-cause mortality
up to 42 months
- +8 more secondary outcomes
Study Arms (2)
vicadrostat/empagliflozin
EXPERIMENTALplacebo/empagliflozin
PLACEBO COMPARATORInterventions
Eligibility Criteria
You may qualify if:
- At least 18 years old and at least of the legal age of consent in countries where it is greater than 18 years
- Signed and dated written informed consent in accordance with ICH-GCP and local legislation prior to admission to the trial
- Male or female participants. Women of childbearing potential (WOCBP) must be ready and able to use highly effective methods of birth control per International Conference on Harmonisation (ICH) M3 (R2) that result in a low failure rate of less than 1% per year when used consistently and correctly. A list of contraception methods meeting these criteria and instructions on the duration of their use is provided in the participant information
- Chronic Heart failure (HF) diagnosed at least 3 months before Visit 1, and in New York Heart Association (NYHA) class II-IV at Visit 1, with left ventricular ejection fraction (LVEF) ≥40% per local reading. A historical LVEF may be used if it was measured within 12 months prior to Visit 1, or the LVEF may be measured after study consent has been obtained and before randomisation at Visit 2
- Presence of structural heart abnormality (confirmed by any imaging modality; i.e. echocardiography at Visit 1, as defined by left ventricular hypertrophy or left atrial enlargement). Historical imaging may be used if performed within 12 months prior to Visit 1, or imaging may be completed after study consent has been obtained and before Visit 2
- Elevated N-terminal pro-brain natriuretic peptide (NT-proBNP) at Visit 1, analysed at the central laboratory at Visit 1:
- in participants with body mass index (BMI) \<27 kg/m²: ≥300 pg/mL for participants without atrial fibrillation (Afib) or atrial flutter (Aflutter) (at Visit 1 electrocardiogram (ECG)) and ≥900 pg/mL for participants with Afib or Aflutter (at Visit 1 ECG)
- in participants with BMI ≥27 kg/m² to \<35 kg/m²: ≥220 pg/mL for participants without Afib or Aflutter (at Visit 1 ECG) and ≥660 pg/mL for participants with Afib or Aflutter (at Visit 1 ECG)
- in participants with BMI ≥35 kg/m²: ≥125 pg/mL for participants without Afib or Aflutter (at Visit 1 ECG) and ≥375 pg/mL for participants with Afib or Aflutter (at Visit 1 ECG)
- At least one of the following:
- Currently treated with diuretic therapy e.g. loop diuretics or thiazides, and on a stable dose for at least 1 week prior to Visit 1
- Documented hospitalisation for HF within 6 months prior to Visit 1
- Elevated NT-proBNP at Visit 1, analysed at the central laboratory at Visit 1
- in participants without Afib or Aflutter (at Visit 1 ECG): ≥900 pg/mL
- for participants with Afib or Aflutter (at Visit 1 ECG): ≥1800 pg/mL
- +1 more criteria
You may not qualify if:
- Treatment with an mineralocorticoid receptor antagonist (MRA) (e.g. spironolactone, eplerenone, finerenone) within 14 days prior to Visit 1 or requiring such treatment before randomisation or planned during the trial based on the judgment of the investigator. Treatment with MRA should not be interrupted with the intention of enrolment into the study
- Treatment with amiloride, or other potassium-sparing diuretic within 14 days prior to Visit 1 or requiring such treatment before randomisation or planned during the trial based on the judgment of the investigator
- Receiving the following treatments:
- a direct renin inhibitor (e.g. aliskiren) at Visit 2
- more than one angiotensin-converting enzyme inhibitor (ACEI), angiotensin receptor blocker (ARB) or angiotensin receptor-neprilysin inhibitor (ARNI) used simultaneously at Visit 2
- In case of acute decompensated HF:
- i.v. inotrope, i.v. vasodilating drug (e.g. nitrate, nitroprusside), or i.v. natriuretic peptide (e.g. nesiritide, carperitide), or mechanical support (e.g. intra-aortic balloon pump, endotracheal intubation, mechanical ventilation, any ventricular assist device) within 24 hours prior to randomisation (Visit 2)
- Systemic mineralocorticoid replacement therapy (e.g. fludrocortisone) at Visit 2
- Other aldosterone synthase inhibitors, e.g. baxdrostat at Visit 2 or planned during the trial
- Myocardial infarction (MI), transient ischemic attack (TIA), stroke, coronary artery bypass graft (CABG) surgery, heart valve surgery/intervention or any other major surgery (major according to the investigator's assessment) within 90 days prior to Visit 2, or scheduled for major elective surgery (e.g. hip replacement, coronary artery bypass graft surgery/CABG)
- Percutaneous coronary intervention (PCI) ( scheduled or unscheduled) or any angiography using iodinated contrast agents in the 7 days prior to Visit 2
- Heart transplant recipient, awaiting heart transplant, or currently implanted left ventricular assist device (LVAD)
- Known cardiomyopathy based on infiltrative diseases (e.g. amyloidosis), accumulation diseases (e.g. haemochromatosis, Fabry disease), muscular dystrophies, hypertrophic obstructive cardiomyopathy or genetic hypertrophic cardiomyopathy,known pericardial constriction, or cardiomyopathy with potentially reversible cause such as stress or peripartum cardiomyopathy or cardiomyopathy induced by chemotherapy within the 12 months prior to Visit 1 and until Visit 2
- Acute inflammatory heart disease, such as acute myocarditis, within the 90 days preceding prior to Visit 1 and until Visit 2
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (653)
Diagnostic and Medical Clinic
Mobile, Alabama, 36604, United States
Mobile Heart Specialists, PC
Mobile, Alabama, 36608, United States
Velocity Clinical Research-Chula Vista
Chula Vista, California, 91911, United States
University of California Irvine
Orange, California, 92868, United States
North America Research Institute
San Dimas, California, 91773, United States
Amicis Research Center - Valencia
Santa Clarita, California, 91355, United States
Orange County Research Center
Tustin, California, 92780, United States
Bridgeport Hospital
Bridgeport, Connecticut, 06610, United States
Excel Medical Clinical Trials
Boca Raton, Florida, 33434, United States
Bay Area Cardiology
Brandon, Florida, 33511, United States
Clearwater Cardiovascular and Interventional Consultants
Clearwater, Florida, 33756, United States
Cardiology Associates Research Co.
Daytona Beach, Florida, 32117, United States
Malcom Randall VA Medical Center
Gainesville, Florida, 32608, United States
Velocity Clinical Research-Hallandale Beach-67888
Hallandale, Florida, 33009, United States
University of Florida Health Jacksonville
Jacksonville, Florida, 32209, United States
East Coast Institute for Research, LLC - Jacksonville
Jacksonville, Florida, 32216, United States
East Coast Institute for Research, LLC - Jacksonville
Jacksonville, Florida, 32216, United States
First Coast Cardiovascular Institute
Jacksonville, Florida, 32256, United States
Clearwater Cardiovascular Consultants-Largo-69917
Largo, Florida, 33777, United States
University of Miami
Miami, Florida, 33136, United States
Sacred Heart Medical Specialty Group
Miramar Beach, Florida, 32550, United States
Advanced Research for Health Improvement, LLC
Naples, Florida, 34102, United States
Southwest Florida Research, LLC
Naples, Florida, 34102, United States
Ocala Cardiovascular Research
Ocala, Florida, 34471, United States
Ocala Research Institute, Inc
Ocala, Florida, 34471, United States
Charlotte Cardiovascular Institute, PA
Port Charlotte, Florida, 33952, United States
East Coast Institute for Research, LLC-Saint Augustine-63032
Saint Augustine, Florida, 32086, United States
University of South Florida
Tampa, Florida, 33612, United States
Cardiology Partners Clinical Research Institute
Wellington, Florida, 33449, United States
Cozy Research LLC
Wesley Chapel, Florida, 33544, United States
Clinical Site Partners, LLC
Winter Park, Florida, 32789, United States
Atlanta Clinical Research Centers
Atlanta, Georgia, 30342, United States
Columbus Regional Research Institute
Columbus, Georgia, 31904, United States
NSC Research Inc
Johns Creek, Georgia, 30024, United States
Kootenai Medical Center
Coeur d'Alene, Idaho, 83814, United States
Northwest Heart Clinical Research, LLC
Arlington Heights, Illinois, 60005, United States
Illinois Masonic Hospital
Chicago, Illinois, 60657, United States
Chicago Medical Research
Hazel Crest, Illinois, 60429, United States
Clinical Investigation Specialists, Inc.-Libertyville-69941
Libertyville, Illinois, 60048, United States
AMR Park Ridge
Park Ridge, Illinois, 60068, United States
Midwest Cardiovascular Research and Education Foundation
Elkhart, Indiana, 46514, United States
St. Francis Medical Group-Indiana Heart Physicians, Inc
Indianapolis, Indiana, 46237, United States
Indiana Medical Research Institute
Merrillville, Indiana, 46410, United States
Cardiovascular Research of Northwest Indiana, LLC
Munster, Indiana, 46321, United States
Reid Hospital
Richmond, Indiana, 47374, United States
The Iowa Clinic, PC
West Des Moines, Iowa, 50266, United States
West Houston Area Clinical Trial Consultants, LLC
Wichita, Kansas, 67226, United States
West Houston Area Clinical Trial Consultants, LLC
Wichita, Kansas, 67226, United States
Norton Heart Specialists
Louisville, Kentucky, 40205, United States
Grace Research, LLC-Bossier City-51040
Bossier City, Louisiana, 71111, United States
Heart Clinic of Hammond
Hammond, Louisiana, 70403, United States
Grace Research, LLC-Shreveport-64616
Shreveport, Louisiana, 71105, United States
Louisiana Heart Center - Slidell
Slidell, Louisiana, 70458, United States
Ascension Saint Agnes Heart Care
Baltimore, Maryland, 21229, United States
AMR Dearborn
Dearborn, Michigan, 48126, United States
Sparrow Clinical Research Institute
Lansing, Michigan, 48910-0826, United States
Henry Ford Providence Hospital
Southfield, Michigan, 48075, United States
Trinity Health Michigan D/B/A Michigan Heart
Ypsilanti, Michigan, 48197, United States
Minneapolis VA Health Care System
Minneapolis, Minnesota, 55417, United States
Jackson Heart Clinic, P.A.
Jackson, Mississippi, 39216, United States
Kansas City VA Medical Center
Kansas City, Missouri, 64128, United States
North Kansas City Hospital
North Kansas City, Missouri, 64116, United States
St. Louis Heart and Vascular, P.C.
St Louis, Missouri, 63136, United States
Velocity Clinical Research-Lincoln-69943
Lincoln, Nebraska, 68506, United States
Advanced Heart Care, LLC
Bridgewater, New Jersey, 08807, United States
Garden State Heart Care, PC
Manalapan, New Jersey, 07726, United States
Cardio Metabolic Institute
Somerset, New Jersey, 08873, United States
NYU Langone Health
New York, New York, 10001, United States
Mount Sinai Hospital-New York-52529
New York, New York, 10029, United States
Cardiac Care and Vascular Medicine, PLLC
The Bronx, New York, 10469, United States
Medication Management, LLC
Greensboro, North Carolina, 27405, United States
WakeMed
Raleigh, North Carolina, 27610, United States
K and R Research LLC
Marion, Ohio, 43302, United States
Mercy Health St. Vincent Medical Center
Toledo, Ohio, 43608, United States
Bon Secours Medical Group Greenville Specialty Care, LLC
Greenville, South Carolina, 29607, United States
Monument Health
Rapid City, South Dakota, 57701, United States
Helios CR Inc
Jackson, Tennessee, 38305, United States
East Coast Institute For Research LLC
Jefferson City, Tennessee, 37760, United States
Pharmatex Research
Amarillo, Texas, 79109, United States
Amarillo Heart Clinical Research Institute, Incorporated
Amarillo, Texas, 79124, United States
Texas Health Research and Education Institute
Dallas, Texas, 75231, United States
Texas Health Research and Education Institute
Dallas, Texas, 75231, United States
Southwest Family Medicine Associates
Dallas, Texas, 75235, United States
University of Texas Southwestern Medical Center
Dallas, Texas, 75390, United States
Helios CR Inc
Fort Worth, Texas, 76104, United States
Private Practice Leadership, LLC
Katy, Texas, 77493, United States
Texas Cardiology Research Center PLLC
Kingwood, Texas, 77339, United States
DCOL Center for Clinical Research
Longview, Texas, 75605, United States
North Texas Research Associates
McKinney, Texas, 75071, United States
Texas Institute Of Cardiology
McKinney, Texas, 75071, United States
University of Utah Hospital
Salt Lake City, Utah, 84132, United States
Carient Heart and Vascular
Manassas, Virginia, 20109, United States
Sentara Norfolk General Hospital
Norfolk, Virginia, 23507, United States
Selma Medical Associates, Winchester
Winchester, Virginia, 22601, United States
Virginia Mason Medical Center
Seattle, Washington, 98101, United States
Drug Research and Analysis Corporation
Madison, Wisconsin, 53717, United States
ProHealth Care Research Institute and Cardiology Associates
Waukesha, Wisconsin, 53188, United States
Inst de Inv Clinicas-Bahia Blanca
Bahía Blanca, B8000FTD, Argentina
Swiss Medical Center Barrio Parque
Buenos Aire, C1425, Argentina
Centro de Investigaciones Metabolicas (CINME)-Ciudad Autonoma Buenos Aires-41221
Ciudad Autonoma Buenos Aires, C1056ABJ, Argentina
Mautalen- Salud e Investigacion
Ciudad Autonoma Buenos Aires, C1128AAF, Argentina
Centro Medico Dra Laura Maffei
Ciudad Autonoma Buenos Aires, C1425AGC, Argentina
Fundacion Favaloro
Ciudad Autonoma Buenos Aires, C1428ART, Argentina
Instituto Cardiovascular de Buenos Aires
Ciudad Autonoma Buenos Aires, C1428DCO, Argentina
Glenny Corp. S.A. Bioclinica Argentina
Ciudad Autonoma Buenos Aires, C1430CKE, Argentina
Centro Medico Viamonte
Ciudad Autonoma de Bs As, A1120AAC, Argentina
Hospital Italiano de Buenos Aires
Ciudad Autónoma de Bs As, C1181ACH, Argentina
Instituto Medico Elsa Perez SRL (IMEP)
Ciudadela, 1702, Argentina
Clinica Coronel Suárez
Coronel Suárez, B7540GHD, Argentina
Sanatorio Allende S.A.
Córdoba, X5000JHQ, Argentina
Sanatorio Privado Duarte Quiros De Clinica Colombo SA
Córdoba, X5002AOQ, Argentina
Well Medica
Córdoba, X5002HWE, Argentina
Instituto Médico DAMIC S.R.L.
Córdoba, X5003DCE, Argentina
Centro Medico Luquez
Córdoba, X5006CBI, Argentina
Centro de Investigaciones Medicas Mar del Plata
Mar del Plata, B7600FYK, Argentina
Hospital Universitario Austral
Pilar, B1629ODT, Argentina
Instituto de Investigaciones Clínicas de Quilmes
Quilmes, B1878GEG, Argentina
DIM Clinica Privada
Ramos Mejía, 1704, Argentina
Instituto de Investigaciones Clinicas de Rosario
Rosario, 2000, Argentina
Instituto CAICI
Rosario, S2000PBJ, Argentina
Centro Cardiovascular Salta
Salta, A4406BFP, Argentina
Corporacion Medica de Gral. San Martin S.A.
San Martín, B1650CSQ, Argentina
Investigaciones en Patologias Respiratorias
San Miguel de Tucumán, T4000IAI, Argentina
Investigaciones Clinicas Tucuman
San Miguel de Tucumán, T4000ICL, Argentina
Centro Modelo de Cardiologia
San Miguel de Tucumán, T4000, Argentina
Clinica Mayo
San Miguel de Tucumán, T4000, Argentina
Instituto de Investigaciones Clinicas San Nicolas
San Nicolás, B2900DMH, Argentina
Centro de Investigaciones Clínicas del Litoral
Santa Fe, S3000FWO, Argentina
CEMEDIC - Centro de Especialidades Medicas
Villa Luro, 1407, Argentina
Canberra Hospital
Garran, Australian Capital Territory, 2605, Australia
Concord Repatriation General Hospital
Concord, New South Wales, 2139, Australia
Gosford Hospital
Gosford, New South Wales, 2250, Australia
Nepean Hospital
Kingswood, New South Wales, 2747, Australia
Pendlebury Research
Kotara, New South Wales, 2289, Australia
Royal Brisbane and Women's Hospital
Brisbane, Queensland, 4029, Australia
Prince Charles Hospital
Chermside, Queensland, 4032, Australia
John Flynn Private Hospital
Tugun, Queensland, 4224, Australia
Royal Adelaide Hospital
Adelaide, South Australia, 5000, Australia
The Queen Elizabeth Hospital
Woodville, South Australia, 5011, Australia
Total Cardiovascular Care
Frankston, Victoria, 3199, Australia
Royal Melbourne Hospital
Parkville, Victoria, 3050, Australia
Mount Hospital
Perth, Western Australia, 6000, Australia
Ziekenhuis Oost-Limburg
Genk, 3600, Belgium
AZ Sint-Lucas
Ghent, 9000, Belgium
Grand Hôpital de Charleroi
Gilly, 6060, Belgium
Jessa Ziekenhuis
Hasselt, 3500, Belgium
AZ Groeninge
Kortrijk, 8500, Belgium
UZ Leuven
Leuven, 3000, Belgium
Centro de Pesquisa Clínica do Coração
Aracaju, 49055-530, Brazil
Hospital Felicio Rocho
Belo Horizonte, 30110-934, Brazil
Hospital Vera Cruz
Belo Horizonte, 30140-092, Brazil
Cardresearch Cardiologia Assistencial e de Pesquisas Ltda
Belo Horizonte, 30150-240, Brazil
Hospital Universitário São Francisco na Providência de Deus
Bragança Paulista, 1291-6542, Brazil
L2IP -Instituto de Pesquisas Clínicas Ltda.
Brasília, 70200-730, Brazil
Hospital DF Star
Brasília, 70390-140, Brazil
Hospital do Coracao do Brasil
Brasília, 70390-903, Brazil
CECAP - Centro de Cardiologia Clínica
Brasília, 70710-100, Brazil
Hospital Brasilia
Brasília, 71635-580, Brazil
Hospital Angelina Caron
Campina Grande do Sul, 83430-000, Brazil
IPECC - Instituto de Pesquisa Clínica de Campinas
Campinas, 13060-080, Brazil
Centro Especializado em Cardiol Loema Instituto de Pesq Clin
Campinas, 13092-133, Brazil
Hospital do Rocio
Campo Largo, 83606-177, Brazil
PUC Trials - Núcleo de Pesquisa Clínica da Escola de Medicina da PUC-PR
Curitiba, 80230-130, Brazil
Via Medica
Goiânia, 74223-130, Brazil
ICM - Instituto do Coracao de Marilia
Marília, 17515-000, Brazil
Instituto Atena de Pesquisa Clinica
Natal, 59020-035, Brazil
Instituto Mederi de Pesquisa e Saude
Passo Fundo, 99010-120, Brazil
Santa Casa de Misericórdia de Porto Alegre
Porto Alegre, 90020-090, Brazil
Hospital de Clínicas de Porto Alegre
Porto Alegre, 90035-903, Brazil
Universidade Federal do Rio Grande do Sul
Porto Alegre, 90430-001, Brazil
Hospital Mae de Deus
Porto Alegre, 90840-440, Brazil
Hospital Esperança Recife
Recife, 50070-480, Brazil
Clinicor Clínica Cardiológica LTDA/ Cardio Prime - CAPED
Ribeirão Preto, 14026-900, Brazil
Hospital das Clínicas FMRP-USP
Ribeirão Preto, 14048-900, Brazil
Instituto Brasil de Pesquisa Clinica (IBPClin)
Rio de Janeiro, 20241-180, Brazil
Ruschel Medicina e Pesquisa Clínica
Rio Do Janeiro, 22270-060, Brazil
Hospital Cardio Pulmonar
Salvador, 40170-310, Brazil
Pesquisare
Santo André, 09080-110, Brazil
Praxis Pesquisa Medica
Santo André, 09090-970, Brazil
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto
Sao Jose Rio Preto, 15090-000, Brazil
Hospital Sao Domingos
São Luís, 65060-645, Brazil
CPCLIN - Centro de Pesquisas Clínicas Ltda.
São Paulo, 01228-200, Brazil
CEPIC - Centro Paulista de Investigacao Clinica
São Paulo, 04266-010, Brazil
Eurolatino Pesquisas Médicas Ltda.
Uberlândia, 38411-186, Brazil
CEDOES - Diagnóstico e Pesquisa,Vitória
Vitória, 29055-450, Brazil
Integral Pesquisa e Ensino
Votuporanga, 15501-405, Brazil
Medical Center Doktor Staykov Ltd.
Burgas, 8008, Bulgaria
Diamedical Medical Center 2013
Dimitrovgrad, 6400, Bulgaria
MHAT Ivan Skenderov EOOD
Gotse Delchev, 2900, Bulgaria
Medical Center Rodopimed EOOD
Kardzhali, 6600, Bulgaria
Medical Center Hera - Kyustendil EOOD
Kyustendil, 2500, Bulgaria
Ambulatory Individual Practice for Cardiology Specialized Medical Care
Pernik, 2300, Bulgaria
Medical Center Medconsult Pleven OOD
Pleven, 5800, Bulgaria
MHAT Heart and brain
Pleven, 5800, Bulgaria
Ambulatory for Individual Practice for Specialized Medical Care in Cardiology - Dr Nikolay Iliev
Pleven, 5803, Bulgaria
UMHAT "Sv. Georgi", EAD
Plovdiv, 4002, Bulgaria
Medical Center Rusemed EOOD
Rousse, 7013, Bulgaria
National Multiprofile Transport Hospital "Tzar Boris III"
Sofia, 1233, Bulgaria
Medical Center For Specialized Medical Help In Cardiovascular Diseases OOD
Sofia, 1309, Bulgaria
Alexandrovska University Hospital
Sofia, 1431, Bulgaria
Diagnostic Consultative Center Alexandrovska
Sofia, 1431, Bulgaria
University Multidisciplinary Hospital for Active Treatment Sveta Ekaterina EAD
Sofia, 1431, Bulgaria
Medical Center Hera EOOD
Sofia, 1510, Bulgaria
UMHAT "Tsaritsa Yoanna-ISUL" EAD
Sofia, 1527, Bulgaria
ASOMHIDC - Individual practice "Cardio Tonus" EOOD
Sofia, 1582, Bulgaria
Multiprofile Hospital MHATEM 'Pirogov', Sofia
Sofia, 1606, Bulgaria
Diagnostic Consultation Center XX-Sofia EOOD
Sofia, 1618, Bulgaria
MHAT "St. Sofia"
Sofia, 1618, Bulgaria
Kalimat Medical Center Ltd.
Sofia, 1680, Bulgaria
Medical Center Intermedica Ltd.
Sofia, 1680, Bulgaria
Medical Center Medicabilis Ltd.
Sofia, 1756, Bulgaria
UMHAT Prof. Dr. Stoyan Kirkovich AD
Stara Zagora, 6000, Bulgaria
Medical Center Zara-Med EOOD
Stara Zagora, 6010, Bulgaria
Diagnostichno-Consultativen Center Chaika EOOD
Varna, 9000, Bulgaria
Medical Centre Nevromedics EOOD
Veliko Tarnovo, 5006, Bulgaria
MHAT St Panteleimon
Yambol, 8600, Bulgaria
MHAT St Panteleimon
Yambol, 8600, Bulgaria
Cambridge Cardiac Care Centre
Cambridge, Ontario, N1R 6V6, Canada
Curnew Medicine Professional Corporation
Hamilton, Ontario, L8L 0A9, Canada
KMH Cardiology Centres (Mississauga)
Mississauga, Ontario, L5K 2L3, Canada
Oakville Trafalgar Memorial Hospital
Oakville, Ontario, L6M 0L8, Canada
James Cha, MD
Oshawa, Ontario, L1J 2K1, Canada
Kawartha Cardiology Clinical Trials
Peterborough, Ontario, K9J 0B2, Canada
CardioQuest Research Centre
Sarnia, Ontario, N7T 4P5, Canada
KMH Cardiology Centers (Hamilton)
Stoney Creek, Ontario, L8J 3W2, Canada
Diabetes Heart Research Centre
Toronto, Ontario, M6G 1M2, Canada
ViaCar Recherches Cliniques Inc. (Greenfield Park)
Greenfield Park, Quebec, J4V 2G8, Canada
Jewish General Hospital
Montreal, Quebec, H3T 1E2, Canada
Diex Recherche (Trois-Rivieres)
Trois-Rivières, Quebec, G9A 4P3, Canada
Royal Alexandra Hospital (Edmonton)
Edmonton, T5H 3V9, Canada
Health Sciences North
Greater Sudbury, P3E 5J1, Canada
Clinical Research Solutions Inc. (Kitchener)
Kitchener, N2H5Z8, Canada
Centre Hospitalier de l'Universite de Montreal (CHUM)
Montreal, H2X 0C1, Canada
Montreal General Hospital - McGill University Health Centre
Montreal, H3G 1A4, Canada
CardioVasc HR Inc.
Saint-Jean-sur-Richelieu, J3A 1J2, Canada
Quantum Research Santiago, Puerto Varas
Puerto Varas, 5550170, Chile
Sociedad Medica Cardiologica El Llano
Santiago, 8900000, Chile
Hospital Las Higueras
Talcahuano, 4270918, Chile
CECMI Ltda
Temuco, 4780000, Chile
CINVEC - Centro de Investigacion Clinica V Reg.,Vina del Mar
Viña del Mar, 2570017, Chile
The First Affiliated Hospital of Baotou Medical College
Baotou, 014010, China
Baotou Central Hospital
Baotou, 014040, China
Beijing AnZhen Hospital, Capital Medical University
Beijing, 100029, China
Cardiovascular Institute and Fu Wai Hospital
Beijing, 100037, China
Peking University Third Hospital
Beijing, 100191, China
Jilin Province People's Hospital
Changchun, 130021, China
The First Hospital of Jilin University
Changchun, 130021, China
China-Japan Union Hospital of Jilin University
Changchun, 130033, China
Changde Second People's Hospital
Changde, 415001, China
Changsha Central Hospital
Changsha, 410004, China
The Second Xiangya Hospital Of Central South University
Changsha, 410011, China
The third xiangya hospital of Central South University
Changsha, 410013, China
The Third Hospital of Changsha
Changsha, 410015, China
Chengdu Second People's Hospital
Chengdu, 610021, China
West China Hospital, Sichuan University
Chengdu, 610041, China
The First Affiliated Hospital of Chengdu Medical College
Chengdu, 610500, China
Chenzhou No.1 people's Hospital
Chenzhou, 423000, China
Affiliated Zhongshan Hospital of Dalian University
Dalian, 116001, China
Daqing Oilfield General Hospital
Daqing, 163001, China
Daqingshi People's Hospital
Daqing, 163711, China
Deyang People's Hospital
Deyang, 618099, China
The First People's Hospital of Foshan
Foshan, 528000, China
The First Affiliated Hospital of Fujian Medical University
Fuzhou, 350005, China
No.900 Hospital of PLA Joint Logistics Support Force
Fuzhou, 350025, China
Guangdong Provincial People's Hospital
Guangzhou, 510080, China
Sun yet-sen Memorial Hospital, Sun yet-sen Univesity
Guangzhou, 510120, China
Third Affiliated Hospital of Guangzhou Medical University
Guangzhou, 510150, China
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Guangzhou, 510400, China
The Affiliated Panyu Central Hospital of Guangzhou Medical University
Guangzhou, 511400, China
The Affiliated Hospital of Guizhou Medical University
Guiyang, 550000, China
Guizhou People's Hospital
Guiyang, 550002, China
Hainan General Hospital
Haikou, 570311, China
Hangzhou First People's Hospital
Hangzhou, 311199, China
The First Affiliated Hospital of Harbin Medical University
Harbin, 150040, China
Huainan First People's Hospital
Huainan, 232007, China
Jiangmen Central Hospital
Jiangmen, 529030, China
Center Hospital of Jinan
Jinan, 250013, China
Jining No.1 people's hospital
Jining, 272011, China
Lanzhou University Second Hospital
Lanzhou, 730030, China
Linfen Central Hospital
Linfen, 041000, China
The First Affiliated Hospital of Henan University of Science and Technology
Luoyang, 471000, China
Luoyang Third People's Hospital
Luoyang, 471002, China
Jiangxi Province Integrated Tractional Chinese Medicine& Western Medicine Hospital
Nanchang, 330003, China
The First Affiliated Hospital of Nanchang University
Nanchang, 330006, China
Nanchang People's Hospital
Nanchang, 330009, China
Nanjing Drum Tower Hospital
Nanjing, 210008, China
Nanjing Jiangning Hospital
Nanjing, 211100, China
The First Affiliated Hospital of Guangxi Medical University
Nanning, 530021, China
Nanyang First People's Hospital
Nanyang, 473004, China
Nanyang Second General Hospital
Nanyang, 473009, China
Panjin Liao Oil Gem Flower Hospital
Panjin, 124010, China
Pingxiang People's Hospital
Pingxiang, 337055, China
Zhongshan Hospital Affiliated to Fudan University
Shanghai, 200032, China
Tongren hospital, Shanghai Jiaotong University School of Medicine
Shanghai, 200050, China
Shanghai General Hospital
Shanghai, 200080, China
Shengjing Hospital of China Medical University
Shengyang, 110004, China
Shenzhen People's Hospital
Shenzhen, 518172, China
The Second Hospital of Hebei Medical University
Shijiazhuang, 050000, China
Tianjin Union Medical Center Nankai University Affiliated Hospital
Tianjin, 300121, China
Wenzhou People's Hospital
Wenzhou, 325000, China
Hubei Province Zhongshan Hospital
Wuhan, 430032, China
Wuhan Puai Hospital
Wuhan, 430033, China
Renmin Hospital of Wuhan University
Wuhan, 430060, China
Shaanxi Provincial People's Hospital
Xi'an, 710068, China
Xiangtan Central Hospital
Xiangtan, 411100, China
The Third Affiliated Hospital of Xinxiang Medical University
Xinxiang, 453003, China
The People's Hospital Of Xuancheng City
Xuancheng, 242000, China
The General Hospital of XZCMG (The Second Affiliated Hospital of Xuzhou Medical University)
Xuzhou, 221006, China
Yanbian University Hospital
Yanji, 133000, China
The first People's Hosptal of Yinchuan
Yinchuan, 750001, China
Yueyang Central Hospital
Yueyang, 414000, China
Yuncheng Central Hospital
Yuncheng, 44000, China
The First Affiliated Hospital of Hebei North University
Zhangjiakoou, 75000, China
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, 450052, China
Affiliated Hospital of Jiangsu University
Zhenjiang, 212001, China
Cardiomet CEQUIN S.A.S
Armenia, 630004, Colombia
IPS Centro Cientifico-Asistencial S.A.S
Barranquilla, 080020, Colombia
Corazon IPS S.A.S.
Barranquilla, 74158, Colombia
Centro de Investigacion Medico Asistencial S.A.S
Barranquilla, 80020, Colombia
IPS Centro Medico Julián Coronel S.A.
Cali, 760001, Colombia
Centro De Diagnostico Cardiologico Ltda
Cartagena, 130001, Colombia
Fundacion Cardiovascular de Colombia
Floridablanca, 6810002, Colombia
IPS médicos internistas de Caldas S.A.S.
Manizales, 170004, Colombia
Fundacion Centro de Investigacion Clinica CIC
Medellín, 05001, Colombia
Cardiomet Pereira
Pereira, 66001, Colombia
T Y C Inversiones S.A.S Grupsalud
Santa Marta, 470001, Colombia
Healthy Medical Center S.A.S, Zipaquirá
Zipaquirá, 250252, Colombia
MUDr. Hana Burianova
Bílovec, 743 01, Czechia
Medicus Services Ltd.
Brandýs nad Labem, 250 01, Czechia
Interni Ordinace s.r.o.
Brandýs nad Labem, 25001, Czechia
MUDr. Libor Nechvatal s.r.o.
Brno, 602 00, Czechia
St. Anna Hospital
Brno, 602 00, Czechia
MUDr. Karel Kamenik s.r.o
Brno, 603 00, Czechia
Vojenska nemocnice Brno
Brno, 61500, Czechia
University Hospital Brno
Brno, 625 00, Czechia
University Hospital Brno
Brno, 62500, Czechia
MUDr. Jan Hubac s.r.o.
Chrudim, 537 01, Czechia
Regional Hospital Havlickuv Brod
Havlíčkův Brod, 580 01, Czechia
Kardiologie KarMa s.r.o
Jablonec nad Nisou, 46601, Czechia
Hospital Jihlava
Jihlava, 586 33, Czechia
MUDr Petra Maskova PhD
Litovel, 784 01, Czechia
InterKardioML s.r.o.
Mariánské Lázně, 353 01, Czechia
MUDr. Jan Kvasnicka CSc
Prague, 10100, Czechia
Kardiologie Vinohrady s r o
Prague, 11000, Czechia
Institute for Clinical and Experimental Medicine
Prague, 140 21, Czechia
University Hospital Motol
Prague, 15006, Czechia
University Thomayer´s Hospital
Praha 4-Krc, 140 59, Czechia
Internist Care s.r.o
Smiřice, 5000, Czechia
Kardiologicka ambulance MUDr. Ferkl s.r.o.
Trutnov, 541 01, Czechia
Clinical Trials Services s.r.o
Uherské Hradiště, 68601, Czechia
MUDr. Nina Zemkova s.r.o.
Uherské Hradiště, 68601, Czechia
Cardio Research s.r.o.
Zlín, 76001, Czechia
Universitätsklinikum Aachen, AöR
Aachen, 52074, Germany
Klinikum am Plattenwald
Bad Friedrichshall, 74177, Germany
Velocity Clinical Research Germany GmbH, Berlin
Berlin, 10787, Germany
Studienzentrum Rankestrasse
Berlin, 10789, Germany
Charité - Universitätsmedizin Berlin
Berlin, 12203, Germany
Praxis Dr. Toursarkissian
Berlin, 13347, Germany
Charité Campus Virchow-Klinikum
Berlin, 13353, Germany
Vivantes Netzwerk für Gesundheit GmbH
Berlin, 13407, Germany
Vivantes Humboldt-Klinikum
Berlin, 13509, Germany
Universitätsklinikum Bonn AöR
Bonn, 53127, Germany
Praxis Dr. Menzel
Dessau, 06846, Germany
Städtisches Klinikum Dresden
Dresden, 01067, Germany
Facharztzentrum Dresden-Neustadt Betriebsgesellschaft mbH
Dresden, 01099, Germany
Helios Klinikum Erfurt
Erfurt, 99089, Germany
Universitätsklinikum Frankfurt
Frankfurt, 60590, Germany
ClinPhenomics CVC GmbH
Frankfurt, 60596, Germany
Velocity Clinical Research Germany GmbH, Hamburg
Hamburg, 22143, Germany
Medizinische Hochschule Hannover
Hanover, 30625, Germany
Universitätsklinikum Jena
Jena, 07747, Germany
Praxis Joachim Heisters
Kamp-Lintfort, 47475, Germany
Universitätsklinikum Schleswig-Holstein, Campus Kiel
Kiel, 24105, Germany
Asklepios Klinik Langen-Seligenstadt GmbH
Langen, 63225, Germany
Velocity Clinical Research Germany GmbH, Leipzig
Leipzig, 04177, Germany
Praxis Oedeme
Lüneburg, 21339, Germany
Marienhaus Klinikum St. Elisabeth
Neuwied, 56564, Germany
Gemeinschaftspraxis Dres Haggenmiller/Jeserich
Nuremberg, 90402, Germany
Kardiologische Praxis Papenburg
Papenburg, 26871, Germany
Universitätsklinikum Regensburg
Regensburg, 93053, Germany
Praxisgemeinschaft Melcherstätte
Stuhr, 28816, Germany
Gemeinschaftspraxis Dr. Großkopf
Wallerfing, 94574, Germany
Kardiologische Praxis, Wermsdorf
Wermsdorf, 04779, Germany
Velocity Clinical Research Germany GmbH, Wiesbaden
Wiesbaden, 65189, Germany
Lausmed Kft. Outpatient Unit of Internal Medicine
Baja, 6500, Hungary
Budai Irgalmasrendi Korhaz
Budapest, 1023, Hungary
Obudai Egeszegugyi Centrum Kft.
Budapest, 1036, Hungary
Belvaros-Lipotvaros Egeszsegugyi Szolgalat
Budapest, 1051, Hungary
Geomedical Kft.
Budapest, 1066, Hungary
Semmelweis University
Budapest, 1083, Hungary
Gottsegen National Cardiovascular Center
Budapest, 1096, Hungary
Semmelweis University
Budapest, 1122, Hungary
Privat Doktor Egeszseguegyi Szolgaltato Zrt.
Budapest, 1132, Hungary
Kardio Innova Kft.
Budapest, 1134, Hungary
UNO Medical Trials Kft.
Budapest, 1152, Hungary
Bekes Varmegyei Koezponti Korhaz
Gyula, 5700, Hungary
BKS Research Ltd
Hatvan, 3000, Hungary
KomplexLabor Kft.
Kecskemét, 6000, Hungary
Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi Oktato Korhaz
Miskolc, 3526, Hungary
IPR Hungary Kft.
Miskolc, 3530, Hungary
Dr. Nagy Laszlo Kardiologiai Maganrendeles
Orosháza, 5900, Hungary
Coromed-Smo Kft.
Pécs, 7623, Hungary
Pécsi Tudományegyetem Klinikai Központ
Pécs, 7624, Hungary
Da Vinci Private Clinic
Pécs, 7635, Hungary
Ujszeged Egeszsegkozpont Diabetes Centrum
Szeged, 6726, Hungary
Tolna County Balassa Janos Hospital
Szekszárd, 7100, Hungary
Jasz-Nagykun-Szolnok Megyei Hetenyi G. Korhaz-Rendelointezet
Szolnok, 5000, Hungary
Belvarosi Egeszseghaz Kft.
Zalaegerszeg, 8900, Hungary
Kamalnayan Bajaj Hospital
Aurangabad, 431 005, India
Narayana Institute of Cardiac Sciences
Bangalore, 560099, India
Bangalore Medical college
Bengaluru, 560002, India
S.P. Medical College & Associated Group of Hospitals
Bikaner, 334003, India
Tamil Nadu Government Multi Super Speciality Hospital TNGMSSH
Chennai, 600002, India
Apollo Main Hospital
Chennai, 600006, India
GNRC Hospital
Guwahati, 781006, India
Medanta-The Medicity
Gūrgaon, 122 001, India
Lisie Hospital
Kochi, 682 018, India
IPGMER and SSKM Hospital
Kolkata, 700020, India
Chopda Medicare and Research Centre Pvt Ltd
Nashik, 422005, India
Max Super Speciality Hospital
New Delhi, 110017, India
Unicare Heart Institute
Surat, 395002, India
King George Hospital
Visakhapatnam, 530002, India
Humanitas Gavazzeni
Bergamo, 24125, Italy
ASST Papa Giovanni XXIII
Bergamo, 24127, Italy
Az.Osp. Universitaria "Ospedali Riuniti"
Foggia, 71122, Italy
Azienda Ospedaliera San Martino
Genova, 16132, Italy
Azienda Ospedaliera Universitaria "Federico II"
Naples, 80131, Italy
Fondazione IRCCS Policlinico S. Matteo
Pavia, 27100, Italy
Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza
Roma, 00189, Italy
Istituto Clinico Humanitas
Rozzano, 20089, Italy
Kasugai Municipal Hospital
Aichi, Kasugai, 486-8510, Japan
Azumino Red Cross Hospital
Azumino-shi, 399-8292, Japan
Chiba Heart Clinic
Chiba, Chiba, 263-0043, Japan
Tokyo-Eki Center-building Clinic
Chūōku, 103-0027, Japan
Shonan Fujisawa Tokushukai Hospital
Fujisawa-shi, 251-0041, Japan
Kokura Memorial Hospital
Fukuoka, Kitakyushu, 802-8555, Japan
National Hospital Organization Hamada Medical Center
Hamada-shi, 697-8511, Japan
NHO Mito Medical Center
Higashiibaraki-gun, 311-3193, Japan
Hyogo Prefectural Harima-Himeji General Medical Center
Himeji-shi, 670-8560, Japan
Hiratsuka Kyosai Hospital
Hiratsuka-shi, 254-8502, Japan
Matsuda Cardiovascular Clinic
Hokkaido, Sapporo, 003-0026, Japan
Oji General Hospital
Hokkaido, Tomakomai, 053-8506, Japan
Hyogo Prefectural Amagasaki General Medical Center
Hyogo, Amagasaki, 660-8550, Japan
National Hospital Organization Kanazawa Medical Center
Ishikawa, Kanazawa, 920-8650, Japan
National Hospital Organization Iwakuni Clinical Center
Iwakuni-shi, 740-8510, Japan
Tokushukai Shonan Kamakura General Hospital
Kamakura-shi, 247-8533, Japan
Tokushukai Hayama Heart Center
Kanagawa, Miura-gun, 240-0116, Japan
Kanagawa Cardiovascular and Respiratory Center
Kanagawa, Yokohama, 236-0051, Japan
Yokohama Sakae Kyosai Hospital
Kanagawa, Yokohama, 247-8581, Japan
Mitoyo General Hospital
Kanonji-shi, 769-1695, Japan
Tokushukai Kishiwada Tokushukai Hospital
Kishiwada-shi, 596-0042, Japan
North Alps Medical Center Azumi Hospital
Kitaazumi-gun, 399-8695, Japan
National Hospital Organization Kobe Medical Center
Kobe, 654-0155, Japan
Japanese Red Cross Kumamoto Hospital
Kumamoto, 861-8520, Japan
Shinshu University Hospital
Matsumoto-shi, 390-8621, Japan
Ehime Prefectural Central Hospital
Matsuyama, 790-0024, Japan
Matsuyama Shimin Hospital
Matsuyama, 790-0067, Japan
Mito Saiseikai General Hospital
Mito, 311-4198, Japan
Hokushin General Hospital
Nakano-shi, 383-8505, Japan
Okayama City General Medical Center Okayama City Hospital
Okayama, Okayama, 700-8557, Japan
Naha City Hospital
Okinawa, Naha, 902-8511, Japan
Urasoe General Hospital
Okinawa, Urasoe, 901-2102, Japan
Kitano Hospital
Osaka, Osaka, 530-8480, Japan
Osaka Keisatsu Hospital
Osaka, Osaka, 543-8922, Japan
Nippon Life Hospital
Osaka, Osaka, 550-0006, Japan
Japan Community Health care Organization Osaka Hospital
Osaka, Osaka, 553-0003, Japan
Osaka General Medical Center
Osaka, Osaka, 558-8558, Japan
NHO Oita Medical Center
Ōita, 870-0263, Japan
Saga-Ken Medical Centre Koseikan
Saga, 840-8571, Japan
Sainokuni Higashiomiya Medical Center
Saitama-shi, 331-8577, Japan
San-Ai Hospital
Saitama-shi, 338-0837, Japan
NHO Sendai Medical Center
Sendai, 983-8520, Japan
The University of Osaka Hospital
Suita-shi, 565-0871, Japan
Tachikawa Hospital
Tachikawa-shi, 190-8531, Japan
Kagawa Prefectural Central Hospital
Takamatsu, 760-8557, Japan
Tokushima Prefectural Central Hospital
Tokushima, 770-8539, Japan
Ome Municipal General Hospital
Tokyo, Ome, 198-0042, Japan
Tomakomai City Hospital
Tomakomai-shi, 053-8567, Japan
Fundación Cardiovascular de Aguascalientes A.C
Aguascalientes, 20230, Mexico
Hospital Cardiologica Aguascalientes
Aguascalientes, 20230, Mexico
Centro Medico Culiacán
Culiacán, 80230, Mexico
Centro de Investigacion Biomedica y Farmaceutica, S.C.
Distrito Federal, 03100, Mexico
CICEJ Centro de Investigacion Clinica Endocrinologica de Jalisco S.C.
Guadalajara, 44670, Mexico
Salud Cardiovascular
Guadalajara, 45519, Mexico
Proactive CR Mexico S.A. de C.V.
Irapuato, 36520, Mexico
Clinstile S.A. de C.V.
México, 06700, Mexico
Cardiolink Clin Trials S.C.
Monterrey, 64060, Mexico
Hospital Universitario Dr Jose Eleuterio Gonzalez
Monterrey, 64460, Mexico
Clinical Research Institute S.C.
Tlalnepantla, 54055, Mexico
Centro de Investigacion Medica Alberto Bazzoni S.A. de C.V.
Torreón, 27000, Mexico
Jeroen Bosch Ziekenhuis-Hertogenbosch
's-Hertogenbosch, 5223 GZ, Netherlands
Rijnstate Hospital
Arnhem, 6815 AD, Netherlands
Amphia Ziekenhuis
Breda, 4818 CK, Netherlands
Deventer Ziekenhuis
Deventer, 7416 SE, Netherlands
Catharina Ziekenhuis
Eindhoven, 5623 EJ, Netherlands
Groene Hart ziekenhuis
Gouda, 2803 HH, Netherlands
Alrijne Leiderdorp
Leiderdorp, 2353 GA, Netherlands
St. Antonius Ziekenhuis
Nieuwegein, 3435 CM, Netherlands
Ikazia Ziekenhuis
Rotterdam, 3083 AN, Netherlands
De Heel - Zaans Medisch Centrum
Zaandam, 1502 DV, Netherlands
Univ. Clinic Hosp, Bialystok
Bialystok, 15-540, Poland
Centrum Medyczne Intercor Sp. z o.o.
Bydgoszcz, 85-605, Poland
NZOZ Medical Center KERmed
Bydgoszcz, 85231, Poland
Pratia Chojnice Medical Center
Chojnice, 89-600, Poland
Medical Center Pratia Czestochowa
Częstochowa, 42-217, Poland
Trevo Clinic Centrum Medyczne
Elblag, 82-300, Poland
Poradnia Kardiologiczna Jaroslaw Jurowiecki
Gdansk, 80-286, Poland
Individual Specialist Medical Practice Krzysztof Cymerman
Gdynia, 81-157, Poland
Pratia Katowice Medical Center
Katowice, 40-081, Poland
Clinical Medical Research Sp. z o.o.
Katowice, 40-156, Poland
Specialistic Cardiology&Hypertension Out-patient Clin,Kielce
Kielce, 25525, Poland
Leszek Bryniarski Specialized Medical Cabinet
Krakow, 30-082, Poland
Linden Sp. z o.o. sp.k.
Krakow, 30-721, Poland
Pratia MCM Krakow
Krakow, 30-727, Poland
Beata Miklaszewicz & Dariusz Dabrowski Cardiamed Sp. j.
Legnica, 59-220, Poland
SANTA FAMILIA Centrum Badan, Profilaktyki i Leczenia
Lodz, 90-302, Poland
Individual Specialized Practice
Lodz, 94-255, Poland
Lowickie Cardiology Center
Lowicz, 99-400, Poland
Velocity Nova Sp. z o.o.
Lublin, 20-362, Poland
Zanamed Medical Clinic Sp. z o.o.
Lublin, 20-601, Poland
Medeusz-Plus
Olsztyn, 10 165, Poland
Medicome Sp. z o.o.
Oświęcim, 32-600, Poland
Nzoz Heureka
Piaseczno, 05-500, Poland
Non-Public Outpatient Clinic Neuro-Kard Ilkowski & Partners
Poznan, 61-853, Poland
Aka-Med Centrum Sp. z o.o. S.K.
Ruda Śląska, 41-710, Poland
Centrum Medyczne Medyk
Rzeszów, 35-055, Poland
Lukmed Lukasz Wozniak
Siedlce, 08-110, Poland
Velocity Skierniewice Sp. z o.o
Skierniewice, 96-100, Poland
RCMed- Regionalne Centrum Medyczne
Sochaczew, 96-500, Poland
NZOZ Procordis, Cardiology Research Center of Sopot
Sopot, 81-717, Poland
Velocity Staszow
Staszów, 28-200, Poland
FutureMeds Sp. z o.o.
Warsaw, 00-215, Poland
Balsammedica Sp. z o. o.
Warsaw, 01-249, Poland
MTZ Clinical Research Powered by Pratia
Warsaw, 02-172, Poland
4. Military Clinical Hospital with Polyclinic SP ZOZ
Wroclaw, 50-981, Poland
Sedimed Sp. z o.o.
Wroclaw, 53-030, Poland
KO-MED Clinical Centers Zamosc
Zamość, 22-400, Poland
Centrum Medyczne Serafin med
Żarów, 58-130, Poland
Spitalul Judetean De Urgenta Dr. Constantin Opris Baia Mare
Baia Mare, 430031, Romania
Spitalul Clinic De Urgenta Prof Dr Agrippa Ionescu
Baloteşti, 77015, Romania
S.C.Centrul Medical Unirea SRL
Brasov, 500091, Romania
Spitalul Judetean de Urgenta Braila
Brăila, 810325, Romania
Emergency University Hospital
Bucharest, 050098, Romania
Clinica Medicala Data Plus SRL
Bucharest, 10192, Romania
S.C. Policlinica CCBR S.R.L.
Bucharesti, 030463, Romania
Spitalul Angiocare SRL
Cluj-Napoca, 400015, Romania
Emergency County Hospital Craiova
Craiova, 200642, Romania
S.C.Centrul Medical Unirea S.R.L.
Iași, 700023, Romania
Spitalul Clinic Judetean de Urgenta Bihor
Oradea, 410169, Romania
Sal Med Srl
Piteşti, 110424, Romania
Country Clinical Emergency Hospital, Targu-Mures
Târgu Mureş, 540136, Romania
Spitalul Clinic Judetean de Urgenta Targu Mures
Târgu Mureş, 540136, Romania
Podoleanu G. Cristian-Gheorghe-Calin
Târgu Mureş, 540143, Romania
S.C Medicali's S.R.L
Timișoara, 300362, Romania
King AbdulAziz University Hospital
Jeddah, 21589, Saudi Arabia
King Faisal Specialist Hospital and Research Center
Riyadh, 11211, Saudi Arabia
King Abdulaziz Medical City
Riyadh, 11426, Saudi Arabia
King Fahad Medical City
Riyadh, 11525, Saudi Arabia
King Saud Medical City
Riyadh, 11623, Saudi Arabia
Clinical Center " Dr Dragisa Misovic Dedinje"
Belgrade, 11000, Serbia
Clinical Hospital Center Dr. Dragisa Misovic
Belgrade, 11000, Serbia
Institute for Cardiovascular diseases Dedinje
Belgrade, 11000, Serbia
University Clinical Center of Serbia
Belgrade, 11000, Serbia
Clinical Hospital Center Zemun
Belgrade, 11080, Serbia
University Clinical Center of Kragujevac
Kragujevac, 34000, Serbia
University Clinical Center Nis
Niš, 18000, Serbia
Institute for Treatment and Rehabilitation, Niska Banja
Niška Banja, 18205, Serbia
General Hospital Pancevo
Pančevo, 26000, Serbia
General Hospital Sveti Luka
Smederevo, 11300, Serbia
Health Centre Zajecar
Zaječar, 19000, Serbia
General Hospital Celje
Celje, 3000, Slovenia
University Hospital Golnik
Golnik, 4204, Slovenia
General Hospital Jesenice
Jesenice, 4270, Slovenia
University Medical Center Ljubljana
Ljubljana, 1000, Slovenia
General Hospital Murska Sobota
Murska Sobota, 9000, Slovenia
General Hospital Trbovlje
Trbovlje, 1420, Slovenia
Iatros International
Bloemfontein, 9301, South Africa
Josha Research Centre
Bloemfontein, 9301, South Africa
TREAD Research
Cape Town, 7500, South Africa
Badenhorst, JCW
Centurion, 0157, South Africa
Johese Clinical Research: Unitas
Centurion, 0157, South Africa
Chris Hani Baragwanath Hospital: Cardiology Department
Johannesburg, 1862, South Africa
Dr JM Engelbrecht
Somerset West, 7130, South Africa
Clinical Projects Research
Worcester, 6850, South Africa
Inje University Busan Paik Hospital
Busan, 47392, South Korea
Dong-A University Hospital
Busan, 49201, South Korea
Pusan National University Hospital
Busan, 49241, South Korea
Chonnam National University Hospital
Gwangju, 61469, South Korea
Gachon University Gil Medical Center
Incheon, 21565, South Korea
Seoul National University Bundang Hospital
Seongnam, 13620, South Korea
Seoul National University Hospital
Seoul, 03080, South Korea
Severance Hospital
Seoul, 03722, South Korea
Samsung Medical Center
Seoul, 06351, South Korea
Korea University Guro Hospital
Seoul, 08308, South Korea
Korea University Anam Hospital
Seoul, 2841, South Korea
Yonsei University Wonju Severance Christian Hospital
Wonju-si, Gangwon State, 26426, South Korea
Hospital Germans Trias i Pujol
Badalona, 08916, Spain
Hospital Quiron. I.C.U.
Barcelona, 08023, Spain
Hospital Universitari Vall d'Hebron
Barcelona, 08035, Spain
Hospital Universitario Virgen de la Arrixaca
El Palmar, 30120, Spain
Hospital Universitari de Bellvitge
L'Hospitalet de Llobregat, 08907, Spain
Hospital General Universitario Gregorio Marañón
Madrid, 28007, Spain
Hospital Universitario Ramon Y Cajal
Madrid, 28034, Spain
Hospital Universitario 12 de Octubre
Madrid, 28041, Spain
Hospital Universitario La Paz
Madrid, 28046, Spain
Hospital Universitario Virgen de la Victoria
Málaga, 29010, Spain
Hospital Virgen del Camino
Sanlúcar de Barrameda, 11540, Spain
Complexo Hospitalario Universitario De Santiago
Santiago de Compostela, 15706, Spain
Hospital Clinico Universitario de Valencia
Valencia, 46010, Spain
Hospital General Universitario de Valencia
Valencia, 46014, Spain
Hospital Universitari i Politècnic La Fe
Valencia, 46026, Spain
Hospital Virgen de las Montañas
Villamartin, Cardiz, 11650, Spain
E-Da Hospital
Kaohsiung City, 82445, Taiwan
Taipei Medical University-Shuang Ho Hospital
New Taipei City, 235, Taiwan
China Medical University Hospital
Taichung, 404327, Taiwan
Taichung Veterans General Hospital
Taichung, 40705, Taiwan
National Taiwan University Hospital
Taipei, 100, Taiwan
Taipei Medical University Hospital
Taipei, 110, Taiwan
Taipei Veterans General Hospital
Taipei, 11217, Taiwan
Cheng Hsin General Hospital
Taipei, 112, Taiwan
Tri-Service General Hospital
Taipei, 114, Taiwan
Chang Gung Memorial Hospital, Linkou
Taoyuan, 333, Taiwan
Çukurova Ü. Tip Fak., Balcali Hastanesi, Kardiyoloji
Adana, 01330, Turkey (Türkiye)
Afyon Kocatepe University Medical Faculty
Afyonkarahisar, 03200, Turkey (Türkiye)
Etlik City Hospital
Ankara, 06170, Turkey (Türkiye)
Firat University Hospital
Elâzığ, 23119, Turkey (Türkiye)
Ataturk Universitesi Tip Fakultesi
Erzurum, 25240, Turkey (Türkiye)
Osmangazi Uni Medical Faculty
Eskişehir, 26480, Turkey (Türkiye)
Gaziantep University Medical Faculty Sahinbey Educational Research Hospital
Gaziantep, 27310, Turkey (Türkiye)
Siyami Ersek Gogus Kalp ve Damar Cerrahisi Hastanesi
Istanbul, 34668, Turkey (Türkiye)
Marmara University Pendik Training and Research Hospital
Istanbul, 34899, Turkey (Türkiye)
Medical Park Pendik Hospital
Istanbul, 34899, Turkey (Türkiye)
Kutahya Health Science University
Kütahya, 43040, Turkey (Türkiye)
Inonu Universitesi Tip Fakultesi Gogus Hastaliklari ABD
Malatya, 44280, Turkey (Türkiye)
Mersin University Medical Faculty
Mersin, 33020, Turkey (Türkiye)
KTU Tip Fakultesi Farabi Hastanesi
Trabzon, 61080, Turkey (Türkiye)
Barnet Hospital
Barnet, EN5 3DJ, United Kingdom
Southmead Hospital
Bristol, BS10 5NB, United Kingdom
Royal Devon and Exeter Hospital
Exeter, EX2 5DW, United Kingdom
Calderdale Royal Hospital
Halifax, HX3 0PW, United Kingdom
Wycombe Hospital
High Wycombe, HP11 2TT, United Kingdom
St Bartholomew's Hospital
London, EC1A 7BE, United Kingdom
The Royal Oldham Hospital
Oldham, OL1 2JH, United Kingdom
Northern General Hospital
Sheffield, S5 7AU, United Kingdom
Royal Cornwall Hospital
Truro, TR1 3LJ, United Kingdom
York Hospital
York, YO31 8HE, United Kingdom
Da Nang Hospital
Da Nang, 550000, Vietnam
Bach Mai hospital
Hanoi, 100000, Vietnam
Cho Ray Hospital
Ho Chi Minh City, 700000, Vietnam
Nguyen Tri Phuong Hospital
Ho Chi Minh City, 700000, Vietnam
Tam Duc Heart Hospital
Ho Chi Minh City, 700000, Vietnam
Thong Nhat Hospital HCMC
Ho Chi Minh City, 700000, Vietnam
University Medical Center HCMC
Ho Chi Minh City, 748806, Vietnam
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 10, 2024
First Posted
May 22, 2024
Study Start
June 17, 2024
Primary Completion (Estimated)
May 22, 2028
Study Completion (Estimated)
May 22, 2028
Last Updated
April 15, 2026
Record last verified: 2026-04
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, SAP, CSR
- Time Frame
- One year after the approval has been granted by major Regulatory Authorities and after the primary manuscript has been accepted for publication, or after termination of the development program.
- Access Criteria
- For study documents - upon signing of a 'Document Sharing Agreement'. For study data - 1. after the submission and approval of the research proposal (checks will be performed by the sponsor and/or the independent review panel, including checking that the planned analysis does not compete with sponsor's publication plan); 2. and upon signing of a legal agreement.
Once the criteria in section "Time Frame" are fulfilled, researchers can use the following link https://www.clinicalstudies.boehringer-ingelheim.com/msw/datasharing to request access to the clinical study documents regarding this study, and upon a signed "Document Sharing Agreement". Furthermore, researchers can request access to the clinical study data, for this and other listed studies, after the submission of a research proposal and according to the terms outlined in the website.