NCT05350202

Brief Summary

This is a multinational non-interventional study based on newly collected data to assess demographics, disease, and treatment pattern of patients with chronic Heart Failure (HF) in a two-cohort design: one cohort will receive first prescription of empagliflozin as routine therapy for HF, the other cohort will receive HF therapy with drugs with another mechanism of action. Treatment of HF according to routine practice is determined by the physician independent of the participation of the patient in this non-interventional study.

Trial Health

93
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
3,431

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Dec 2022

Geographic Reach
6 countries

350 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 22, 2022

Completed
6 days until next milestone

First Posted

Study publicly available on registry

April 28, 2022

Completed
8 months until next milestone

Study Start

First participant enrolled

December 18, 2022

Completed
1.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 25, 2024

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 25, 2024

Completed
1.1 years until next milestone

Results Posted

Study results publicly available

August 26, 2025

Completed
Last Updated

August 26, 2025

Status Verified

August 1, 2025

Enrollment Period

1.6 years

First QC Date

April 22, 2022

Results QC Date

July 16, 2025

Last Update Submit

August 21, 2025

Conditions

Outcome Measures

Primary Outcomes (1)

  • Change of the Kansas City Cardiomyopathy Questionnaire (KCCQ) Scores in Patients Newly Treated With Empagliflozin According to Routine Practice

    Change from baseline to Week 24 of the Kansas City Cardiomyopathy Questionnaire (KCCQ) scores, calculated as \[Week 24\] - \[Baseline\]. The KCCQ includes 23 items across 7 domains: physical limitation, symptom stability, symptom frequency, symptom burden, self-efficacy, quality of life, and social limitation. This outcome measured the total symptom score (TTS), clinical summary score (CSS), and overall summary score (OSS) in the empagliflozin-treated patients as defined in the clinical study protocol. The TTS evaluates symptom frequency and burden and is calculated as the mean of the symptom frequency score and symptom burden score. The CSS is calculated as the mean of the physical limitation score and total symptom score. The OSS is calculated as the mean of the physical limitation score, total symptom score, quality of life score, and social limitation score. The TTS, CSS, and OSS are represented on a 0-to-100-point scale, where a higher score reflects better health status.

    At baseline and at week 24.

Secondary Outcomes (4)

  • Change of the New York Heart Association (NYHA) Class in Patients Newly Treated With Empagliflozin

    At baseline and at Week 24.

  • Number of Participants With Comorbidities

    At baseline.

  • Number of Participants With Concomitant Heart-failure (HF) Related Medication

    At baseline.

  • Hospitalizations Due to Heart-failure in the Past 6 Months Before Baseline

    Up to 6 months prior to baseline visit.

Study Arms (2)

Empagliflozin-treated patients

Patients with heart failure (HF), with or without diabetes, who received their first prescription of empagliflozin were treated according to the approved product information, with a recommended daily dose of 10 milligrams (mg).

Drug: Empagliflozin

Non-SGLT2i-treated patients

Patients with heart failure (HF), with or without diabetes, who received drugs with mechanisms of action other than empagliflozin (drugs other than SGLT2i (Sodium-Glucose Co-Transporter 2 inhibitors)) were treated according to the approved product information.

Interventions

Empagliflozin was administered according to the approved product information.

Also known as: Jardiance®
Empagliflozin-treated patients

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients with chronic Heart Failure (HF) in a two cohort design: one cohort will receive first prescription of empagliflozin as routine therapy for HF, the other cohort will receive HF therapy with drugs with another mechanism of action.

You may qualify if:

  • Written informed consent prior to study participation
  • Male and female patients ≥ 18 years at Visit 1
  • Patients must be contractually capable and mentally able to understand and follow the instructions of the study personnel
  • Patients with diagnosis of chronic heart failure NYHA Class 2-4
  • Treatment-naïve for SGLT2i at visit 1
  • Women of childbearing potential must take appropriate precautions against getting pregnant according to approval of chosen HF drug(s)

You may not qualify if:

  • Missing physician's diagnosis of chronic heart failure
  • Patients hospitalized at visit 1
  • Life expectancy ≤ 12 months according to physician's assessment
  • Lack of informed consent
  • Pregnant or lactating females
  • Participation in a parallel interventional clinical trial
  • Chosen treatment with another SGLT2i drug than empagliflozin
  • Having been enrolled into the non-empagliflozin-arm of this non-interventional study
  • Current or prior treatment with SGLT2i at visit 1
  • Patients with contraindications according to current Summary of Product Characteristics (SmPC)
  • Patients with dependency or relationship to the treating physician

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (350)

Dr. Mircheva

Burgas, 8000, Bulgaria

Location

Dr. Yordanov

Haskovo, 6304, Bulgaria

Location

MBAL Atanas Dafovski, Kardzhali

Kardzhali, 6600, Bulgaria

Location

Dr. Krasteva

Kyustendil, 2501, Bulgaria

Location

Dr. Todorov

Lovech, 5500, Bulgaria

Location

Dr. Tsoneva

Lovech, 5500, Bulgaria

Location

Dr. Pavlov

Parvomay, 4270, Bulgaria

Location

Medical Center, Pazardjik

Pazardzhik, 4400, Bulgaria

Location

Dr. Stankova

Pernik, 2300, Bulgaria

Location

assoc.prof. Gospodinov

Pleven, 5800, Bulgaria

Location

dr. Kostadinovska

Pleven, 5800, Bulgaria

Location

prof.Tisheva

Pleven, 5800, Bulgaria

Location

Dr. Mekenian

Plovdiv, 4001, Bulgaria

Location

Dr. Ilchev

Plovdiv, 4002, Bulgaria

Location

Dr. Hairabedian

Plovdiv, 4018, Bulgaria

Location

Dr. Filipov

Plovdiv, 4020, Bulgaria

Location

MBAL Sliven, Dr. Bletsova

Sliven, 8800, Bulgaria

Location

Dr. Pancheva

Sofia, 1000, Bulgaria

Location

prof. Velchev

Sofia, 1000, Bulgaria

Location

dr. Georgieva

Sofia, 1202, Bulgaria

Location

dr. Karchinova

Sofia, 1202, Bulgaria

Location

prof.Vitlianova

Sofia, 1202, Bulgaria

Location

dr. Petrusheva

Sofia, 1233, Bulgaria

Location

dr. Garvanski

Sofia, 1407, Bulgaria

Location

Dr. Naidenova

Sofia, 1431, Bulgaria

Location

Dr. Varnaliiska

Sofia, 1431, Bulgaria

Location

prof. Karamfiloff

Sofia, 1431, Bulgaria

Location

Dr. Nossikov

Sofia, 1784, Bulgaria

Location

Dr. Gospodinov

Stara Zagora, 6004, Bulgaria

Location

Dr. Trendafilova

Targovishte, 7700, Bulgaria

Location

dr. Belcheva

Varna, 9000, Bulgaria

Location

dr. Mancheva

Varna, 9003, Bulgaria

Location

dr. Gyuzelev

Varna, 9010, Bulgaria

Location

Dr. Petrova

Yambol, 8600, Bulgaria

Location

Dr. Toneva-Zhelaeva

Yambol, 8600, Bulgaria

Location

MUDr. Hana Burianová

Bílovec, 743 01, Czechia

Location

Fakultní nemocnice u sv. Anny v Brně

Brno, 602 00, Czechia

Location

MUDr. Karel Kameník s.r.o.

Brno, 603 00, Czechia

Location

MUDr. Libor Nechvátal s.r.o.

Brno, 61600, Czechia

Location

Zdravá srdce s.r.o.

Brno, 62700, Czechia

Location

Kardiologická ambulance Brno, s.r.o.

Brno-Královo Pole, 61200, Czechia

Location

EDUMED s.r.o. - Dr. Nováková

Broumov, 55001, Czechia

Location

EDUMED s.r.o. - Dr. Polášková

Broumov, 55001, Czechia

Location

EDUMED s.r.o. - Dr. Švarcová

Broumov, 55001, Czechia

Location

EDUMED s.r.o.

Broumov, 55001, Czechia

Location

Kardiologická ambulance Český krumlov

Český Krumlov, 38101, Czechia

Location

CorMedico s.r.o.

Frýdek-Místek, 73801, Czechia

Location

DIKa centrum s.r.o.

Havířov, 73601, Czechia

Location

Lékařský servis, a.s.

Havířov, 73601, Czechia

Location

Kardio Pudich s.r.o.

Hlučín, 748 01, Czechia

Location

ProKardio HK, s.r.o.

Hradec Králové, 50011, Czechia

Location

Nemocnice Jihlava - Kardiologické oddělení

Jihlava, 58633, Czechia

Location

Oblastní nemocnice Kolín, a.s. nemocnice Středočeského kraje

Kolín, 2802, Czechia

Location

KardioBušák s.r.o.

Louny, 440 01, Czechia

Location

Kardiomost s.r.o.

Most, 43401, Czechia

Location

Nemocnice AGEL Nový Jičín, a.s.

Nový Jičín, 74101, Czechia

Location

Kardiologická ambulance Olomouc

Olomouc, 77900, Czechia

Location

Nemocnice AGEL Ostrava-Vítkovice a.s. - Kardiologická ambulance

Ostrava, 70030, Czechia

Location

Kardiologická ambulance Mammed

Ostrava, 70200, Czechia

Location

OVAKARD s.r.o.

Ostrava, 70200, Czechia

Location

Poliklinika Nová Huť

Ostrava, 71900, Czechia

Location

Fakultní nemocnice Ostrava

Ostrava - Poruba, 708 52, Czechia

Location

Kardiologie Vinohrady s.r.o.

Prague, 120 00, Czechia

Location

Kardiologie prof. Táborský s.r.o.

Prague, 12000, Czechia

Location

Vseobecna fakultni nemocnice v Praze

Prague, 128 00, Czechia

Location

MEDICON a.s.

Prague, 140 00, Czechia

Location

Nemocnice na Homolce

Prague, 150 30, Czechia

Location

Clinical Trials Service s.r.o.

Prague, 15600, Czechia

Location

ROcardia s.r.o.

Prostějov, 79604, Czechia

Location

Galenica Medical s.r.o.

Prostřední Suchá, 73564, Czechia

Location

KARDIO GRÉZL, s.r.o.

Šumperk, 78701, Czechia

Location

Všeobecná interní ambulance s.r.o.

Tábor, 39003, Czechia

Location

Kardiologická ambulance MUDr. Ferkl s.r.o.

Trutnov, 54101, Czechia

Location

Nemocnice AGEL Třinec-Podlesí a.s.

Třinec Podlesí, 73961, Czechia

Location

Lunacor s.r.o.

Vizovice, 76312, Czechia

Location

Krajská nemocnice T. Bati, a.s.

Zlín, 76275, Czechia

Location

Állami Szívkórház

Balatonfüred, 8230, Hungary

Location

Gottsegen György National Cardiovascular Center

Budapest, 1096, Hungary

Location

Heart and Vascular Centre, Semmelweis University

Budapest, 1122, Hungary

Location

Sante Cons Bt.

Budapest, 1133, Hungary

Location

DE Klinikai Központ Kardiológia és Szívsebészet

Debrecen, 4032, Hungary

Location

Dombóvári Szent Lukács Kórház

Dombóvár, 7200, Hungary

Location

Lahynara Bt

Dunavarsány, 2336, Hungary

Location

Kardiológia Magánrendelő

Eger, 3300, Hungary

Location

Mohácsi Kórház

Mohács, 7700, Hungary

Location

Coromed-Smo

Pécs, 7623, Hungary

Location

University of Pécs

Pécs, 7624, Hungary

Location

Soproni Erzsébet Oktató Kórház

Sopron, 9400, Hungary

Location

Újszeged Egészségközpont

Szeged, 6726, Hungary

Location

ECHOKardio Poradnia Kardiologiczna

Bialystok, 15-028, Poland

Location

Klinika Kardiologii Uniwersyteckiego Szpitala Klinicznego w Białymstoku

Bialystok, 15-276, Poland

Location

Kardiologiczna Praktyka Lekarska Anna Tomaszuk-Kazberuk

Bialystok, 15-546, Poland

Location

Podlaski Ośrodek Kardiologii

Bialystok, 15-875, Poland

Location

Specjalistyczna Praktyka Lekarska Marek Styczkiewicz

Brzozów, 36-200, Poland

Location

BlueMed - Centrum Medyczne

Bydgoszcz, 85-088, Poland

Location

Centrum Kardiologii Paweł Grzelakowski

Bydgoszcz, 85-095, Poland

Location

Centrum Medyczne A i D Nowak sj

Bydgoszcz, 85-314, Poland

Location

Indywidualna Specjalistyczna Praktyka Lekarska Tomasz Ługowski

Bydgoszcz, 85-791, Poland

Location

Specjalistyczna Praktyka Lekarska Grzegorz Grześk

Bydgoszcz, 85-796, Poland

Location

Indywidualna Specjalistyczna Praktyka Lekarska Jolanta Nowak

Bytom, 41-902, Poland

Location

Specjalistyczna Praktyka Lekarska Agata Fenger

Chorozow, 41500, Poland

Location

Med. - Zone sp zoo

Cieszyn, 43-400, Poland

Location

Specjalistyczna Praktyka Lekarska lek.n.med.Lucyna Góras-Hetmańczyk

Czeladź, 41250, Poland

Location

Gabinet Kardiologiczny - Jacek Jafra

Częstochowa, 42-202, Poland

Location

Prywatna Praktyka Lekarska Artur Dekiela

Częstochowa, 42-202, Poland

Location

Specjalistyczna Praktyka Lekarska Magdalena Miczko

Dąbrowa Górnicza, 41-300, Poland

Location

ISPL Małgorzata Dobrowolska Gabinet Tendo

Gdynia, 81-395, Poland

Location

Specjalistyczna Praktyka Lekarska Wojciech Czapla

Gliwice, 44-100, Poland

Location

Dorota Adamczyk-Kot NZOZ-KARDIO

Gmina Jędrzejów, 28-300, Poland

Location

Lekarze na Dworskiej

Gmina Świebodzin, 66-200, Poland

Location

Indywidualna Praktyka Lekarska Tomasz Zieliński

Grodzisk Mazowiecki, 05-825, Poland

Location

Przychodnia Lekarska Zdrowy Miś

Grójec, 05-600, Poland

Location

Miedziowe Centrum Zdrowia S.A.

Głogów, 67-200, Poland

Location

Centrum Medyczne NIWA

Głogów Małopolski, 36-060, Poland

Location

Indywidualna Praktyka Lekarska Piotr Tokarczyk

Inowrocław, 88-100, Poland

Location

Familia Medicina Sp. z o.o.

Iwanowice Włościańskie, 32-095, Poland

Location

Specjalistyczna Praktyka Lekarska Urszula Winiarska-Waluś

Jastrzębie Zdrój, 44-330, Poland

Location

Specjalistyczna Praktyka Lekarska Jarosław Paździerz

Jasło, 38-200, Poland

Location

Centrum Medyczne Kinesis

Kamień, 36-053, Poland

Location

Praktyka Lekarska Wojciech Kwaśniewski

Katowice, 40-645, Poland

Location

Prywatna Przychodnia Specjalistyczna Drozd Zbigniew Gąsior

Katowice, ul. Drozdów 26, Poland

Location

CUM PromontMed

Kielce, 25-020, Poland

Location

Arsmedica Specjalistyczna Praktyka Lekarska lek.med. Krzysztof Czerniejewski

Konin, 62-500, Poland

Location

Prywatny Gabinet Kardiologiczny lek. med. Sławomir Kępski

Konin, 62-500, Poland

Location

Specjalistyczna Praktyka Lekarska Paweł Michalski

Konin, 62-500, Poland

Location

Uromed Sp Zoo

Koszalin, 75-402, Poland

Location

Poliklinika MSWiA/Indywidualna Specjalistyczna Praktyka Lekarska Krzysztof Jarząbek

Koszalin, 75-604, Poland

Location

Indywidualna Praktyka Lekarska Krzysztof Maślak

Koźminek, 62-840, Poland

Location

Centrum Medyczne Dietla 19 sp. Z o.o.

Krakow, 31-070, Poland

Location

Centrum Twojego Zdrowia

Krakow, 31-101, Poland

Location

Specjalistyczna Praktyka Lekarska "Kardiolek" Dr med. Piotr Wilkołek

Krakow, 31-216, Poland

Location

CM Oficerskie

Krakow, 31-513, Poland

Location

Poradnia Kardiologiczna, Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie

Krakow, 31-826, Poland

Location

Prywatny Gabinet Kardiologiczny Dr n.med Janusz Bąk

Kranse, 36-007, Poland

Location

Centrum Medyczne Dębina

Krościenko Wyżne, 38-422, Poland

Location

Beata Mikłaszewicz&Dariusz Dąbrowski Cardiamed S.J.

Legnica, 59-220, Poland

Location

NZOZ DUOMED S.C. Poradnia Kardiologiczna

Legnica, 59-220, Poland

Location

Prywatny Specjalistyczny Gabinet Kardiologiczno-Internistyczny

Libiąż, 32-590, Poland

Location

Santa Sp. z o.o.

Lodz, 90-302, Poland

Location

Nzoz Salusmed

Lodz, 91-002, Poland

Location

Kardiologiczna Praktyka Lekarska Wojciech Kula

Lublin, 20-053, Poland

Location

NZOZ Sanus Jacek Madej Poradnia kardiologiczna

Lublin, 20-143, Poland

Location

NZOZ Sanus Jacek Madej

Lublin, 20-143, Poland

Location

Provivo Specjalistyczne Centrum Medyczne

Lublin, 20-400, Poland

Location

Indywidualna Specjalistyczna Praktyka Lekarska - Renata Leniec

Lublin, 59-300, Poland

Location

Niepubliczny Zakład Opieki Zdrowotnej Specjalistyczne Gabinety lekarskie

Mikołów, 43-190, Poland

Location

Gabinet Lekarski Kardiologiczny

Mirków, 55-095, Poland

Location

Prywatne Usługi Medyczne Jacek Morka

Modliszewice, 26-200, Poland

Location

Indywidualna Specjalistyczna PraktyKa Lekarska-Piotr Utz

Moszczenica, 97-310, Poland

Location

Gabinet Lekarski Ewa Burchard

Nowe Miasto nad Pilicą, 26-420, Poland

Location

Medyczne Centrum Zdrovita

Nowy Tomyśl, 64-300, Poland

Location

Oleśnica Prywatna Praktyka Lekarska

Oleśnica, 56-400, Poland

Location

SZOZ Jantar Sp. z o.o. Poradnia Lekarzy Specjalistów

Ostrów Wielkopolski, 63-400, Poland

Location

GVM CARINT Oświęcim

Oświęcim, 32-600, Poland

Location

Specjalistyczna Praktyka Lekarska Rafał Nowak

Piasek, 43-211, Poland

Location

Specjalistyczna Praktyka Lekarska Andrzej Bęben

Piotrkow Trybunalski, 97-300, Poland

Location

Indywidualna Specjalistyczna Praktyka Lekarska Andrzej Bolewski

Poznan, 60-461, Poland

Location

Wojewódzki Szpital im. św. Ojca Pio w Przemyślu

Przemyśl, 37-700, Poland

Location

Leszek Kaminski Specjalistyczny Gabinet Lekarski

Przeworsk, 37-200, Poland

Location

Praktyka Lekarska Katarzyna Czarnecka

Pszczyna, 43-200, Poland

Location

PCK - Puławskie Centrum Kardiologiczne Przychodnia Specjalistyczna

Puławy, 24-100, Poland

Location

Poradnia Kardiologiczna SPZOZ Pulawy

Puławy, 24-100, Poland

Location

Indywidualna Specjalistyczna Praktyka Lekarska Maciej Strawczyński

Płock, 09-402, Poland

Location

Indywidualna Specjalistyczna Praktyka Lekarska Magdalena Poterala

Radom, 26-600, Poland

Location

Poradnia Kardioogiczna Zegara Słonecznego

Radom, 26-600, Poland

Location

Specjalistyczna Praktyka Lekarska Radzionków

Radzionków, 41-922, Poland

Location

Indywidualna Specjalistyczna Praktyka Lekarska dr n. med. Alicja Gałuszka-Bilińska

Rybnik, 44-203, Poland

Location

Specjalistyczna Praktyka Lekarska Wiesława Faberska-Blicharska

Rybnik, 44-217, Poland

Location

Centrum Medyczne Sabamed

Rzeszów, 35-006, Poland

Location

Prywatny Gabinet Kardiologiczny dr n.med Janusz Romanek

Rzeszów, 35-055, Poland

Location

My Life Centrum chorób serca

Sanok, 38-500, Poland

Location

Monika Kujawiak Prywatna Praktyka Lekarska

Siedlce, 08-110, Poland

Location

Prywatny Gabinet Lekarski Hanna Wilk-Manowiec

Siedlce, 08-110, Poland

Location

Indywidualna praktyka lekarska Artur Marcinkiewicz

Siemianowice Śląskie, 41-106, Poland

Location

Asnyka 78d Gabinety Lekarskie

Skierniewice, 96-100, Poland

Location

Specjalistyczna Praktyka Lekarska Maciej Kaźmierski

Sosnowiec, 41-200, Poland

Location

Specjalistyczna Praktyka Lekarska Marek Kondys

Sosnowiec, 41-200, Poland

Location

Powiatowy Szpital Specjalistyczny w Stalowej Woli

Stalowa Wola, 37-450, Poland

Location

Centrum Medyczne VITA

Szczecin, 70-341, Poland

Location

Specjalistyczna Praktyka Lekarska Tomasz Urbanik

Szczecin, 71-790, Poland

Location

ISPL Anna Bis

Szczecin, 71-804, Poland

Location

Szpital w Szczecinku

Szczecinek, 78-400, Poland

Location

Gabinet Lekarski Weronika Greberska

Szczytniki, 62-023, Poland

Location

Specjalistyczna Praktyka Lekarska Kamila Stembalska

Ścinawa, 59-330, Poland

Location

Leomed Centrum Medyczne

Tarnowskie Góry, 42-606, Poland

Location

Specjalistyczna Praktyka Lekarska Paweł Kocik

Tarnów, 33-100, Poland

Location

Prywatna Praktyka Lekarska na wezwanie Mirosław Marciniak

Torun, 87-100, Poland

Location

Indywidualna Specjalistyczna Praktyka Lekarska - Witold Orszulak

Tychy, 43-100, Poland

Location

Urszula Urbanowicz Specjalistyczna Praktyka Lekarska

Tychy, 43100, Poland

Location

SERCE S.C. Przychodnia Lekarzy Specjalistów

Warsaw, 02-496, Poland

Location

Klinika 37 Centrum Kardiologii Płowiecka

Warsaw, 02-991, Poland

Location

Prywatny Gabinet Lekarski Bożena Norwa-Otto

Warsaw, 04-188, Poland

Location

Gabinet Lekarski lek med. Robert Włodarczyk

Wawrzeńczyce, 32-125, Poland

Location

Centrum Medyczne Nowe Miasto

Wałbrzych, 58-302, Poland

Location

Specjalistyczny Gabinet Lekarski Łukasz Graczykowski

Włocławek, 87-800, Poland

Location

Specjalistyczna Prajtyka Lekarska Grażyna Glanowska

Zabrze, 10444, Poland

Location

Gabinet Prywatnej Praktyki Lekarskiej Kard.-Int . Dr n.med. Brygida Przywara-Chowaniec

Zabrze, 41-800, Poland

Location

Ns Zoz Kardiologia Sp. Z.O.O.

Zamość, 22-400, Poland

Location

ALDEMED Centrum Medyczne

Zielona Góra, 65-001, Poland

Location

Gabinety Lekarskie JM Kulczyccy

Żary, 68-200, Poland

Location

Prywatna Praktyka Lekarska Anna Chudoba

Żyrardów, 96-300, Poland

Location

Poradnia Kardiologiczna Centrum Medyczne w Łańcucie

Łańcut, 37-100, Poland

Location

SP ZOZ Łęczna

Łęczna, 21-010, Poland

Location

Kardiologiczno - Internistyczny Gabinet Lekarski Skrzyński Andrzej

Łuków, 21-400, Poland

Location

Miclea Ioana - Mariana MEDIC SPECIALIST CARDIOLOG

Alba Iulia, 510137, Romania

Location

Dr. Morar Mihnea-Dragoscabinet Medical Individual - Specialist Cardiologie

Arad, 310009, Romania

Location

Dr. Pop-Moldovan Adina-Ligia - Medicina Interna - Cardiologie

Arad, 310182, Romania

Location

CMI Iosipescu Laura Cristina

Bacau, 600037, Romania

Location

Cardio Animus SRL

Bacau, 600204, Romania

Location

CMI - Centrul medical Diacord

Baia Mare, 430076, Romania

Location

Mercea Corina-Delia - Medic

Baia Mare, 430123, Romania

Location

Ambrinomed SRL

Botoșani, 710095, Romania

Location

Cardioland SRL

Brasov, 500326, Romania

Location

Rus V. Horatiu - Cabinet Medical Individual de Cardiologie

Brasov, RO-500188, Romania

Location

S.C. Ilro Medical S.R.L

Bucharest, 010991, Romania

Location

PFA Balahura Cristian

Bucharest, 011026, Romania

Location

Dr. Danet Ruxandra - Medic Cardiologie

Bucharest, 011258, Romania

Location

Dr. Bogdan Stefan Nicolae

Bucharest, 011925, Romania

Location

Cardiocare Center SRL

Bucharest, 012052, Romania

Location

Cordmedica SRL

Bucharest, 012082, Romania

Location

Dr. Serban Irina-Ruxandra - MEDIC PRIMAR CARDIOLOGIE

Bucharest, 020281, Romania

Location

Urocard Plus Srl

Bucharest, 020281, Romania

Location

Medi Pro Consult SRL

Bucharest, 020501, Romania

Location

Cmi Dr Georgescu Dragos

Bucharest, 021705, Romania

Location

Dr. Geavlete Dana-Oliviana - Activitate Medicala

Bucharest, 021967, Romania

Location

Mihaila I. Sorina - Medic Pfi

Bucharest, 030915, Romania

Location

S.C. Cardiomedical Team Pro S.R.L.

Bucharest, 040343, Romania

Location

Dumitrescu Silviu-Ionel Persoana Fizica Autorizata

Bucharest, 060926, Romania

Location

Mihalcea Janina-Diana Medic Specialist Cardiologie

Bucharest, 061192, Romania

Location

Patrascu R. Natalia - Medic Specialist Medicina Interna

Bucharest, 061304, Romania

Location

Popescu I. Ileana Nicoleta Medic specialist cardiologie

Bucharest, 061406, Romania

Location

CMI Dr. Parsa Motlagh Babak

Bucharest, 062282, Romania

Location

Magister Research SRL

Bucharest, 070000, Romania

Location

Dr. Lungeanu-Juravle Laura-Activitate Medicala

Bucharest, RO-011038, Romania

Location

Cardio Clinique NCS SRL

Buzău, 120195, Romania

Location

Medcon SRL

Buzău, 120203, Romania

Location

Medicard SRL

Buzău, 120279, Romania

Location

Angioplast Medical srl

Ciurea, RO-707085, Romania

Location

CMI Diaconescu Iulia Dana

Cluj-Napoca, 400347, Romania

Location

Mediprax Centrum Cluj Napoca

Cluj-Napoca, 400347, Romania

Location

SC Adisan SRL

Cluj-Napoca, 400347, Romania

Location

Sc Medicardio Andreea Srl

Cluj-Napoca, 400347, Romania

Location

Cardiotreat SRL

Cluj-Napoca, 400349, Romania

Location

SC Clujana Medica Srl

Cluj-Napoca, 400394, Romania

Location

PFA Comsa M.Dan-Horatiu

Cluj-Napoca, 400441, Romania

Location

Cabinet Cardiohealt Srl

Cluj-Napoca, 400479, Romania

Location

SC Cardioprotect MED SRL

Cluj-Napoca, 400535, Romania

Location

Sc Dentcor Srl

Cluj-Napoca, RO-400480, Romania

Location

Cardio World Health

Com Mosoaia, 117512, Romania

Location

Cardio Manea Adelina SRL

Constanța, 610219, Romania

Location

Endodiahealth Srl

Constanța, 900002, Romania

Location

Dr. Maxim George Razvan - Activitate Medicala

Constanța, 900168, Romania

Location

CMI Dr Ilie Ivona Valeria

Constanța, 900519, Romania

Location

Asclepios Medicalhealth SRL

Constanța, 900615, Romania

Location

Sc Daxiela Impex Srl

Craiova, 200085, Romania

Location

Hortopan Med SRL

Craiova, 200323, Romania

Location

Neurocord Medical Srl

Craiova, 200383, Romania

Location

Vesalius Medical S.R.L

Craiova, 200470, Romania

Location

Cabinet Medical Individual - Dr. Popescu Monica

Craiova, 200519, Romania

Location

SC A&C Medical Prime SRL

Craiova, RO-200692, Romania

Location

S & R Cardiobalance Srl

Curtea de Argeş, 115300, Romania

Location

Cardiolife

Deva, 330011, Romania

Location

Bendl H. Laura Elena - Cabinet Medical Individual Plus Clinic

Drobeta-Turnu Severin, 220004, Romania

Location

SC Maycor SRL

Galati, 800217, Romania

Location

CMI Dr. Chiscaneanu Teodor

Galati, 800584, Romania

Location

Cardiomedplus SRL

Gheorghieni, 535500, Romania

Location

Procardia Serv-Med 2009 SRL srl

Iași, 700111, Romania

Location

Sc Cardiocare Clinic Srl

Iași, 700260, Romania

Location

Sc Cardiortomed Srl

Iași, 700282, Romania

Location

Medical Cardio Anghel SRL

Iași, 700451, Romania

Location

Niculescu G. Ana Irina - Medic colaborator

Iași, 700688, Romania

Location

SC Cardiomed SRL Iasi

Iași, 700732, Romania

Location

Cardioszakacs Srl, Cui 34404518

Miercurea-Ciuc, 530112, Romania

Location

Polimed Center SRL, CUI 26072639

Odorheiu Secuiesc, 535600, Romania

Location

CMI Dr. Rotariu Dragos

Oradea, 410009, Romania

Location

CMI Societatea civila Magheru&Magheru

Oradea, 410027, Romania

Location

CMI Cardiomed SRL

Oradea, 410169, Romania

Location

PFA Dr. Ardelean Adriana Ioana

Oradea, 410388, Romania

Location

Dradiand SRL

Oradea, 410473, Romania

Location

Sc Adriacard Srl

Oradea, 410474, Romania

Location

Simed Concept SRL

Ostratu, 012052, Romania

Location

Andries I. Elena - Medic Primar Cardiologie Si Medic Specialist Mi

Piatra Neamţ, 610065, Romania

Location

Cardiomed Alexandrescu Srl-D

Piatra Neamţ, 610078, Romania

Location

Dr. Corcoz Cardiologie SRL

Piatra Neamţ, 610150, Romania

Location

Davisof San Srl

Piteşti, 110003, Romania

Location

Clinica Cardiologie Dr Stanciu Viorel

Piteşti, 110074, Romania

Location

Sc Procordia Concept Srl

Piteşti, 110172, Romania

Location

Cavi Clinique SRL

Ploieşti, 100562, Romania

Location

SC Cardiologie Dr. Cristina Radoi SRL

Râmnicu Vâlcea, 240022, Romania

Location

Sc Lidermed Plus Srl

Râmnicu Vâlcea, 240282, Romania

Location

Sc Incarmed Srl

Râmnicu Vâlcea, 240284, Romania

Location

Munteanu Alice-Elena - Medic Cardiolog

Sat Rosu, Comuna Chiajna, 077041, Romania

Location

Cardio Stim Center SRL

Sânpetru, 507190, Romania

Location

Gx.Hatconsulting Srl

Săcele, 505600, Romania

Location

Voineag Olivia Medic Colaborator

Scheia, 720282, Romania

Location

SC Endocordis SRL

Sfântu Gheorghe, 520068, Romania

Location

Rusu N. Ramona Iulia Medic Primar Cardiologie

Suceava, 720067, Romania

Location

Batar D. Sergiu Constantin

Şelimbăr, 557260, Romania

Location

German Sallo Marta - Medic primar cardiolog, CIF 35699735

Târgu Mureş, 540095, Romania

Location

CMI Tatar A. Maria Cristina, CUI 19814204

Târgu Mureş, RO-540496, Romania

Location

Diaconu Diana - Medic Cif 31885867

Tifgu Mures, 540281, Romania

Location

Cardiomed Health SRL

Timișoara, 300172, Romania

Location

Mornos Cristian Medic Independent

Timișoara, 300230, Romania

Location

Cardio Suport SRL

Timișoara, 300244, Romania

Location

Medicalife Tim SRL

Timișoara, 300362, Romania

Location

Cardio - DRS S.R.L

Timișoara, 300369, Romania

Location

Policlinica Dr. Tudoran

Timișoara, 300480, Romania

Location

Croitoru G Rodica Medic Colaborator

Valea Adâncă, 700732, Romania

Location

CMI Demle S. Adriana-Cristina

Zalău, 450103, Romania

Location

Dr. Dragos Lupu - Medic Specialist Cardiolog

Zarnesti, 505800, Romania

Location

Universitätsspital Basel

Basel, 4051, Switzerland

Location

Spital Sonnenhof

Bern, 3006, Switzerland

Location

Engeried-Spital (Bern)

Bern, 3012, Switzerland

Location

Spitalzentrum Biel

Biel, 2501, Switzerland

Location

Hôpital de La Tour

Carouge, 1227, Switzerland

Location

Cardiomed - Jura

Courrendlin, 2830, Switzerland

Location

Centre de Cardiologie

Delémont, 2800, Switzerland

Location

Schlossberg Ärztezentrum

Frauenfeld, 8500, Switzerland

Location

Hôpitaux Universitaires de Genève

Geneva, 1205, Switzerland

Location

Hôpitaux Universitaires de Genève

Geneva, 1211, Switzerland

Location

Spital Lachen AG

Lachen, 8853, Switzerland

Location

CHUV-Centre hospitalier universitaire vaudois

Lausanne, 1011, Switzerland

Location

Luzerner Kantonsspital

Lucerne, 6004, Switzerland

Location

Herzzentrum Hirslanden Zentralschweiz

Lucerne, 6006, Switzerland

Location

Hôpital de Morges

Morges, 1110, Switzerland

Location

Dr. med. Eleni Goulouti

Neuchâtel, 2000, Switzerland

Location

Kantonsspital Olten

Olten, 4600, Switzerland

Location

Herzpraxis Regensdorf

Regensdorf, 8105, Switzerland

Location

Herzpraxis Sankt Gallen

Sankt Gallen, 9000, Switzerland

Location

Kantonsspital Obwalden

Sarnen, 6060, Switzerland

Location

Rehaklinik Seewis

Seewis, 7212, Switzerland

Location

Dr. med. Kiril Tzvetanov

Sierre, 3960, Switzerland

Location

Herzpraxis Sursee

Sursee, 6210, Switzerland

Location

Kardiologie Aarezentrum Thun

Thun, 3600, Switzerland

Location

Spital STS AG

Thun, 3600, Switzerland

Location

Hôpital Fribourgeois

Villars-sur-Glâne, 1752, Switzerland

Location

Herz- und Physiozentrum

Wallisellen, 8304, Switzerland

Location

Arztpraxis Waltenschwil

Waltenschwil, 5622, Switzerland

Location

Spital Will

Will, 9500, Switzerland

Location

Herz- und Kreislaufpraxis Winterthur

Winterthur, 8400, Switzerland

Location

Medbase Winterthur Neuwiesen

Winterthur, 8400, Switzerland

Location

Hôpital d'Yverdon-les-Bains

Yverdon-les-Bains, 1400, Switzerland

Location

Spital Zollikerberg

Zollikerberg, 8125, Switzerland

Location

SICADE Clinic

Zurich, 8001, Switzerland

Location

Herzpraxis Enge ZH

Zurich, 8002, Switzerland

Location

Gruppenpraxis Dr. Deseö / Dr. Deseö-Schütz / Dr. Lorger

Zurich, 8008, Switzerland

Location

Herzklinik Hirslanden

Zurich, 8032, Switzerland

Location

HerzKlinik Zürich Hirslanden

Zurich, 8032, Switzerland

Location

Herzkreislaufpraxis

Zurich, 8055, Switzerland

Location

Universitätsspital Zürich

Zurich, 8091, Switzerland

Location

Related Links

MeSH Terms

Conditions

Heart Failure

Interventions

empagliflozin

Condition Hierarchy (Ancestors)

Heart DiseasesCardiovascular Diseases

Results Point of Contact

Title
Boehringer Ingelheim, Call Center
Organization
Boehringer Ingelheim

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
OTHER
Restrictive Agreement
Yes

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 22, 2022

First Posted

April 28, 2022

Study Start

December 18, 2022

Primary Completion

July 25, 2024

Study Completion

July 25, 2024

Last Updated

August 26, 2025

Results First Posted

August 26, 2025

Record last verified: 2025-08

Data Sharing

IPD Sharing
Will share

Once the criteria in section "Time Frame" are fulfilled, researchers can use the following link https://www.mystudywindow.com/msw/datasharing to request access to the clinical study documents regarding this study, and upon a signed "Document Sharing Agreement". Furthermore, researchers can request access to the clinical study data, for this and other listed studies, after the submission of a research proposal and according to the terms outlined in the website.

Shared Documents
STUDY PROTOCOL, SAP, CSR
Time Frame
After structured results have been posted, all regulatory activities are completed in the US and EU for the product and indication, and after the primary manuscript has been accepted for publication.
Access Criteria
For study documents - upon signing of a 'Document Sharing Agreement'. For study data - 1. after the submission and approval of the research proposal (checks will be performed by the sponsor and/or the independent review panel, including checking that the planned analysis does not compete with sponsor's publication plan); 2. and upon signing of a legal agreement.
More information

Locations