A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
EASi-HF Reduced - A Phase III Double-blind, Randomised, Parallel-group Superiority Trial to Evaluate Efficacy and Safety of the Combined Use of Oral Vicadrostat (BI 690517) and Empagliflozin Compared With Placebo and Empagliflozin in Participants With Symptomatic Chronic Heart Failure (HF: NYHA II-IV) and Left Ventricular Ejection Fraction (LVEF) < 40%
3 other identifiers
interventional
4,200
29 countries
638
Brief Summary
This study is open to adults with chronic heart failure (HF) who have a reduced left ventricular ejection fraction (LVEF) of less than 40%. People can join the study if they have been diagnosed with chronic HF at least 3 months before they start on the study. The purpose of this study is to find out whether a medicine called vicadrostat, in combination with another medicine called empagliflozin, helps people with chronic heart failure. In this study, participants are put into 2 groups randomly. Participants have an equal chance of being in either group. One group takes vicadrostat/empagliflozin tablets, and the other group takes placebo/empagliflozin tablets. Placebo tablets look like vicadrostat tablets but do not contain any medicine. Participants take the study medicines as tablets once a day for between about 6 months and about 3.5 years. During this time, they can continue their regular treatment for heart failure. Participants can stay in the study as long as they benefit from treatment and can tolerate it, for a maximum of about 3.5 years. During this time, they visit the study site regularly. The exact number of visits is different for each participant, depending on how long they stay in the study. The study staff may also contact the participants by phone for some visits. Participants also regularly answer questions about their well-being. The doctors document when participants experience worsening of their heart failure symptoms, go to hospital due to heart failure or die during the study. The time until these events are observed is compared between the two treatment groups to see whether the treatment works. The doctors also regularly check participants' health and take note of any unwanted effects.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3 heart-failure
Started May 2025
Typical duration for phase_3 heart-failure
638 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 17, 2025
CompletedFirst Posted
Study publicly available on registry
April 20, 2025
CompletedStudy Start
First participant enrolled
May 20, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 4, 2029
ExpectedStudy Completion
Last participant's last visit for all outcomes
February 22, 2029
April 29, 2026
April 1, 2026
3.7 years
April 17, 2025
April 28, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Time to first event of Cardiovascular (CV) death, or Hospitalisation for heart failure (HHF), or Urgent heart failure (HF) visit
up to 43 months
Secondary Outcomes (13)
Key secondary endpoint: Time to first event of cardiovascular death or HHF
up to 43 months
Key secondary endpoint: Occurrences of HHF (first and recurrent)
up to 43 months
Key secondary endpoint: Absolute change from baseline in Kansas City Cardiomyopathy Questionnaire-Total Symptom Score (KCCQ-TSS) at Week 32
at baseline, at week 32
Key secondary endpoint: Time to cardiovascular death
up to 43 months
Key secondary endpoint: Time to all-cause mortality
up to 43 months
- +8 more secondary outcomes
Study Arms (2)
vicadrostat/empagliflozin treatment group
EXPERIMENTALPlacebo to vicadrostat/empagliflozin treatment group
PLACEBO COMPARATORInterventions
empagliflozin
Eligibility Criteria
You may qualify if:
- At least 18 years old and at least at the legal age of consent in countries where it is greater than 18 years
- Signed and dated written informed consent in accordance with International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use - Good Clinical Practice (ICH-GCP) and local legislation prior to admission to the trial
- Male or female participants. Women of childbearing potential (WOCBP) must be ready and able to use highly effective methods of birth control per ICH M3 (R2) that result in a low failure rate of less than 1% per year when used consistently and correctly. A list of contraception methods meeting these criteria and instructions on the duration of their use is provided in the protocol.
- Chronic heart failure (HF) diagnosed at least 3 months before Visit 1, and in New York Heart Association (NYHA) classes II to IV at Visit 1, with left ventricular ejection fraction (LVEF) \< 40% per local reading (obtained by echocardiography, radionuclide ventriculography, invasive angiography, magnetic resonance imaging (MRI), or computed tomography (CT)).
- Elevated N-terminal pro-brain natriuretic peptide (NT-proBNP) at Visit 1, analysed at the central laboratory
- Treated according to best possible standard of care (SOC) (disregarding sodium-dependent glucose co-transporter 2 inhibitor (SGLT2i) and mineralocorticoid receptor antagonist (MRA)) in accordance with applicable heart failure (HF) local/international guidelines and judgement of the investigator.
You may not qualify if:
- Treatment with an MRA (e.g. spironolactone, eplerenone, finerenone) within 14 days prior to Visit 1 or requiring such treatment before randomisation or planned during the trial based on the judgment of the investigator. Treatment with an MRA should not be discontinued with the intention of study enrolment.
- Treatment with amiloride or other potassium-sparing diuretic within 14 days prior to Visit 1 or requiring such treatment before randomisation or planned during the trial based on the judgment of the investigator.
- Receiving the following treatments:
- A direct renin inhibitor (e.g. aliskiren) at Visit 2
- More than one angiotensin-converting enzyme inhibitor (ACEi), angiotensin receptor blocker (ARB) or angiotensin receptor-neprilysin inhibitor (ARNi) used simultaneously at Visit 2
- Other aldosterone synthase inhibitors, e.g. baxdrostat at Visit 2 or planned during the trial
- Systemic mineralocorticoid replacement therapy (e.g. fludrocortisone) at Visit 2
- In case of acute decompensated HF:
- i.v. inotrope, i.v. vasodilating drug (e.g. nitrate, nitroprusside), or i.v. natriuretic peptide (e.g. nesiritide, carperitide), or mechanical support (e.g. intra-aortic balloon pump, endotracheal intubation, mechanical ventilation, any ventricular assist device) within 24 hours prior to randomisation
- Myocardial infarction (MI), transient ischemic attack (TIA), stroke, coronary artery bypass graft surgery (CABG), heart valve surgery/intervention or any other major surgery (major according to the investigator's assessment) within 90 days prior to Visit 2, or scheduled for major elective surgery (e.g. hip replacement, CABG)
- Percutaneous coronary intervention (PCI) or any angiography using iodinated contrast agents in the 7 days prior to Visit 2
- Heart transplant recipient, awaiting heart transplant, or currently implanted left ventricular assist device (LVAD)
- Known cardiomyopathy based on infiltrative diseases (e.g. amyloidosis), accumulation diseases (e.g. haemochromatosis, Fabry disease), muscular dystrophies, hypertrophic obstructive cardiomyopathy or known pericardial constriction, or cardiomyopathy with potentially reversible cause such as stress or peripartum cardiomyopathy or cardiomyopathy induced by chemotherapy within 12 months prior to Visit 1 and until Visit 2
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (638)
Alliance for Multispecialty Research, LLC
Mobile, Alabama, 36608, United States
Drug Research and Analysis Corporation
Montgomery, Alabama, 36106, United States
Cure Clinical Research
Beverly Hills, California, 90211, United States
Valley Clinical Trials, Inc.
Covina, California, 91723, United States
North Coast Cardiology
Encinitas, California, 92024, United States
Orange County Research Center
Lake Forest, California, 92630, United States
Merced Vein and Vascular Center
Merced, California, 95340, United States
Radin Cardiovascular Medical Group
Newport Beach, California, 92663, United States
Amicis Research Center - Nordhoff
Northridge, California, 91324, United States
University of California San Diego
San Diego, California, 92103, United States
Paradigm Clinical Research - San Diego
San Diego, California, 92108, United States
Amicis Research Corporate
Santa Clarita, California, 91355, United States
Care Access Research
Thousand Oaks, California, 91360, United States
Bridgeport Hospital
Bridgeport, Connecticut, 06610, United States
Bay Area Cardiology
Brandon, Florida, 33511, United States
Cardiology Associates Research Co.
Daytona Beach, Florida, 32117, United States
Suncoast Research Associates, LLC
Doral, Florida, 33172, United States
Malcom Randall VA Medical Center
Gainesville, Florida, 32608, United States
Velocity Clinical Research-Hallandale Beach-67888
Hallandale, Florida, 33009, United States
University of Florida
Jacksonville, Florida, 32209, United States
East Coast Institute For Research, LLC
Jacksonville, Florida, 32216, United States
First Coast Cardiovascular Institute
Jacksonville, Florida, 32216, United States
Jacksonville Center for Clinical Research
Jacksonville, Florida, 32216, United States
University of Miami - Miller School of Medicine
Miami, Florida, 33125, United States
Infinite Clinical Research Inc
Miami, Florida, 33133, United States
Inpatient Research Clinic, LLC
Miami Lakes, Florida, 33014, United States
Innovation Medical Research Center
Palmetto Bay, Florida, 33157, United States
Peace River Cardiovascular Center
Port Charlotte, Florida, 33952, United States
St. Johns Center for Clinical Research
Saint Augustine, Florida, 32086, United States
Cardiology Partners Clinical Research Institute
Wellington, Florida, 33449, United States
Cozy Research LLC
Wesley Chapel, Florida, 33544, United States
Clinical Site Partners, LLC
Winter Park, Florida, 32789, United States
Atlanta Clinical Research Centers
Atlanta, Georgia, 30342, United States
Columbus Regional Research Institute
Columbus, Georgia, 31904, United States
NSC Research Inc
Johns Creek, Georgia, 30024, United States
Northwest Heart Clinical Research, LLC
Arlington Heights, Illinois, 60005, United States
Illinois Masonic Hospital
Chicago, Illinois, 60657, United States
Chicago Medical Research
Hazel Crest, Illinois, 60429, United States
Clinical Investigation Specialists, Inc.
Libertyville, Illinois, 60048, United States
AMR Park Ridge
Park Ridge, Illinois, 60068, United States
Springfield Clinic
Springfield, Illinois, 62703, United States
Midwest Cardiovascular Research and Education Foundation
Elkhart, Indiana, 46514, United States
St. Francis Medical Group-Indiana Heart Physicians, Inc
Indianapolis, Indiana, 46237, United States
Indiana Medical Research Institute
Merrillville, Indiana, 46410, United States
Cardiovascular Research of Northwest Indiana, LLC
Munster, Indiana, 46321, United States
Reid Hospital
Richmond, Indiana, 47374, United States
The Iowa Clinic, PC
West Des Moines, Iowa, 50266, United States
University of Kansas Medical Center
Kansas City, Kansas, 66160, United States
Kansas Nephrology Research Institute, LLC
Wichita, Kansas, 67214, United States
Robert J Dole Veterans Affairs Medical Center
Wichita, Kansas, 67218, United States
West Houston Area Clinical Trial Consultants, LLC
Wichita, Kansas, 67226, United States
Norton Healtcare - Norton Heart and Vascular Institute
Louisville, Kentucky, 40217, United States
Heart Clinic of Hammond
Hammond, Louisiana, 70403, United States
Grace Research, LLC-Shreveport-64616
Shreveport, Louisiana, 71105, United States
Ascension Saint Agnes Heart Care
Baltimore, Maryland, 21229, United States
Metropolitan Cardiovascular Consultants
Beltsville, Maryland, 20705, United States
Capitol Cardiology Associates
Lanham, Maryland, 20706, United States
McLaren Bay Region Medical Center
Bay City, Michigan, 48708, United States
Cardiology and Vascular Associates - CAVA
Bloomfield Hills, Michigan, 48304, United States
Michigan Healthcare Professionals Pulse Cardiology
Farmington Hills, Michigan, 48334, United States
St. John Providence Hospital
Novi, Michigan, 48374, United States
Michigan Heart, PC
Ypsilanti, Michigan, 48197, United States
Minneapolis VA Health Care System
Minneapolis, Minnesota, 55417, United States
Mayo Clinic, Rochester
Rochester, Minnesota, 55905, United States
Regions Hospital
Saint Paul, Minnesota, 55101, United States
Jackson Heart Clinic, P.A.
Jackson, Mississippi, 39216, United States
North Kansas City Hospital
Kansas City, Missouri, 64116, United States
Kansas City VA Medical Center
Kansas City, Missouri, 64128, United States
St. Louis Heart and Vascular, P.C.
St Louis, Missouri, 63136, United States
Be Well Clinical Studies
Omaha, Nebraska, 68144, United States
Advanced Heart Care, LLC
Bridgewater, New Jersey, 08807, United States
Garden State Heart Care, PC
Manalapan, New Jersey, 07726, United States
Bassett Medical Center
Cooperstown, New York, 13326, United States
Mount Sinai Hospital-New York-52529
New York, New York, 10019, United States
Icahn School of Medicine at Mount Sinai
New York, New York, 10029, United States
IMA Clinical Research Lenoir
Lenoir, North Carolina, 28645, United States
Pinehurst Medical Clinic, Inc. - East
Pinehurst, North Carolina, 28374, United States
WakeMed
Raleigh, North Carolina, 27610, United States
Piedmont Healthcare, Inc.
Statesville, North Carolina, 28625, United States
Wilmington Health
Wilmington, North Carolina, 28401, United States
VA Northeast Ohio Healthcare System
Cleveland, Ohio, 44106, United States
K and R Research LLC
Marion, Ohio, 43302, United States
Cardiology Consultants of Philadelphia
Yardley, Pennsylvania, 19067, United States
Bon Secours Medical Group Greenville Specialty Care, LLC
Greenville, South Carolina, 29607, United States
Monument Health
Rapid City, South Dakota, 57701, United States
Pharmatex Research
Amarillo, Texas, 79109, United States
Amarillo Heart Clinical Research Institute, Incorporated
Amarillo, Texas, 79124, United States
NextStage Clinical Research
Beaumont, Texas, 77702-1513, United States
Headlands Research Brownsville
Brownsville, Texas, 78526, United States
Texas Health Research and Education Institute
Dallas, Texas, 75231, United States
Southwest Family Medicine Associates
Dallas, Texas, 75235, United States
Helios CR Inc - Fort Worth
Fort Worth, Texas, 76104, United States
The Methodist Hospital Research Institute
Houston, Texas, 77030, United States
DM Clinical Research Dallas
Irving, Texas, 75061, United States
DCOL Center for Clinical Research
Longview, Texas, 75605, United States
DCOL Center for Clinical Research
Longview, Texas, 75605, United States
North Texas Research Associates
McKinney, Texas, 75071, United States
Revival Research Institute, LLC - McKinney
McKinney, Texas, 75071, United States
Texas Institute Of Cardiology
McKinney, Texas, 75071, United States
Stryde Research
Plano, Texas, 75093, United States
Accurate Clinical Research, Inc.
Richmond, Texas, 77469, United States
Baylor Scott and White Health
Temple, Texas, 76508, United States
Northwest Heart Center
Tomball, Texas, 77375, United States
NextStage Clinical Research
Waco, Texas, 76712, United States
Virginia Heart - Falls Church
Falls Church, Virginia, 22042, United States
Carient Heart and Vascular
Manassas, Virginia, 20109, United States
Sentara Norfolk General Hospital
Norfolk, Virginia, 23507, United States
Carilion Clinic
Roanoke, Virginia, 24014, United States
Inst de Inv Clinicas-Bahia Blanca
Bahía Blanca, B8000FTD, Argentina
Hospital Regional de Bahia Blanca
Bahía Blanca, B8000, Argentina
CIPREC
Buenos Aires, C1061AAS, Argentina
Centro de Investigaciones Metabolicas (CINME)-C.A.B.A-61553
C.a.b.a, C1056ABJ, Argentina
Hospital Italiano de Buenos Aires
Ciudad Autonoma Buenos Aires, 1199, Argentina
Fundacion Favaloro
Ciudad Autonoma Buenos Aires, C1093AAS, Argentina
Mautalen- Salud e Investigacion
Ciudad Autonoma Buenos Aires, C1128AAF, Argentina
Centro Medico Dra Laura Maffei
Ciudad Autonoma Buenos Aires, C1425AGC, Argentina
Glenny Corp. S.A. Bioclinica Argentina
Ciudad Autonoma Buenos Aires, C1430CKE, Argentina
Clinica Coronel Suárez
Coronel Suárez, B7540GHD, Argentina
Sanatorio Allende
Córdoba, 5000, Argentina
Sanatorio Privado Duarte Quiros De Clinica Colombo SA
Córdoba, X5002AOQ, Argentina
Well Medica
Córdoba, X5002HWE, Argentina
Instituto Médico DAMIC S.R.L.
Córdoba, X5003DCE, Argentina
Centro Medico Luquez
Córdoba, X5006CBI, Argentina
Centro de Investigaciones Clinicas Baigorria
Granadero Baigorria, 2152, Argentina
Hospital Italiano de La Plata
La Plata, B1900AXI, Argentina
Centro de Investigaciones Medicas Mar del Plata
Mar del Plata, 7600, Argentina
Hospital Universitario Austral
Pilar, B1629ODT, Argentina
Instituto Medico CER
Quilmes, B1878DVB, Argentina
Instituto de Investigaciones Clínicas de Quilmes
Quilmes, B1878GEG, Argentina
DIM Clinica Privada
Ramos Mejía, 1704, Argentina
INECO Neurociencias Oroño
Rosario, 2000, Argentina
Instituto de Investigaciones Clinicas de Rosario
Rosario, 2000, Argentina
Instituto Medico Fundacion Grupo Colaborativo Rosario Investigacion y Prevencion Medica
Rosario, 2000, Argentina
Sanatorio Parque S.A.
Rosario, S2000DSV, Argentina
Instituto CAICI
Rosario, S2000PBJ, Argentina
Investigaciones Clinicas Salta (ICSAL)
Salta, 4400, Argentina
Centro Cardiovascular Salta
Salta, A4406BFP, Argentina
Corporacion Medica de Gral. San Martin S.A.
San Martin, B1650CSQ, Argentina
Investigaciones en Patologias Respiratorias
San Miguel de Tucumán, T4000IAI, Argentina
Investigaciones Clinicas Tucuman
San Miguel de Tucumán, T4000ICL, Argentina
Centro Integral de Arritmias Tucuman
San Miguel de Tucumán, T4000, Argentina
Centro Modelo de Cardiologia
San Miguel de Tucumán, T4000, Argentina
Clinica Mayo
San Miguel de Tucumán, T4000, Argentina
Instituto de Investigaciones Clinicas San Nicolas
San Nicolás, B2900DMH, Argentina
Hospital "Dr. José Maria Cullen"
Santa Fe, S3000EOZ, Argentina
Centro de Investigaciones Clínicas del Litoral
Santa Fe, S3000FWO, Argentina
CEMEDIC - Centro de Especialidades Medicas
Villa Luro, C1440CFD, Argentina
AZ Sint-Blasius
Dendermonde, 9200, Belgium
Ziekenhuis Oost-Limburg
Genk, 3600, Belgium
AZ Sint-Lucas
Ghent, 9000, Belgium
Grand Hôpital de Charleroi
Gilly, 6060, Belgium
AZ Groeninge
Kortrijk, 8500, Belgium
C.H.U. de Tivoli
La Louvière, 7100, Belgium
CHR de la Citadelle
Liège, 4000, Belgium
Hospital Sirio Libanes
Bela Vista, 01308-050, Brazil
Hospital Felicio Rocho
Belo Horizonte, 30110-934, Brazil
Cardresearch Cardiologia Assistencial e de Pesquisas Ltda
Belo Horizonte, 30150-274, Brazil
L2IP -Instituto de Pesquisas Clínicas Ltda.
Brasília, 70200-730, Brazil
Hospital DF Star
Brasília, 70390-140, Brazil
CECAP - Centro de Cardiologia Clínica
Brasília, 70710-100, Brazil
Hospital Angelina Caron
Campina Grande do Sul, 83430-000, Brazil
IPECC - Instituto de Pesquisa Clínica de Campinas
Campinas, 13060-080, Brazil
Hospital PUC-Campinas
Campinas, 13060-904, Brazil
I9 Pesquisas Clinicas - Loema Instituto de Pesquisa Clínica e Consultores SS Ltda
Campinas, 13092-133, Brazil
Hospital do Rocio
Campo Largo, 83606-177, Brazil
Fundacao Universidade de Caxias do Sul
Caxias do Sul, 95070-560, Brazil
PUC Trials - Núcleo de Pesquisa Clínica da Escola de Medicina da PUC-PR
Curitiba, 80230-130, Brazil
Via Medica
Goiânia, 74223-130, Brazil
HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás
Goiânia, 74680160, Brazil
ICM - Instituto do Coracao de Marilia
Marília, 17515-000, Brazil
Hospital Vera Cruz
Minas Gerais, 30220-140, Brazil
Instituto Atena de Pesquisa Clinica
Natal, 59020-035, Brazil
Instituto Mederi de Pesquisa e Saude
Passo Fundo, 99010-120, Brazil
Hospital de Clínicas de Porto Alegre
Porto Alegre, 90035-903, Brazil
Irmandade da Santa Casa de Misericórdia de Porto Alegre
Porto Alegre, 90050-170, Brazil
Nucleo de Pesquisa Clinica do Rio Grande do Sul (NPCRS)
Porto Alegre, 90430-001, Brazil
Hospital Mae de Deus
Porto Alegre, 90840-440, Brazil
Hospital Esperança Recife
Recife, 50070-480, Brazil
Clinicor Clínica Cardiológica LTDA/ Cardio Prime - CAPED
Ribeirão Preto, 14026-900, Brazil
Instituto Brasil de Pesquisa Clinica (IBPClin)
Rio de Janeiro, 20241-180, Brazil
Ruschel Medicina e Pesquisa Clínica
Rio de Janeiro, 22270-060, Brazil
Instituto D'Or Pesquisa e Ensino - Rio de Janeiro
Rio de Janeiro, 22281-100, Brazil
Hospital Cardio Pulmonar
Salvador, 40170-310, Brazil
Pesquisare
Santo André, 09080-110, Brazil
Praxis Pesquisa Medica
Santo André, 09090-970, Brazil
Instituto Domingo Braile
São José do Rio Preto, 15015-750, Brazil
Fundação Faculdade Regional de Medicina de São José do Rio Preto
São José do Rio Preto, 15090-000, Brazil
CIPES - Centro Internacional de Pesquisa Clínica
São José dos Campos, 12230-001, Brazil
Cpquali Pesquisa Clinica Ltda
São Paulo, 01228-000, Brazil
CPCLIN - Centro de Pesquisas Clínicas Ltda.
São Paulo, 01228-200, Brazil
CEPIC - Centro Paulista de Investigacao Clinica
São Paulo, 04266-010, Brazil
Eurolatino Pesquisas Médicas Ltda.
Uberlândia, 38400-500, Brazil
CEDOES - Diagnóstico e Pesquisa,Vitória
Vitória, 29055-450, Brazil
Medical center 4LIFE Ltd.
Burgas, 8000, Bulgaria
MHAT Heart and brain
Burgas, 8000, Bulgaria
Medical Center Doktor Staykov Ltd.
Burgas, 8008, Bulgaria
Diamedical Medical Center 2013
Dimitrovgrad, 6400, Bulgaria
MHAT "Sveta Ekaterina-Dimitrovgrad", EOOD
Dimitrovgrad, 6400, Bulgaria
Medical Center New Polyclinic Gabrovo Ltd.
Gabrovo, 5300, Bulgaria
MHAT Ivan Skenderov EOOD
Gotse Delchev, 2900, Bulgaria
Medical Center Rodopimed EOOD
Kardzhali, 6600, Bulgaria
Medical Center Hera - Kyustendil EOOD
Kyustendil, 2500, Bulgaria
Tonus 2013 Ltd.
Pazardzhik, 4400, Bulgaria
Ambulatory Individual Practice for Cardiology Specialized Medical Care
Pernik, 2300, Bulgaria
Medical Center Medconsult Pleven OOD
Pleven, 5800, Bulgaria
MHAT Heart and brain
Pleven, 5800, Bulgaria
UMHAT "Sv. Georgi", EAD
Plovdiv, 4002, Bulgaria
UMHAT "Sv. Georgi", EAD
Plovdiv, 4002, Bulgaria
MBAL Sveta Karidad EAD
Plovdiv, 4004, Bulgaria
Medical Center Rusemed EOOD
Rousse, 7013, Bulgaria
National Multiprofile Transport Hospital "Tzar Boris III"
Sofia, 1233, Bulgaria
Medical Center For Specialized Medical Help In Cardiovascular Diseases OOD
Sofia, 1309, Bulgaria
University Hospital Lozenetz
Sofia, 1407, Bulgaria
Alexandrovska University Hospital
Sofia, 1431, Bulgaria
Diagnostic Consultative Center Alexandrovska
Sofia, 1431, Bulgaria
University Multidisciplinary Hospital for Active Treatment Sveta Ekaterina EAD
Sofia, 1431, Bulgaria
Medical Center Hera EOOD
Sofia, 1510, Bulgaria
UMHAT "Tsaritsa Yoanna-ISUL" EAD
Sofia, 1527, Bulgaria
ASOMHIDC - Individual practice "Cardio Tonus" EOOD
Sofia, 1582, Bulgaria
Multiprofile Hospital MHATEM 'Pirogov', Sofia
Sofia, 1606, Bulgaria
Diagnostic Consultation Center XX-Sofia EOOD
Sofia, 1618, Bulgaria
MHAT "St. Sofia"
Sofia, 1618, Bulgaria
Kalimat Medical Center Ltd.
Sofia, 1680, Bulgaria
Medical Center Intermedica Ltd.
Sofia, 1680, Bulgaria
Medical Center Medicabilis Ltd.
Sofia, 1756, Bulgaria
Medical center DEA Medicals Ltd.
Sofia, Bulgaria
Medical Center Zara-Med EOOD
Stara Zagora, 6000, Bulgaria
UMHAT Prof. Dr. Stoyan Kirkovich AD
Stara Zagora, 6000, Bulgaria
MDHAT 'Dr. Stefan Cherkezov', AD
Veliko Tarnovo, 5000, Bulgaria
Medical Center Medica Plus Ltd.
Veliko Tarnovo, 5000, Bulgaria
Medical Centre Nevromedics EOOD
Veliko Tarnovo, 5006, Bulgaria
MHAT St Panteleimon
Yambol, 8600, Bulgaria
Saul Vizel Medicine Professional Corporation
Cambridge, Ontario, N1R 7R1, Canada
Health Sciences North
Greater Sudbury, Ontario, P3E 5J1, Canada
Elevate Clinical Research - KMH Hamilton
Kitchener, Ontario, N2M 5N4, Canada
KMH Cardiology Centres (Mississauga)
Mississauga, Ontario, L5K 2L3, Canada
Oakville Trafalgar Memorial Hospital
Oakville, Ontario, L6K 3W7, Canada
James Cha, MD
Oshawa, Ontario, L1J 2K1, Canada
Kawartha Cardiology Clinical Trials
Peterborough, Ontario, K9J 0B2, Canada
CardioQuest Research Centre
Sarnia, Ontario, N7T 4P5, Canada
Niagara Health System - St. Catharines Site
St. Catharines, Ontario, L2R 7C6, Canada
Fadia El Boreky Medicine Professional Corporation
Waterloo, Ontario, N2J 1C4, Canada
ViaCar Recherches Cliniques Inc. (Brossard)
Brossard, Quebec, J4Z 2K9, Canada
Diex Recherche (Sherbrooke)
Sherbrooke, Quebec, J1L 0H8, Canada
Diex Recherche (Trois-Rivieres)
Trois-Rivières, Quebec, G9A 4P3, Canada
Institut Universitaire de Cardiologie et de Pneumologie de Quebec (IUCPQ)
Québec, G1V 4G5, Canada
CIUSSS du Saguenay - Lac-Saint-Jean
Québec, G7H 5H6, Canada
CardioVasc HR Inc.
Saint-Jean-sur-Richelieu, J3A 1J2, Canada
Enroll Spa
Santiago, 7500587, Chile
CeCim - Centro de Estudios Clinicos e Investigacion Medica
Santiago, 8331143, Chile
Centro de Investigación del Maule
Talca, 3465586, Chile
Hospital Las Higueras
Talcahuano, 4270918, Chile
CECMI Ltda
Temuco, 4780000, Chile
CINVEC - Centro de Investigacion Clinica V Reg.,Vina del Mar
Viña del Mar, 2520997, Chile
Beijing AnZhen Hospital, Capital Medical University
Beijing, 100029, China
Cardiovascular Institute and Fu Wai Hospital
Beijing, 100037, China
Jilin Province People's Hospital
Changchun, 130021, China
The First Hospital of Jilin University
Changchun, 130021, China
China-Japan Union Hospital of Jilin University
Changchun, 130033, China
Changde Second People's Hospital
Changde, 415001, China
Hunan Province People's Hospital (The First Affiliated Hospital of Hunan Normal University)
Changsha, 410005, China
The Second Xiangya Hospital Of Central South University
Changsha, 410011, China
The Third Hospital of Changsha
Changsha, 410015, China
People's Hospital of Sichuan Province
Chengdu, 610072, China
Chenzhou No.1 people's Hospital
Chenzhou, 423000, China
Second Affiliated Hospital Chongqing Medical University
Chongqing, 400010, China
Chongqing Three Gorges Central Hospital
Chongqing, 404000, China
Affiliated Zhongshan Hospital of Dalian University
Dalian, 116001, China
Daqingshi People's Hospital
Daqing, 163711, China
Deyang People's Hospital
Deyang, 618099, China
The First People's Hospital of Foshan
Foshan, 528000, China
The First Affiliated Hospital of Fujian Medical University
Fuzhou, 350005, China
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Guangzhou, 510000, China
Guangdong Provincial People's Hospital
Guangzhou, 510080, China
Third Affiliated Hospital of Guangzhou Medical University
Guangzhou, 510150, China
The Affiliated Panyu Central Hospital of Guangzhou Medical University
Guangzhou, 511400, China
Guizhou People's Hospital
Guiyang, 550002, China
Hainan General Hospital
Haikou, 570311, China
The First Affiliated Hospital of Harbin Medical University
Harbin, 150040, China
Jiangmen Central Hospital
Jiangmen, 529030, China
Center Hospital of Jinan
Jinan, 250013, China
Lanzhou University Second Hospital
Lanzhou, 730030, China
Linfen Central Hospital
Linfen, 041000, China
Luoyang Third People's Hospital
Luoyang, 471002, China
The First Affiliated Hospital of Henan University of Science and Technology
Luoyang, 471003, China
Jiangxi Province Integrated Tractional Chinese Medicine& Western Medicine Hospital
Nanchang, 330003, China
The First Affiliated Hospital of Nanchang University
Nanchang, 330006, China
Zhongda Hospital Southeast University
Nanjing, 210009, China
Nanjing Jiangning Hospital
Nanjing, 211100, China
The First Affiliated Hospital of Guangxi Medical University
Nanning, 530021, China
Nanyang First People's Hospital
Nanyang, 473004, China
Nanyang Second General Hospital
Nanyang, 473009, China
Ningbo Second Hospital
Ningbo, 315010, China
The First Affiliated Hospital of Ningbo University
Ningbo, 315010, China
Panjin Liao Oil Gem Flower Hospital
Panjin, 124010, China
Pingxiang People's Hospital
Pingxiang, 337000, China
Zhongshan Hospital Affiliated to Fudan University
Shanghai, 200032, China
Tongren hospital, Shanghai Jiaotong University School of Medicine
Shanghai, 200050, China
Shanghai General Hospital
Shanghai, 200080, China
Shengjing Hospital of China Medical University
Shenyang, 110004, China
People's Hospital of Liaoning Province
Shenyang, 110067, China
Shenzhen People's Hospital
Shenzhen, 518172, China
The Second Hospital of Hebei Medical University
Shijiazhuang, 050000, China
Shanxi Bethune Hospital
Taiyuan, 030032, China
Shanxi Cardiovascular Hospital
Taiyuan, 30013, China
Taian City Central Hospital
Tai’an, 271000, China
Tianjin Union Medical Center Nankai University Affiliated Hospital
Tianjin, 300121, China
The 2nd Hospital of Tianjin Medical University
Tianjin, 300211, China
Hubei Province Zhongshan Hospital
Wuhan, 430032, China
Renmin Hospital of Wuhan University
Wuhan, 430060, China
Shaanxi Provincial People's Hospital
Xi'an, 710068, China
Xinxiang Central Hospital
Xinxiang, 453000, China
The People's Hospital Of Xuancheng City
Xuancheng, 242000, China
The General Hospital of XZCMG (The Second Affiliated Hospital of Xuzhou Medical University)
Xuzhou, 221006, China
The first People's Hosptal of Yinchuan
Yinchuan, 750001, China
Yueyang Central Hospital
Yueyang, 414000, China
Yuncheng Central Hospital
Yuncheng, 44000, China
The First Affiliated Hospital of Hebei North University
Zhangjiakoou, 75000, China
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, 450008, China
Affiliated Hospital of Jiangsu University
Zhenjiang, 212001, China
Cardiomet CEQUIN S.A.S
Armenia, 630001, Colombia
Centro de Investigacion Medico Asistencial S.A.S
Barranquilla, 80020, Colombia
Corazon IPS S.A.S.
Barranquilla, 80020, Colombia
Fundacion Santa Fe de Bogota
Bogotá, 110111, Colombia
Administradora Country S.A.S.
Bogotá, 110221, Colombia
Fundacion Hospital Infantil Universitario de San José
Bogotá, 111221, Colombia
IPS Centro Medico Julián Coronel S.A.
Cali, 760001, Colombia
Centro de Diagnostico Cardiologico S.A.S.
Cartagena, 130001, Colombia
IPS médicos internistas de Caldas S.A.S.
Manizales, 170004, Colombia
T Y C Inversiones S.A.S Grupsalud
Santa Marta, 470001, Colombia
MUDr. Hana Burianova
Bílovec, 743 01, Czechia
Medicus Services Ltd.
Brandýs nad Labem, 250 01, Czechia
Fakultni nemocnice u sv. Anny v Brne
Brno, 602 00, Czechia
MUDr. Karel Kamenik s.r.o
Brno, 603 00, Czechia
MUDr. Jan Hubac s.r.o.
Chrudim, 537 01, Czechia
EDUMED s.r.o.
Jaroměř, 551 01, Czechia
MUDr Petra Maskova PhD
Litovel, 784 01, Czechia
KardioBusak s.r.o.
Louny, 440 01, Czechia
InterKardioML s.r.o.
Mariánské Lázně, 353 01, Czechia
MUDr. Zdenek Vomacka kardiologie a interna s.r.o.
Olomouc, 779 00, Czechia
MUDr. Jan Kvasnicka CSc
Prague, 10100, Czechia
Kardiologie Vinohrady s r o
Prague, 11000, Czechia
Institute for Clinical and Experimental Medicine
Prague, 140 21, Czechia
University Hospital Motol
Prague, 15006, Czechia
University Thomayer´s Hospital
Praha 4-Krc, 140 59, Czechia
Nemocnice Slany
Slaný, 274 01, Czechia
Kardiologicka ambulance MUDr. Ferkl s.r.o.
Trutnov, 541 01, Czechia
Clinical Trials Services s.r.o
Uherské Hradiště, 68601, Czechia
Sygehus Sønderjylland Åbenrå
Aabenraa, 6200, Denmark
Rigshospitalet Copenhagen
Copenhagen, 2100, Denmark
Bispebjerg og Frederiksberg Hospital
Copenhagen NV, 2400, Denmark
Amager-Hvidovre Hospital
Copenhagen S, 2300, Denmark
Herlev and Gentofte Hospital
Herlev, 2730, Denmark
Holbæk Sygehus
Holbæk, 4300, Denmark
Hvidovre Hospital
Hvidovre, 2650, Denmark
Sjællands Universitetshospital
Roskilde, 4000, Denmark
Slagelse Sygehus
Slagelse, 4200, Denmark
Klinikum am Plattenwald
Bad Friedrichshall, 74177, Germany
Universitätsklinikum Freiburg
Bad Krozingen, 79189, Germany
CIMS Studienzentrum Bamberg GmbH
Bamberg, 96049, Germany
Vivantes Netzwerk für Gesundheit GmbH
Berlin, 10249, Germany
Velocity Clinical Research Germany GmbH, Berlin
Berlin, 10787, Germany
Charité Campus Virchow-Klinikum
Berlin, 13353, Germany
Vivantes Humboldt-Klinikum
Berlin, 13509, Germany
GFO Kliniken Bonn, Betriebsstaette St. Marien
Bonn, 53115, Germany
Universitätsklinikum Bonn AöR
Bonn, 53127, Germany
SANA Kliniken Oberfranken Coburg GmbH
Coburg, 96450, Germany
Klinische Forschung Dresden GmbH
Dresden, 01069, Germany
Facharztzentrum Dresden-Neustadt Betriebsgesellschaft mbH
Dresden, 01099, Germany
Helios Klinikum Erfurt
Erfurt, 99089, Germany
Klinische Forschung Hamburg GmbH
Hamburg, 20253, Germany
Klinische Forschung Hannover-Mitte GmbH
Hanover, 30159, Germany
Medizinische Hochschule Hannover
Hanover, 30625, Germany
Universitätsklinikum Jena
Jena, 07747, Germany
Kardiopraxis Schirmer
Kaiserslautern, 67655, Germany
Universitätsklinikum Schleswig-Holstein, Campus Kiel
Kiel, 24105, Germany
Asklepios Klinik Langen-Seligenstadt GmbH
Langen, 63225, Germany
Velocity Clinical Research Germany GmbH, Leipzig
Leipzig, 04177, Germany
Klinikum der Stadt Ludwigshafen am Rhein GmbH
Ludwigshafen, 67063, Germany
Praxis Oedeme
Lüneburg, 21339, Germany
ze:ro Praxen MVZ fuer Nierenerkrankungen und Bluthochdruck GmbH Mannheim
Mannheim, 68165, Germany
Marienhaus Klinikum St. Elisabeth
Neuwied, 56564, Germany
Kardiologische Praxis Papenburg
Papenburg, 26871, Germany
Universitätsklinikum Regensburg
Regensburg, 93053, Germany
Gemeinschaftspraxis Dr. Josef Grosskopf und Dr. Wilma Grosskopf
Wallerfing, 94574, Germany
Cardiologicum Hamburg GbR
Wandsbek, 22041, Germany
Kardiologische Praxis, Wermsdorf
Wermsdorf, 04779, Germany
Velocity Clinical Research Germany GmbH, Wiesbaden
Wiesbaden, 65189, Germany
Klinikum Worms gGmbH
Worms, 67550, Germany
Belgyogyaszati es Kardiologiai Maganrendelo
Békéscsaba, 5600, Hungary
Betegapolo Irgalmasrend Budai Irgalmasrendi Korhaz
Budapest, 1023, Hungary
Obudai Egeszegugyi Centrum
Budapest, 1036, Hungary
Belvaros-Lipotvaros Egeszsegugyi Szolgalat
Budapest, 1051, Hungary
Gottsegen National Cardiovascular Center
Budapest, 1096, Hungary
Semmelweis University
Budapest, 1122, Hungary
Semmelweis University
Budapest, 1122, Hungary
Privat Doktor Egeszseguegyi Szolgaltato Zrt.
Budapest, 1132, Hungary
Zugloi Egeszsegugyi Szolgalat
Budapest, 1148, Hungary
BKS Research Ltd
Hatvan, 3000, Hungary
Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi Oktato Korhaz
Miskolc, 3526, Hungary
IPR Hungary Kft.
Miskolc, 3530, Hungary
TaNa Med Kft.
Mosonmagyaróvár, 9200, Hungary
Coromed-Smo Kft.
Pécs, 7623, Hungary
Tolna Varmegyei Balassa Janos Korhaz
Szekszárd, 7100, Hungary
Belvarosi Egeszseghaz Kft.
Zalaegerszeg, 8900, Hungary
Kamal Nayan Bajaj Hospital
Aurangabad, 431005, India
Narayana Institute of Cardiac Sciences
Bangalore, 560099, India
S.P. Medical College & Associated Group of Hospitals
Bikaner, 334003, India
Tamil Nadu Government Multi Super Speciality Hospital TNGMSSH
Chennai, 600002, India
Apollo Hospital - Chennai
Chennai, 600006, India
Medanta-The Medicity
Gurgaon, 122 001, India
Lisie Hospital
Kochi, 682 018, India
IPGMER and SSKM Hospital
Kolkata, 700020, India
Supe Heart & Diabetes Hospital & Research Centre
Nashik, 422002, India
Chopda Medicare and Research Centre Pvt Ltd
Nashik, 422005, India
Max Super Speciality Hospital
New Delhi, 110017, India
Indira Gandhi Institute of Medical Sciences
Patna, 800014, India
Nirmal Hospital
Surat, 395002, India
Unicare Heart Institute
Surat, 395002, India
King George Hospital
Visakhapatnam, 530002, India
Humanitas Gavazzeni
Bergamo, 24125, Italy
ASST Papa Giovanni XXIII
Bergamo, 24127, Italy
Az.Osp. Universitaria "Ospedali Riuniti"
Foggia, 71122, Italy
Azienda Ospedaliera Universitaria "Federico II"
Naples, 80131, Italy
Fondazione IRCCS Policlinico S. Matteo
Pavia, 27100, Italy
Azienda Ospedaliera Universitaria Pisana
Pisa, 56126, Italy
Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza
Roma, 00189, Italy
Istituto Clinico Humanitas
Rozzano, 20089, Italy
Hyogo Prefectural Amagasaki General Medical Center
Amagasaki-shi, 660-8550, Japan
Asahi General Hospital
Asahi-shi, 289-2511, Japan
Shonan Fujisawa Tokushukai Hospital
Fujisawa-shi, 251-0041, Japan
Kyushu University Hospital
Fukuoka, 812-8582, Japan
Fukuokaken Saiseikai Futsukaichi Hospital
Fukuoka, Chikushino, 818-8516, Japan
Gunma University Hospital
Gunma, Maebashi, 371-8511, Japan
Minamino Cardiovascular Hospital
Hachioji-shi, 192-0918, Japan
National Hospital Organization Hamada Medical Center
Hamada-shi, 697-8511, Japan
JA-Shizuoka Enshu Hospital
Hamamatsu, 430-0929, Japan
Hyogo Prefectural Harima-Himeji General Medical Center
Himeji-shi, 670-8560, Japan
Hiratsuka Kyosai Hospital
Hiratsuka-shi, 254-8502, Japan
Hitachi Ltd. Hitachinaka General Hospital
Hitachi-Naka, 312-0057, Japan
National Hospital Organization Kanazawa Medical Center
Ishikawa, Kanazawa, 920-8650, Japan
National Hospital Organization Iwakuni Clinical Center
Iwakuni-shi, 740-8510, Japan
Tokushukai Shonan Kamakura General Hospital
Kamakura-shi, 247-8533, Japan
Tokushukai Hayama Heart Center
Kanagawa, Miura-gun, 240-0116, Japan
Mitoyo General Hospital
Kanonji-shi, 769-1695, Japan
Ibaraki Prefectural Central Hospital
Kasama-shi, 309-1793, Japan
Kasugai Municipal Hospital
Kasugai-shi, 486-8510, Japan
Saiseikai Kawaguchi Hospital
Kawaguchi-shi, 332-8558, Japan
St. Marianna University Hospital
Kawasaki-shi, 216-8511, Japan
Tokushukai Kishiwada Tokushukai Hospital
Kishiwada-shi, 596-0042, Japan
National Hospital Organization Kobe Medical Center
Kobe, 654-0155, Japan
Kumamoto University Hospital
Kumamoto, 860-8556, Japan
Japanese Red Cross Kumamoto Hospital
Kumamoto, 861-8520, Japan
National Hospital Organization Kure Medical Center and Chugoku Cancer Center
Kure, 737-0023, Japan
Chibanishi General Hospital
Matsudo-shi, 270-2251, Japan
Shinshu University Hospital
Matsumoto-shi, 390-8621, Japan
Ehime Prefectural Central Hospital
Matsuyama, 790-0024, Japan
Matsuyama Shimin Hospital
Matsuyama, 790-0067, Japan
National Hospital Organization Tokyo Medical Center
Meguro-ku, 152-8902, Japan
Mito Saiseikai General Hospital
Mito, 311-4198, Japan
Tohoku University Hospital
Miyagi, Sendai, 980-8547, Japan
Sendai Cardiovascular Center
Miyagi, Sendai, 981-3133, Japan
Nagasaki Harbor Medical Center
Nagasaki, Nagasaki, 850-8555, Japan
Nagoya Kyoritsu Hospital
Nagoya, 454-0933, Japan
Nagoya City University Hospital
Nagoya, 467-8602, Japan
Hokushin General Hospital
Nakano-shi, 383-8505, Japan
Nara Medical University Hospital
Nara, Kashihara, 634-8522, Japan
Juzenkai The Sakakibara Heart Institute of Okayama
Okayama, Okayama, 700-0804, Japan
Ome Municipal General Hospital
Ome-shi, 198-0042, Japan
Nagasaki Medical Center
Omura-shi, 856-8562, Japan
Osaka Metropolitan University Hospital
Osaka, 545-8586, Japan
Osaka General Medical Center
Osaka, 558-8558, Japan
Kosekai Iwatsuki-minami Hospital
Saitama, Saitama, 339-0033, Japan
Osaka Rosai Hospital
Sakaishi, 591-8025, Japan
Teine Keijinkai Hospital
Sapporo, 006-8555, Japan
NHO Sendai Medical Center
Sendai, 983-8520, Japan
NHO Kanmon Medical Center
Shimonoseki-shi, 752-8510, Japan
National Cerebral and Cardiovascular Center
Suita-shi, 564-8565, Japan
The University of Osaka Hospital
Suita-shi, 565-0871, Japan
Tachikawa Hospital
Tachikawa-shi, 190-8531, Japan
National Hospital Organization Takasaki General Medical Center
Takasaki-shi, 370-0829, Japan
NHO Minami Wakayama Medical Center
Tanabe-shi, 646-8558, Japan
Tokushima Prefectural Central Hospital
Tokushima, 770-8539, Japan
Tomakomai City Hospital
Tomakomai-shi, 053-8567, Japan
Toyota Memorial Hospital
Toyota-shi, 471-8513, Japan
NHO Shinshu Ueda Medical Center
Ueda-shi, 386-8610, Japan
Yokohama Sakae Kyosai Hospital
Yokohama, 247-8581, Japan
Hospital Cardiologica Aguascalientes
Aguascalientes, 20230, Mexico
Centro Especializado de Investigación Medical Group Culiacan
Culiacán, 80200, Mexico
Centro para el Desarrollo de la Medicina y de Asistencia Medica Especializada S.C.
Culiacán, 80230, Mexico
Cardiologia Clinica e Intervencionista
Guadalajara, 44670, Mexico
Proactive CR Mexico S.A. de C.V.
Irapuato, 36520, Mexico
Centro de Estudios de Alta Especialidad de Sinaloa CEAES
Mazatlán, 82126, Mexico
Clinstile S.A. de C.V.
México, 06700, Mexico
Cardiolink Clin Trials S.C.
Monterrey, 64060, Mexico
Hospital Universitario Dr Jose Eleuterio Gonzalez
Monterrey, 64460, Mexico
Centro de Estudios Clinicos de Queretaro S.C
Querétaro, 76000, Mexico
Centro de Investigacion Cardiovascular y Metabolica
Tijuana, 22500, Mexico
CIMAB S.A. de C.V.
Torreón, 27000, Mexico
Jeroen Bosch Ziekenhuis-Hertogenbosch
's-Hertogenbosch, 5223 GZ, Netherlands
Amsterdam University Medical Center
Amsterdam, 1105 AZ, Netherlands
Catharina Ziekenhuis
Eindhoven, 5623 EJ, Netherlands
Universitair Medisch Centrum Groningen
Groningen, 9713 GZ, Netherlands
Maastricht University Medisch Centrum
Maastricht, 6229 HX, Netherlands
St. Antonius Ziekenhuis
Nieuwegein, 3435 CM, Netherlands
Isala Klinieken Stichting
Zwolle, 8025 AB, Netherlands
Polsko-Amerykanskie Kliniki Serca
Bielsko-Biala, 43-316, Poland
Centrum Medyczne Intercor Sp. z o.o.
Bydgoszcz, 85-092, Poland
Pratia Bydgoszcz Clinical Research Site
Bydgoszcz, 85-796, Poland
NZOZ Medical Center KERmed
Bydgoszcz, 85231, Poland
Poradnia Kardiologiczna Jaroslaw Jurowiecki
Gdansk, 80-767, Poland
Centrum Medyczne Pratia Gdynia
Gdynia, 81-338, Poland
Specjalistyczna Praktyka Lekarska Ewa Mirek-Bryniarska
Krakow, 30-082, Poland
Linden Sp. z o.o. sp.k.
Krakow, 30-721, Poland
Pratia MCM Krakow
Krakow, 30-727, Poland
Beata Miklaszewicz & Dariusz Dabrowski Cardiamed Sp. j.
Legnica, 59-220, Poland
Santa SP. z o.o
Lodz, 90-302, Poland
Velocity Nova Sp. z o.o.
Lublin, 20-362, Poland
Zanamed Medical Clinic Sp. z o.o.
Lublin, 20-601, Poland
Nzoz Heureka
Piaseczno, 05-500, Poland
CBK Med Clinic SP Z O O
Płock, 09-407, Poland
Centrum Medyczne Medyk
Rzeszów, 35-055, Poland
Lukmed Lukasz Wozniak
Siedlce, 08-110, Poland
Velocity Skierniewice Sp. z o.o
Skierniewice, 96-100, Poland
Centrum Medyczne Pratia Poznan
Skórzewo, 60-185, Poland
Velocity Staszow
Staszów, 28-200, Poland
Sedimed Sp. z o.o.
Szczecin, 70-238, Poland
Balsammedica Sp. z o. o.
Warsaw, 01249, Poland
MTZ Clinical Research Powered by Pratia
Warsaw, 02-172, Poland
ETG Warszawa
Warsaw, 02-677, Poland
4. Military Clinical Hospital with Polyclinic SP ZOZ
Wroclaw, 50-981, Poland
Sedimed Sp. z o.o.
Wroclaw, 53-030, Poland
Velocity Nova Sp. z o.o.
Zamość, 22-400, Poland
Centrum Medyczne Serafin med
Żarów, 58-130, Poland
Spitalul Judetean De Urgenta Dr. Constantin Opris Baia Mare
Baia Mare, 430031, Romania
Spitalul Clinic De Urgenta Prof Dr Agrippa Ionescu
Baloteşti, 77015, Romania
S.C.Centrul Medical Unirea S.R.L.
Brasov, 500091, Romania
Spitalul Clinic Judetean de Urgenta Brasov
Brasov, 500365, Romania
Emergency University Hospital
Bucharest, 050098, Romania
Clinica Medicala Data Plus SRL
Bucharest, 10192, Romania
Cluj Napoca Clinical County Hospital
Cluj-Napoca, 400006, Romania
Spitalul Angiocare SRL
Cluj-Napoca, 400015, Romania
Emergency County Hospital Craiova
Craiova, 200640, Romania
Spitalul Clinic Judetean de Urgenta Bihor
Oradea, 410167, Romania
Sal Med Srl
Piteşti, 110424, Romania
U 2 Serv Com S.R.L.
Suceava, 720049, Romania
Country Clinical Emergency Hospital, Targu-Mures
Târgu Mureş, 540136, Romania
Podoleanu G. Cristian-Gheorghe-Calin
Târgu Mureş, 540143, Romania
Spitalul Clinic Judetean de Urgenta Targu Mures
Târgu Mureş, 54136, Romania
S.C Medicali's S.R.L
Timișoara, 300043, Romania
Timisoara Municipal Emergency Clinical Hospital
Timișoara, 300079, Romania
King AbdulAziz University Hospital
Al Ahsa, Saudi Arabia
King Fahad Specialist Hospital - Research Center
Dammam, 31444, Saudi Arabia
Imam Abdulrahman bin Faisal University
Dammam, 34212, Saudi Arabia
King Faisal Specialist Hospital and Research Center
Riyadh, 11211, Saudi Arabia
King Fahad Medical City
Riyadh, 12231, Saudi Arabia
Clinical Center " Dr Dragisa Misovic Dedinje"
Belgrade, 11000, Serbia
University Clinical Center of Serbia
Belgrade, 11000, Serbia
University Clinical Center of Kragujevac
Kragujevac, 34000, Serbia
University Clinical Center Nis
Niš, 18000, Serbia
Institute for Treatment and Rehabilitation, Niska Banja
Niška Banja, 18205, Serbia
General Hospital Pancevo
Pančevo, 26000, Serbia
General Hospital Sveti Luka
Smederevo, 11300, Serbia
Institute of Cardiovascular Diseases of Vojvodine
Sremska Mitrovica, 21204, Serbia
Health Centre Zajecar
Zaječar, 19000, Serbia
Stredoslovensky Ustav Srdcovych A Cievnych Chorob A S
Banská Bystrica, 974 01, Slovakia
Kardiointerna s r o
Banská Bystrica, 97401, Slovakia
Alian s.r.o.
Bardejov, 08501, Slovakia
Cliniq s.r.o.
Bratislava, 81109, Slovakia
Premedix Clinic
Bratislava, 83101, Slovakia
Nemocnica S Poliklinikou Brezno N.O.
Brezno, 977 01, Slovakia
Medical Group Kosice s.r.o
Košice, 04001, Slovakia
KARDIO R s r o
Košice, 04011, Slovakia
Cardio D&R s.r.o. Kosice
Košice, 04022, Slovakia
KARDIO 1 s.r.o.
Lučenec, 984 01, Slovakia
Kardiomed s.r.o.
Lučenec, 98401, Slovakia
KVC Kardiovaskularne Centrum s.r.o.
Martin, 036 01, Slovakia
Cardiocenter Nitra, s.r.o
Nitra, 94901, Slovakia
Cardioamb s.r.o
Nové Zámky, 94002, Slovakia
Nemocnica AGEL Zvolen a.s.
Zvolen, 960 01, Slovakia
Inje University Busan Paik Hospital
Busan, 47392, South Korea
Dong-A University Hospital
Busan, 49201, South Korea
Pusan National University Yangsan Hospital
Busan, 49241, South Korea
Chonnam National University Hospital
Gwangju, 61469, South Korea
Gachon University Gil Medical Center
Incheon, 21565, South Korea
Seoul National University Bundang Hospital
Seongnam, 13620, South Korea
Severance Hospital
Seoul, 03722, South Korea
Samsung Medical Center
Seoul, 06351, South Korea
Korea University Guro Hospital
Seoul, 08308, South Korea
Korea University Anam Hospital
Seoul, 2841, South Korea
Yonsei University Wonju Severance Christian Hospital
Wŏnju, 26426, South Korea
Hospital Vall Hebron
Barcelona, 08035, Spain
Hospital Clínic de Barcelona
Barcelona, 08036, Spain
Hospital General Universitario Gregorio Marañón
Madrid, 28007, Spain
Hospital Universitario 12 de Octubre
Madrid, 28041, Spain
Hospital Universitario La Paz
Madrid, 28046, Spain
Hospital Universitario Virgen de la Victoria
Málaga, 29010, Spain
Hospital Virgen del Camino
Sanlúcar de Barrameda, 11540, Spain
Hospital Universitario De Torrejon
Torrejón de Ardoz, 28850, Spain
Hospital Clinico Universitario de Valencia
Valencia, 46010, Spain
Hospital General Universitario de Valencia
Valencia, 46014, Spain
Hospital Universitari i Politècnic La Fe
Valencia, 46026, Spain
Hospital Virgen de las Montañas
Villamartín, 11650, Spain
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, 807, Taiwan
E-Da Hospital
Kaohsiung City, 82445, Taiwan
China Medical University Hospital
Taichung, 40447, Taiwan
Taichung Veterans General Hospital
Taichung, 407219, Taiwan
Taipei Medical University Hospital
Taipei, 110, Taiwan
Taipei Veterans General Hospital
Taipei, 11217, Taiwan
Tri-Service General Hospital
Taipei, 114202, Taiwan
Changhua Christian Hospital
Taipei, 50006, Taiwan
Cukurova Universitesi Tip Fakultesi Gog. Hast. Anabilim Dali
Adana, 01330, Turkey (Türkiye)
Etlik City Hospital
Ankara, 06170, Turkey (Türkiye)
Ataturk Universitesi Tip Fakultesi
Erzurum, 25240, Turkey (Türkiye)
Osmangazi Uni Medical Faculty
Eskişehir, 26480, Turkey (Türkiye)
Gaziantep University Medical Faculty Sahinbey Educational Research Hospital
Gaziantep, 27310, Turkey (Türkiye)
Siyami Ersek Heart Hospital
Istanbul, 34668, Turkey (Türkiye)
Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi
Istanbul, 34899, Turkey (Türkiye)
Medical Park Pendik Hospital
Istanbul, 34899, Turkey (Türkiye)
Dokuz Eylul University Faculty of Medicine
Izmir, 35340, Turkey (Türkiye)
Kutahya Health Science University
Kütahya, 43040, Turkey (Türkiye)
Inonu Uni. Med. Fac., Battalgazi
Malatya, 44280, Turkey (Türkiye)
Mersin University Medical Faculty
Mersin, 33020, Turkey (Türkiye)
Southmead Hospital
Bristol, BS10 5NB, United Kingdom
Golden Jubilee National Hospital
Clydebank, G81 4DY, United Kingdom
Royal Devon and Exeter Hospital
Exeter, EX2 5DW, United Kingdom
Calderdale Royal Hospital
Halifax, HX3 0PW, United Kingdom
Northwick Park Hospital
Harrow, HA1 3UJ, United Kingdom
St Bartholomew's Hospital
London, EC1A 7BE, United Kingdom
Bach Mai hospital
Hanoi, 100000, Vietnam
Tam Anh General Hospital
Hanoi, 100000, Vietnam
Hanoi Heart Hospital
Hà Nội, 150000, Vietnam
Military Hospital 175
Ho Chi Minh City, 700000, Vietnam
Nguyen Tri Phuong Hospital
Ho Chi Minh City, 700000, Vietnam
Tam Anh HCMC
Ho Chi Minh City, 700000, Vietnam
Thong Nhat Hospital HCMC
Ho Chi Minh City, 700000, Vietnam
Cho Ray Hospital
Ho Chi Minh City, 70000, Vietnam
Trung Vuong Hospital
Ho Chi Minh City, Vietnam
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
April 17, 2025
First Posted
April 20, 2025
Study Start
May 20, 2025
Primary Completion (Estimated)
February 4, 2029
Study Completion (Estimated)
February 22, 2029
Last Updated
April 29, 2026
Record last verified: 2026-04
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, SAP, CSR
- Time Frame
- One year after the approval has been granted by major Regulatory Authorities and after the primary manuscript has been accepted for publication, or after termination of the development program.
- Access Criteria
- For study documents - upon signing of a "Document Sharing Agreement". For study data - 1. after the submission and approval of the research proposal (checks will be performed by the sponsor and/or the independent review panel, including checking that the planned analysis does not compete with sponsor's publication plan); 2. and upon signing of a legal agreement.
Once the criteria in section "Time Frame" are fulfilled, researchers can use the following link https://www.clinicalstudies.boehringer-ingelheim.com/msw/datasharing to request access to the clinical study documents regarding this study, and upon a signed "Document Sharing Agreement". Furthermore, researchers can request access to the clinical study data, for this and other listed studies, after the submission of a research proposal and according to the terms outlined in the website.