NCT00005161

Brief Summary

To analyze the genetic and environmental contributions of juvenile hemodynamic determinants of blood pressure, including cardiac output and systemic vascular pressure, to adult cardiovascular risk.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Aug 1983

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 1983

Completed
9.9 years until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 1993

Completed
6.9 years until next milestone

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
Last Updated

March 8, 2016

Status Verified

March 1, 2016

First QC Date

May 25, 2000

Last Update Submit

March 4, 2016

Conditions

Cardiovascular DiseasesHeart DiseasesHypertension

Eligibility Criteria

AgeUp to 100 Years
Sexmale
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (37)

  • van den Bree MB, Schieken RM, Moskowitz WB, Eaves LJ. Genetic regulation of hemodynamic variables during dynamic exercise. The MCV twin study. Circulation. 1996 Oct 15;94(8):1864-9. doi: 10.1161/01.cir.94.8.1864.

    PMID: 8873661BACKGROUND

  • Nance WE. The relevance of twin studies to cardiovascular research. Prog Clin Biol Res. 1984;147:325-48. No abstract available.

    PMID: 6377316BACKGROUND

  • Schieken RM: Exercise Study of Blood Pressure: A Predictor of Future Hypertension? In: NHLBI Workshop on Juvenile Hypertension, Loggie JHM, Horan M, Gruskin AB, et al (Eds.), Biomedical Information Corporation, NY, NY, 1984

    BACKGROUND

  • Schieken RM: Children's Blood Pressure. Report of 8th Ross Conference on Pediatric Research, Columbus Ohio: Ross Laboratories, 1985

    BACKGROUND

  • Corey LA, Eaves LJ, Mellen BG, Nance WE. Testing for developmental changes in gene expression on resemblance for quantitative traits in kinships of twins: application to height, weight, and blood pressure. Genet Epidemiol. 1986;3(2):73-83. doi: 10.1002/gepi.1370030203.

    PMID: 3710139BACKGROUND

  • Eaves LJ, Long J, Heath AC. A theory of developmental change in quantitative phenotypes applied to cognitive development. Behav Genet. 1986 Jan;16(1):143-62. doi: 10.1007/BF01065484. No abstract available.

    PMID: 3707482BACKGROUND

  • Schieken RM, Lauer RM, Clarke WR. Hemodynamics in childhood hypertension. Clin Exp Hypertens A. 1986;8(4-5):703-20. doi: 10.3109/10641968609046588.

    PMID: 3757286BACKGROUND

  • Bodurtha JN, Schieken R, Segrest J, Nance WE. High-density lipoprotein-cholesterol subfractions in adolescent twins. Pediatrics. 1987 Feb;79(2):181-9.

    PMID: 3808790BACKGROUND

  • Schieken RM. Measurement of left ventricular wall mass in pediatric populations. Hypertension. 1987 Feb;9(2 Pt 2):II47-52. doi: 10.1161/01.hyp.9.2_pt_2.ii47.

    PMID: 3804400BACKGROUND

  • Martin NG, Clark P, Ofulue AF, Eaves LJ, Corey LA, Nance WE. Does the PI polymorphism alone control alpha-1-antitrypsin expression? Am J Hum Genet. 1987 Mar;40(3):267-77.

    PMID: 3495177BACKGROUND

  • Hewitt JK, Eaves LJ, Neale MC, Meyer JM. Resolving causes of developmental continuity or "tracking." I. Longitudinal twin studies during growth. Behav Genet. 1988 Mar;18(2):133-51. doi: 10.1007/BF01067836. No abstract available.

    PMID: 3377729BACKGROUND

  • Schieken RM, Moskowitz WB, Bodurtha J, Mosteller M, Eaves L, Nance W. Aortic stiffness: a new Doppler echocardiographic measure predictive of systolic blood pressure in children. J Am Coll Cardiol. 1988 Jun;11(6):1297-300. doi: 10.1016/0735-1097(88)90295-1.

    PMID: 3367005BACKGROUND

  • Eaves LJ, Hewitt JK, Heath AC: The Quantitative Study of Human Developmental Change: A Model and its Limitations. 2nd International Conference on Quantitative Genetics, Sinauer Associates, 1988

    BACKGROUND

  • Schieken RM. Identification of high risk relatives for coronary heart disease. J Am Coll Cardiol. 1988 Oct;12(4):1110-3. doi: 10.1016/0735-1097(88)90487-1.

    PMID: 2971084BACKGROUND

  • Schieken RM. Preventive cardiology: an overview. J Am Coll Cardiol. 1988 Oct;12(4):1090-1. doi: 10.1016/0735-1097(88)90481-0. No abstract available.

    PMID: 3417981BACKGROUND

  • Schieken RM. The management of the family at high risk for coronary heart disease. Cardiol Clin. 1989 May;7(2):467-77.

    PMID: 2659186BACKGROUND

  • Schieken RM, Eaves LJ, Hewitt JK, Mosteller M, Bodurtha JN, Moskowitz WB, Nance WE. Univariate genetic analysis of blood pressure in children (the Medical College of Virginia Twin Study). Am J Cardiol. 1989 Dec 1;64(19):1333-7. doi: 10.1016/0002-9149(89)90577-8.

    PMID: 2686389BACKGROUND

  • Moskowitz WB, Mosteller M, Schieken RM, Bossano R, Hewitt JK, Bodurtha JN, Segrest JP. Lipoprotein and oxygen transport alterations in passive smoking preadolescent children. The MCV Twin Study. Circulation. 1990 Feb;81(2):586-92. doi: 10.1161/01.cir.81.2.586.

    PMID: 2297864BACKGROUND

  • Bodurtha JN, Mosteller M, Hewitt JK, Nance WE, Eaves LJ, Moskowitz WB, Katz S, Schieken RM. Genetic analysis of anthropometric measures in 11-year-old twins: the Medical College of Virginia Twin Study. Pediatr Res. 1990 Jul;28(1):1-4. doi: 10.1203/00006450-199007000-00001.

    PMID: 2377391BACKGROUND

  • Schieken RM. Left ventricular mass. Development versus disease. Circulation. 1990 Oct;82(4):1525-7. doi: 10.1161/01.cir.82.4.1525. No abstract available.

    PMID: 2144801BACKGROUND

  • Fabsitz RR, Carmelli D, Hewitt JK. Evidence for independent genetic influences on obesity in middle age. Int J Obes Relat Metab Disord. 1992 Sep;16(9):657-66.

    PMID: 1328090BACKGROUND

  • Schieken RM. Effects of childhood hypertension on the heart. The heart and hypertension. Child Nephrol Urol. 1992;12(2-3):128-32. No abstract available.

    PMID: 1385756BACKGROUND

  • Goble MM, Mosteller M, Moskowitz WB, Schieken RM. Sex differences in the determinants of left ventricular mass in childhood. The Medical College of Virginia Twin Study. Circulation. 1992 May;85(5):1661-5. doi: 10.1161/01.cir.85.5.1661.

    PMID: 1572024BACKGROUND

  • Goble MM, Schieken RM. Blood pressure response to exercise. A marker for future hypertension? Am J Hypertens. 1991 Nov;4(11):617S-620S. doi: 10.1093/ajh/4.11s.617s.

    PMID: 1789943BACKGROUND

  • Implementation of hospital-based technology assessment. Int J Technol Assess Health Care. 1997 Summer;13(3):495. No abstract available.

    PMID: 9308285BACKGROUND

  • Verhaaren HA, Schieken RM, Mosteller M, Hewitt JK, Eaves LJ, Nance WE. Bivariate genetic analysis of left ventricular mass and weight in pubertal twins (the Medical College of Virginia twin study). Am J Cardiol. 1991 Sep 1;68(6):661-8. doi: 10.1016/0002-9149(91)90361-n.

    PMID: 1877484BACKGROUND

  • Bodurtha JN, Chen CW, Mosteller M, Nance WE, Schieken RM, Segrest J. Genetic and environmental contributions to cholesterol and its subfractions in 11-year-old twins. The Medical College of Virginia Twin Study. Arterioscler Thromb. 1991 Jul-Aug;11(4):844-50. doi: 10.1161/01.atv.11.4.844.

    PMID: 2065038BACKGROUND

  • Moskowitz WB, Newkumet KM, Albrecht GT, Goble MM, Schieken RM. Case of steel versus steal: coil embolization of congenital coronary arteriovenous fistula. Am Heart J. 1991 Mar;121(3 Pt 1):909-11. doi: 10.1016/0002-8703(91)90208-y. No abstract available.

    PMID: 2000759BACKGROUND

  • Newkumet KM, Goble MM, Young RB, Kaplowitz PB, Schieken RM. Altered blood pressure reactivity in adolescent diabetics. Pediatrics. 1994 Apr;93(4):616-21.

    PMID: 8134217BACKGROUND

  • Schieken R. Premature atherosclerosis and familial hypercholesterolemia. Coron Artery Dis. 1993 Feb;4(2):126-32. doi: 10.1097/00019501-199302000-00002. No abstract available.

    PMID: 8269204BACKGROUND

  • Austin MJ, Neale MC, Corey LA, Nance WE, Schieken RM, Brown JA. Common fragile site expression in lymphocytes from an individual mosaic for trisomy 8. Am J Med Genet. 1993 Mar 1;45(5):570-1. doi: 10.1002/ajmg.1320450509.

    PMID: 8456825BACKGROUND

  • Schieken RM. Genetic factors that predispose the child to develop hypertension. Pediatr Clin North Am. 1993 Feb;40(1):1-11. doi: 10.1016/s0031-3955(16)38476-0.

    PMID: 8417398BACKGROUND

  • Verhaaren HA, Schieken RM, Schwartz P, Mosteller M, Matthys D, Maes H, Beunen G, Vlietinck R, Derom R. Cardiovascular reactivity in isometric exercise and mental arithmetic in children. J Appl Physiol (1985). 1994 Jan;76(1):146-50. doi: 10.1152/jappl.1994.76.1.146.

    PMID: 8175499BACKGROUND

  • Moskowitz WB, Mosteller M, Hewitt JK, Eaves LJ, Nance WE, Schieken RM. Univariate genetic analysis of oxygen transport regulation in children: the Medical College of Virginia Twin Study. Pediatr Res. 1993 Jun;33(6):645-8. doi: 10.1203/00006450-199306000-00022.

    PMID: 8378126BACKGROUND

  • Moore WE, Burmeister JA, Brooks CN, Ranney RR, Hinkelmann KH, Schieken RM, Moore LV. Investigation of the influences of puberty, genetics, and environment on the composition of subgingival periodontal floras. Infect Immun. 1993 Jul;61(7):2891-8. doi: 10.1128/iai.61.7.2891-2898.1993.

    PMID: 8514392BACKGROUND

  • Schieken RM. Why screen children for blood cholesterol levels? Ann Epidemiol. 1991 Nov;1(6):571-4. doi: 10.1016/1047-2797(91)90030-g. No abstract available.

    PMID: 1669538BACKGROUND

  • Schieken RM. Effect of exercise on lipids. Ann N Y Acad Sci. 1991;623:269-74. doi: 10.1111/j.1749-6632.1991.tb43736.x. No abstract available.

    PMID: 2042835BACKGROUND

MeSH Terms

Conditions

Cardiovascular DiseasesHeart DiseasesHypertension

Condition Hierarchy (Ancestors)

Vascular Diseases

Study Design

Study Type
observational
Sponsor Type
OTHER

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

August 1, 1983

Study Completion

July 1, 1993

Last Updated

March 8, 2016

Record last verified: 2016-03