Longitudinal Cardiac Outcomes and Body Composition
2 other identifiers
observational
715
0 countries
N/A
Brief Summary
To relate cardiac structure and blood pressure (BP) elevation in adults to childhood BP and body size and composition.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2004
Longer than P75 for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2004
CompletedFirst Submitted
Initial submission to the registry
April 19, 2004
CompletedFirst Posted
Study publicly available on registry
April 21, 2004
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2007
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2007
CompletedAugust 7, 2013
August 1, 2013
3.9 years
April 19, 2004
August 5, 2013
Conditions
Outcome Measures
Primary Outcomes (1)
Established and validated the echocardiographic protocol that was used to generate the serial data on cardiac structure and function in 723 adults in the FLS population .
Investigators are currently finishing an investigation of racial divergence in cardiac structure, cardiac function and blood pressure in relationship to child growth from 9 to 18 years in 700 women who were participants in the National Growth and Health Study participants. Preliminary results show that women who were overweight during childhood (25 ≤ BMI \< 30 kg/m2) had a significantly larger LVM and elevated systolic blood pressure (SBP) at age 22 years than women who were not overweight during childhood. Women who had elevated SBP during childhood had a significantly larger LVM and elevated SBP at age 22 years than women who did not have elevated SBP values during childhood.
1929-2009
Eligibility Criteria
Echocardiographic measurements were made in 437 male and 492 female adults in the Fels Longitudinal Study who had serial measurements of body composition made and recorded as children. The selection criteria include participants who have at least 10 serial anthropometric visits between 2 and 20 years of age. The anthropometric measurements include weight and height for computation of BMI and blood pressure. Approximately one-half of the sample is 50 years and older.
Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.
Sponsors & Collaborators
Related Publications (2)
Sabo RT, Lu Z, Daniels S, Sun SS. Serial childhood BMI and associations with adult hypertension and obesity: the Fels Longitudinal Study. Obesity (Silver Spring). 2012 Aug;20(8):1741-3. doi: 10.1038/oby.2012.58. Epub 2012 Mar 8.
PMID: 22402734RESULTSabo RT, Lu Z, Daniels S, Sun SS. Relationships between serial childhood adiposity measures and adult blood pressure: The Fels longitudinal study. Am J Hum Biol. 2010 Nov-Dec;22(6):830-5. doi: 10.1002/ajhb.21091.
PMID: 20865760RESULT
Biospecimen
Only receiving data
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Shumei Sun, PhD
Virginia Commonwealth University
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
April 19, 2004
First Posted
April 21, 2004
Study Start
January 1, 2004
Primary Completion
December 1, 2007
Study Completion
December 1, 2007
Last Updated
August 7, 2013
Record last verified: 2013-08