NCT00005763

Brief Summary

To coordinate an international study on the relationships between population mean sodium and potassium intake and blood pressure.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Dec 1984

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 1984

Completed
12.3 years until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 1997

Completed
3.2 years until next milestone

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
Last Updated

March 16, 2016

Status Verified

June 1, 2000

First QC Date

May 25, 2000

Last Update Submit

March 15, 2016

Conditions

Cardiovascular DiseasesHeart DiseasesHypertension

Eligibility Criteria

AgeUp to 100 Years
Sexmale
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (36)

  • Elliott P, Stamler J, Nichols R, Dyer AR, Stamler R, Kesteloot H, Marmot M. Intersalt revisited: further analyses of 24 hour sodium excretion and blood pressure within and across populations. Intersalt Cooperative Research Group. BMJ. 1996 May 18;312(7041):1249-53. doi: 10.1136/bmj.312.7041.1249.

    PMID: 8634612BACKGROUND

  • Hanneman RL. Intersalt: hypertension rise with age revisited. BMJ. 1996 May 18;312(7041):1283-4; discussion 1284-7. doi: 10.1136/bmj.312.7041.1283. No abstract available.

    PMID: 8634620BACKGROUND

  • Law M: Commentary: Evidence on Salt is Consistent. (Not supported by the grant. This is another commentary.) BMJ, 312:1284-1285, 1996

    BACKGROUND

  • Dyer AR, Elliott P, Marmot M, Kesteloot H, Stamler R, Stamler J. Commentary: strength and importance of the relation of dietary salt to blood pressure. Intersalt Steering and Editorial Committee. BMJ. 1996 Jun 29;312(7047):1661-4. doi: 10.1136/bmj.312.7047.1661. No abstract available.

    PMID: 8664726BACKGROUND

  • Naruse Y, Nakagawa H, Kagamimori S, Fujita Y, Hashimoto T, Kasamatsu T, Mikawa K, Ueshima H. Relationship of parental history of high blood pressure to blood pressure: combined findings of three Japanese population samples, the INTERSALT study. J Hum Hypertens. 1998 Apr;12(4):215-20. doi: 10.1038/sj.jhh.1000469.

    PMID: 9607688BACKGROUND

  • Rennolls K. Intersalt data. Science demands data sharing. BMJ. 1997 Aug 23;315(7106):486-7. No abstract available.

    PMID: 9284679BACKGROUND

  • Liebman BF, Jacobson MF. Intersalt data. Sodium contents of restaurant foods in United States are high. BMJ. 1997 Aug 23;315(7106):488. No abstract available.

    PMID: 9284681BACKGROUND

  • Grimm RH. Intersalt data. Collaborative efforts must be made to reduce sodium in diet. BMJ. 1997 Aug 23;315(7106):487. No abstract available.

    PMID: 9284680BACKGROUND

  • Davey Smith G, Phillips AN. Intersalt data. Correction for regression dilution bias in Intersalt study was misleading. BMJ. 1997 Aug 23;315(7106):485-6; author reply 487. No abstract available.

    PMID: 9284677BACKGROUND

  • Day NE. Intersalt data. Epidemiological studies should be designed to reduce correction needed for measurement error to a minimum. BMJ. 1997 Aug 23;315(7106):485; author reply 487. No abstract available.

    PMID: 9284676BACKGROUND

  • Macnair A. Intersalt data. Conclusions drawn in paper "revisiting" Intersalt data are of questionable validity. BMJ. 1997 Aug 23;315(7106):485; author reply 487. No abstract available.

    PMID: 9284675BACKGROUND

  • Alderman M. Intersalt data. Data linking sodium intake to subsequent morbid and fatal outcomes must be studied. BMJ. 1997 Aug 23;315(7106):484-5; author reply 487. No abstract available.

    PMID: 9284674BACKGROUND

  • Dyer A, Elliott P, Chee D, Stamler J. Urinary biochemical markers of dietary intake in the INTERSALT study. Am J Clin Nutr. 1997 Apr;65(4 Suppl):1246S-1253S. doi: 10.1093/ajcn/65.4.1246S.

    PMID: 9094929BACKGROUND

  • Stamler J, Elliott P, Kesteloot H, Nichols R, Claeys G, Dyer AR, Stamler R. Inverse relation of dietary protein markers with blood pressure. Findings for 10,020 men and women in the INTERSALT Study. INTERSALT Cooperative Research Group. INTERnational study of SALT and blood pressure. Circulation. 1996 Oct 1;94(7):1629-34. doi: 10.1161/01.cir.94.7.1629.

    PMID: 8840854BACKGROUND

  • Joossens JV, Hill MJ, Elliott P, Stamler R, Lesaffre E, Dyer A, Nichols R, Kesteloot H. Dietary salt, nitrate and stomach cancer mortality in 24 countries. European Cancer Prevention (ECP) and the INTERSALT Cooperative Research Group. Int J Epidemiol. 1996 Jun;25(3):494-504. doi: 10.1093/ije/25.3.494.

    PMID: 8671549BACKGROUND

  • INTERSALT Study an international co-operative study on the relation of blood pressure to electrolyte excretion in populations. I. Design and methods. The INTERSALT Co-operative Research Group. J Hypertens. 1986 Dec;4(6):781-7. doi: 10.1097/00004872-198612000-00014.

    PMID: 3819392BACKGROUND

  • Elliott P, Stamler R. Manual of operations for "INTERSALT", an international cooperative study on the relation of sodium and potassium to blood pressure. Control Clin Trials. 1988 Jun;9(2 Suppl):1S-117S. No abstract available.

    PMID: 3396367BACKGROUND

  • Intersalt: an international study of electrolyte excretion and blood pressure. Results for 24 hour urinary sodium and potassium excretion. Intersalt Cooperative Research Group. BMJ. 1988 Jul 30;297(6644):319-28. doi: 10.1136/bmj.297.6644.319.

    PMID: 3416162BACKGROUND

  • Stamler J, Rose G, Stamler R, Elliott P, Dyer A, Marmot M. INTERSALT study findings. Public health and medical care implications. Hypertension. 1989 Nov;14(5):570-7. doi: 10.1161/01.hyp.14.5.570.

    PMID: 2807518BACKGROUND

  • Rose G, Stamler J. The INTERSALT study: background, methods and main results. INTERSALT Co-operative Research Group. J Hum Hypertens. 1989 Oct;3(5):283-8.

    PMID: 2810325BACKGROUND

  • Elliott P, Marmot M, Dyer A, Joossens J, Kesteloot H, Stamler R, Stamler J, Rose G. The INTERSALT study: main results, conclusions and some implications. Clin Exp Hypertens A. 1989;11(5-6):1025-34. doi: 10.3109/10641968909035389.

    PMID: 2791323BACKGROUND

  • Elliott P, Dyer A, Stamler R. The INTERSALT study: results for 24 hour sodium and potassium, by age and sex. INTERSALT Co-operative Research Group. J Hum Hypertens. 1989 Oct;3(5):323-30.

    PMID: 2810328BACKGROUND

  • Dyer AR, Elliott P. The INTERSALT study: relations of body mass index to blood pressure. INTERSALT Co-operative Research Group. J Hum Hypertens. 1989 Oct;3(5):299-308.

    PMID: 2810326BACKGROUND

  • Elliott P. The INTERSALT study: an addition to the evidence on salt and blood pressure, and some implications. J Hum Hypertens. 1989 Oct;3(5):289-98.

    PMID: 2681780BACKGROUND

  • Carvalho JJ, Baruzzi RG, Howard PF, Poulter N, Alpers MP, Franco LJ, Marcopito LF, Spooner VJ, Dyer AR, Elliott P, et al. Blood pressure in four remote populations in the INTERSALT Study. Hypertension. 1989 Sep;14(3):238-46. doi: 10.1161/01.hyp.14.3.238.

    PMID: 2767757BACKGROUND

  • Dyer AR, Elliott P, Shipley M. Body mass index versus height and weight in relation to blood pressure. Findings for the 10,079 persons in the INTERSALT Study. Am J Epidemiol. 1990 Apr;131(4):589-96. doi: 10.1093/oxfordjournals.aje.a115543.

    PMID: 2180281BACKGROUND

  • Elliott P, Rogers S, Scally G, Beevers DG, Lichtenstein MJ, Keenan G, Hornby R, Evans A, Shipley MJ, Elwood PC. Sodium, potassium, body mass, alcohol and blood pressure in three United Kingdom centres (the INTERSALT study). Eur J Clin Nutr. 1990 Sep;44(9):637-45.

    PMID: 2261896BACKGROUND

  • Stamler J, Rose G, Elliott P, Dyer A, Marmot M, Kesteloot H, Stamler R. Findings of the International Cooperative INTERSALT Study. Hypertension. 1991 Jan;17(1 Suppl):I9-15. doi: 10.1161/01.hyp.17.1_suppl.i9.

    PMID: 1987018BACKGROUND

  • Stamler R. Implications of the INTERSALT study. Hypertension. 1991 Jan;17(1 Suppl):I16-20. doi: 10.1161/01.hyp.17.1_suppl.i16. No abstract available.

    PMID: 1986996BACKGROUND

  • Stamler R, Shipley M, Elliott P, Dyer A, Sans S, Stamler J. Higher blood pressure in adults with less education. Some explanations from INTERSALT. Hypertension. 1992 Mar;19(3):237-41. doi: 10.1161/01.hyp.19.3.237.

    PMID: 1548050BACKGROUND

  • Marmot MG, Elliott P, Shipley MJ, Dyer AR, Ueshima H, Beevers DG, Stamler R, Kesteloot H, Rose G, Stamler J. Alcohol and blood pressure: the INTERSALT study. BMJ. 1994 May 14;308(6939):1263-7. doi: 10.1136/bmj.308.6939.1263.

    PMID: 7802765BACKGROUND

  • Dyer AR, Elliott P, Shipley M, Stamler R, Stamler J. Body mass index and associations of sodium and potassium with blood pressure in INTERSALT. Hypertension. 1994 Jun;23(6 Pt 1):729-36. doi: 10.1161/01.hyp.23.6.729.

    PMID: 8206570BACKGROUND

  • Le Fanu J. Intersalt data. Cross cultural studies such as Intersalt study cannot be used to infer causality. BMJ. 1997 Aug 23;315(7106):484; author reply 487. No abstract available.

    PMID: 9284673BACKGROUND

  • Watt G, Hart JT. Intersalt data. Slow decremental change in dietary sodium load in whole populations is needed. BMJ. 1997 Aug 23;315(7106):486; author reply 487. No abstract available.

    PMID: 9284678BACKGROUND

  • Stamler J. The INTERSALT Study: background, methods, findings, and implications. Am J Clin Nutr. 1997 Feb;65(2 Suppl):626S-642S. doi: 10.1093/ajcn/65.2.626S.

    PMID: 9022559BACKGROUND

  • Elliott P, Dyer A, Stamler R, Stamler J. Correcting for regression dilution in INTERSALT. Lancet. 1993 Oct 30;342(8879):1123. doi: 10.1016/0140-6736(93)92112-7. No abstract available.

    PMID: 8105352BACKGROUND

MeSH Terms

Conditions

Cardiovascular DiseasesHeart DiseasesHypertension

Condition Hierarchy (Ancestors)

Vascular Diseases

Study Officials

  • Jeremiah Stamler

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

December 1, 1984

Study Completion

April 1, 1997

Last Updated

March 16, 2016

Record last verified: 2000-06