NCT00005180

Brief Summary

To determine the distribution of left ventricular hypertrophy and retinal vascular abnormalities in children and adolescents with essential hypertension; to evaluate potential risk factors and the time sequence for the development of these end-organ complications in this population.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Sep 1985

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 1985

Completed
9.8 years until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 1995

Completed
5 years until next milestone

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
Last Updated

February 18, 2016

Status Verified

May 1, 2000

First QC Date

May 25, 2000

Last Update Submit

February 17, 2016

Conditions

Cardiovascular DiseasesHeart DiseasesHypertension

Eligibility Criteria

AgeUp to 100 Years
Sexmale
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (14)

  • Morrison JA, Alfaro MP, Khoury P, Thornton BB, Daniels SR. Determinants of resting energy expenditure in young black girls and young white girls. J Pediatr. 1996 Nov;129(5):637-42. doi: 10.1016/s0022-3476(96)70142-7.

    PMID: 8917226BACKGROUND

  • Daniels SR, Kimball TR, Khoury P, Witt S, Morrison JA. Correlates of the hemodynamic determinants of blood pressure. Hypertension. 1996 Jul;28(1):37-41. doi: 10.1161/01.hyp.28.1.37.

    PMID: 8675261BACKGROUND

  • Daniels SR, Loggie JM, Burton T, Kaplan S. Difficulties with ambulatory blood pressure monitoring in children and adolescents. J Pediatr. 1987 Sep;111(3):397-400. doi: 10.1016/s0022-3476(87)80462-6. No abstract available.

    PMID: 3625408BACKGROUND

  • Daniels SR, Meyer RA, Liang YC, Bove KE. Echocardiographically determined left ventricular mass index in normal children, adolescents and young adults. J Am Coll Cardiol. 1988 Sep;12(3):703-8. doi: 10.1016/s0735-1097(88)80060-3.

    PMID: 3403828BACKGROUND

  • Daniels SR, Meyer RA, Strife CF, Lipman M, Loggie JM. Distribution of target-organ abnormalities by race and sex in children with essential hypertension. J Hum Hypertens. 1990 Apr;4(2):103-4.

    PMID: 2140133BACKGROUND

  • Daniels SR, Lipman MJ, Burke MJ, Loggie JM. The prevalence of retinal vascular abnormalities in children and adolescents with essential hypertension. Am J Ophthalmol. 1991 Feb 15;111(2):205-8. doi: 10.1016/s0002-9394(14)72260-3.

    PMID: 1992741BACKGROUND

  • Daniels SR, Kimball TR, Morrison JA, Khoury P, Witt S, Meyer RA. Effect of lean body mass, fat mass, blood pressure, and sexual maturation on left ventricular mass in children and adolescents. Statistical, biological, and clinical significance. Circulation. 1995 Dec 1;92(11):3249-54. doi: 10.1161/01.cir.92.11.3249.

    PMID: 7586311BACKGROUND

  • Daniels SR, Kimball TR, Morrison JA, Khoury P, Meyer RA. Indexing left ventricular mass to account for differences in body size in children and adolescents without cardiovascular disease. Am J Cardiol. 1995 Oct 1;76(10):699-701. doi: 10.1016/s0002-9149(99)80200-8.

    PMID: 7572628BACKGROUND

  • Daniels SR, Lipman MJ, Burke MJ, Loggie JM. Determinants of retinal vascular abnormalities in children and adolescents with essential hypertension. J Hum Hypertens. 1993 Jun;7(3):223-8.

    PMID: 8345488BACKGROUND

  • Daniels SR, Strife CF, Dolan LM, Loggie JM. Distribution and correlates of creatinine clearance in children and adolescents with blood pressure elevation. J Pediatr. 1993 Jun;122(6):S68-73. doi: 10.1016/s0022-3476(09)90046-4.

    PMID: 8501551BACKGROUND

  • Kimball TR, Daniels SR, Loggie JM, Khoury P, Meyer RA. Relation of left ventricular mass, preload, afterload and contractility in pediatric patients with essential hypertension. J Am Coll Cardiol. 1993 Mar 15;21(4):997-1001. doi: 10.1016/0735-1097(93)90359-9.

    PMID: 8450171BACKGROUND

  • Daniels SR, Loggie JM, Khoury P, Kimball TR. Left ventricular geometry and severe left ventricular hypertrophy in children and adolescents with essential hypertension. Circulation. 1998 May 19;97(19):1907-11. doi: 10.1161/01.cir.97.19.1907.

    PMID: 9609083BACKGROUND

  • Young LA, Kimball TR, Daniels SR, Standiford DA, Khoury PR, Eichelberger SM, Dolan LM. Nocturnal blood pressure in young patients with insulin-dependent diabetes mellitus: correlation with cardiac function. J Pediatr. 1998 Jul;133(1):46-50. doi: 10.1016/s0022-3476(98)70176-3.

    PMID: 9672509BACKGROUND

  • de Simone G, Kimball TR, Roman MJ, Daniels SR, Celentano A, Witt SA, Devereux RB. Relation of left ventricular chamber and midwall function to age in normal children, adolescents and adults. Ital Heart J. 2000 Apr;1(4):295-300.

    PMID: 10824731BACKGROUND

MeSH Terms

Conditions

Cardiovascular DiseasesHeart DiseasesHypertension

Condition Hierarchy (Ancestors)

Vascular Diseases

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

September 1, 1985

Study Completion

June 1, 1995

Last Updated

February 18, 2016

Record last verified: 2000-05