NCT00005158

Brief Summary

To determine the genetic components of hypertension using a series of simulation experiments designed to determine the power and validity of the then recently developed methods of segregation and linkage analysis.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Jul 1982

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 1, 1982

Completed
8.9 years until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 1991

Completed
9 years until next milestone

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
Last Updated

February 18, 2016

Status Verified

June 1, 2000

First QC Date

May 25, 2000

Last Update Submit

February 17, 2016

Conditions

Cardiovascular DiseasesHeart DiseasesHypertension

Eligibility Criteria

AgeUp to 100 Years
Sexmale
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (20)

  • Siervogel RM, Weinshilboum R, Wilson AF, Elston RC. Major gene model for the inheritance of catechol-O-methyltransferase activity in five large families. Am J Med Genet. 1984 Oct;19(2):315-23. doi: 10.1002/ajmg.1320190214.

    PMID: 6594929BACKGROUND

  • Wilson AF, Elston RC, Siervogel RM, Weinshilboum R, Ward LJ. Linkage relationships between a major gene for catechol-o-methyltransferase activity and 25 polymorphic marker systems. Am J Med Genet. 1984 Nov;19(3):525-32. doi: 10.1002/ajmg.1320190314.

    PMID: 6507499BACKGROUND

  • Townley RG, Bewtra A, Wilson AF, Hopp RJ, Elston RC, Nair N, Watt GD. Segregation analysis of bronchial response to methacholine inhalation challenge in families with and without asthma. J Allergy Clin Immunol. 1986 Jan;77(1 Pt 1):101-7. doi: 10.1016/0091-6749(86)90330-1.

    PMID: 3944368BACKGROUND

  • Amos CI, Wilson AF, Rosenbaum PA, Srinivasan SR, Webber LS, Elston RC, Berenson GS. An approach to the multivariate analysis of high-density-lipoprotein cholesterol in a large kindred: the Bogalusa Heart Study. Genet Epidemiol. 1986;3(4):255-67. doi: 10.1002/gepi.1370030406.

    PMID: 3744022BACKGROUND

  • Asamoah A, Wilson AF, Elston RC, Dalferes E Jr, Berenson GS. Segregation and linkage analyses of dopamine-beta-hydroxylase activity in a six-generation pedigree. Am J Med Genet. 1987 Jul;27(3):613-21. doi: 10.1002/ajmg.1320270314.

    PMID: 3631133BACKGROUND

  • Amos CI, Elston RC, Srinivasan SR, Wilson AF, Cresanta JL, Ward LJ, Berenson GS. Linkage and segregation analyses of apolipoproteins A1 and B, and lipoprotein cholesterol levels in a large pedigree with excess coronary heart disease: the Bogalusa Heart Study. Genet Epidemiol. 1987;4(2):115-28. doi: 10.1002/gepi.1370040206.

    PMID: 3108069BACKGROUND

  • Wilson AF, Bailey-Wilson JE, Cleton FJ, Elston RC, King MC. Linkage analysis of Dutch families at high risk for breast cancer. Genet Epidemiol Suppl. 1986;1:87-92. doi: 10.1002/gepi.1370030714. No abstract available.

    PMID: 3471674BACKGROUND

  • Crowe RR, Noyes R Jr, Wilson AF, Elston RC, Ward LJ. A linkage study of panic disorder. Arch Gen Psychiatry. 1987 Nov;44(11):933-7. doi: 10.1001/archpsyc.1987.01800230013003.

    PMID: 3675131BACKGROUND

  • Asamoah A, Wyatt RJ, Julian BA, Quiggins PA, Wilson AF, Elston RC. A major gene model for the familial aggregation of plasma IgA concentration. Am J Med Genet. 1987 Aug;27(4):857-66. doi: 10.1002/ajmg.1320270413.

    PMID: 3480689BACKGROUND

  • Wilson AF, Elston RC, Siervogel RM, Tran LD. Linkage of a gene regulating dopamine-beta-hydroxylase activity and the ABO blood group locus. Am J Hum Genet. 1988 Jan;42(1):160-6.

    PMID: 3422127BACKGROUND

  • Hill EM, Wilson AF, Elston RC, Winokur G. Evidence for possible linkage between genetic markers and affective disorders. Biol Psychiatry. 1988 Dec;24(8):903-17. doi: 10.1016/0006-3223(88)90225-9.

    PMID: 3233232BACKGROUND

  • Tanna VL, Wilson AF, Winokur G, Elston RC. Possible linkage between alcoholism and esterase-D. J Stud Alcohol. 1988 Sep;49(5):472-6. doi: 10.15288/jsa.1988.49.472.

    PMID: 3216652BACKGROUND

  • Wilson AF, Cohen JC. Hypotheses for testing deviations from random integration: evidence for nonrandom retroviral integration. Genomics. 1988 Aug;3(2):137-42. doi: 10.1016/0888-7543(88)90144-9.

    PMID: 3224979BACKGROUND

  • Wilson AF, Tanna VL, Winokur G, Elston RC, Hill EM. Linkage analysis of depression spectrum disease. Biol Psychiatry. 1989 Jun;26(2):163-75. doi: 10.1016/0006-3223(89)90020-6.

    PMID: 2736265BACKGROUND

  • Amos CI, Elston RC, Wilson AF, Bailey-Wilson JE. A more powerful robust sib-pair test of linkage for quantitative traits. Genet Epidemiol. 1989;6(3):435-49. doi: 10.1002/gepi.1370060306.

    PMID: 2753353BACKGROUND

  • Tanna VL, Wilson AF, Winokur G, Elston RC. Linkage analysis of pure depressive disease. J Psychiatr Res. 1989;23(2):99-107. doi: 10.1016/0022-3956(89)90001-0.

    PMID: 2585349BACKGROUND

  • Bailey-Wilson JE, Elston RC, Wilson AF, Amos CI. A comparison of some sib-pair linkage methods and multiple locus extensions. Prog Clin Biol Res. 1989;329:129-34. No abstract available.

    PMID: 2622941BACKGROUND

  • Wilson AF, Elston RC, Sellers TA, Bailey-Wilson JE, Gersting JM, Deen DK, Sorant AJ, Tran LD, Amos CI, Siervogel RM. Stepwise oligogenic segregation and linkage analysis illustrated with dopamine-beta-hydroxylase activity. Am J Med Genet. 1990 Mar;35(3):425-32. doi: 10.1002/ajmg.1320350321.

    PMID: 2309793BACKGROUND

  • Bailey-Wilson JE, Dobbins TE. Sib-pair linkage analysis applied to pedigrees with melanoma and dysplastic nevi. Cytogenet Cell Genet. 1992;59(2-3):176-8. doi: 10.1159/000133237. No abstract available.

    PMID: 1737492BACKGROUND

  • Wilson AF, Elston RC, Tran LD, Siervogel RM. Use of the robust sib-pair method to screen for single-locus, multiple-locus, and pleiotropic effects: application to traits related to hypertension. Am J Hum Genet. 1991 May;48(5):862-72.

    PMID: 2018038BACKGROUND

MeSH Terms

Conditions

Cardiovascular DiseasesHeart DiseasesHypertension

Condition Hierarchy (Ancestors)

Vascular Diseases

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

July 1, 1982

Study Completion

June 1, 1991

Last Updated

February 18, 2016

Record last verified: 2000-06