Sodium Transport: Genetics and Hypertension

NCT00005166 | Completed

• 2 other identifiers: 1040R01HL030428
• Study Type: observational
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

Originally, to determine whether genetic alterations in pathways of sodium ion transport in the red blood cells of children could predict their risk of developing primary hypertension in adulthood. In 1992, the objective was to determine the genetic basis of interindividual variation in the risk of essential hypertension in the population at large using the Rochester Family Heart Study.

Conditions

Cardiovascular Diseases; Heart Diseases; Hypertension

Eligibility Criteria

• Age: Up to 100 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI): lead

Related Publications (36)

• Boerwinkle E, Turner ST, Sing CF. The role of the genetics of sodium lithium countertransport in the determination of blood pressure variability in the population at large. Prog Clin Biol Res. 1984;165:479-507. No abstract available.

  PMID: 6504919 BACKGROUND

• Sing CF, Boerwinkle E: The Genetics of Blood Pressure Variability: An Overview. In: Proceedings, Children's Blood Pressure: The Eighty-Eighth Ross Conference on Pediatric Research. Ross Laboratories, 1984

  BACKGROUND

• Turner ST, Fairbanks VF. Is measurement of erythrocyte Na+ influx useful for ascertainment of essential hypertension? Mayo Clin Proc. 1984 Jul;59(7):506-8. doi: 10.1016/s0025-6196(12)60442-x. No abstract available.

  PMID: 6738116 BACKGROUND

• Turner ST, Johnson M, Boerwinkle E, Richelson E, Taswell HF, Sing CF. Sodium-lithium countertransport and blood pressure in healthy blood donors. Hypertension. 1985 Nov-Dec;7(6 Pt 1):955-62. doi: 10.1161/01.hyp.7.6.955.

  PMID: 4077225 BACKGROUND

• Boerwinkle E, Chakraborty R, Sing CF. The use of measured genotype information in the analysis of quantitative phenotypes in man. I. Models and analytical methods. Ann Hum Genet. 1986 May;50(2):181-94. doi: 10.1111/j.1469-1809.1986.tb01037.x.

  PMID: 3435047 BACKGROUND

• Sing CF, Boerwinkle E, Turner ST. Genetics of primary hypertension. Clin Exp Hypertens A. 1986;8(4-5):623-51. doi: 10.3109/10641968609046580.

  PMID: 3530548 BACKGROUND

• Richelson E, Snyder K, Carlson J, Johnson M, Turner S, Lumry A, Boerwinkle E, Sing CF. Lithium ion transport by erythrocytes of randomly selected blood donors and manic-depressive patients: lack of association with affective illness. Am J Psychiatry. 1986 Apr;143(4):457-62. doi: 10.1176/ajp.143.4.457.

  PMID: 2420218 BACKGROUND

• Boerwinkle E, Turner ST, Weinshilboum R, Johnson M, Richelson E, Sing CF. Analysis of the distribution of erythrocyte sodium lithium countertransport in a sample representative of the general population. Genet Epidemiol. 1986;3(5):365-78. doi: 10.1002/gepi.1370030509.

  PMID: 3781241 BACKGROUND

• Turner ST, Boerwinkle E, Johnson M, Richelson E, Sing CF. Sodium-lithium countertransport in ambulatory hypertensive and normotensive patients. Hypertension. 1987 Jan;9(1):24-34. doi: 10.1161/01.hyp.9.1.24.

  PMID: 2432010 BACKGROUND

• Turner ST, Weidman WH, Michels VV, Reed TJ, Ormson CL, Fuller T, Sing CF. Distribution of sodium-lithium countertransport and blood pressure in Caucasians five to eighty-nine years of age. Hypertension. 1989 Apr;13(4):378-91. doi: 10.1161/01.hyp.13.4.378.

  PMID: 2925236 BACKGROUND

• Rebbeck TR, Turner ST, Michels VV, Moll PP. Genetic and environmental explanations for the distribution of sodium-lithium countertransport in pedigrees from Rochester, MN. Am J Hum Genet. 1991 Jun;48(6):1092-104.

  PMID: 2035530 BACKGROUND

• Sing CF, Haviland MB, Templeton AR, Zerba KE, Reilly SL. Biological complexity and strategies for finding DNA variations responsible for inter-individual variation in risk of a common chronic disease, coronary artery disease. Ann Med. 1992 Dec;24(6):539-47. doi: 10.3109/07853899209167008.

  PMID: 1485951 BACKGROUND

• Reilly SL, Ferrell RE, Kottke BA, Sing CF. The gender-specific apolipoprotein E genotype influence on the distribution of plasma lipids and apolipoproteins in the population of Rochester, Minnesota. II. Regression relationships with concomitants. Am J Hum Genet. 1992 Dec;51(6):1311-24.

  PMID: 1463013 BACKGROUND

• Turner ST, Rebbeck TR, Sing CF. Sodium-lithium countertransport and probability of hypertension in Caucasians 47 to 89 years old. Hypertension. 1992 Dec;20(6):841-50. doi: 10.1161/01.hyp.20.6.841.

  PMID: 1452301 BACKGROUND

• Schwartz GL, Turner ST, Sing CF. Twenty-four-hour blood pressure profiles in normotensive sons of hypertensive parents. Hypertension. 1992 Dec;20(6):834-40. doi: 10.1161/01.hyp.20.6.834.

  PMID: 1452300 BACKGROUND

• Mailly F, Moll P, Kottke BA, Kamboh MI, Humphries SE, Ferrell RE. Estimation of the frequency of isoform-genotype discrepancies at the apolipoprotein E locus in heterozygotes for the isoforms. Genet Epidemiol. 1992;9(4):239-48. doi: 10.1002/gepi.1370090403.

  PMID: 1398044 BACKGROUND

• Reilly SL, Ferrell RE, Kottke BA, Kamboh MI, Sing CF. The gender-specific apolipoprotein E genotype influence on the distribution of lipids and apolipoproteins in the population of Rochester, MN. I. Pleiotropic effects on means and variances. Am J Hum Genet. 1991 Dec;49(6):1155-66.

  PMID: 1842218 BACKGROUND

• Kottke BA, Moll PP, Michels VV, Weidman WH. Levels of lipids, lipoproteins, and apolipoproteins in a defined population. Mayo Clin Proc. 1991 Dec;66(12):1198-208. doi: 10.1016/s0025-6196(12)62470-7.

  PMID: 1749288 BACKGROUND

• Kaprio J, Ferrell RE, Kottke BA, Kamboh MI, Sing CF. Effects of polymorphisms in apolipoproteins E, A-IV, and H on quantitative traits related to risk for cardiovascular disease. Arterioscler Thromb. 1991 Sep-Oct;11(5):1330-48. doi: 10.1161/01.atv.11.5.1330.

  PMID: 1911720 BACKGROUND

• Turner ST, Michels VV. Sodium-lithium countertransport and hypertension in Rochester, Minnesota. Hypertension. 1991 Aug;18(2):183-90. doi: 10.1161/01.hyp.18.2.183.

  PMID: 1885226 BACKGROUND

• Perusse L, Moll PP, Sing CF. Evidence that a single gene with gender- and age-dependent effects influences systolic blood pressure determination in a population-based sample. Am J Hum Genet. 1991 Jul;49(1):94-105.

  PMID: 2063879 BACKGROUND

• Reilly SL, Kottke BA, Sing CF. The effects of generation and gender on the joint distributions of lipid and apolipoprotein phenotypes in the population at large. J Clin Epidemiol. 1990;43(9):921-40. doi: 10.1016/0895-4356(90)90076-2.

  PMID: 2213081 BACKGROUND

• Kwon JM, Boehnke M, Burns TL, Moll PP. Commingling and segregation analyses: comparison of results from a simulation study of a quantitative trait. Genet Epidemiol. 1990;7(1):57-68. doi: 10.1002/gepi.1370070113.

  PMID: 2184092 BACKGROUND

• Zerba KE, Friedlaender JS, Sing CF. Heterogeneity of the blood pressure distribution among Solomon Islands societies with increasing acculturation. Am J Phys Anthropol. 1990 Apr;81(4):493-511. doi: 10.1002/ajpa.1330810406.

  PMID: 2333938 BACKGROUND

• Rebbeck TR, Turner ST, Sing CF. Sodium-lithium countertransport genotype and the probability of hypertension in adults. Hypertension. 1993 Oct;22(4):560-8. doi: 10.1161/01.hyp.22.4.560.

  PMID: 8406661 BACKGROUND

• Reilly SL, Sing CF, Savageau MA, Turner ST. Analysis of systems influencing renal hemodynamics and sodium excretion. I. Biochemical systems theory. Integr Physiol Behav Sci. 1994 Jan-Mar;29(1):55-73. doi: 10.1007/BF02691281.

  PMID: 8018552 BACKGROUND

• Turner ST, Reilly SL. Renal sodium excretion in sons of hypertensive parents. Hypertension. 1993 Sep;22(3):323-30. doi: 10.1161/01.hyp.22.3.323.

  PMID: 8349325 BACKGROUND

• Kardia SL, Sing CF, Turner ST. The response of renal plasma flow to angiotensin II infusion in a population-based sample and its association with the parental history of essential hypertension. J Hypertens. 1997 May;15(5):483-93. doi: 10.1097/00004872-199715050-00003.

  PMID: 9170000 BACKGROUND

• Stengard JH, Zerba KE, Turner ST, Sing CF. A biometrical study of the relationship between sodium-lithium countertransport and triglycerides. Ann Hum Genet. 1997 Mar;61(Pt 2):121-36. doi: 10.1046/j.1469-1809.1997.6120121.x.

  PMID: 9177119 BACKGROUND

• Turner ST, Sing CF. Erythrocyte sodium transport and the probability of having hypertension. J Hypertens. 1996 Jul;14(7):829-37. doi: 10.1097/00004872-199607000-00005.

  PMID: 8818921 BACKGROUND

• Flickinger AL, Lerman LO, Sheedy PF 2nd, Turner ST. The relationship between renal cortical volume and predisposition to hypertension. Am J Hypertens. 1996 Aug;9(8):779-86. doi: 10.1016/0895-7061(96)00097-0.

  PMID: 8862224 BACKGROUND

• Schwartz GL, Turner ST, Sing CF. Association of genetic variation with interindividual variation in ambulatory blood pressure. J Hypertens. 1996 Feb;14(2):251-8. doi: 10.1097/00004872-199602000-00015.

  PMID: 8728304 BACKGROUND

• Rebbeck TR, Turner ST, Sing CF. Probability of having hypertension: effects of sex, history of hypertension in parents, and other risk factors. J Clin Epidemiol. 1996 Jul;49(7):727-34. doi: 10.1016/0895-4356(96)00015-7.

  PMID: 8691221 BACKGROUND

• Flickinger AL, Burnett JC Jr, Turner ST. Atrial natriuretic peptide and blood pressure in a population-based sample. Mayo Clin Proc. 1995 Oct;70(10):932-8. doi: 10.4065/70.10.932.

  PMID: 7564543 BACKGROUND

• Turner ST, Reilly SL. Fallacy of indexing renal and systemic hemodynamic measurements for body surface area. Am J Physiol. 1995 Apr;268(4 Pt 2):R978-88. doi: 10.1152/ajpregu.1995.268.4.R978.

  PMID: 7733408 BACKGROUND

• Sing CF, Moll PP. Genetics of atherosclerosis. Annu Rev Genet. 1990;24:171-87. doi: 10.1146/annurev.ge.24.120190.001131. No abstract available.

  PMID: 2088166 BACKGROUND

MeSH Terms

Conditions

Cardiovascular Diseases; Heart Diseases; Hypertension

Condition Hierarchy (Ancestors)

Vascular Diseases

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: May 25, 2000
• First Posted: May 26, 2000
• Study Start: April 1, 1984
• Study Completion: March 1, 1996
• Last Updated: May 13, 2016

Record last verified: 2000-05