Effects of Acute Sleep Deprivation on Human Behaviours

NCT07393607 | Not Yet Recruiting

• 1 other identifier: 202412HM033-2
• Study Type: interventional
• Target: 48
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study will investigate whether acute sleep deprivation affects appetite, eating behavior, and physical activity in both regular exercisers and physically inactive individuals.

Conditions

Energy Intake; Appetite; Food Choice; Physical Activity

Keywords

Physical activity; Energy intake; Appetite; Food choice

Outcome Measures

Primary Outcomes (2)

• Energy intake

  Energy and macronutrients intake will be collected using pictures and via a food scale

  4 days in a free-living conditions.

• Physical activity

  Physical activity level and intensity will be collected using wearable devices

  4 days in a free-living conditions.

Secondary Outcomes (6)

• Food preference

  Baseline and at the end of the 3-hour oral glucose tolerance test (OGTT).

• Appetite sensations

  At 0 (baseline), 30, 60, 90, 120, 150, and 180 minutes during the 3-hour oral glucose tolerance test (OGTT).

• Mood sensations

  At 0 (baseline), 30, 60, 90, 120, 150, and 180 minutes during the 3-hour oral glucose tolerance test (OGTT).

• Sleep sensations

  At 0 (baseline), 30, 60, 90, 120, 150, and 180 minutes during the 3-hour oral glucose tolerance test (OGTT).

• Sleep

  4 days in a free-living conditions.

Study Arms (2)

Normal sleep

EXPERIMENTAL

Participants will have an 8-hour sleep opportunity in the lab from 23:00 to 07:00.

Behavioral: Normal sleep

Partial sleep deprivation

EXPERIMENTAL

Participants will have a 3-hour sleep opportunity in the lab from 03:00 to 07:00.

Behavioral: Partial sleep deprivation

Interventions

Normal sleep BEHAVIORAL

Participants will have an 8-hour sleep opportunity in the lab from 23:00 to 07:00.

Normal sleep

Partial sleep deprivation BEHAVIORAL

Participants will have a 3-hour sleep opportunity in the lab from 03:00 to 07:00.

Partial sleep deprivation

Eligibility Criteria

• Age: 20 Years - 45 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age between 20 and 45 years.
• Body Mass Index (BMI) between 18.5 to 27 kg/m².
• No sleep-related medical conditions and good sleep quality, defined as a Pittsburgh Sleep Quality Index (PSQI) score ≤ 5.
• Usual bedtime between 22:00 and 01:00, wake-up time between 06:00 and 09:00, with an average sleep duration of 7 to 9 hours. Chronotype classified as "definitely not evening type" (score ≥ 42 on the Morningness-Eveningness Questionnaire), with no changes in sleep patterns over the past 3 months.
• Without any metabolic or cardiovascular diseases, and not using medications that could affect metabolic responses.
• No specific dietary habits, such as intermittent fasting or a ketogenic diet.
• Maintaining a stable weight (no self-reported weight change greater than ±3 kg) for at least 3 months.
• Resting blood pressure ≤ 130/80 mmHg.
• No smoking or excessive alcohol consumption.
• Not a shift worker.
• No international travel across time zones in the past 3 months.

You may not qualify if:

• Special diets (e.g., intermittent fasting, ketogenic diet)
• Recent injuries or contraindications to intense exercise.

Sponsors & Collaborators

• National Taiwan Normal University: lead

MeSH Terms

Conditions

Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: January 23, 2026
• First Posted: February 6, 2026
• Study Start: March 1, 2026
• Primary Completion (Estimated): March 1, 2027
• Study Completion (Estimated): March 1, 2027
• Last Updated: February 6, 2026

Record last verified: 2026-02