NCT07403864

Brief Summary

This study will investigate whether various types of regular exercise can provide protective effects against metabolic abnormalities induced by sleep restriction. It will examine responses related to metabolic health, cognitive function, energy expenditure, subjective feelings, and human behaviors, including physical activity and energy intake.

Trial Health

65
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
48

participants targeted

Target at P25-P50 for not_applicable

Timeline
10mo left

Started Mar 2026

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress19%
Mar 2026Mar 2027

First Submitted

Initial submission to the registry

January 23, 2026

Completed
19 days until next milestone

First Posted

Study publicly available on registry

February 11, 2026

Completed
18 days until next milestone

Study Start

First participant enrolled

March 1, 2026

Completed
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2027

Last Updated

February 11, 2026

Status Verified

February 1, 2026

Enrollment Period

1 year

First QC Date

January 23, 2026

Last Update Submit

February 4, 2026

Conditions

Glucose IntoleranceEnergy ExpenditureVascular StiffnessCognition

Keywords

Partial sleep deprivationSleep lossPhysical inactivityExercise habits

Outcome Measures

Primary Outcomes (4)

  • Glycemic Control

    Glucose responses during the 3-hour oral glucose tolerance test (OGTT)

    Baseline measurements and continuously at regular intervals throughout the 3-hour OGTT.

  • Pulse wave velocity (PWV)

    Pulse wave velocity assessments (i.e., meters per second) will be collected before and during the 3-hour oral glucose tolerance test (OGTT).

    0 (baseline), 60, 120 and 180 minutes during OGTT

  • Cognitive function (Accuracy)

    Accuracy (i.e., %) in computerized tests will be tested before and during the 3-hour oral glucose tolerance test (OGTT).

    0 (baseline), 90 and 180 minutes during OGTT

  • Cognitive function (Reaction time)

    Reaction time (i.e., milliseconds) in computerized tests will be tested before and during the 3-hour oral glucose tolerance test (OGTT).

    0 (baseline), 90 and 180 minutes during OGTT

Secondary Outcomes (6)

  • Resting energy expenditure

    0 (baseline), 60, 120 and 180 minutes during OGTT

  • Carbohydrate oxidation

    0 (baseline), 60, 120 and 180 minutes during OGTT

  • Fat oxidation

    0 (baseline), 60, 120 and 180 minutes during OGTT

  • Heart rate variability

    0 (baseline), 60, 120 and 180 minutes during OGTT

  • Muscle oxygen saturation

    0 minute (baseline) and throughout the entire 3-hour OGTT

  • +1 more secondary outcomes

Study Arms (2)

Normal sleep

EXPERIMENTAL

Participants will have an 8-hour sleep opportunity in the lab from 23:00 to 07:00.

Behavioral: Normal sleep

Partial sleep deprivation

EXPERIMENTAL

Participants will have a 3-hour sleep opportunity in the lab from 03:00 to 07:00.

Behavioral: Partial sleep deprivation

Interventions

Normal sleepBEHAVIORAL

Participants will have an 8-hour sleep opportunity in the lab from 23:00 to 07:00.

Normal sleep
Partial sleep deprivationBEHAVIORAL

Participants will have a 3-hour sleep opportunity in the lab from 03:00 to 07:00.

Partial sleep deprivation

Eligibility Criteria

Age20 Years - 45 Years
Sexmale(Gender-based eligibility)
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Age between 20-45 years.
  • Body Mass Index (BMI) between 18.5-27 kg/m².
  • No sleep-related medical conditions and good sleep quality, defined as a Pittsburgh Sleep Quality Index (PSQI) score ≤ 5.
  • Usual bedtime between 22:00-01:00, wake-up time between 06:00-09:00, with an average sleep duration of 7 to 9 hours; chronotype classified as "definitely not evening type" (score ≥ 42 on the Morningness-Eveningness Questionnaire), and no changes in sleep patterns over the past 3 months.
  • Without any metabolic or cardiovascular diseases, and not using medications that could affect metabolic responses.
  • No specific dietary habits, such as intermittent fasting or a ketogenic diet.
  • Maintaining a stable weight (no self-reported weight change ± 3 kg) for at least 3 months.
  • Resting blood pressure ≤ 130/80 mmHg.
  • No smoking or excessive alcohol consumption.
  • Not a shift worker.
  • No international travel across time zones has occurred within the past 3 months.

You may not qualify if:

  • Special diets (e.g., intermittent fasting, ketogenic diet)
  • Recent injuries or contraindications to intense exercise.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Glucose IntoleranceSedentary Behavior

Condition Hierarchy (Ancestors)

HyperglycemiaGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesBehavior

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

January 23, 2026

First Posted

February 11, 2026

Study Start

March 1, 2026

Primary Completion (Estimated)

March 1, 2027

Study Completion (Estimated)

March 1, 2027

Last Updated

February 11, 2026

Record last verified: 2026-02