Effect of Sleep Extension in Prevention to Sleep Deprivation

NCT06928168 | Recruiting

• 2 other identifiers: 24CH2962024-A02857-40
• Study Type: interventional
• Target: 69
• Locations: 1 country
• Sites: 1

Brief Summary

The approach of a competition can be associated to a decrease in sleep duration and quality which can negatively impact athlete's performance and health (injury risk, fall, accident). Ultra-endurance competitions even involve partial and/or total sleep deprivation over one or several nights. Studied investigating this question suggest that endurance performance under sleep deprivation is altered, mainly because of an effect on the rate of perceived exertion (RPE), which regulates effort intensity. One of the methods used by athletes to limit the impact of sleep deprivation in competition is to implement sleep extension in the days prior to a competition. However, few studies have investigated the impact of sleep deprivation et its reproducibility on performance and fatigue during a prolonged running exercise, as well as the efficiency of prior sleep extension. The importance of such a preventive measure might also depend on individual resistance to sleep deprivation, which is variable between persons and could have genetic determinants. This aspect remains under-studied, particularly regarding the impact of sleep deprivation on physical performance. Therefore, this study aims at investigating the effects of sleep deprivation and prior sleep extension on prolonged duration performance.

Conditions

Healthy

Keywords

Sleep deprivation; Sleep extension; Endurance running; Fatigue

Outcome Measures

Primary Outcomes (1)

• Performance over a standardized incremental running test

  Sporting performance, measured by the duration of exercise in a time-limited incremental effort test in running to exhaustion, i.e. the inability to maintain the imposed pace.

  Day 7

Secondary Outcomes (10)

• Reproducibility of sleep deprivation effects.

  Day 7

• Resistance to sleep deprivation and genetic polymorphism

  DAy 1

• Fatigue (objective and subjective, )

  DAy 7

• Fatigue (sleepiness)

  DAy 7

• Fatigue (perception of effort)

  DAy 7

Study Arms (3)

REP (reproducibility).

EXPERIMENTAL

This group will perform an incremental running test, driven to exhaustion, after a night of total sleep deprivation twice, at least two weeks apart.

Other: Reproductibility

PT (total sleep deprivation).

EXPERIMENTAL

This group will perform an incremental running test, conducted until exhaustion, in: * a control condition (usual sleep) * a one-night condition of partial sleep deprivation * a one-night partial sleep deprivation condition with 5 nights of prior extension. The order of conditions will be randomized.

Other: Total sleep deprivation

PP (partial sleep deprivation)

EXPERIMENTAL

This group will perform an incremental running test, run to exhaustion, in : * a control condition (usual sleep), * a one-night total sleep deprivation condition * a one-night total sleep deprivation condition with 5 nights of extension beforehand. The order of conditions will be randomized.

Other: partial sleep deprivation

Interventions

Total sleep deprivation OTHER

This group will perform an incremental running test, conducted until exhaustion, in: - a control condition (usual sleep) - a one-night condition of partial sleep deprivation - a one-night partial sleep deprivation condition with 5 nights of prior extension. The order of conditions will be randomized.

PT (total sleep deprivation).

partial sleep deprivation OTHER

This group will perform an incremental running test, conducted until exhaustion, in: - a control condition (usual sleep) - a one-night condition of partial sleep deprivation - a one-night partial sleep deprivation condition with 5 nights of prior extension. The order of conditions will be randomized.

PP (partial sleep deprivation)

Reproductibility OTHER

This group will perform an incremental running test, driven to exhaustion, after a night of total sleep deprivation twice, at least two weeks apart.

REP (reproducibility).

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Volunteer who signed the written consent form.
• Man or woman.
• Aged 18-50.
• Physically active and running at least one session of more than one hour per week.
• Haven't participated in any competition in the month before the first visit.
• Not participating in any competition during the study.
• Usual sleep time between 6h-8h per night.

You may not qualify if:

• \- Any chronic pathology.
• Working night shift.
• Having sleep disorders: score \> 5 at Pittsburg Sleep Quality Index.
• Excessive sleepiness: score \>10 at Epworth Sleepiness scale.

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Saint Etienne: lead
• Jean Monnet University: collaborator

Study Sites (1)

FEASSON Léonard

Saint-Etienne, 42055, France

RECRUITING

MeSH Terms

Conditions

Sleep Deprivation; Fatigue

Condition Hierarchy (Ancestors)

Dyssomnias; Sleep Wake Disorders; Nervous System Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Mental Disorders

Study Officials

• Frédéric ROCHE, PhD

  CHU SAINT-ETIENNE

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Diana RIMAUD, science Doctor

CONTACT

0477120467; Diana.Rimaud@chu-st-etienne.fr

Léonard FEASSON, PhD

CONTACT

04 77 12 03 83; leonard.feasson@univ-st-etienne.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 28, 2025
• First Posted: April 15, 2025
• Study Start: June 12, 2025
• Primary Completion (Estimated): January 1, 2028
• Study Completion (Estimated): March 1, 2028
• Last Updated: June 17, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)