Aerobic Exercise: A Potential Rescue From the Negative Ramifications of Poor Sleep

NCT06956963 | Completed Results

• 1 other identifier: STUDY00006067
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this interventional study is to differentiate the effects of an acute partial sleep deprivation intervention on markers of cardiovascular health, cardio-autonomic function, physical and cognitive performance, as well as overall wellbeing in active vs sedentary individuals. The main aims of the project are:

• To differentiate the effects of partial sleep deprivation on central hemodynamics (i.e., central blood pressure and arterial stiffness) in active vs sedentary individuals.
• To differentiate the effects of partial sleep deprivation on physical (i.e., handgrip strength and reactive strength index) and cognitive performance (i.e., reaction time and impulse control) in active vs sedentary individuals.
• To differentiate the effects of partial sleep deprivation on overall wellbeing (i.e., cardio-autonomic function, inflammation levels, and psychological mood states) in active vs sedentary individuals. Participants will be divided into two groups based on aerobic activity level - active or sedentary - and assessed for markers of cardiovascular health, cardio-autonomic function, physical and cognitive performance, as well as overall wellbeing before and after three days of normal sleep and three days of partially deprived sleep (i.e., 30% reduction in total time in bed).

Conditions

Cardiovascular Health; Sleep

Outcome Measures

Primary Outcomes (1)

• Arterial Stiffness

  Carotid-femoral pulse wave velocity measured via applanation tonometry

  Following 3-days of Acute Sleep Deprivation (i.e., 30% reduction in total time in bed) as well as following 3-days of Normal Sleep (i.e., 100% habitual time in bed); performed in a randomized order

Study Arms (2)

Normal Sleep

NO INTERVENTION

Acute Partial Sleep Deprivation

EXPERIMENTAL

30% reduction in habitual time in bed

Other: Partial Sleep Deprivation

Interventions

Partial Sleep Deprivation OTHER

30% reduction in habitual time in bed

Also known as: Reduced Sleep

Acute Partial Sleep Deprivation

Eligibility Criteria

• Age: 18 Years - 39 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Chronically active (≥150 minutes of moderate- and/or ≥75 minutes of vigorous-intensity aerobic exercise per week for the last 3 months) OR
• Sedentary (≤60 minutes of aerobic exercise per week for the last 3 months)

You may not qualify if:

• Chronic, uncontrolled disease (cardiovascular, metabolic)
• Poor sleep (regularly achieving \<7 hours of sleep per night)
• Musculoskeletal injury in the last 6 months
• Obese (grade II or higher)
• Pregnant

Sponsors & Collaborators

• Florida State University: lead

Study Sites (1)

Institute of Sports Sciences and Medicine

Tallahassee, Florida, 32301, United States

Location

Results Point of Contact

• Title: Michael Ormsbee, PhD
• Organization: Florida State University

issm@fsu.edu

8506451016

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: April 10, 2025
• First Posted: May 4, 2025
• Study Start: July 21, 2025
• Primary Completion: January 31, 2026
• Study Completion: January 31, 2026
• Last Updated: June 8, 2026
• Results First Posted: June 8, 2026

Record last verified: 2026-06

Locations

US (1)