Effects of Partial Sleep Deprivation on Cardiac Output During Cycling

NCT06679543 | Recruiting

• 1 other identifier: 24-03-017
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to determine if attenuations in cardiac output drive the blunted blood pressure response during cycling exercise following a night of partial sleep deprivation in young healthy adults (%50 females). The secondary outcome is to assess sex differences. The main questions it aims to answer are:

• Do reductions in plasma volume drive reductions in cardiac output and therefore blood pressure during exercise following a night of partial sleep deprivation?
• Do sex differences exist? Participants will:
• Visit the lab after a night of normal sleep and a night of partial sleep deprivation.
• Keep a daily diary of their sleep and food/beverage intake.
• Perform maximal and submaximal exercise on a cycle ergometer.

Conditions

Sleep Deprivation

Keywords

exercise blood pressure; cardiac output; plasma volume; sleep deprivation

Outcome Measures

Primary Outcomes (1)

• cardiac output responses to cycling exercise

  Cardiac output during exercise after a night of normal sleep and after a night of partial sleep deprivation

  Comparison between normal sleep and partial sleep deprivation, ~3 weeks

Secondary Outcomes (2)

• Blood pressure responses to cycling exercise

  Comparison between normal sleep and partial sleep deprivation, ~3 weeks

• Plasma volume

  Comparison between normal sleep and partial sleep deprivation, ~3 weeks

Study Arms (2)

Normal sleep

NO INTERVENTION

During this arm, participants will be asked to come to the lab for testing after a night of normal sleep. Normal sleep will be defined as participants habitual sleep-wake timing.

Partial sleep deprivation

EXPERIMENTAL

During this arm, participants will be asked to come to the lab for testing after a night of partial sleep deprivation. Participants will be asked to fall asleep at their habitual bedtime but wake up early (\~40% of normal sleep duration).

Other: Partial sleep deprivation

Interventions

Partial sleep deprivation OTHER

Participants will be asked to come to the lab for testing after a night of partial sleep deprivation. Participants will be asked to fall asleep at their habitual bedtime but wake up early (\~40% of normal sleep duration).

Partial sleep deprivation

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Free of known cardiovascular or metabolic diseases or sleep disorders
• No history of smoking (within the past 3 months)
• Able to engage in physical activity assessed through the physical activity readiness questionnaire (PAR-Q+)
• No prescription of chronic medications other than oral contraceptives
• Able to abide by sleep protocols for all visits
• Individuals who are not allergic to ultrasound gel
• Individuals who are not pregnant

You may not qualify if:

• Individuals diagnosed with cardiovascular or metabolic disease or sleep disorders
• Has a history of smoking (within the past 3 months)
• Not ready to engage in physical activity as assessed by the PAR-Q+
• Individuals prescribed chronic medications other than oral contraceptives
• Unable to abide by sleep protocols for any testing visit
• Allergic to ultrasound gel
• Pregnancy

Sponsors & Collaborators

• University of Guelph: lead

Study Sites (1)

University of Guelph

Guelph, Ontario, N1G 2W1, Canada

RECRUITING

MeSH Terms

Conditions

Sleep Deprivation

Condition Hierarchy (Ancestors)

Dyssomnias; Sleep Wake Disorders; Nervous System Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Mental Disorders

Study Officials

• Julian Bommarito, MSc

  University of Guelph

  STUDY DIRECTOR

• Philip Millar, PhD

  University of Guelph

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Julian Bommarito, MSc

CONTACT

9052209829; jbomma01@uoguelph.ca

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: November 5, 2024
• First Posted: November 7, 2024
• Study Start: January 2, 2025
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: April 28, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will share
• Time Frame: Beginning after publication with no end date

Locations

CA (1)