A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy
CAMBRIA-1
CAMBRIA-1: A Phase III, Open-Label, Randomised Study to Assess the Efficacy and Safety of Extended Therapy With Camizestrant (AZD9833, a Next Generation, Oral Selective Estrogen Receptor Degrader) Versus Standard Endocrine Therapy (Aromatase Inhibitor or Tamoxifen) in Patients With ER+/HER2- Early Breast Cancer and an Intermediate or High Risk of Recurrence Who Have Completed Definitive Locoregional Therapy and at Least 2 Years of Standard Adjuvant Endocrine-Based Therapy Without Disease Recurrence
2 other identifiers
interventional
4,300
38 countries
703
Brief Summary
This is a Phase III open-label study to assess if camizestrant improves outcomes compared to standard endocrine therapy in patients with ER+/HER2 - early breast cancer with intermediate or high risk for disease recurrence who completed definitive locoregional therapy (with or without chemotherapy) and standard adjuvant endocrine therapy (ET) for at least 2 years and up to 5 years. The planned duration of treatment in either arm of the study is 60 months.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Mar 2023
Longer than P75 for phase_3
703 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 16, 2023
CompletedFirst Posted
Study publicly available on registry
March 20, 2023
CompletedStudy Start
First participant enrolled
March 31, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 20, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
May 29, 2036
April 13, 2026
April 1, 2026
4.1 years
February 16, 2023
April 9, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Invasive breast cancer-free survival (IBCFS)
IBCFS is defined as time from randomisation until date of first occurrence of: * Invasive ipsilateral breast tumour recurrence (invasive IBTR) * Locoregional invasive breast cancer recurrence * Distant recurrence * Invasive contralateral breast cancer * Death attributable to any cause.
Up to 10 years
Secondary Outcomes (14)
Invasive disease-free survival (IDFS)
Up to 10 years
Distant relapse-free survival (DRFS)
Up to 10 years
Overall survival (OS)
Up to 10 years
Incidence and Severity of Adverse Events, with Severity Determined According to National Cancer Institute Common Terminology Criteria for Adverse Events, version 5.0 (NCI-CTCAE v5.0)
Until 28 days after the final dose of study treatment (up to 5 years)
Absolute and percent change from baseline in Clinical Laboratory Parameters
Until 28 days after the final dose of study treatment (up to 5 years)
- +9 more secondary outcomes
Study Arms (2)
Arm A: standard endocrine therapy of investigator´s choice
ACTIVE COMPARATORContinue standard endocrine therapy of investigator's choice (aromatase inhibitors \[AI; exemestane, letrozole, anastrozole\] or tamoxifen)
Arm B: camizestrant
EXPERIMENTALCamizestrant
Interventions
Exemestane. Comparator. Administered per local approved label
Camizestrant. Experimental. Administered orally
Tamoxifen. Comparator. Administered per local approved label
Anastrozole. Comparator. Administered per local approved label
Letrozole. Comparator. Administered per local approved label
Eligibility Criteria
You may qualify if:
- Women and Men, ≥18 years at the time of screening (or per national guidelines)
- Histologically confirmed ER+/HER2- early-stage resected invasive breast cancer with high or intermediate risk of recurrence, based on clinical-pathological risk features, as defined in the protocol.
- Completed adequate (definitive) locoregional therapy (surgery with or without radiotherapy) for the primary breast tumour(s), with or without (neo)adjuvant chemotherapy
- Completed at least 2 years but no more than 5 years (+3 months) of adjuvant ET (+/- CDK4/6 inhibitor)
- Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 1
- Adequate organ and marrow function
You may not qualify if:
- Inoperable locally advanced or metastatic breast cancer
- Pathological complete response following treatment with neoadjuvant therapy
- History of any other cancer (except non-melanoma skin cancer or carcinoma in situ of the cervix or considered at very low risk of recurrence per investigator judgement) unless in complete remission with no therapy for a minimum of 5 years from the date of randomisation
- Any evidence of severe or uncontrolled systemic diseases which, in the investigator's opinion precludes participation in the study or compliance
- Known LVEF \<50% with heart failure NYHA Grade ≥2.
- Mean resting QTcF interval \>480 ms at screening
- Concurrent exogenous sex hormone therapy
- Any concurrent anti-cancer treatment not specified in the protocol with the exception of bisphosphonates (e.g. zoledronic acid) or RANKL inhibitors (eg, denosumab)
- Previous treatment with camizestrant, investigational SERDs/investigational ER targeting agents, or fulvestrant
- Currently pregnant (confirmed with positive serum pregnancy test) or breastfeeding
- Patients with known hypersensitivity to active or inactive excipients of camizestrant or drugs with a similar chemical structure or class to camizestrant. In pre-/peri-menopausal female and male patients, known hypersensitivity or intolerance to LHRH agonists, that would preclude the patient from receiving any LHRH agonist
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- AstraZenecalead
Study Sites (711)
Research Site
Birmingham, Alabama, 35205, United States
Research Site
Dothan, Alabama, 36303, United States
Research Site
Anchorage, Alaska, 99508, United States
Research Site
Chandler, Arizona, 85224, United States
Research Site
Hot Springs, Arkansas, 71913, United States
Research Site
Anaheim, California, 92801, United States
Research Site
Beverly Hills, California, 90211, United States
Research Site
Concord, California, 94520, United States
Research Site
Corona, California, 92882, United States
Research Site
Fountain Valley, California, 92708, United States
Research Site
Greenbrae, California, 94904, United States
Research Site
Los Alamitos, California, 90720, United States
Research Site
Palo Alto, California, 94304, United States
Research Site
San Diego, California, 92121, United States
Research Site
San Diego, California, 92123, United States
Research Site
Whittier, California, 90603, United States
Research Site
Aurora, Colorado, 80045, United States
Research Site
Hartford, Connecticut, 06102, United States
Research Site
Fort Myers, Florida, 33901, United States
Research Site
Gainesville, Florida, 32603, United States
Research Site
Miami Beach, Florida, 33140, United States
Research Site
Orlando, Florida, 32806, United States
Research Site
Plantation, Florida, 33324, United States
Research Site
Port Saint Lucie, Florida, 34952, United States
Research Site
Saint Augustine, Florida, 32086, United States
Research Site
St. Petersburg, Florida, 33705, United States
Research Site
St. Petersburg, Florida, 33709, United States
Research Site
Tallahassee, Florida, 32308, United States
Research Site
West Palm Beach, Florida, 33401, United States
Research Site
Winter Haven, Florida, 33880, United States
Research Site
Atlanta, Georgia, 30310, United States
Research Site
Atlanta, Georgia, 30318, United States
Research Site
Columbus, Georgia, 31904, United States
Research Site
Honolulu, Hawaii, 96813, United States
Research Site
Chicago, Illinois, 60608, United States
Research Site
Chicago, Illinois, 60637, United States
Research Site
Decatur, Illinois, 62526, United States
Research Site
Elmhurst, Illinois, 60126, United States
Research Site
Hinsdale, Illinois, 60521, United States
Research Site
Park Ridge, Illinois, 60068, United States
Research Site
Park Ridge, Illinois, 60068, United States
Research Site
Fort Wayne, Indiana, 46804, United States
Research Site
Iowa City, Iowa, 52242, United States
Research Site
Iowa City, Iowa, 52242, United States
Research Site
Fort Mitchell, Kentucky, 41017, United States
Research Site
Lexington, Kentucky, 40536, United States
Research Site
Louisville, Kentucky, 40202, United States
Research Site
Baton Rouge, Louisiana, 70809, United States
Research Site
Brewer, Maine, 04412, United States
Research Site
Scarborough, Maine, 04074, United States
Research Site
Frederick, Maryland, 21702, United States
Research Site
Glenn Dale, Maryland, 20769, United States
Research Site
Silver Spring, Maryland, 20910, United States
Research Site
Towson, Maryland, 21204, United States
Research Site
Boston, Massachusetts, 02111, United States
Research Site
Hyannis, Massachusetts, 02601, United States
Research Site
Ann Arbor, Michigan, 48109, United States
Research Site
Detroit, Michigan, 48202, United States
Research Site
East Lansing, Michigan, 48824, United States
Research Site
Lansing, Michigan, 48910, United States
Research Site
Royal Oak, Michigan, 48073, United States
Research Site
Independence, Missouri, 64057, United States
Research Site
Lincoln, Nebraska, 68506, United States
Research Site
Las Vegas, Nevada, 89148, United States
Research Site
Laconia, New Hampshire, 03246, United States
Research Site
Belleville, New Jersey, 07109, United States
Research Site
Farmington, New Mexico, 87401, United States
Research Site
Santa Fe, New Mexico, 87505, United States
Research Site
East Syracuse, New York, 13057, United States
Research Site
New Hyde Park, New York, 11042, United States
Research Site
New York, New York, 10011, United States
Research Site
New York, New York, 10019, United States
Research Site
New York, New York, 10029, United States
Research Site
Stony Brook, New York, 11794, United States
Research Site
The Bronx, New York, 10461, United States
Research Site
White Plains, New York, 10601, United States
Research Site
Charlotte, North Carolina, 28204, United States
Research Site
Durham, North Carolina, 27710-0001, United States
Research Site
Greensboro, North Carolina, 27403, United States
Research Site
Raleigh, North Carolina, 27607, United States
Research Site
Rocky Mount, North Carolina, 27804, United States
Research Site
Winston-Salem, North Carolina, 27103, United States
Research Site
Winston-Salem, North Carolina, 27104, United States
Research Site
Cincinnati, Ohio, 45219, United States
Research Site
Cincinnati, Ohio, 45255, United States
Research Site
Cleveland, Ohio, 44106, United States
Research Site
Cleveland, Ohio, 44195, United States
Research Site
Youngstown, Ohio, 44504, United States
Research Site
Clairton, Pennsylvania, 15025, United States
Research Site
Philadelphia, Pennsylvania, 19106, United States
Research Site
Philadelphia, Pennsylvania, 19111, United States
Research Site
Pittsburgh, Pennsylvania, 15213, United States
Research Site
Pittsburgh, Pennsylvania, 15213, United States
Research Site
Reading, Pennsylvania, 19611, United States
Research Site
State College, Pennsylvania, 16803, United States
Research Site
Providence, Rhode Island, 02903, United States
Research Site
Lancaster, South Carolina, 29720, United States
Research Site
Spartanburg, South Carolina, 29303, United States
Research Site
Aberdeen, South Dakota, 57401, United States
Research Site
Mitchell, South Dakota, 57301, United States
Research Site
Pierre, South Dakota, 57501, United States
Research Site
Sioux Falls, South Dakota, 57105, United States
Research Site
Yankton, South Dakota, 57078, United States
Research Site
Chattanooga, Tennessee, 37404, United States
Research Site
Knoxville, Tennessee, 37920, United States
Research Site
Nashville, Tennessee, 37203, United States
Research Site
Nashville, Tennessee, 37204, United States
Research Site
Austin, Texas, 78731, United States
Research Site
Dallas, Texas, 75230, United States
Research Site
Denton, Texas, 76201, United States
Research Site
Houston, Texas, 77024, United States
Research Site
Houston, Texas, 77030, United States
Research Site
Irving, Texas, 75063, United States
Research Site
Ogden, Utah, 84405, United States
Research Site
Salt Lake City, Utah, 84106, United States
Research Site
Fairfax, Virginia, 22031, United States
Research Site
Lynchburg, Virginia, 24501, United States
Research Site
Midlothian, Virginia, 23114, United States
Research Site
Reston, Virginia, 20190, United States
Research Site
Richmond, Virginia, 23235, United States
Research Site
Seattle, Washington, 98101, United States
Research Site
Seattle, Washington, 98104, United States
Research Site
Spokane, Washington, 99202, United States
Research Site
Tacoma, Washington, 98405, United States
Research Site
Charleston, West Virginia, 25304, United States
Research Site
Morgantown, West Virginia, 26505, United States
Research Site
Appleton, Wisconsin, 54911, United States
Research Site
Madison, Wisconsin, 53792, United States
Research Site
Milwaukee, Wisconsin, 53226, United States
Research Site
Buenos Aires, C1430EGF, Argentina
Research Site
CABA, C1119ACN, Argentina
Research Site
Capital Federal, C1417DTB, Argentina
Research Site
Ciudad Autónoma Buenos Aires, 1125, Argentina
Research Site
Ciudad de Buenos Aires, 1280, Argentina
Research Site
Ciudad de Buenos Aires, C1118AAT, Argentina
Research Site
Ciudad de Buenos Aires, C1426ANZ, Argentina
Research Site
Córdoba, 5000, Argentina
Research Site
Córdoba, 5001, Argentina
Research Site
La Plata, 1900, Argentina
Research Site
Mar del Plata, 7600, Argentina
Research Site
Salta, A4400EMI, Argentina
Research Site
San Juan, 5400, Argentina
Research Site
San Miguel de Tucumán, 4000, Argentina
Research Site
San Miguel de Tucumán, T4000IAK, Argentina
Research Site
Viedma, R8500ACE, Argentina
Research Site
Birtinya, 4575, Australia
Research Site
Concord, 2139, Australia
Research Site
Nedlands, 6009, Australia
Research Site
Nedlands, 6009, Australia
Research Site
Randwick, 2031, Australia
Research Site
Tweed Heads, 2485, Australia
Research Site
Waratah, 2298, Australia
Research Site
Wendouree, 3355, Australia
Research Site
Graz, 8036, Austria
Research Site
Kufstein, 6330, Austria
Research Site
Ried, 4910, Austria
Research Site
Sankt Veit an der Glan, 9300, Austria
Research Site
Vienna, 1090, Austria
Research Site
Vienna, 1180, Austria
Research Site
Wein, 1130, Austria
Research Site
Wels, 4600, Austria
Research Site
Brussels, 1090, Belgium
Research Site
Edegem, 2650, Belgium
Research Site
Ghent, 9000, Belgium
Research Site
Leuven, 8500, Belgium
Research Site
Liège, 4000, Belgium
Research Site
Ottignies, 1340, Belgium
Research Site
Wilrijk, 2610, Belgium
Research Site
Yvoir, 5530, Belgium
Research Site
Alfenas, 37130-000, Brazil
Research Site
Belo Horizonte, 30130-100, Brazil
Research Site
Belo Horizonte, 30150-274, Brazil
Research Site
Brasília, 70390-700, Brazil
Research Site
Brasília, 71681-603, Brazil
Research Site
Chapecó, 89812-220, Brazil
Research Site
Cuiabá, 78040-400, Brazil
Research Site
Curitiba, 80810-050, Brazil
Research Site
Curitiba, 81520-060, Brazil
Research Site
Fortaleza, 60170-170, Brazil
Research Site
Fortaleza, 60430-230, Brazil
Research Site
Lajeado, 95900000, Brazil
Research Site
Londrina, 86015-520, Brazil
Research Site
Natal, 59075-740, Brazil
Research Site
Niterói, 24020-096, Brazil
Research Site
Piracicaba, 13419-155, Brazil
Research Site
Porto Alegre, 90035-001, Brazil
Research Site
Porto Alegre, 90035-903, Brazil
Research Site
Porto Alegre, 90050-170, Brazil
Research Site
Porto Alegre, 90880-480, Brazil
Research Site
Pouso Alegre, 37554-216, Brazil
Research Site
Recife, 50070-070, Brazil
Research Site
Ribeirão Preto, 14051-140, Brazil
Research Site
Rio de Janeiro, 20560-120, Brazil
Research Site
Rio de Janeiro, 22250-905, Brazil
Research Site
Rio de Janeiro, 22290-160, Brazil
Research Site
Salvador, 40110-060, Brazil
Research Site
Salvador, 41253-190, Brazil
Research Site
São Paulo, 01236-030, Brazil
Research Site
São Paulo, 01317-001, Brazil
Research Site
São Paulo, 01323-001, Brazil
Research Site
São Paulo, 01508-010, Brazil
Research Site
São Paulo, 01509-900, Brazil
Research Site
São Paulo, 08270-070, Brazil
Research Site
Taubaté, 12030-200, Brazil
Research Site
Três Lagoas, 79601-001, Brazil
Research Site
Vitória, 29055-450, Brazil
Research Site
Dobrich, 9300, Bulgaria
Research Site
Plovdiv, 4002, Bulgaria
Research Site
Plovdiv, 4004, Bulgaria
Research Site
Sofia, 1330, Bulgaria
Research Site
Sofia, 1407, Bulgaria
Research Site
Sofia, 1431, Bulgaria
Research Site
Sofia, 1606, Bulgaria
Research Site
Sofia, 1784, Bulgaria
Research Site
Vratsa, 3000, Bulgaria
Research Site
Calgary, Alberta, T2N 4N2, Canada
Research Site
Kelowna, British Columbia, V1Y 5L3, Canada
Research Site
Winnipeg, Manitoba, R3E 0V9, Canada
Research Site
Barrie, Ontario, L4M 6M2, Canada
Research Site
Ottawa, Ontario, K1H 8L6, Canada
Research Site
Sault Ste. Marie, Ontario, P6A 0A8, Canada
Research Site
Toronto, Ontario, M5G 1X5, Canada
Research Site
Windsor, Ontario, N8W 2X3, Canada
Research Site
Chicoutimi, Quebec, G7H 5H6, Canada
Research Site
Greenfield Park, Quebec, J4V 2H1, Canada
Research Site
Montreal, Quebec, H1T 2M4, Canada
Research Site
Montreal, Quebec, H2X 3E4, Canada
Research Site
Montreal, Quebec, H4A 3J1, Canada
Research Site
Saint-Jérôme, Quebec, J7Z 5T3, Canada
Research Site
Concepción, 4070196, Chile
Research Site
La Serena, 1720430, Chile
Research Site
Port Montt, 5500243, Chile
Research Site
Santiago, 8150215, Chile
Research Site
Santiago, 8330032, Chile
Research Site
Santiago, 8330336, Chile
Research Site
Talca, 3460000, Chile
Research Site
Temuco, 4780000, Chile
Research Site
Viña del Mar, 2520000, Chile
Research Site
Baoding, 071000, China
Research Site
Beijing, 100005, China
Research Site
Beijing, 100021, China
Research Site
Beijing, 100044, China
Research Site
Beijing, 100142, China
Research Site
Beijing, China
Research Site
Changchun, 130021, China
Research Site
Changsha, 410008, China
Research Site
Chengdu, 610000, China
Research Site
Chengdu, 610041, China
Research Site
Chengdu, 610072, China
Research Site
Chifeng, 024000, China
Research Site
Dalian, 116023, China
Research Site
Foshan, 528000, China
Research Site
Fuzhou, 350001, China
Research Site
Fuzhou, 350011, China
Research Site
Guangzhou, 510060, China
Research Site
Guangzhou, 510120, China
Research Site
Guangzhou, 510168, China
Research Site
Haikou, 570102, China
Research Site
Haikou, 570311, China
Research Site
Hangzhou, 310003, China
Research Site
Hangzhou, 310009, China
Research Site
Hangzhou, 310020, China
Research Site
Hangzhou, 310022, China
Research Site
Harbin, 150081, China
Research Site
Hefei, 230001, China
Research Site
Hefei, 230012, China
Research Site
Hefei, 230601, China
Research Site
Hohhot, 010010, China
Research Site
Huangpu District, 200025, China
Research Site
Jinan, 2501117, China
Research Site
Lanzhou, 730050, China
Research Site
Liuchow, 545005, China
Research Site
Nanchang, 330009, China
Research Site
Nanjing, 210009, China
Research Site
Nanjing, 210029, China
Research Site
Nanning, 530021, China
Research Site
Nanning, 530021, China
Research Site
Neijiang, 641000, China
Research Site
Qingdao, 266100, China
Research Site
Shanghai, 200032, China
Research Site
Shanghai, 200032, China
Research Site
Shanghai, 200127, China
Research Site
Shantou, 515031, China
Research Site
Shaoguan, 512027, China
Research Site
Shenyang, 110001, China
Research Site
Shenyang, 110016, China
Research Site
Shijiazhuang, 050020, China
Research Site
Suining, 629000, China
Research Site
Suzhou, 215006, China
Research Site
Taiyuan, 030000, China
Research Site
Taizhou, 317000, China
Research Site
Tianjin, 300060, China
Research Site
Weifang, 261000, China
Research Site
Wuhan, 430022, China
Research Site
Wuhan, 430070, China
Research Site
Wuhan, 430079, China
Research Site
Xiangfan, 441021, China
Research Site
Xining, 810001, China
Research Site
Xinxiang, 453100, China
Research Site
Xuzhou, 221000, China
Research Site
Xuzhou, 221009, China
Research Site
Yanji, 133000, China
Research Site
Yantai, 264000, China
Research Site
Zhengzhou, 450052, China
Research Site
Barranquilla, 080020, Colombia
Research Site
Barranquilla, 80020, Colombia
Research Site
Bogotá, 110221, Colombia
Research Site
Bogotá, 111511, Colombia
Research Site
Cali, 760042, Colombia
Research Site
Floridablanca, 681004, Colombia
Research Site
Medellín, 50030, Colombia
Research Site
Montería, 23001, Colombia
Research Site
Pereira, Colombia
Research Site
Valledupar, 200001, Colombia
Research Site
Hořovice, 268 31, Czechia
Research Site
Pardubice, 532 03, Czechia
Research Site
Prague, 140 00, Czechia
Research Site
Prague, 15006, Czechia
Research Site
Pragues, 18081, Czechia
Research Site
Příbram, 261 01, Czechia
Research Site
Angers, 49055, France
Research Site
Argenteuil, 95100, France
Research Site
Avignon, 84918, France
Research Site
Bordeaux, 33000, France
Research Site
Bordeaux, 33077, France
Research Site
Bourg-en-Bresse, 01012, France
Research Site
Caen, 14076, France
Research Site
Cholet, 49300, France
Research Site
Clermont-Ferrand, 63011, France
Research Site
Dijon, 21079, France
Research Site
Epagny Metz-Tessy, 74370, France
Research Site
Lille, 59000, France
Research Site
Lorient, 56322, France
Research Site
Lyon, 69008, France
Research Site
Marseille, 13273, France
Research Site
Metz, 57085, France
Research Site
Montpellier, 34070, France
Research Site
Montpellier, 34298, France
Research Site
Nantes, 44202, France
Research Site
Nîmes, 30029, France
Research Site
Paris, 75010, France
Research Site
Paris, 75013, France
Research Site
Pierre-Bénite, 69310, France
Research Site
Plerin SUR MER, 22190, France
Research Site
Poitiers, 86021, France
Research Site
Quimper, 29107, France
Research Site
Rennes, 35042, France
Research Site
Saint-Cloud, 92210, France
Research Site
Saint-Herblain, 44805, France
Research Site
Saint-Priest-en-Jarez, 42270, France
Research Site
Suresnes, 92151, France
Research Site
Toulouse, 31059, France
Research Site
Tours, 37044, France
Research Site
Villejuif, 94805, France
Research Site
Batumi, 6400, Georgia
Research Site
Tbilisi, 0179, Georgia
Research Site
Tbilisi, 112, Georgia
Research Site
Tbilisi, 160, Georgia
Research Site
Tbilisi, 186, Georgia
Research Site
Aachen, 52074, Germany
Research Site
Augsburg, 86150, Germany
Research Site
Bayreuth, 95445, Germany
Research Site
Berlin, 10317, Germany
Research Site
Berlin, 12623, Germany
Research Site
Bonn, 53111, Germany
Research Site
Deggendorf, 94469, Germany
Research Site
Dessau, 6847, Germany
Research Site
Dresden, 01307, Germany
Research Site
Düsseldorf, 40225, Germany
Research Site
Düsseldorf, 40235, Germany
Research Site
Eggenfelden, 84307, Germany
Research Site
Esslingen am Neckar, 73730, Germany
Research Site
Georgsmarienhütte, 49124, Germany
Research Site
Gütersloh, 33332, Germany
Research Site
Hamburg, 20259, Germany
Research Site
Hamburg, 21073, Germany
Research Site
Heidelberg, 69120, Germany
Research Site
Kiel, 24105, Germany
Research Site
Landshut, 84036, Germany
Research Site
Lübeck, 23562, Germany
Research Site
Mainz, 55131, Germany
Research Site
Memmingen, 87700, Germany
Research Site
München, 80637, Germany
Research Site
Ravensburg, 88212, Germany
Research Site
Rüsselsheim am Main, 65428, Germany
Research Site
Stralsund, 18439, Germany
Research Site
Torgau, 4860, Germany
Research Site
Trier, 54290, Germany
Research Site
Ulm, 89075, Germany
Research Site
Velbert, 42551, Germany
Research Site
Wiesbaden, 65189, Germany
Research Site
Wiesbaden, 65199, Germany
Research Site
Worms, 67550, Germany
Research Site
Wuppertal, 42283, Germany
Research Site
Athens, 11528, Greece
Research Site
Athens, 15123, Greece
Research Site
Athens, 18537, Greece
Research Site
Chaïdári, 124 62, Greece
Research Site
Heraklion, 71110, Greece
Research Site
Ioannina, 45500, Greece
Research Site
Rio, 265 04, Greece
Research Site
Thessaloniki, 546 39, Greece
Research Site
Thessaloniki, 54631, Greece
Research Site
Thessaloniki, 54645, Greece
Research Site
Thessaloniki, 54645, Greece
Research Site
Thessaloniki, 57001, Greece
Research Site
Budapest, 1083, Hungary
Research Site
Budapest, 1106, Hungary
Research Site
Budapest, 1115, Hungary
Research Site
Budapest, 1122, Hungary
Research Site
Debrecen, 4032, Hungary
Research Site
Győr, 9024, Hungary
Research Site
Gyula, 5700, Hungary
Research Site
Kaposvár, 7400, Hungary
Research Site
Miskolc, 3526, Hungary
Research Site
Nyíregyháza, 4400, Hungary
Research Site
Szekszárd, 7100, Hungary
Research Site
Szolnok, 5000, Hungary
Research Site
Bangalore, 560027, India
Research Site
Bangalore, 560076, India
Research Site
Belagavi, 590010, India
Research Site
Bhubaneswar, 751019, India
Research Site
Hubli, 580029, India
Research Site
Hyderabad, 500082, India
Research Site
Jaipur, 302017, India
Research Site
Kolkata, 700020, India
Research Site
Mumbai, 400 012, India
Research Site
Nagpur, 440026, India
Research Site
Nashik, 422005, India
Research Site
New Delhi, 110 085, India
Research Site
New Delhi, 110005, India
Research Site
New Delhi, 110076, India
Research Site
Pune, 411004, India
Research Site
Thane, 401107, India
Research Site
Visakhapatnam, 530040, India
Research Site
West Bengal, 700 156, India
Research Site
Afula, 1834111, Israel
Research Site
Ashdod, 7747629, Israel
Research Site
Haifa, 31096, Israel
Research Site
Jerusalem, 00000, Israel
Research Site
Jerusalem, 9103102, Israel
Research Site
Kfar Saba, 4428164, Israel
Research Site
Nahariya, 22100, Israel
Research Site
Ramat Gan, 52621, Israel
Research Site
Rehovot, 7661041, Israel
Research Site
Tel Aviv, 69710, Israel
Research Site
Bari, 70124, Italy
Research Site
Catania, 95126, Italy
Research Site
Catanzaro, 88100, Italy
Research Site
Florence, 50134, Italy
Research Site
Genova, 16132, Italy
Research Site
Grosseto, 58100, Italy
Research Site
Milan, 20132, Italy
Research Site
Milan, 20141, Italy
Research Site
Modena, 41125, Italy
Research Site
Naples, 80131, Italy
Research Site
Naples, 80131, Italy
Research Site
Pisa, 56126, Italy
Research Site
Reggio Emilia, 42122, Italy
Research Site
Roma, 00168, Italy
Research Site
Rozzano, 20089, Italy
Research Site
Turin, 10128, Italy
Research Site
Chiba, 260-8717, Japan
Research Site
Chūōku, 104-8560, Japan
Research Site
Fukuoka, 811-1395, Japan
Research Site
Fukushima, 960-1295, Japan
Research Site
Hidaka-shi, 350-1298, Japan
Research Site
Hirakata-shi, 573-1191, Japan
Research Site
Hiroshima, 730-0011, Japan
Research Site
Isehara-shi, 259-1193, Japan
Research Site
Kagoshima, 892-0833, Japan
Research Site
Kashiwa, 227-8577, Japan
Research Site
Kitaadachi-gun, 362-0806, Japan
Research Site
Kōtoku, 135-8550, Japan
Research Site
Kumamoto, 860-8556, Japan
Research Site
Kurume-shi, 830-0013, Japan
Research Site
Kyoto, 606-8507, Japan
Research Site
Matsuyama, 791-0280, Japan
Research Site
Nagoya, 464-8681, Japan
Research Site
Nagoya, 466-8560, Japan
Research Site
Nagoya, 467-0001, Japan
Research Site
Niigata, 951-8566, Japan
Research Site
Osaka, 533-0024, Japan
Research Site
Osaka, 540-0006, Japan
Research Site
Osaka, 541-8567, Japan
Research Site
Ota-shi, 373-8550, Japan
Research Site
Ōita, 870-8511, Japan
Research Site
Sagamihara-shi, 252-0375, Japan
Research Site
Sapporo, 060-8648, Japan
Research Site
Sendai, 980-8574, Japan
Research Site
Shinagawa-ku, 142-8666, Japan
Research Site
Suita-shi, 565-0871, Japan
Research Site
Sunto-gun, 411-8777, Japan
Research Site
Takasaki-shi, 370-0829, Japan
Research Site
Tsu, 514-8507, Japan
Research Site
Yokohama, 241-8515, Japan
Research Site
George Town, 10350, Malaysia
Research Site
George Town, 10450, Malaysia
Research Site
Johor Bahru, 81100, Malaysia
Research Site
Kota Bharu, 16150, Malaysia
Research Site
Kuala Lumpur, 50300, Malaysia
Research Site
Kuala Lumpur, 50450, Malaysia
Research Site
Kuala Lumpur, 50603, Malaysia
Research Site
Kuching, 93586, Malaysia
Research Site
Malacca, 75000, Malaysia
Research Site
Sabak Bernam, 88996, Malaysia
Research Site
Aguascalientes, 20230, Mexico
Research Site
Alc. Cuauhtémoc, 06100, Mexico
Research Site
Colonia Lindavista, 7300, Mexico
Research Site
Mexico City, 03310, Mexico
Research Site
Mérida, 97300, Mexico
Research Site
México, 14080, Mexico
Research Site
México, 14080, Mexico
Research Site
México, 6700, Mexico
Research Site
Monterrey, 64460, Mexico
Research Site
Monterrey, 64460, Mexico
Research Site
Monterrey, 64570, Mexico
Research Site
San Luis Potosí City, 78250, Mexico
Research Site
Toluca, 50180, Mexico
Research Site
Veracruz, 91900, Mexico
Research Site
Veracruz, 91910, Mexico
Research Site
Dirksland, 3247 BW, Netherlands
Research Site
Geleen, 6162 BG, Netherlands
Research Site
Groningen, 9728 NT, Netherlands
Research Site
Hoofddorp, 2134 TM, Netherlands
Research Site
Rotterdam, 3079 DZ, Netherlands
Research Site
Rotterdam, 3083 AN, Netherlands
Research Site
Arequipa, 04001, Peru
Research Site
Arequipa, 4001, Peru
Research Site
Arequipa, AREQUIPA01, Peru
Research Site
Callao, 7021, Peru
Research Site
La Libertad, 13013, Peru
Research Site
Lima, 0051, Peru
Research Site
Lima, 15076, Peru
Research Site
Lima, Lima 32, Peru
Research Site
Lima, Lima 34, Peru
Research Site
Trujillo, Peru
Research Site
Bacolod, 6100, Philippines
Research Site
Cebu, 6000, Philippines
Research Site
Iloilo City, 5000, Philippines
Research Site
Manila, 1000, Philippines
Research Site
Quezon City, 0870, Philippines
Research Site
Quezon City, 1101, Philippines
Research Site
Quezon City, 1112, Philippines
Research Site
Bialystok, 15-027, Poland
Research Site
Grudziądz, 86-300, Poland
Research Site
Koszalin, 75-581, Poland
Research Site
Lodz, 90-302, Poland
Research Site
Lublin, 20-718, Poland
Research Site
Opole, 45-061, Poland
Research Site
Poznan, 61-485, Poland
Research Site
Racibórz, 47-400, Poland
Research Site
Rzeszów, 35-021, Poland
Research Site
Warsaw, 02-781, Poland
Research Site
Wieliszew, 05-135, Poland
Research Site
Amadora, 2720-276, Portugal
Research Site
Braga, 4710-243, Portugal
Research Site
Guimarães, 4835-044, Portugal
Research Site
Lisbon, 1649-035, Portugal
Research Site
Lisbon, 1998-018, Portugal
Research Site
Matosinhos Municipality, 4454-509, Portugal
Research Site
Porto, 4100-180, Portugal
Research Site
Porto, 4200-072, Portugal
Research Site
Porto, 4200-319, Portugal
Research Site
Vila Nova de Gaia, 4434-502, Portugal
Research Site
Baia Mare, 430031, Romania
Research Site
Brasov, 500283, Romania
Research Site
Cluj-Napoca, 400015, Romania
Research Site
Cluj-Napoca, 400641, Romania
Research Site
Constanța, 900591, Romania
Research Site
Craiova, 200094, Romania
Research Site
Craiova, 200347, Romania
Research Site
Craiova, 200385, Romania
Research Site
Floreşti, 407280, Romania
Research Site
Iași, 700106, Romania
Research Site
Oradea, 410167, Romania
Research Site
Piteşti, 110283, Romania
Research Site
Sibiu, 550245, Romania
Research Site
Timișoara, 300166, Romania
Research Site
Timișoara, 300239, Romania
Research Site
Belgrade, 11000, Serbia
Research Site
Belgrade, 11010, Serbia
Research Site
Belgrade, 11080, Serbia
Research Site
Kamenitz, 21204, Serbia
Research Site
Kragujevac, 34000, Serbia
Research Site
Niš, 18000, Serbia
Research Site
Valjevo, 14000, Serbia
Research Site
Zrenjanin, 23000, Serbia
Research Site
Singapore, 119074, Singapore
Research Site
Singapore, 228510, Singapore
Research Site
Singapore, 308433, Singapore
Research Site
Singapore, 329563, Singapore
Research Site
Bloemfontein, 9301, South Africa
Research Site
Bloemfontein, 9301, South Africa
Research Site
eManzimtoti, 4126, South Africa
Research Site
George, 6529, South Africa
Research Site
George, 6529, South Africa
Research Site
Johannesburg, 2193, South Africa
Research Site
Johannesburg, 2196, South Africa
Research Site
Pietermaritzburg, 3201, South Africa
Research Site
Pretoria, 0084, South Africa
Research Site
Pretoria, 31, South Africa
Research Site
Soweto, 2193, South Africa
Research Site
Busan, 48108, South Korea
Research Site
Daegu, 42601, South Korea
Research Site
Donggu, 44033, South Korea
Research Site
Goyang-si, 10408, South Korea
Research Site
Jeonnam, 58128, South Korea
Research Site
Seongbuk-Gu, 2841, South Korea
Research Site
Seoul, 03080, South Korea
Research Site
Seoul, 03722, South Korea
Research Site
Seoul, 06273, South Korea
Research Site
Seoul, 06351, South Korea
Research Site
Seoul, 06591, South Korea
Research Site
Seoul, 08308, South Korea
Research Site
Seoul, 158-710, South Korea
Research Site
A Coruña, 15006, Spain
Research Site
A Coruña, 15009, Spain
Research Site
Albacete, 02006, Spain
Research Site
Alcoy, 3804, Spain
Research Site
Alicante, 3015, Spain
Research Site
Alzira, 46600, Spain
Research Site
Badajoz, 06080, Spain
Research Site
Badalona, 08003, Spain
Research Site
Badalona, 08916, Spain
Research Site
Barakaldo, 48903, Spain
Research Site
Barcelona, 08028, Spain
Research Site
Barcelona, 08036, Spain
Research Site
Barcelona, 8035, Spain
Research Site
Cáceres, 10003, Spain
Research Site
Elche(Alicante), 03202, Spain
Research Site
Galdakao, 48960, Spain
Research Site
Girona, 17007, Spain
Research Site
Granada, 18007, Spain
Research Site
Granada, 18014, Spain
Research Site
Jerez de La Frontera (Cádiz), 11407, Spain
Research Site
L'Hospitalet de Llobregat, 08908, Spain
Research Site
Leganés, 28911, Spain
Research Site
Lleida, 25198, Spain
Research Site
Madrid, 28033, Spain
Research Site
Madrid, 28040, Spain
Research Site
Madrid, 28040, Spain
Research Site
Madrid, 28050, Spain
Research Site
Majadahonda, 28222, Spain
Research Site
Manresa, 8242, Spain
Research Site
Murcia, 30008, Spain
Research Site
Oviedo, 33011, Spain
Research Site
Parla, 28981, Spain
Research Site
Port de Sagunt, 46520, Spain
Research Site
Reus, 43204, Spain
Research Site
Salamanca, 37007, Spain
Research Site
San Sebastián, 20014, Spain
Research Site
Sant Joan d'Alacant, 03550, Spain
Research Site
Santander, 39008, Spain
Research Site
Seville, 41009, Spain
Research Site
Seville, 41013, Spain
Research Site
Teruel, 44001, Spain
Research Site
Toledo, 45007, Spain
Research Site
Valencia, 46009, Spain
Research Site
Valencia, 46015, Spain
Research Site
Valencia, 46017, Spain
Research Site
Hsinchu, 300, Taiwan
Research Site
Kaohsiung City, 82445, Taiwan
Research Site
Taichung, 40447, Taiwan
Research Site
Tainan, 70403, Taiwan
Research Site
Tainan, 710, Taiwan
Research Site
Taipei, 10002, Taiwan
Research Site
Taipei, 110, Taiwan
Research Site
Taipei, 11259, Taiwan
Research Site
Bangkok, 10400, Thailand
Research Site
Bangkok, 10700, Thailand
Research Site
Khon Kaen, 40002, Thailand
Research Site
Phisanulok, 65000, Thailand
Research Site
Phitsanulok, 65000, Thailand
Research Site
Rachathewi, 10400, Thailand
Research Site
Songkhla, 90110, Thailand
Research Site
Ankara, 06100, Turkey (Türkiye)
Research Site
Ankara, 06200, Turkey (Türkiye)
Research Site
Ankara, 06520, Turkey (Türkiye)
Research Site
Ankara, 06620, Turkey (Türkiye)
Research Site
Ankara, 6800, Turkey (Türkiye)
Research Site
Aydin, 9010, Turkey (Türkiye)
Research Site
Bursa, 16059, Turkey (Türkiye)
Research Site
Dinar, 03400, Turkey (Türkiye)
Research Site
Istanbul, 34010, Turkey (Türkiye)
Research Site
Istanbul, 34218, Turkey (Türkiye)
Research Site
Istanbul, 34899, Turkey (Türkiye)
Research Site
Izmir, 35120, Turkey (Türkiye)
Research Site
Izmir, 35150, Turkey (Türkiye)
Research Site
Izmir, 35530, Turkey (Türkiye)
Research Site
Izmir, 35575, Turkey (Türkiye)
Research Site
Samsun, 55200, Turkey (Türkiye)
Research Site
Brighton, BN2 5BE, United Kingdom
Research Site
Burton-on-Trent, DE13 0RB, United Kingdom
Research Site
Cambridge, CB2 0QQ, United Kingdom
Research Site
Derby, DE22 3NE, United Kingdom
Research Site
Edinburgh, EH4 2XU, United Kingdom
Research Site
Guildford, United Kingdom
Research Site
Ipswich, IP4 5PD, United Kingdom
Research Site
Keighley, BD20 6TD, United Kingdom
Research Site
London, SE1 9RT, United Kingdom
Research Site
London, SW3 6JJ, United Kingdom
Research Site
Manchester, M20 4BX, United Kingdom
Research Site
Oxford, OX3 7LJ, United Kingdom
Research Site
Peterborough, PE3 9GZ, United Kingdom
Research Site
Stoke-on-Trent, ST4 6QG, United Kingdom
Research Site
Sutton, SM2 5PT, United Kingdom
Research Site
Hanoi, 100000, Vietnam
Research Site
Ho Chi Minh City, 700000, Vietnam
Research Site
Ho Chi Minh City, 70000, Vietnam
Research Site
Huế, 530000, Vietnam
Related Publications (1)
Hamilton EP, Loibl S, Bachelot T, Gnant M, Niikura N, Park YH, Tolaney SM, Pistilli B, Rastogi P, Saini KS, Gioni I, Johnston S, Nunes R, Quintana A, Stuart M, Syta E, Walding A, Klinowska T, Mayer IA. CAMBRIA-1 & CAMBRIA-2 phase III trials: camizestrant versus standard endocrine therapy in ER+/HER2- early breast cancer. Future Oncol. 2025 Mar;21(7):795-806. doi: 10.1080/14796694.2025.2459548. Epub 2025 Feb 27.
PMID: 40017004DERIVED
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Central Study Contacts
AstraZeneca Clinical Study Information Center
CONTACT
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 16, 2023
First Posted
March 20, 2023
Study Start
March 31, 2023
Primary Completion (Estimated)
April 20, 2027
Study Completion (Estimated)
May 29, 2036
Last Updated
April 13, 2026
Record last verified: 2026-04
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, SAP
- Time Frame
- AstraZeneca will meet or exceed data availability as per the commitments made to the EFPIA Pharma Data Sharing Principles. For details of our timelines, please rerefer to our disclosure commitment at https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure.
- Access Criteria
- When a request has been approved AstraZeneca will provide access to the deidentified individual patient-level data in an approved sponsored tool . Signed Data Sharing Agreement (non-negotiable contract for data accessors) must be in place before accessing requested information. Additionally, all users will need to accept the terms and conditions of the SAS MSE to gain access. For additional details, please review the Disclosure Statements at https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure
Qualified researchers can request access to anonymized individual patient-level data from AstraZeneca group of companies sponsored clinical trials via the request portal. All request will be evaluated as per the AZ disclosure commitment: https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure Yes, indicates that AZ are accepting requests for IPD, but this does not mean all requests will be shared.