Success Metrics

Clinical Success Rate
81.6%

Based on 209 completed trials

Completion Rate
82%(209/256)
Active Trials
103(24%)
Results Posted
66%(137 trials)
Terminated
47(11%)

Phase Distribution

Ph phase_4
36
8%
Ph phase_1
58
13%
Ph early_phase_1
12
3%
Ph phase_3
95
22%
Ph not_applicable
39
9%
Ph phase_2
175
41%

Phase Distribution

70

Early Stage

175

Mid Stage

131

Late Stage

Phase Distribution415 total trials
Early Phase 1First-in-human
12(2.9%)
Phase 1Safety & dosage
58(14.0%)
Phase 2Efficacy & side effects
175(42.2%)
Phase 3Large-scale testing
95(22.9%)
Phase 4Post-market surveillance
36(8.7%)
N/ANon-phased studies
39(9.4%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

77.4%

209 of 270 finished

Non-Completion Rate

22.6%

61 ended early

Currently Active

103

trials recruiting

Total Trials

430

all time

Status Distribution
Active(110)
Completed(209)
Terminated(61)
Other(50)

Detailed Status

Completed209
Recruiting57
unknown49
Terminated47
Active, not recruiting46
Withdrawn14

Development Timeline

Analytics

Development Status

Total Trials
430
Active
103
Success Rate
81.6%
Most Advanced
Phase 4

Trials by Phase

Early Phase 112 (2.9%)
Phase 158 (14.0%)
Phase 2175 (42.2%)
Phase 395 (22.9%)
Phase 436 (8.7%)
N/A39 (9.4%)

Trials by Status

completed20949%
unknown4911%
not_yet_recruiting61%
suspended10%
active_not_recruiting4611%
enrolling_by_invitation10%
withdrawn143%
terminated4711%
recruiting5713%

Recent Activity

Clinical Trials (430)

Showing 20 of 430 trialsScroll for more
NCT07391774Phase 3

Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed by Hormone Therapy With Ribociclib for the Treatment of High Anatomic Stage Breast Cancer With Low Recurrence Risk, The RxFINE-Low Trial

Recruiting
NCT01272037Phase 3

Tamoxifen Citrate, Letrozole, Anastrozole, or Exemestane With or Without Chemotherapy in Treating Patients With Invasive RxPONDER Breast Cancer

Active Not Recruiting
NCT01872260Phase 1

Study of LEE011, BYL719 and Letrozole in Advanced ER+ Breast Cancer

Active Not Recruiting
NCT05161195Phase 4

Roll-over Study to Allow Continued Access to Ribociclib

Active Not Recruiting
NCT00310180Phase 3

Hormone Therapy With or Without Combination Chemotherapy in Treating Women Who Have Undergone Surgery for Node-Negative Breast Cancer (The TAILORx Trial)

Active Not Recruiting
NCT03006172Phase 1

To Evaluate the Safety, Tolerability, and Pharmacokinetics of Inavolisib Single Agent in Participants With Solid Tumors and in Combination With Endocrine and Targeted Therapies in Participants With Breast Cancer

Active Not Recruiting
NCT06253195Phase 1

BGB-43395 Alone or as Part of Combination Therapies in Chinese Participants With HR+/HER2- Breast Cancer and Other Advanced Solid Tumors

Completed
NCT05827081Phase 3

Phase IIIb Study of Ribociclib + ET in Early Breast Cancer

Recruiting
NCT06671912Phase 3

Testing Low Dose Tamoxifen for Invasive Breast Cancer, LoTam Trial

Suspended
NCT04931342Phase 2

A Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors

Active Not Recruiting
NCT06570031Phase 1

ONO-4578-06:Phase I Study of ONO-4578 and Letrozole Plus CDK4 /6 Inhibitors in Breast Cancer

Completed
NCT07604571Phase 1

Study of IEV407 as Single Agent or in Combination in Patients With Advanced HR+/HER2- Breast Cancer

Recruiting
NCT05035836Phase 2

A Phase 2 Single-Arm Open-Label Pilot Trial Evaluating Zanidatamab (ZW25) in Patients With Early Stage HER2/Neu Positive (HER2+) Breast Cancer (BC)

Recruiting
NCT05183828Phase 4

Effect of HSD3B1 (1245C) Gene Mutation on Treatment of Stage I-III Breast Cancer

Terminated
NCT03011684Phase 3

Fertility Preservation Using Tamoxifen and Letrozole in Estrogen Sensitive Tumors Trial

Recruiting
NCT07288359Phase 1

Study of GVV858 as a Single Agent or in Combination With Endocrine Therapy in Patients With HR+/HER2- Breast Cancer and Other Advanced Solid Tumors

Recruiting
NCT05768139Phase 1

First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors

Recruiting
NCT07174336Phase 3

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

Recruiting
NCT07492641Phase 3

BGB-43395 Plus Letrozole Versus CDK4/6i Plus Letrozole for Patients With Advanced or Metastatic HR+/HER2- Breast Cancer Who Have Not Received Prior Treatment for Advanced or Metastatic Disease

Recruiting
NCT06790693Phase 3

A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
430