A Study of Imlunestrant Versus Standard Endocrine Therapy in Participants With Early Breast Cancer
EMBER-4
EMBER-4: A Randomized, Open-Label, Phase 3 Study of Adjuvant Imlunestrant vs Standard Adjuvant Endocrine Therapy in Patients Who Have Previously Received 2 to 5 Years of Adjuvant Endocrine Therapy for ER+, HER2- Early Breast Cancer With an Increased Risk of Recurrence
3 other identifiers
interventional
8,000
30 countries
666
Brief Summary
The main purpose of this study is to measure how well imlunestrant works compared to standard hormone therapy in participants with early breast cancer that is estrogen receptor positive (ER+) and human epidermal receptor 2 negative (HER2-). Participants must have already taken endocrine therapy for two to five years and must have a higher-than-average risk for their cancer to return. Study participation could last up to 10 years.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Oct 2022
Longer than P75 for phase_3
666 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 23, 2022
CompletedFirst Posted
Study publicly available on registry
August 24, 2022
CompletedStudy Start
First participant enrolled
October 4, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
March 1, 2032
April 2, 2026
April 1, 2026
5 years
August 23, 2022
April 1, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Invasive Disease-Free Survival (IDFS)
IDFS excluding second non-breast primary invasive cancers
Randomization to recurrence or death from any cause (up to 10 years)
Secondary Outcomes (7)
Distant Recurrence-Free Survival (DRFS)
Randomization to Distant Recurrence or Death from Any Cause (up to 10 Years)
Overall Survival (OS)
Randomization to Death from Any Cause (up to 10 Years)
Pharmacokinetics (PK): Steady State Plasma Concentrations of Imlunestrant
Year 1, Month 2 to Month 4
Change from Baseline in the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Core Questionnaire (EORTC QLQ-C30) Physical Functioning
Visit 1 Day 1 up to end of Year 5
Change from Baseline in the EORTC QLQ-C30 Role Functioning
Visit 1 Day 1 up to end of Year 5
- +2 more secondary outcomes
Study Arms (2)
Imlunestrant
EXPERIMENTALImlunestrant administered orally.
Investigator's Choice of Endocrine Therapy
ACTIVE COMPARATORInvestigator's choice of tamoxifen, anastrozole, letrozole, or exemestane administered per local approved label.
Interventions
Eligibility Criteria
You may qualify if:
- Have a diagnosis of ER+, HER2- early-stage, resected, invasive breast cancer without evidence of distant metastasis.
- Participants must have received at least 24 months but not more than 60 months of any adjuvant ET, from time of adjuvant ET initiation.
- Participants may have received (neo) adjuvant chemotherapy and/or targeted therapy with a CDK4/6- or PARP- inhibitor.
- Must have an increased risk of disease recurrence based on clinical-pathological risk features.
- Have a Performance Status of 0 or 1 on the Eastern Cooperative Oncology Group scale.
- Have adequate organ function.
You may not qualify if:
- Have any evidence of metastatic disease (including contralateral ALN) or inflammatory breast cancer at primary breast cancer diagnosis.
- Participants with more than a 6-month consecutive gap in therapy during the course of prior adjuvant ET.
- Participants who have completed or discontinued prior adjuvant ET \>6 months prior to screening.
- Participants with a history of previous breast cancer are excluded, with the exception of ipsilateral DCIS treated by locoregional therapy alone ≥5 years ago.
- Pregnant, breastfeeding, or expecting to conceive or father children within the projected duration of the trial, starting with the screening visit through 180 days after the last dose of study intervention.
- Participant has previously received ET of any duration for breast cancer prevention (tamoxifen or AIs) or raloxifene.
- Participants with a history of any other cancer.
- Have serious preexisting medical conditions that, in the judgment of the investigator, would preclude participation in this study.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (672)
USO - Southern Cancer Center
Daphne, Alabama, 36526, United States
Clearview Cancer Institute
Huntsville, Alabama, 35805, United States
Infirmary Cancer Care
Mobile, Alabama, 36607, United States
Banner MD Anderson Cancer Center
Gilbert, Arizona, 85234, United States
USO - Arizona Oncology Associates - HAL
Glendale, Arizona, 85308, United States
St. Joseph's Hospital and Medical Center
Phoenix, Arizona, 85004, United States
Mayo Clinic in Arizona - Phoenix
Phoenix, Arizona, 85054, United States
TMC HealthCare
Tucson, Arizona, 85711, United States
The University of Arizona Cancer Center - North Campus
Tucson, Arizona, 85719, United States
Highlands Oncology Group
Springdale, Arkansas, 72762, United States
UCSF - John Muir Health Cancer Center Berkeley
Berkeley, California, 94702, United States
Washington Health
Fremont, California, 94538, United States
Chao Family Comprehensive Cancer Center and Ambulatory Care (CIACC) - Irvine
Irvine, California, 92612, United States
Loma Linda University Cancer Center
Loma Linda, California, 92350-1700, United States
Pacific Cancer Care
Monterey, California, 93940, United States
St. Joseph Hospital
Orange, California, 92868, United States
University of California, Irvine (UCI) Health - UC Irvine Medical Center
Orange, California, 92868, United States
University of California Davis (UC Davis) Comprehensive Cancer Center
Sacramento, California, 95817, United States
Kaiser Permanente San Diego Mission Road
San Diego, California, 92108, United States
Zuckerberg San Francisco General Hospital and Trauma Center
San Francisco, California, 94110, United States
UCSF Medical Center at Mission Bay
San Francisco, California, 94158, United States
Saint Joseph's Medical Center
Stockton, California, 95204, United States
Anschutz Cancer Pavilion
Aurora, Colorado, 80045, United States
UCHealth Memorial Hospital
Colorado Springs, Colorado, 80909, United States
UCHealth Harmony
Fort Collins, Colorado, 80528, United States
Banner MD Anderson Cancer Center at North Colorado Medical Center
Greeley, Colorado, 80631, United States
USO - Rocky Mountain Cancer Centers
Lakewood, Colorado, 80228, United States
Banner MD Anderson Cancer Center at McKee Medical Center
Loveland, Colorado, 80538, United States
Yale-New Haven Hospital
New Haven, Connecticut, 06510, United States
Georgetown University Medical Center
Washington D.C., District of Columbia, 20007, United States
MedStar Washington Hospital Center
Washington D.C., District of Columbia, 20010, United States
AdventHealth Altamonte Springs
Altamonte Springs, Florida, 32701, United States
Memorial Regional Hospital
Hollywood, Florida, 33021, United States
Millennium Oncology Research Clinic
Hollywood, Florida, 33024, United States
Mayo Clinic in Florida
Jacksonville, Florida, 32224, United States
Miami Cancer Institute at Baptist Health, Inc.
Miami, Florida, 33176, United States
USO - Cancer Care Centers of Brevard
Palm Bay, Florida, 32901, United States
USO - Woodlands Medical Specialists
Pensacola, Florida, 32503, United States
Miami Cancer Institute - Plantation
Plantation, Florida, 33324, United States
Tampa General Hospital
Tampa, Florida, 33606, United States
Winship Cancer Institute, Emory University
Atlanta, Georgia, 30322, United States
Northside Hospital
Atlanta, Georgia, 30342, United States
Summit Cancer Care, PC
Savannah, Georgia, 31405, United States
Kaiser Permanente Moanalua Medical Center
Honolulu, Hawaii, 96819, United States
Kapiolani Medical Center for Women and Children
Honolulu, Hawaii, 96826, United States
Northwestern Memorial Hospital
Chicago, Illinois, 60611, United States
University of Illinois at Chicago
Chicago, Illinois, 60612, United States
Illinois Cancer Care
Peoria, Illinois, 61615, United States
Simmons Cancer Institute at SIU
Springfield, Illinois, 62702, United States
The University of Kansas Cancer Center - Westwood
Westwood, Kansas, 66205, United States
Ochsner Clinic Foundation
Covington, Louisiana, 70433, United States
Pontchartrain Cancer Center
Hammond, Louisiana, 70403, United States
Ochsner Clinic Foundation
New Orleans, Louisiana, 70121, United States
York Hospital
York Village, Maine, 03909, United States
Walter Reed National Military Medical Center
Bethesda, Maryland, 20889, United States
Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
Mass General/North Shore Cancer Center
Danvers, Massachusetts, 01923, United States
Southcoast Centers for Cancer Care
Fairhaven, Massachusetts, 02719, United States
Dana-Farber Cancer Institute - Foxborough
Foxborough, Massachusetts, 02035, United States
Dana-Farber Cancer Institute - Merrimack Valley
Methuen, Massachusetts, 01844, United States
Dana-Farber/Brigham and Women's Cancer Center at Milford Regional Medical Center
Milford, Massachusetts, 01757, United States
Mass General Cancer Center at Newton-Wellesley
Newton, Massachusetts, 02462, United States
Dana-Farber/Brigham and Women's Cancer Center - South Shore Hospital
South Weymouth, Massachusetts, 02190, United States
University of Massachusetts Medical School
Worcester, Massachusetts, 01655, United States
M Health Fairview Cancer Clinic -Edina
Edina, Minnesota, 55435, United States
USO - Minnesota Oncology Hematology
Minneapolis, Minnesota, 55404, United States
Allina Health Cancer Institute
Minneapolis, Minnesota, 55407, United States
Mayo Clinic in Rochester, Minnesota
Rochester, Minnesota, 55905, United States
University of Missouri Hospital
Columbia, Missouri, 65212, United States
Washington University School of Medicine
St Louis, Missouri, 63108, United States
Nebraska Methodist Hospital
Omaha, Nebraska, 68114, United States
Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, 03756, United States
Dana-Farber - New Hampshire Oncology/Hematology
Londonderry, New Hampshire, 03053, United States
MD Anderson Cancer Center at Cooper
Camden, New Jersey, 08103, United States
Astera Cancer Care
East Brunswick, New Jersey, 08816, United States
Regional Cancer Care Associates
Little Silver, New Jersey, 07739, United States
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, 08901, United States
Capital Health Medical Center - Hopewell
Pennington, New Jersey, 08534, United States
New Mexico Oncology Hematology Consultants Ltd.
Albuquerque, New Mexico, 87109, United States
University of New Mexico Comprehensive Cancer Center
Albuquerque, New Mexico, 87131, United States
New York Oncology Hematology Associate
Albany, New York, 12206, United States
Maimonides Cancer Center
Brooklyn, New York, 11220, United States
NYU Langone Health - Brooklyn
Brooklyn, New York, 11220, United States
R.J. Zuckerberg Cancer Center
Lake Success, New York, 11042, United States
Perlmutter Cancer Center at NYU Langone Hospital - Long Island
Mineola, New York, 11501, United States
Northern Westchester Hospital
Mount Kisco, New York, 10549, United States
Laura and Isaac Perlmutter Cancer Center
New York, New York, 10016, United States
NYC Health + Hospitals / Bellevue
New York, New York, 10016, United States
Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
Queens Medical Associates
Queens, New York, 11374, United States
University of Rochester - Wilmot Cancer Institute
Rochester, New York, 14642, United States
Phelps Hospital
Sleepy Hollow, New York, 10591, United States
Staten Island University Hospital
Staten Island, New York, 10305, United States
Clinical Research Alliance
Westbury, New York, 11590, United States
Messino Cancer Center
Asheville, North Carolina, 28806, United States
Aultman Hospital
Canton, Ohio, 44710, United States
USO - Oncology Hematology Care
Cincinnati, Ohio, 45242, United States
Mercy Health - St. Vincent Medical Center
Toledo, Ohio, 43608, United States
Good Samaritan Regional Medical Center
Corvallis, Oregon, 97330, United States
USO - Oncology Associates of Oregon
Eugene, Oregon, 97401, United States
Oregon Health and Science University
Portland, Oregon, 97239, United States
USO - Compass Oncology
Tigard, Oregon, 97223, United States
St. Luke's University Health Network
Bethlehem, Pennsylvania, 18015, United States
USO - Alliance Cancer Specialists, PC
Horsham, Pennsylvania, 19044, United States
Thomas Jefferson University - Clinical Research Institute
Philadelphia, Pennsylvania, 19107, United States
Lifespan Cancer Institute
Providence, Rhode Island, 02906, United States
St Francis Cancer Center
Greenville, South Carolina, 29607, United States
The West Clinic, PLLC dba West Cancer Center
Germantown, Tennessee, 38138, United States
University of Tennessee Medical Center
Knoxville, Tennessee, 37920, United States
Sarah Cannon Research Institute
Nashville, Tennessee, 37203, United States
USO - Texas Oncology
Austin, Texas, 78731, United States
USO - Texas Oncology
Dallas, Texas, 75231, United States
USO - Texas Oncology
Dallas, Texas, 75246, United States
USO - Texas Oncology
Denison, Texas, 75020, United States
Texas Oncology - West Texas
El Paso, Texas, 79902, United States
William Beaumont Army Medical Center
El Paso, Texas, 79918, United States
USO - Texas Oncology
Flower Mound, Texas, 75028, United States
Brooke Army Medical Center
Fort Sam Houston, Texas, 78234, United States
John Peter Smith Hospital
Fort Worth, Texas, 76104, United States
The Center for Cancer and Blood Disorders
Fort Worth, Texas, 76104, United States
USO - Texas Oncology
Fort Worth, Texas, 76104, United States
USO - Texas Oncology
Fredericksburg, Texas, 78624, United States
USO - Texas Oncology
McAllen, Texas, 78503, United States
USO - Texas Oncology
Plano, Texas, 75075, United States
Scott & White Hospital - Round Rock
Round Rock, Texas, 78665, United States
Mays Cancer Center
San Antonio, Texas, 78229, United States
Baylor Scott & White Medical Center - Temple
Temple, Texas, 76508, United States
US Oncology Research Network
The Woodlands, Texas, 77380, United States
USO - Texas Oncology
Webster, Texas, 77598, United States
University of Virginia Health System
Charlottesville, Virginia, 22908, United States
Inova Schar Cancer Institute
Fairfax, Virginia, 22031, United States
Fort Belvoir Community Hospital
Fort Belvoir, Virginia, 22060, United States
Bon Secours St. Francis Medical Center
Midlothian, Virginia, 23114, United States
USO - Virginia Oncology Associates
Norfolk, Virginia, 23502, United States
USO - Virginia Cancer Specialists
Reston, Virginia, 20190, United States
USO - Oncology & Hematology Associates of Southwest Virginia
Roanoke, Virginia, 24014, United States
Centro de Oncología e Investigación de Buenos Aires
Berazategui, B1884BBF, Argentina
Centro de Investigaciones Medicas y Desarrollo LC
Buenos Aires, 1113, Argentina
Investigaciones Clinicas Moleculares (ICM)
Buenos Aires, 1425, Argentina
Centro Oncologico Korben
Buenos Aires, 1426, Argentina
CIPREC
Buenos Aires, C1061, Argentina
Mautalen Salud e Investigación
Buenos Aires, C1128AAF, Argentina
Fundación Respirar
Buenos Aires, C1426ABP, Argentina
Instituto Alexander Fleming
Buenos Aires, C1426ANZ, Argentina
Clinica Adventista Belgrano
CABA, C1430EGF, Argentina
Centro Medico Privado CEMAIC
Capital, X5008HHW, Argentina
Fundación CORI para la Investigación y Prevención del Cáncer
La Rioja, F5300COE, Argentina
Instituto de Investigaciones Clínicas Mar del Plata
Mar del Plata, B7600FZO, Argentina
Fundacion Scherbovsky
Mendoza, 5500, Argentina
Instituto Médico Río Cuarto
Río Cuarto, 5800, Argentina
Fundacion Estudios Clinicos
Rosario, S2000DEJ, Argentina
Centro Polivalente de Asistencia e Investigacion Clinica - CER San Juan
San Juan, 5400, Argentina
Instituto San Marcos
San Juan, 5400, Argentina
Exelsus Oncología Clínica
San Miguel de Tucumán, 4000, Argentina
Go Centro Medico San Nicolás
San Nicolás, 2900, Argentina
Clinica Viedma S. A
Viedma, R8500ACE, Argentina
Ballarat Health Services
Ballarat Central, 3350, Australia
Box Hill Hospital
Box Hill, 3128, Australia
Monash Health
Clayton, 3168, Australia
Coffs Harbour Health Campus
Coffs Harbour, 2450, Australia
St Vincent's Hospital
Darlinghurst, 2010, Australia
Barwon Health
Geelong, 3220, Australia
Royal Hobart Hospital
Hobart, 7000, Australia
Launceston General Hospital
Launceston, 7250, Australia
Liverpool Hospital
Liverpool, 2170, Australia
Mackay Base Hospital
Mackay, 4740, Australia
St Vincent's Hospital
Melbourne, 3065, Australia
Northern Hospital
Melbourne, 3076, Australia
Maroondah Hospital
Melbourne, 3135, Australia
Breast Cancer Research Centre-WA
Nedlands, 6009, Australia
Lake Macquarie Private Hospital
Newcastle, 2290, Australia
Goulburn Valley Health
Shepparton, 3630, Australia
Gold Coast University Hospital
Southport, 4215, Australia
Mater Hospital Sydney
Sydney, 2060, Australia
Royal Darwin Hospital
Tiwi, 0810, Australia
The Townsville Hospital
Townsville, 4814, Australia
Hervey Bay Hospital
Urraween, 4655, Australia
The Queen Elizabeth Hospital
Woodville, 5011, Australia
Medizinische Universität Graz
Graz, 8036, Austria
Uniklinikum Salzburg
Salzburg, 5020, Austria
Private Practice - Dr. Hubalek
Schwaz, 6130, Austria
Medizinische Universität Wien
Vienna, 1090, Austria
Universitaetsklinikum Allgemeines Krankenhaus Wien
Vienna, 1090, Austria
Klinik Hietzing
Vienna, 1130, Austria
Institut Jules Bordet
Anderlecht, 1070, Belgium
CHIREC - site delta
Auderghem, 1160, Belgium
CHU Saint-Pierre
Brussels, 1000, Belgium
Centre Hospitalier Universitaire Brugmann
Brussels, 1020, Belgium
Cliniques universitaires Saint-Luc
Brussels, 1200, Belgium
Grand Hôpital de Charleroi
Charleroi, 6000, Belgium
Jessa Ziekenhuis
Hasselt, 3500, Belgium
Jan Yperman Ziekenhuis
Ieper, 8900, Belgium
AZ Groeninge Campus Kennedylaan
Kortrijk, 8500, Belgium
Groupe Jolimont
La Louvière, 7100, Belgium
UZ Leuven
Leuven, 3000, Belgium
Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman
Liège, 4000, Belgium
CHU UCL Namur/Site Sainte Elisabeth
Namur, 5000, Belgium
AZ Oostende vzw
Ostend, 8400, Belgium
Clinique Saint Pierre
Ottignies, 1340, Belgium
AZ Nikolaas
Sint-Niklaas, B-9100, Belgium
CHR Verviers - La Tourelle
Verviers, 4800, Belgium
Fundação Pio XII - Hospital de Câncer de Barretos
Barretos, 14784400, Brazil
CTO - Centro de Tratamento Oncológico
Belém, 66063-495, Brazil
Oncocentro de Minas Gerais
Belo Horizonte, 30180-060, Brazil
Hospital Sirio Libanes
Brasília, 70200-730, Brazil
Centro Integrado de Oncologia de Curitiba
Curitiba, 80810050, Brazil
Centro de Pesquisa Clínica do Instituto do Câncer do Ceará
Fortaleza, 60430230, Brazil
Hospital Araújo Jorge
Goiânia, 74605070, Brazil
ONCOSITE - Centro de Pesquisa Clinica em Oncologia
Ijuí, 98700-000, Brazil
Hospital de Cancer de Londrina
Londrina, 86015-520, Brazil
Hospital Moinhos de Vento
Porto Alegre, 90035001, Brazil
Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa
Porto Alegre, 90110-270, Brazil
Hospital São Lucas da PUCRS
Porto Alegre, 90610-000, Brazil
Hospital de Amor Amazônia
Porto Velho, 76834-899, Brazil
Multihemo
Recife, 50070-170, Brazil
Hospital de Clínicas de Ribeirão Preto
Ribeirão Preto, 14051-140, Brazil
Instituto Nacional de Câncer - INCA
Rio de Janeiro, 20560121, Brazil
Hospital São Lucas de Copacabana
Rio de Janeiro, 22061-080, Brazil
Centro de Tratamento de Tumores Botafogo para Oncoclinicas Rio de Janeiro SA
Rio de Janeiro, 22250-905, Brazil
Instituto de Educação, Pesquisa e Gestão em Saúde
Rio de Janeiro, 22793080, Brazil
Nucleo de Oncologia da Bahia
Salvador, 40170-110, Brazil
Faculdade de Medicina do ABC
Santo André, 09060-650, Brazil
Fundação Faculdade Regional de Medicina de São José do Rio Preto
São José do Rio Preto, 15090000, Brazil
IPITEC
São Paulo, 01221-020, Brazil
NotreDame Intermedica Saude S.A
São Paulo, 01229-010, Brazil
Instituto de Ensino e Pesquisa São Lucas
São Paulo, 01236030, Brazil
Icesp - Instituto Do Câncer Do Estado de São Paulo
São Paulo, 01246-000, Brazil
Hospital Sírio Libanês
São Paulo, 01308-060, Brazil
Clínica de Pesquisa e Centro de Estudos em Ginecologia Oncológica e Mamária LTDA
São Paulo, 01317-001, Brazil
Hospital BP
São Paulo, 01321-001, Brazil
Hospital Alemao Oswaldo Cruz
São Paulo, 01327-001, Brazil
A. C. Camargo Cancer Center
São Paulo, 01509-010, Brazil
Núcleo de Pesquisa Clínica da Rede São Camilo
São Paulo, 04014-002, Brazil
Instituto de Assistência Médica ao Servidor Público Estadual - IAMSPE/HSPE-FMO Conhecer Centro de Oncolog -T
São Paulo, 04039-901, Brazil
Instituto D'Or de Pesquisa e Ensino (IDOR)
São Paulo, 04543-000, Brazil
Hospital Santa Paula
São Paulo, 04556-100, Brazil
CEDOES
Vitória, 29055450, Brazil
Arthur J.E. Child Comprehensive Cancer Centre
Calgary, T2N 5G2, Canada
Victoria Hospital & Children's Hospital - London Health Sciences Centre
London, N6A 5W9, Canada
Centre Hospitalier de l'Université de Montréal
Montreal, H2X 3E4, Canada
Jewish General Hospital
Montreal, H3T 1E2, Canada
Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Île-de-Montréal (CIUSSS NÎM) - H -T
Montreal, H4J 1C5, Canada
CHU de Québec-Université Laval, Hôpital du Saint-Sacrement
Québec, G1S 4L8, Canada
BC Cancer Surrey
Surrey, V3V 1Z2, Canada
Humber River Hospital
Toronto, M3M 0B2, Canada
Sunnybrook Research Institute
Toronto, M4N 3M5, Canada
Anyang Cancer Hospital
Anyang, 455000, China
Affiliated Hospital of Hebei University
Baoding, 071000, China
Beijing Hospital
Beijing, 100005, China
Cancer Hospital Chinese Academy of Medical Science
Beijing, 100021, China
Peking University People's Hospital
Beijing, 100034, China
Beijing Friendship Hospital Affiliate of Capital University
Beijing, 100050, China
The First Hospital of Jilin University
Changchun, 130021, China
The First People's Hospital of Changde City
Changde, 415003, China
Xiangya Hospital Central South University
Changsha, 410008, China
Hunan Cancer Hospital
Changsha, 421000, China
Sichuan Cancer hospital
Chengdu, 610042, China
Deyang City People's Hospital
Deyang, 618000, China
Dongguan People's Hospital
Dongguan, 523059, China
Shunde Hospital of Southern Medical Univesity
Foshan, 528399, China
Fujian Medical University Union Hospital-1 Bingfanglou
Fuzhou, 350001, China
The 900th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army
Fuzhou, 350025, China
Sun Yat-sen University Cancer Center
Guangzhou, 510060, China
Guangdong Maternity and Child Health Care Hospital
Guangzhou, 511400, China
Hainan General Hospital
Haikou, 570311, China
The First People's Hospital of Hangzhou
Hangzhou, 310000, China
Zhejiang Provincial People's Hospital
Hangzhou, 310014, China
Zhejiang Cancer Hospital
Hangzhou, 310022, China
First Huai'an Hospital Affiliated to Nanjing Medical University
Huai'an, 223300, China
Huizhou Municipal Central Hospital
Huizhou, 516001, China
Jiangmen Center Hospital
Jiangmen, 529000, China
Jinan Central Hospital
Jinan, 250013, China
Jining Medical University - Affiliated Hospital
Jining, 272100, China
The First Affiliated Hospital of Henan University of Science &Technology
Luoyang, 471003, China
The Third Hospital of Nanchang
Nanchang, 330009, China
Jiangsu Province Hospital
Nanjing, 210029, China
The Second People's Hospital of Neijiang
Neijiang, 641000, China
Hwa Mei Hospital University of Chinese Academy of Sciences
Ningbo, 315010, China
Ningbo First Hospital
Ningbo, 315010, China
Fudan University Shanghai Cancer Center
Shanghai, 200032, China
Cancer Hospital of Shantou University Medical College
Shantou, 515041, China
ShenZhen People's Hospital
Shenzhen, 518020, China
Shenzhen Second People's Hospital
Shenzhen, 518035, China
Cancer Hospital Chinese Academy of Medical Sciences. Shenzhen Center
Shenzhen, China
The First Affiliated Hospital of Soochow University
Suzhou, 215006, China
Tianjin Medical University Cancer Institute & Hospital
Tianjing, 300060, China
Xinjiang Medical University Cancer Hospital - Urumqi
Ürümqi, 830000, China
Union Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, 430022, China
Renmin Hospital of Wuhan University
Wuhan, 430060, China
Hubei Cancer Hospital
Wuhan, 430079, China
Wannan Medical College Yijishan Hospital
Wuhu, 241001, China
The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, 710061, China
Xiangyang Central Hospital
Xiangyang, 441021, China
The Central Hospital of Yongzhou - North Campus
Yongzhou, 425000, China
The First People's Hospital of Yueyang
Yueyang, 414000, China
Yuncheng Central Hospital - Eastern Hospital
Yuncheng, 044000, China
Central Hospital of Guangdong Provincial Agricutural Reclamation
Zhanjiang, 524002, China
Masarykuv onkologicky ustav
Brno, 656 53, Czechia
Nemocnice Horovice
Hořovice, 268 31, Czechia
Fakultni nemocnice Hradec Kralove
Hradec Králové, 500 05, Czechia
Fakultni nemocnice Ostrava
Ostrava, 708 52, Czechia
Multiscan
Pardubice, 53203, Czechia
Fakultni Thomayerova nemocnice
Prague, 14059, Czechia
Fakultni nemocnice Motol
Prague, 150 06, Czechia
Fakultni nemocnice Bulovka
Prague, 180 81, Czechia
Sainte Catherine Institut du Cancer Avignon Provence
Avignon, 84918, France
Centre Hospitalier de la Côte Basque
Bayonne, 64109, France
CHU Besançon
Besançon, 25000, France
Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest
Bordeaux, 33076, France
CHRU de Brest
Brest, 29609, France
Pole Santé République
Clermont-Ferrand, 63050, France
Henri Mondor Hospital
Créteil, France
Polyclinique De Blois
La Chaussée-Saint-Victor, 41260, France
CHD Vendee
La Roche-sur-Yon, 85000, France
Groupe Hospitalier La Rochelle-Ré-Aunis - Hôpital Saint Louis
La Rochelle, 17019, France
Chu Grenoble Alpes
La Tronche, 38700, France
Clinique Victor Hugo Le Mans
Le Mans, 72000, France
Clinique Francois Chenieux
Limoges, 87039, France
Hopital Prive Jean Mermoz
Lyon, 69008, France
Centre Hospitalier Régional Metz Thionville - Hôpital de Mercy
Metz, 57085, France
Centre Hospitalier Intercommunal de Mont-de-Marsan et du Pays des Sources
Mont-de-Marsan, 40024, France
Centre de Cancérologie du Grand Montpellier
Montpellier, 34070, France
Polyclinique de Gentilly
Nancy, 54100, France
Centre Antoine-Lacassagne
Nice, 06189, France
Hôpital Saint-Louis
Paris, 75010, France
Groupe hospitalier Paris saint Joseph
Paris, 75014, France
Hôpital Européen Georges Pompidou
Paris, 75015, France
Groupe Hospitalier Diaconesses Croix Saint Simon
Paris, 75020, France
Institut Curie
Paris, 75248, France
Hôpital Tenon
Paris, 75970, France
Centre Hospitalier de Pau
Pau, 64000, France
Centre Catalan d'Oncologie
Perpignan, 66000, France
Centre Hospitalier Universitaire de Poitiers
Poitiers, 86021, France
Institut Jean Godinot
Reims, 51726, France
Institut Curie - site Saint-Cloud
Saint-Cloud, 92210, France
Centre Hospitalier Privé Saint-Grégoire
Saint-Grégoire, 35768, France
Institut de Cancérologie de l'Ouest
Saint-Herblain, 44805, France
Centre de cancérologie des Dentellières
Valenciennes, 59300, France
Institut de Cancérologie de Lorraine Alexis Vautrin
Vandœuvre-lès-Nancy, 54519, France
Gemeinschaftspraxis hop-augsburg
Augsburg, 86150, Germany
Universitaetsklinikum Augsburg
Augsburg, 86156, Germany
Praxisklinik Krebsheilkunde fur Frauen
Berlin, 10367, Germany
Onkologische Schwerpunktpraxis Kurfuerstendamm
Berlin, 10707, Germany
Helios Klinikum Berlin-Buch
Berlin, 13125, Germany
Marienhospital Bottrop
Bottrop, 46236, Germany
Universitaetsklinikum Koeln
Cologne, 50937, Germany
Städtisches Klinikum Dessau
Dessau, 06847, Germany
Onkologiezentrum Donauwörth
Donauwörth, 86609, Germany
St.-Johannes-Hospital Dortmund
Dortmund, 44137, Germany
MVZ Medical Center Düsseldorf GmbH
Düsseldorf, 40235, Germany
Universitaetsklinikum Erlangen
Erlangen, 91054, Germany
Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung
Essen, 45136, Germany
Agaplesion Markus Krankenhaus
Frankfurt, 60431, Germany
Universitaetsklinikum Freiburg
Freiburg im Breisgau, 79106, Germany
Private Practice - Dr. Helmut Oettle und Prof.Dr.med. Frank Mayer
Friedrichshafen, 88045, Germany
SRH Wald-Klinikum Gera
Gera, 07548, Germany
OSP Göttingen
Göttingen, 37073, Germany
St. Anna Hospital
Herne, 44649, Germany
Universitaetsklinikum des Saarlandes
Homburg, 66421, Germany
Klinikverbund Allgäu gGmbH
Kempten, 87439, Germany
Universitaetsklinikum Schleswig-Holstein Campus Kiel
Kiel, 24105, Germany
Zentrum fuer ambulante gynaekologische Onkologie (ZAGO)
Krefeld, 47805, Germany
Universitätsmedizin Mannheim
Mannheim, 68167, Germany
Onkologisch-hämatologisches Forschungsinstitut am Habsburgring
Mayen, 56727, Germany
Klinikum der Ludwig-Maximilians-Universitaet Muenchen
München, 80336, Germany
Klinikum Ernst von Bergmann
Potsdam, 14467, Germany
HELIOS Kliniken Schwerin
Schwerin, 19055, Germany
Robert-Bosch-Krankenhaus
Stuttgart, 70376, Germany
SRH Zentralklinikum Suhl
Suhl, 98527, Germany
Klinikum Mutterhaus der Borromäerinnen
Trier, 54290, Germany
Universitaetsklinikum Tuebingen
Tübingen, 72076, Germany
Universitaetsklinikum Ulm
Ulm, 89075, Germany
Helios HSK Wiesbaden
Wiesbaden, 65199, Germany
Agios Savvas Regional Cancer Hospital
Athens, 115 22, Greece
Alexandra Hospital
Athens, 115 28, Greece
IASO Obstetrics - Gynecology Clinic
Athens, 151 23, Greece
Iaso Private General Obstetrics Gynecological & Pediatric Clinic Diagnostic Therapeutic & Research Center -T
Athens, 151 23, Greece
Attikon General University Hospital
Chaïdári, 12462, Greece
University General Hospital of Heraklion
Heraklion, 711 10, Greece
University Hospital of Ioannina
Ioannina, 455 00, Greece
University General Hospital of Larissa
Larissa, 41110, Greece
General Oncology Hospital of Kifissia "Agioi Anargiroi"
Nea Kifissia, 145 64, Greece
Olympion General Clinic
Pátrai, 26443, Greece
University Hospital of Patras
Pátrai, 26504, Greece
BioClinic Thessaloniki
Thessaloniki, 546 22, Greece
Agios Loukas Clinic
Thessaloniki, 552 36, Greece
European Interbalkan Medical Center
Thessaloniki, 570 01, Greece
Queen Mary Hospital
Hksar, Hong Kong
Országos Onkológiai Intézet
Budapest, 1122, Hungary
Uzsoki Utcai Kórház
Budapest, 1145, Hungary
Debreceni Egyetem Klinikai Kozpont
Debrecen, 4032, Hungary
Bacs-Kiskun Megyei Korhaz
Kecskemét, 6000, Hungary
Szabolcs Szatmár Bereg Vármegyei Oktatókórház
Nyíregyháza, 4400, Hungary
Hemato Oncology Clinic
Ahmedabad, 380054, India
KD Hospital
Ahmedabad, 382421, India
Medstar Speciality Hospital
Bangalore, 560092, India
KLES Dr. Prabhakar Kore Hospital & M.R.C
Belagavi, 590010, India
All India Institute of Medical Sciences
Bhubaneswar, 751019, India
Postgraduate Institute of Medical Education & Research
Chandigarh, 160012, India
Cancer Institute (WIA)
Chennai, 600036, India
Nizam's Institute of Medical Sciences
Hyderabad, 500082, India
Regency Hospital
Kanpur, 208005, India
Krishna Institute of Medical Sciences - Karad
Karad, 415539, India
Kolhapur Cancer Centre Private Limited
Kolhāpur, 416234, India
Tata Memorial Hospital
Mumbai, 400012, India
Rashtrasant Tukdoji Regional Cancer Hospital
Nagpur, 440027, India
Delhi State Cancer Institute
New Delhi, 110095, India
Grant Medical Foundation - Ruby Hall Clinic
Pune, 411001, India
Lifepoint Multispeciality Hospital
Pune, 411057, India
Regional Cancer Centre - Thiruvananthapuram
Thiruvananthapuram, 695011, India
Mahatma Gandhi Cancer Hospital and Research Institute
Visakhapatnam, 530017, India
Bon Secours Cork Hospital
Cork, T12 DV56, Ireland
Cork University Hospital
Cork, T12 E8YV, Ireland
St. Vincent's University Hospital
Dublin, D04 N2E0, Ireland
St. James's Hospital
Dublin, D08 E9P6, Ireland
UCD School of Medicine Beacon Hospital
Dublin, D18 AK68, Ireland
Beaumont Hospital, Dublin
Dublin, D9, Ireland
Galway University Hospital
Galway, H91 YR71, Ireland
Sligo General Hospital
Sligo, F91 H684, Ireland
Waterford Regional Hospital
Waterford, X91 ER8E, Ireland
Carmel Hospital
Haifa, 3436212, Israel
Shaare Zedek Medical Center
Jerusalem, 9013102, Israel
Hadassah Medical Center
Jerusalem, 9112001, Israel
Meir Medical Center
Kfar Saba, 4428164, Israel
Rabin Medical Center
Petah Tikva, 4941492, Israel
Sheba Medical Center
Ramat Gan, 5265601, Israel
Sourasky Medical Center
Tel Aviv, 6423906, Israel
Yitzhak Shamir Medical Center
Ẕerifin, 70300, Israel
Aou Ospedali Riuniti Umberto I
Ancona, 60126, Italy
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII
Bergamo, 24127, Italy
IRCCS - AOU di Bologna
Bologna, 40138, Italy
Ospedale Antonio Perrino
Brindisi, 72100, Italy
Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'Oncologia
Candiolo, 10060, Italy
Azienda Ospedaliera Universitaria Careggi
Florence, 50134, Italy
Ospedale San Martino
Genova, 16132, Italy
Ospedale Generale Provinciale Macerata
Macerata, 62100, Italy
Istituto Europeo di Oncologia IRCCS
Milan, 20141, Italy
Humanitas Istituto Clinico Catanese
Misterbianco, 95045, Italy
Azienda Ospedaliero Universitaria
Modena, 41125, Italy
Ospedale San Gerardo-ASST Monza
Monza, 20900, Italy
University of Naples Federico II
Naples, 80100, Italy
Istituto Nazionale Tumori IRCCS Fondazione Pascale
Naples, 80131, Italy
Istituto Oncologico Veneto IRCCS
Padua, 35128, Italy
Azienda Ospedaliero Universitaria di Parma
Parma, 43126, Italy
Istituto Nazionale Tumori Regina Elena
Rome, 00144, Italy
Humanitas
Rozzano, 20089, Italy
Ospedale San Giovanni Moscati
Statte, 74100, Italy
Azienda Ospedaliera Santa Maria Terni
Terni, 05100, Italy
Juntendo University Hospital
Bunkyō City, 113-8431, Japan
Chiba University Hospital
Chiba, 260-8677, Japan
Chiba cancer center
Chiba, 260-8717, Japan
St. Luke's International Hospital
Chūōku, 104-8560, Japan
National Hospital Organization Kyushu Cancer Center
Fukuoka, 811-1395, Japan
Fukushima Medical University
Fukushima, 960-1295, Japan
Fukuyama City Hospital
Fukuyama, 721-8511, Japan
Gifu University Hospital
Gifu, 501-1194, Japan
Tokai University Hachioji Hospital
Hachioji-shi, 192-0032, Japan
Kansai Medical University Hospital
Hirakata, 573-1191, Japan
Hiroshima City Hospital
Hiroshima, 730-8518, Japan
Hiroshima University Hospital
Hiroshima, 734-8551, Japan
Shimane University Hospital
Izumo, 693-0021, Japan
Sagara Hospital
Kagoshima, 892-0833, Japan
Kameda Clinic
Kamogawa, 296-0041, Japan
Ishikawa Prefectural Central Hospital
Kanazawa, 920-8530, Japan
St. Marianna University Hospital
Kawasaki, 216-8511, Japan
Japanese Foundation for Cancer Research
Kōtō City, 135-8550, Japan
Kumamoto Breast Surgical Hospital
Kumamoto, 860-0812, Japan
Kumamoto Shinto General Hospital
Kumamoto, 862-8655, Japan
University Hospital,Kyoto Prefectural University of Medicine
Kyoto, 602-8566, Japan
Kyoto University Hospital
Kyoto, 606-8507, Japan
Shinshu University Hospital
Matsumoto, 390-8621, Japan
National Hospital Organization Shikoku Cancer Center
Matsuyama, 791-0280, Japan
Miyazaki Prefectural Miyazaki Hospital
Miyazaki, 880-8510, Japan
Kanazawa Medical University Hospital
Mukai-awagasaki, 920-0265, Japan
Nagoya University Hospital
Nagoya, 466-8560, Japan
Nagoya City University Hospital
Nagoya, 467-8602, Japan
Naha Nishi Clinic
Naha, 901-0154, Japan
Niigata Cancer Center Hospital
Niigata, 951-8566, Japan
Hyogo Medical University Hospital
Nishinomiya, 663-8501, Japan
Okayama University Hospital
Okayama, 700-8558, Japan
Nakagami Hospital Okinawa
Okinawa, 904-2195, Japan
National Hospital Organization - Osaka National Hospital - Institute For Clinical Research
Osaka, 540-0006, Japan
Gunma Prefectural Cancer Center
Otashi, 373-8550, Japan
Kitasato University Hospital
Sagamihara, 252-0375, Japan
Saitama Red Cross Hospital
Saitama, 330-8553, Japan
National Hospital Organization Hokkaido Cancer Center
Sapporo, 003-0804, Japan
Hokkaido University Hospital
Sapporo, 060-8648, Japan
Tohoku University Hospital
Sendai, 980-8574, Japan
Showa Medical University Hospital
Shinagawa City, 142-8555, Japan
National Center for Global Health and Medicine
Shinjyuku-ku, 162-8655, Japan
Shizuoka General Hospital
Shizuoka, 420-8527, Japan
National Hospital Organization Takasaki General Medical Center
Takasaki, 370-0829, Japan
Tokushima University Hospital
Tokushima, 770-8503, Japan
Tsukuba University Hospital
Tsukuba, 305-8576, Japan
Tochigi Cancer Center
Utsunomiya, 320-0834, Japan
Iwate Medical University Hospital
Yahaba-cho, Shiwa-gun, 028-3695, Japan
Yokohama City University Medical Center
Yokohama, 232-0024, Japan
Kanagawa cancer center
Yokohama, 2418515, Japan
Scientia Investigacion Clinica S.C.
Chihuahua City, 31207, Mexico
Centro de Estudios de Investigacion Metabolicos y Cardiovasculares
Ciudad Madero, 89440, Mexico
CIO - Centro de Inmuno-Oncología de Occidente
Guadalajara, 44630, Mexico
Clinica de Investigacion en Reumatologia y Obesidad S. C.
Guadalajara, 44650, Mexico
Preparaciones Oncologicas
León, 37178, Mexico
CENEIT Oncológicos. Centro Especializado en Investigación y Tratamientos Oncológicos
Mexico City, 03100, Mexico
Grupo Medico Camino Sc
Mexico City, 03310, Mexico
Axis Heilsa S. de R.L. de C.V.
Monterrey, 64040, Mexico
Centro Regiomontano de Investigación
Monterrey, 64060, Mexico
Filios Alta Medicina
Monterrey, 64460, Mexico
Oaxaca Site Management Organization
Oaxaca City, 68000, Mexico
Centro de Investigacion Clinica de Oaxaca
Oaxaca City, 68020, Mexico
Unidad Médica Onco-hematológica
Puebla City, 72424, Mexico
PanAmerican Clinical Research - Querétaro - Avenida Antea
Querétaro, 76100, Mexico
Oncologico Potosino, S.C.
San Luis Potosí City, 78209, Mexico
Centro Medico Zambrano Hellion
San Pedro Garza García, 66278, Mexico
Hospital Angeles
Tijuana, 22010, Mexico
Centro Oncologico Estatal ISSEMyM ( COEI )
Toluca, 50180, Mexico
Wilhelmina Ziekenhuis Assen
Assen, 9401 RK, Netherlands
Amphia Ziekenhuis, locatie Breda Molengracht
Breda, 4818 CK, Netherlands
Reinier de Graaf Ziekenhuis, locatie Delft
Delft, 2625 AD, Netherlands
Deventer Ziekenhuis
Deventer, 7416 SE, Netherlands
Albert Schweitzer Ziekenhuis, locatie Dordwijk
Dordrecht, 3318 AT, Netherlands
Ziekenhuisgroep Twente, locatie Almelo
Hengelo, 7555 DL Hengelo, Netherlands
Spaarne Gasthuis - Hoofddorp
Hoofddorp, 2134 TM, Netherlands
Maastricht UMC+
Maastricht, 6229 HX, Netherlands
Haga Ziekenhuis locatie Leyweg
The Hague, 2545 AA, Netherlands
VieCuri Medisch Centrum, locatie Venlo
Venlo, 5912 BL, Netherlands
Zaans Medisch Centrum
Zaandam, 1502 DV, Netherlands
Szpitale Pomorskie Sp. z o. o.
Gdynia, 81-519, Poland
Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie
Koszalin, 75-581, Poland
Salve Medica
Lodz, 91-211, Poland
Opolskie Centrum Onkologii w Opolu im. prof. Tadeusza Koszarowskiego
Opole, 45-061, Poland
FORMED2
Oświęcim, 32-600, Poland
Mazowiecki Szpital Wojewódzki w Siedlcach
Siedlce, 08-110, Poland
MICS Centrum Medyczne Torun
Torun, 87-100, Poland
Luxmed Onkologia sp. z o. o.
Warsaw, 01-748, Poland
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie
Warsaw, 02-781, Poland
Hopital Garcia de Orta
Almada, 2805-267, Portugal
Champalimaud Foundation
Lisbon, 1400-038, Portugal
Hospital da Luz Lisboa
Lisbon, 1500-650, Portugal
Centro Hospitalar Universitário Lisboa Norte, E.P.E. - Hospital de Santa Maria
Lisbon, 1649-035, Portugal
Hospital Beatriz Ângelo
Lisbon, 2674-514, Portugal
Centro Hospitalar de Vila Nova de Gaia/Espinho - Unidade I
Vila Nova de Gaia, 4434-502, Portugal
C.M.D.T.A. Neomed
Brasov, 500283, Romania
Onco Medint Srl
Bucharest, 010644, Romania
Lotus-Med
Bucharest, 012292, Romania
SC Memorial Healthcare International SRL
Bucharest, 013812, Romania
Spitalul Clinic Colțea
Bucharest, 030171, Romania
Gral Medical Diagnostic Center
Bucharest, 031422, Romania
Institutul Oncologic Cluj
Cluj-Napoca, 400015, Romania
Centrul de Oncologie "Sfântul Nectarie"
Craiova, 200542, Romania
Radiology Therapeutic Center
Otopeni, 075100, Romania
Ovidius Clinical Hospital OCH
Ovidiu, 905900, Romania
S C Oncocenter Oncologie Clinica S R L
Timișoara, 300166, Romania
National Cancer Centre Singapore
Singapore, 168583, Singapore
Raffles Hospital
Singapore, 188770, Singapore
Onkologicky Ustav sv. Alzbety
Bratislava, 812 50, Slovakia
Narodny onkologicky ustav
Bratislava, 833 10, Slovakia
Dongnam Institute of Radiological and Medical Sciences
Busan, 46033, South Korea
Soon Chun Hyang University Cheonan Hospital
Cheonan-si, 31151, South Korea
Chungbuk National University Hospital
Cheongju-si, 28644, South Korea
Kyungpook National University Chilgok Hospital
Daegu, 41404, South Korea
National Cancer Center
Goyang-si, 10408, South Korea
Yeungnam Univeristy Medical Center
Gyeongsan-si, 42415, South Korea
Chonnam National University Hwasun Hospital
Hwasun-gun, 58128, South Korea
Inha University Hospital
Incheon, 22332, South Korea
Gachon University Gil Medical Center
Namdong-gu, 21565, South Korea
Seoul National University Bundang Hospital
Seongnam, 13620, South Korea
CHA Bundang Medical Center, CHA University
Seongnam-si, 13496, South Korea
Korea University Anam Hospital
Seoul, 02841, South Korea
Seoul National University Hospital
Seoul, 03080, South Korea
Severance Hospital, Yonsei University Health System
Seoul, 03722, South Korea
Asan Medical Center
Seoul, 05505, South Korea
Gangnam Severance Hospital
Seoul, 06273, South Korea
Samsung Medical Center
Seoul, 06351, South Korea
The Catholic Univ. of Korea Seoul St. Mary's Hospital
Seoul, 06591, South Korea
Korea University Guro Hospital
Seoul, 08308, South Korea
Ajou University Hospital
Suwon, 16499, South Korea
Ulsan University Hospital
Ulsan, 44033, South Korea
CHUAC-Hospital Teresa Herrera
A Coruña, 15006, Spain
Hospital General Universitario de Alicante
Alicante, 03010, Spain
Hospital Universitario Torrecárdenas
Almería, 04009, Spain
Hospital Infanta Cristina
Badajoz, 06006, Spain
Parc de Salut Mar - Hospital del Mar
Barcelona, 08003, Spain
Hospital Quiron Barcelona
Barcelona, 08023, Spain
Hospital Universitari Dexeus
Barcelona, 08028, Spain
Hospital Universitari Vall d'Hebron
Barcelona, 08035, Spain
Hospital Clínic de Barcelona
Barcelona, 08036, Spain
Hospital de la Santa Creu i Sant Pau
Barcelona, 08041, Spain
Osi Bilbao-Basurto
Bilbao, 48013, Spain
Hospital Universitario de Burgos
Burgos, 09006, Spain
Hospital San Pedro de Alcántara
Cáceres, 10003, Spain
Hospital Clínico Universitario Virgen de la Arrixaca
El Palmar, Murcia, 30120, Spain
Hospital Universitario Getafe
Getafe, 28905, Spain
Hospital Universitario San Cecilio
Granada, 18016, Spain
Complejo Hospitalario de Jaén
Jaén, 23007, Spain
Hospital Universitario Arnau de Vilanova de Lleida
Lleida, 25198, Spain
Hospital San Pedro
Logroño, 26006, Spain
Hospital Lucus Augusti
Lugo, 27003, Spain
Hospital La Princesa
Madrid, 28006, Spain
Hospital Beata María Ana
Madrid, 28007, Spain
Hospital General Universitario Gregorio Marañon
Madrid, 28009, Spain
Hospital Universitario Infanta Leonor
Madrid, 28031, Spain
Hospital Ruber Internacional
Madrid, 28034, Spain
Hospital Universitario Ramón y Cajal
Madrid, 28034, Spain
Hospital Clinico San Carlos
Madrid, 28040, Spain
Hospital Universitario 12 de Octubre
Madrid, 28041, Spain
Hospital Universitario La Paz
Madrid, 28046, Spain
H.R.U Málaga - Hospital Materno-infantil
Málaga, 29011, Spain
Hospital Vithas Málaga
Málaga, 29016, Spain
Hospital Universitari Son Espases
Palma, 07120, Spain
Complejo Hospitalario de Navarra
Pamplona, 31009, Spain
Hospital Universitari Sant Joan de Reus
Reus, 43204, Spain
Hospital Universitario de Canarias
San Cristóbal de La Laguna, 38320, Spain
Hospital Universitari General de Catalunya
Sant Cugat del Vallès, 08915, Spain
Hospital Universitario Nuestra Señora de Candelaria
Santa Cruz de Tenerife, 38010, Spain
Hospital Universitario Virgen Macarena
Seville, 41009, Spain
Hospital Universitario Virgen Del Rocio
Seville, 41013, Spain
Hospital Universitario de Toledo
Toledo, 45007, Spain
Hospital Clinico de Valencia
Valencia, 46010, Spain
Hospital Quirónsalud Valencia
Valencia, 46010, Spain
Hospital Clínico Universitario de Valladolid
Valladolid, 47003, Spain
Hospital Clínico Universitario Lozano Blesa
Zaragoza, 50009, Spain
Changhua Christian Hospital
Changhua County, 50006, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, 807, Taiwan
Taipei Tzu Chi General Hospital
New Taipei City, 231, Taiwan
Taichung Veterans General Hospital
Taichung, 407219, Taiwan
National Cheng Kung University Hospital
Tainan, 704, Taiwan
Chi Mei Hospital - Liouying Branch
Tainan, 73657, Taiwan
National Taiwan University Hospital
Taipei, 10002, Taiwan
Mackay Memorial Hospital
Taipei, 10449, Taiwan
Taipei Veterans General Hospital
Taipei, 11217, Taiwan
Koo Foundation Sun Yat-Sen Cancer Center
Taipei, 112, Taiwan
Chang Gung Medical Foundation-Linkou Branch
Taoyuan District, 333, Taiwan
Adana Medical Park Seyhan Hastanesi
Adana, 01140, Turkey (Türkiye)
Adana City Hospital
Adana, 01370, Turkey (Türkiye)
Sakarya Training and Research Hospital
Adapazarı, 54290, Turkey (Türkiye)
Hacettepe Universitesi
Altindağ, 06230, Turkey (Türkiye)
Ankara Gülhane Eitim ve Aratrma Hastanesi
Ankara, 06010, Turkey (Türkiye)
Ankara Etlik City Hospital
Ankara, 06170, Turkey (Türkiye)
Memorial Ankara Hastanesi
Ankara, 06520, Turkey (Türkiye)
Ankara Bilkent Şehir Hastanesi
Ankara, 06800, Turkey (Türkiye)
Akdeniz Universitesi Hastanesi
Antalya, 07059, Turkey (Türkiye)
Antalya Egitim ve Arastırma Hastanesi
Antalya, 07100, Turkey (Türkiye)
Uludag Universitesi
Bursa, 16059, Turkey (Türkiye)
Dicle Üniversitesi
Diyarbakır, 21200, Turkey (Türkiye)
Trakya University Medical Faculty Hospital
Edirne, 22030, Turkey (Türkiye)
Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi
Gaziantep, 27310, Turkey (Türkiye)
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi
Istanbul, 34722, Turkey (Türkiye)
Marmara Universitesi Pendik Egitim Arastirma Hastanesi
Istanbul, Pendik, 34899, Turkey (Türkiye)
Ege Universitesi Hastanesi
Izmir, 35100, Turkey (Türkiye)
zmir Katip Çelebi Üniversitesi Atatürk Eitim Ve Aratrma Hastanesi
Izmir, 35360, Turkey (Türkiye)
Izmir Medical Park Hospital
Izmir, Karsiyaka, 009035575, Turkey (Türkiye)
Kocaeli Üniversitesi
Kocaeli, 41380, Turkey (Türkiye)
İnönü Üniversitesi Turgut Özal Tıp Merkezi Eğitim ve Araştırma Hastanesi
Malatya, 44280, Turkey (Türkiye)
Mersin University
Mersin, 33110, Turkey (Türkiye)
Mugla Sitki Kocman Universitesi Egitim ve Arastirma Hastanesi
Muğla, 48000, Turkey (Türkiye)
Ondokuz Mayıs Universitesi
Samsun, 55270, Turkey (Türkiye)
Medipol Mega Universite Hastanesi
Stanbul, 34214, Turkey (Türkiye)
Colchester General Hospital
Colchester, CO4 5JL, United Kingdom
Hairmyres Hospital
East Kilbride, Glasgow, G75 8RG, United Kingdom
Western General Hospital
Edinburgh, EH4 2XU, United Kingdom
Clatterbridge Cancer Centre - Liverpool
Liverpool, L7 8YA, United Kingdom
St Bartholomew's Hospital
London, EC1A 7BE, United Kingdom
The Christie NHS Foundation Trust
Manchester, M20 4BX, United Kingdom
Mount Vernon Hospital
Northwood, HA6 2RN, United Kingdom
Derriford Hospital
Plymouth, Pl6 8DH, United Kingdom
Panthera Biopartners - Preston
Preston, PR2 9QB, United Kingdom
Royal Berkshire Hospital
Reading, RG1 5AN, United Kingdom
Panthera Biopartners - Manchester
Rochdale, OL11 4AU, United Kingdom
Lister Hospital
Stevenage, SG1 4AB, United Kingdom
Oncology Research
Wigan, WN1 2NN, United Kingdom
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST)
Eli Lilly and Company
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 23, 2022
First Posted
August 24, 2022
Study Start
October 4, 2022
Primary Completion (Estimated)
October 1, 2027
Study Completion (Estimated)
March 1, 2032
Last Updated
April 2, 2026
Record last verified: 2026-04
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, SAP, CSR
- Time Frame
- Data are available 6 months after the primary publication and approval of the indication studied in the US and European Union (EU), whichever is later. Data will be indefinitely available for requesting.
- Access Criteria
- A research proposal must be approved by an independent review panel and researchers must sign a data sharing agreement.
Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.