Study on Susceptibility Genes and Pathogenic Mechanism of Non-syndromic Familial Aortic Dissection

NCT04439565 | Unknown

• 1 other identifier: https://orcid.org/0000-0002-05
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Aortic dissection is dangerous and difficult to predict, so it is particularly important to carry out early prevention, diagnosis and rational treatment for high-risk groups. The related genes found in previous studies can not be detected in all patients with dissection; at present, the pathogenesis of non-syndromic aortic dissection is not clear, of which about 20% of patients have family aggregation and have the general representative characteristics of non-syndromic dissection. In this project, the peripheral blood samples of core family subjects were detected by sequencing technique. analyze disease-related susceptibility genes; 2 determine the effect of susceptibility genes on the incidence of dissection in mice through animal experiments; and 3 explore the effect of susceptibility genes on cell function at the cellular level.

Conditions

Aortic Dissection; Family Research; Aortic Dissection, Familial, With or Without Aortic Aneurysm

Keywords

aortic dissection; pathogenesis; familial inheritance; susceptibility gene

Outcome Measures

Primary Outcomes (1)

• gege

  Discovery of known or unknown genes

  2023

Interventions

movement GENETIC

aortic dissection or aneurysm patients this is an observation cohort study about a Non-syndromic Familial Aortic Dissection without intervention.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

1, family members have no traumatic aortic dissection; 2, no pregnancy or tumor.

Sponsors & Collaborators

• Chinese Medical Association: lead

Study Sites (1)

Changhaihospital

Shanghai, Shanghai Municipality, 200433, China

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

DNA is extracted from blood and preserved for a long time.

MeSH Terms

Conditions

Aortic Dissection

Interventions

Movement

Condition Hierarchy (Ancestors)

Dissection, Blood Vessel; Aneurysm; Vascular Diseases; Cardiovascular Diseases; Acute Aortic Syndrome; Aortic Diseases

Intervention Hierarchy (Ancestors)

Physiological Phenomena; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Central Study Contacts

Jing Zaiping, professor

CONTACT

02131161670; xueguanky@163.com

Study Design

• Study Type: observational
• Observational Model: FAMILY BASED
• Time Perspective: OTHER
• Sponsor Type: NETWORK
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: professor

Study Record Dates

• First Submitted: June 17, 2020
• First Posted: June 19, 2020
• Study Start: June 17, 2020
• Primary Completion: June 17, 2023
• Study Completion: July 17, 2023
• Last Updated: June 19, 2020

Record last verified: 2020-06

Locations

CN (1)