A Validation Study of The Relationship Between ALDH2 and Aortic Dissection
VaRALAD
1 other identifier
observational
200
1 country
1
Brief Summary
The purpose of this study is to validate the impact of ALDH2 Glu504Lys polymorphism on aortic dissection.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Oct 2018
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2018
CompletedFirst Submitted
Initial submission to the registry
December 18, 2018
CompletedFirst Posted
Study publicly available on registry
December 19, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 30, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
September 30, 2019
CompletedDecember 19, 2018
August 1, 2018
12 months
December 18, 2018
December 18, 2018
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Number of patients with different ALDH2 genotype
DNA was extracted from venous blood;genomic DNA underwent PCR amplification; finally, PCR products were purified and directly sequenced by Invitrogen Corp or Biosune Corp.Then ALDH2 genotype was distinguished depend on a G-to-A missense mutation on exon 12 of ALDH2 gene.
1-30 days after samples collected
Study Arms (2)
Control
Chinese Han people to do physical examination in physical examination center of Guangdong Provincial People's Hospital
Aortic dissection
Chinese Han people diagnosed with aortic dissection in Guangdong Provincial People's Hospital
Eligibility Criteria
Patients diagnosed with aortic dissection in Guangdong Provincial People's Hospital
You may qualify if:
- Chinese Han people diagnosed with aortic dissection in Guangdong Provincial People's Hospital
You may not qualify if:
- Aortic dissection based on trauma, connective tissue diseases and pregnancy
- Patients with tumor
- Patients with no written consensus
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Guangdong Provincial People's Hospital
Guanzhou, Guangdong, 510080, China
Biospecimen
4 ml vein blood samples were collected from aortic dissection or controls in tubes containing EDTA. The samples would be centrifuged and saved in a -80℃ ultra-low temperature refrigerator.
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
December 18, 2018
First Posted
December 19, 2018
Study Start
October 1, 2018
Primary Completion
September 30, 2019
Study Completion
September 30, 2019
Last Updated
December 19, 2018
Record last verified: 2018-08