Additive Anti-inflammatory Action for Aortopathy & Arteriopathy (Multicenter Cohort Study) III

NCT04918108 | Completed

• 1 other identifier: 5A Plan
• Study Type: observational
• Target: 2,000
• Locations: 1 country
• Sites: 1

Brief Summary

Anatomopathological classifications have been well identified in aortic dissection with important therapeutic implications. The authors evaluated the inflammatory response in patients with aortic dissection (AD) and assessed the presence of distinct inflammatory subphenotypes within this disease.

Conditions

Aortic Dissection

Keywords

Aortic Dissection; Inflammatory Response

Outcome Measures

Primary Outcomes (1)

• 30-day mortality

  any cause death within 30 days of surgery

  30 days after surgery

Secondary Outcomes (1)

• ICU mortality

  7 days after surgery

Study Arms (1)

inflammatory subphenotype

Biological: inflammatory response

Interventions

inflammatory response BIOLOGICAL

laboratory data (leukocyte, neutrophils, monocyte, lymphocytes, platelet, fibrinogen, D-dimer, neutrophils-lymphocyte ratio, platelet-lymphocyte ratio, lymphocyte-monocyte ratio)

inflammatory subphenotype

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients underwent venipuncture during primary evaluation in the Emergency Department. Venous blood samples were immediately sent to the laboratory for analysis.

You may qualify if:

• acute type Aortic dissection;

You may not qualify if:

• Iatrogenic aortic dissection OR traumatic aortic dissection
• Patients with hematological diseases, infectious diseases, malignant tumors, immune system diseases, or severe liver diseases.
• Preoperative use of mechanical ventilation, blood transfusion, renal replacement therapy, extracorporeal membrane oxygenation, or intra-aortic balloon pump during the current admission.

Sponsors & Collaborators

• Nanjing Medical University: lead
• The First Affiliated Hospital with Nanjing Medical University: collaborator
• Beijing Anzhen Hospital: collaborator
• The Affiliated Hospital of Qingdao University: collaborator
• First Affiliated Hospital of Shantou University Medical College: collaborator
• The First Affiliated Hospital of Guangzhou Medical University: collaborator
• TEDA International Cardiovascular Hospital: collaborator
• Xiamen Cardiovascular Hospital: collaborator
• Shanghai East Hospital Tongji University: collaborator
• Tianjin Chest Hospital, Tianjin Medical University: collaborator
• Nanjing First Hospital, Nanjing Medical University: collaborator
• Xiangya Hospital of Central South University: collaborator
• The First Affiliated Hospital of Bengbu Medical University: collaborator

Study Sites (1)

The first affiliated hospital of nanjing medical university

Nanjing, Jiangsu, 210029, China

Location

Related Publications (5)

• Liu H, Zhang YY, Ding XH, Qian SC, Sun MY, Hamzah AW, Gao YN, Shao YF, Li HY, Wang K, Ni BQ, Zhang HJ; Additive Anti-inflammatory Action for Aortopathy & Arteriopathy (5A) Investigators. Proximal vs Extensive Repair in Acute Type A Aortic Dissection Surgery. Ann Thorac Surg. 2023 Aug;116(2):270-278. doi: 10.1016/j.athoracsur.2023.04.019. Epub 2023 Apr 25.

  PMID: 37105511 DERIVED

• Liu H, Qian SC, Shao YF, Li HY, Zhang HJ; 5A Investigators. Prognostic Impact of Systemic Coagulation-Inflammation Index in Acute Type A Aortic Dissection Surgery. JACC Asia. 2022 Oct 4;2(6):763-776. doi: 10.1016/j.jacasi.2022.06.007. eCollection 2022 Nov.

  PMID: 36444319 DERIVED

• Liu H, Qian SC, Han L, Dong ZQ, Shao YF, Li HY, Zhang W, Zhang HJ. Laboratory signatures differentiate the tolerance to hypothermic circulatory arrest in acute type A aortic dissection surgery. Interact Cardiovasc Thorac Surg. 2022 Nov 8;35(6):ivac267. doi: 10.1093/icvts/ivac267.

  PMID: 36271847 DERIVED

• Liu H, Qian SC, Zhang YY, Wu Y, Hong L, Yang JN, Zhong JS, Wang YQ, Wu DK, Fan GL, Chen JQ, Zhang SQ, Peng XX, Shao YF, Li HY, Zhang HJ. A Novel Inflammation-Based Risk Score Predicts Mortality in Acute Type A Aortic Dissection Surgery: The Additive Anti-inflammatory Action for Aortopathy and Arteriopathy Score. Mayo Clin Proc Innov Qual Outcomes. 2022 Sep 25;6(6):497-510. doi: 10.1016/j.mayocpiqo.2022.08.005. eCollection 2022 Dec.

  PMID: 36185465 DERIVED

• Liu H, Qian SC, Shao YF, Li HY; Additive Anti-inflammatory Action for Aortopathy & Arteriopathy (5A) Investigators Group. Anti-Inflammatory Effect of Ulinastatin on the Association Between Inflammatory Phenotypes in Acute Type A Aortic Dissection. J Inflamm Res. 2022 Jun 27;15:3709-3718. doi: 10.2147/JIR.S369703. eCollection 2022.

  PMID: 35783246 DERIVED

MeSH Terms

Conditions

Aortic Dissection

Condition Hierarchy (Ancestors)

Dissection, Blood Vessel; Aneurysm; Vascular Diseases; Cardiovascular Diseases; Acute Aortic Syndrome; Aortic Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Investigator of Nanjing Medical University

Study Record Dates

• First Submitted: June 3, 2021
• First Posted: June 8, 2021
• Study Start: January 1, 2021
• Primary Completion: August 30, 2021
• Study Completion: August 30, 2021
• Last Updated: November 20, 2024

Record last verified: 2024-11

Locations

CN (1)