Clinical Features, Outcomes, and Therapeutics of Pregnancy-Related Aortic Dissection
1 other identifier
observational
75
1 country
4
Brief Summary
Aortic dissection in pregnancy represents a lethal risk to both the mother and fetus, it has yet to yield the optimal therapeutic strategy. The aim of this study was to characterize the clinical features and outcomes in women with pregnancy-related acute aortic dissection, and to suggest therapeutic guidelines.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Jan 2022
Shorter than P25 for all trials
4 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 31, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
July 31, 2022
CompletedFirst Submitted
Initial submission to the registry
August 12, 2022
CompletedFirst Posted
Study publicly available on registry
August 15, 2022
CompletedSeptember 27, 2022
September 1, 2022
7 months
August 12, 2022
September 25, 2022
Conditions
Outcome Measures
Primary Outcomes (1)
30-day mortality
30 days after surgery
Interventions
The timing of aortic repair and delivery have to be determined based on the type of the dissection, the stage of pregnancy (the gestation age), and the status of the fetus, as well as the level of local neonatal service.
Eligibility Criteria
From February 1 2012 through June 30 2022 for identification women who presented with aortic dissection during pregnancy or post partum ≤12 weeks
You may qualify if:
- Women who presented with aortic dissection during pregnancy or post partum ≤12 weeks.
You may not qualify if:
- Loss of surgical information.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Nanjing Medical Universitylead
- Beijing Anzhen Hospitalcollaborator
- Shanghai Zhongshan Hospitalcollaborator
- Guangdong Provincial People's Hospitalcollaborator
Study Sites (4)
Beijing Anzhen Hospital
Beijing, 10029, China
Department of Obstetrics and Gynecology, Guangdong Provincial People's Hospital
Guangzhou, China
Department of Cardiac Surgery, Affiliated Hospital of Qingdao University
Qingdao, China
Department of Obstetrics and Gynecology, Zhongshan Hospital
Shanghai, China
Related Publications (1)
Liu H, Yang L, Chen CY, Qian SC, Ma LY, Diao YF, Wu XY, Wu SY, Dong ZQ, Shao YF, Zhang HJ, Sun LZ, Zhu JM, Zhang JR, Li H. Management strategies and outcomes in pregnancy-related acute aortic dissection: a multicentre cohort study in China. Heart. 2024 Oct 28;110(22):1298-1306. doi: 10.1136/heartjnl-2024-324009.
PMID: 39266045DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Hong-jia Zhang, MD
Beijing Anzhen Hospital
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator of Cardiovascular Surgery
Study Record Dates
First Submitted
August 12, 2022
First Posted
August 15, 2022
Study Start
January 1, 2022
Primary Completion
July 31, 2022
Study Completion
July 31, 2022
Last Updated
September 27, 2022
Record last verified: 2022-09