Angiotensin II Pathway and Postoperative Hypoxemia

NCT05055570 | Completed Results

• 1 other identifier: 2021107X
• Study Type: observational
• Target: 88
• Locations: 1 country
• Sites: 1

Brief Summary

Acute type A aortic dissection is often accompanied by postoperative hypoxemia, the cause of which is not fully understood. Angiotensin II is an important component of the renin-angiotensin system (RAS), which has been suggested to be involved in the development of aortic dissection and pulmonary inflammation.The purpose of this study was to investigate the role and mechanism of angiotensin II pathway in postoperative hypoxemia after acute type A aortic dissection, and to provide reference for clinical application

Conditions

Aortic Dissection

Outcome Measures

Primary Outcomes (1)

• The Difference Concentrations of ANG II in Serum Between Patients With and Without Postoperative Hypoxemia.

  Blood samples were taken within 24 hours after operation to detect the contents of ANG II in serum. Postoperative hypoxemia is defined by the oxygenation index (OI), which is the ratio of arterial partial pressure of oxygen to fraction inspired oxygen (PaO2 / FiO2), of less than or equal to 200 for two consecutive times within the first 24 h after operation

  Within 24 hours after surgery

Secondary Outcomes (2)

• The Risk Factors for Postoperative Hypoxemia in Stanford Type A Acute Aortic Dissection Patients.

  up to 60 days

• Duration of Stay in the Intensive Care Unit

  up to 60 days

Study Arms (2)

Hypoxemia group

oxygenation index (OI)≤200

Other: No intervention

Non-hypoxemia group

oxygenation index (OI)\>200

Other: No intervention

Interventions

No intervention OTHER

No intervention

Hypoxemia group; Non-hypoxemia group

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients undergoing surgical treatment for acute type A aortic dissection in our hospital were selected. The age was 18 years ≤ age ≤80years, and gender was not limited. The overall study patients were divided into the hypoxemia group and non-hypoxemia group according to the presence or lack of hypoxemia after surgery.

You may qualify if:

• patients undergoing surgery for acute type A aortic dissection
• age between 18 to 80

You may not qualify if:

• perioperative severe cardiac insufficiency
• rejection of consent

Sponsors & Collaborators

• Beijing Anzhen Hospital: lead

Study Sites (1)

Anzhen hospital, Beijing

Beijing, Beijing Municipality, 100029, China

Location

Related Publications (1)

• Wang X, Ma J, Lin D, Dong X, Wu J, Bai Y, Zhang D, Gao J. The risk factors of postoperative hypoxemia in patients with Stanford type A acute aortic dissection. Medicine (Baltimore). 2023 Aug 18;102(33):e34704. doi: 10.1097/MD.0000000000034704.

  PMID: 37603505 DERIVED

MeSH Terms

Conditions

Aortic Dissection

Condition Hierarchy (Ancestors)

Dissection, Blood Vessel; Aneurysm; Vascular Diseases; Cardiovascular Diseases; Acute Aortic Syndrome; Aortic Diseases

Results Point of Contact

• Title: Dr. Jun Ma
• Organization: Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University

majun@mail.ccmu.edu.cn

13370103671

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 7 Days
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: The chief of department of anesthesiology

Study Record Dates

• First Submitted: September 7, 2021
• First Posted: September 24, 2021
• Study Start: August 12, 2021
• Primary Completion: June 1, 2022
• Study Completion: June 1, 2022
• Last Updated: January 26, 2024
• Results First Posted: January 26, 2024

Record last verified: 2023-04

Locations

CN (1)