NCT01589224

Brief Summary

Coronary MDCT (multi-detector computed tomography) has been useful screening imaging modality for the coronary artery disease. Recently, novel adipokines and hepatokines as well as various inflammatory markers have been known as direct regulators of atherosclerosis. Therefore, the investigators examine the correlation of various metabolic risk factors including adipokines and hepatokines with coronary atherosclerosis measured by coronary MDCT in apparently healthy people.

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
150

participants targeted

Target at P50-P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 24, 2012

Completed
7 days until next milestone

First Posted

Study publicly available on registry

May 1, 2012

Completed
Same day until next milestone

Study Start

First participant enrolled

May 1, 2012

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2012

Completed
Last Updated

October 14, 2015

Status Verified

April 1, 2012

Enrollment Period

3 months

First QC Date

April 24, 2012

Last Update Submit

October 12, 2015

Conditions

AtherosclerosisMetabolic Syndrome

Outcome Measures

Primary Outcomes (1)

  • relation of adipokines and hepatokines with coronary atherosclerosis measured by MDCT

    to examine the correlation of serum concentration of various adipokine such as adiponectin, resistin, A-FABP with coronary atheroslcerosis measured by MDCT as AGATSTON score, modified Gensini score

    3month

Secondary Outcomes (2)

  • relation of adipokines and hepatokines with coronary atherosclerosis measured by MDCT

    3months

  • the correlation of various inflammatory markers with coronary atherosclerosis

    3months

Study Arms (1)

Healthy people

Eligibility Criteria

Age20 Years - 80 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Apparently healthy people who underwent medical routine check up in Korea Helath Promotion Center.

You may qualify if:

  • Apparently healthy people who underwent medical routine check up in Korea Health Promotion Center.
  • age \> 20 years

You may not qualify if:

  • History of cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization)
  • Diabetes
  • Stage 2 hypertension
  • Severe renal or hepatic disease

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

korea University Guro Hospital

Seoul, South Korea

Location

MeSH Terms

Conditions

AtherosclerosisMetabolic Syndrome

Condition Hierarchy (Ancestors)

ArteriosclerosisArterial Occlusive DiseasesVascular DiseasesCardiovascular DiseasesInsulin ResistanceHyperinsulinismGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic Diseases

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

April 24, 2012

First Posted

May 1, 2012

Study Start

May 1, 2012

Primary Completion

August 1, 2012

Last Updated

October 14, 2015

Record last verified: 2012-04

Locations

KR(1)